Abstract:
:Infants born with severe combined immune deficiencies are prone to life-threatening infections and, without treatment, do not survive beyond the first year of life. Haematopoietic stem cell transplantation from a fully matched donor offers the possibility of cure. In the absence of a suitable matched donor, haploidentical transplants from a parental donor may be undertaken, but these are associated with more complications and lower success rates. Recently, an alternative therapeutic option based on retroviral gene delivery has been used to correct X-linked severe combined immune deficiency (SCID-X1) and adenosine deaminase deficiency. Clinical trials have established that in situations where ex vivo gene transfer into haematopoietic progenitor cells confers a strong selective advantage, the procedure is a feasible alternative to haploidentical transplantation, with favourable kinetics of immune reconstitution.
journal_name
Expert Rev Mol Medjournal_title
Expert reviews in molecular medicineauthors
Qasim W,Gaspar HB,Thrasher AJdoi
10.1017/S1462399404007884keywords:
subject
Has Abstractpub_date
2004-07-02 00:00:00pages
1-15issue
13issn
1462-3994pii
S1462399404007884journal_volume
6pub_type
杂志文章,评审abstract::Methylation of the fragile X mental retardation 1 (FMR1) exon 1/intron 1 boundary positioned fragile X related epigenetic element 2 (FREE2), reveals skewed X-chromosome inactivation (XCI) in fragile X syndrome full mutation (FM: CGG > 200) females. XCI skewing has been also linked to abnormal X-linked gene expression ...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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abstract::Limb-girdle muscular dystrophy type 2A (LGMD2A) is a form of muscular dystrophy caused by mutations in calpain 3 (CAPN3). Several studies have implicated Ca2+ dysregulation as an underlying event in several muscular dystrophies, including LGMD2A. In this study we used mouse and human myotube cultures, and muscle biops...
journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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abstract::Engineered tissue derived from ocular surface stem cells (SCs) are a cutting edge biotechnology for repair and restoration of severely damaged eyes as a result of ocular surface dysfunction because of SC failure. Ex-vivo SC expansion techniques have advanced significantly since the first patients were treated in the l...
journal_title:Expert reviews in molecular medicine
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abstract::Many viruses, with distinct replication strategies, activate DNA-damage response pathways, including the lentivirus human immunodeficiency virus (HIV) and the DNA viruses Epstein-Barr virus (EBV), herpes simplex virus 1, adenovirus and SV40. DNA-damage response pathways involving DNA-dependent protein kinase, ataxia-t...
journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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abstract::Advances in molecular biology and immunology have renewed interest in the development of vaccines for the treatment or prevention of cancer. Research over the past 10 years has focused on the identification of suitable tumour antigens to use as targets for a variety of vaccine strategies. Carcinoembryonic antigen (CEA...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章
doi:10.1017/S146239940000168X
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399405009361
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399407000324
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abstract::Prader-Willi syndrome (PWS) is a neurodevelopmental disorder that arises from lack of expression of paternally inherited genes known to be imprinted and located in the chromosome 15q11-q13 region. PWS is considered the most common syndromal cause of life-threatening obesity and is estimated at 1 in 10,000 to 20,000 in...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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abstract::Ebola virus (EBOV) gained public notoriety in the last decade largely as a consequence of the highly publicized isolation of a new EBOV species in a suburb of Washington, DC, in 1989, together with the dramatic clinical presentation of EBOV infection and high case-fatality rate in Africa (near 90% in some outbreaks), ...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399404008300
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abstract::Multiple sclerosis (MS) is an autoimmune disease with an important genetic component. The strongest genetic association is with the major histocompatibility complex (MHC) region. Several MHC alleles predispose to the disease, the most prominent of which are certain alleles in the HLA-DR2 haplotype. Functional and stru...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399405008914
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abstract::Familial Alzheimer's disease (FAD) accounts for 5-10% of deaths from Alzheimer's disease (AD), and approximately 50% of these cases have been definitely linked to missense mutations in three genes, encoding the amyloid precursor protein (APP), presenilin 1 (PS1) and presenilin 2 (PS2). Of these, the vast majority of F...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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abstract::The HEDGEHOG-GLI (HH-GLI) signalling is a key pathway critical in embryonic development, stem cell biology and tissue homeostasis. In recent years, aberrant activation of HH-GLI signalling has been linked to several types of cancer, including those of the skin, brain, lungs, prostate, gastrointestinal tract and blood....
journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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abstract::Experimental and human studies have shown that proteinuria contributes to the progression of renal disease. Overexposure to filtered proteins promotes the expression and release of chemokines by tubular epithelial cells, thus leading to inflammatory cell recruitment and renal impairment. This review focuses on recent ...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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abstract::Carcinoma of the stomach is one of the most prevalent cancer types in the world today. Only a limited number of biomarkers are available for detection and prognostic evaluation of gastric cancer. New advances in identifying molecular biomarkers are essential. Two major forms of gastric cancer are distinguished accordi...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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abstract::The human brain is a highly complex organ with remarkable energy demands. Although it represents only 2% of the total body weight, it accounts for 20% of all oxygen consumption, reflecting its high rate of metabolic activity. Mitochondria have a crucial role in the supply of energy to the brain. Consequently, their de...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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abstract::Human papillomaviruses (HPVs) are ubiquitous DNA viruses that infect cutaneous and mucosal epithelia. A subset of HPVs infects the female genital tract, to induce cervical lesions that can progress to malignancy in some women. DNA from HPVs can be found in >94% of cervical carcinomas (CaCx) worldwide; this strong asso...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章
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更新日期:1998-07-03 00:00:00
abstract::Innate immune receptors play a key role in the early recognition of invading bacterial pathogens and initiate the crucial innate immune response. The diverse macrophage receptors recognise Gram-positive and Gram-negative bacteria via conserved structures on the bacterial surface and facilitate phagocytosis and/or sign...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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更新日期:2006-11-22 00:00:00