Multiple sclerosis: MHC associations and therapeutic implications.

Abstract:

:Multiple sclerosis (MS) is an autoimmune disease with an important genetic component. The strongest genetic association is with the major histocompatibility complex (MHC) region. Several MHC alleles predispose to the disease, the most prominent of which are certain alleles in the HLA-DR2 haplotype. Functional and structural studies have helped to explain the molecular basis of these associations. Although there is currently no curative treatment for MS, an increased understanding of the disease has aided the design of immunotherapies that act on the immune system more specifically than the longstanding drugs. Many of these therapies work at the antigen-specific level, disrupting the interaction between T-cell receptors and MHC molecules that leads to disease.

journal_name

Expert Rev Mol Med

authors

Holmes S,Friese MA,Siebold C,Jones EY,Bell J,Fugger L

doi

10.1017/S1462399405008914

keywords:

subject

Has Abstract

pub_date

2005-02-14 00:00:00

pages

1-17

issue

3

issn

1462-3994

pii

S1462399405008914

journal_volume

7

pub_type

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