abstract::Retinal ganglion cell (RGC) axons provide the only link between the light sensitive and photon transducing neural retina and visual centers of the brain. RGC axon degeneration occurs in a number of blinding diseases and the ability to stimulate axon regeneration from surviving ganglion cells could provide the anatomic...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.320989
更新日期:2022-03-01 00:00:00
abstract::Glial cells play an important role in signal transduction, energy metabolism, extracellular ion homeostasis and neuroprotection of the central nervous system. However, few studies have explained the potential effects of exosomes from glial cells on central nervous system health and disease. In this study, the genes ex...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.320999
更新日期:2022-03-01 00:00:00
abstract::Lipid droplets (LDs) are globular subcellular structures that store neutral lipids. LDs are closely associated with the endoplasmic reticulum (ER) and are limited by a phospholipid monolayer harboring a specific set of proteins. Most of these proteins associate with LDs through either an amphipathic helix or a membran...
journal_title:Journal of cell sciencepub_type: 杂志文章
doi:10.1242/jcs.256206
更新日期:2022-03-01 00:00:00
abstract::The lipid composition of the primary cilia membrane is emerging as a critical regulator of cilia formation, maintenance and function. Here, we show that conditional deletion of the phosphoinositide 5'-phosphatase gene Inpp5e, mutation of which is causative of Joubert syndrome, in terminally developed mouse olfactory s...
journal_title:Journal of cell sciencepub_type: 杂志文章
doi:10.1242/jcs.258364
更新日期:2022-03-01 00:00:00
abstract::Septins colocalize with membrane sterol-rich regions and facilitate recruitment of cell wall synthases during wall remodeling. We show that null mutants missing an Aspergillus nidulans core septin present in hexamers and octamers (ΔaspAcdc11, ΔaspBcdc3 or ΔaspCcdc12) are sensitive to multiple cell wall-disturbing agen...
journal_title:Journal of cell sciencepub_type: 杂志文章
doi:10.1242/jcs.258336
更新日期:2022-03-01 00:00:00
abstract::Olfactory ensheathing cells (OECs) from the olfactory bulb (OB) and the olfactory mucosa (OM) have the capacity to repair nerve injury. However, the difference in the therapeutic effect between OB-derived OECs and OM-derived OECs remains unclear. In this study, we extracted OECs from OB and OM and compared the gene an...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.317986
更新日期:2022-02-01 00:00:00
abstract::The rapid formation of a glial/fibrotic scar is one of the main factors hampering axon growth after spinal cord injury. The bidirectional EphB2/ephrin-B2 signaling of the fibroblast-astrocyte contact-dependent interaction is a trigger for glial/fibrotic scar formation. In the present study, a new in vitro model was pr...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.317988
更新日期:2022-02-01 00:00:00
abstract:...
journal_title:Methods in molecular biology (Clifton, N.J.)pub_type: 杂志文章
doi:10.1007/978-1-0716-1170-8_1
更新日期:2022-01-01 00:00:00
abstract::Polymer simulations and predictive mechanistic modelling are increasingly used in conjunction with experiments to study the organization of eukaryotic chromosomes. Here we review some of the most prevalent models for mechanisms which drive different aspects of chromosome organization, as well as a recent simulation sc...
journal_title:Methods in molecular biology (Clifton, N.J.)pub_type: 杂志文章
doi:10.1007/978-1-0716-1390-0_14
更新日期:2022-01-01 00:00:00
abstract::MicroRNAs are important regulators in many eukaryotic lineages. Typical miRNAs have a length of about 22nt and are processed from precursors that form a characteristic hairpin structure. Once they appear in a genome, miRNAs are among the best-conserved elements in both animal and plant genomes. Functionally, they play...
journal_title:Methods in molecular biology (Clifton, N.J.)pub_type: 杂志文章
doi:10.1007/978-1-0716-1170-8_11
更新日期:2022-01-01 00:00:00
abstract::The 3D organization of chromatin within the nucleus enables dynamic regulation and cell type-specific transcription of the genome. This is true at multiple levels of resolution: on a large scale, with chromosomes occupying distinct volumes (chromosome territories); at the level of individual chromatin fibers, which ar...
journal_title:Methods in molecular biology (Clifton, N.J.)pub_type: 杂志文章
doi:10.1007/978-1-0716-1390-0_4
更新日期:2022-01-01 00:00:00
abstract:Background:Seroprevalence studies of coronavirus disease 2019 (COVID-19) cases, including asymptomatic and past infections, are important to estimate the scale of the disease outbreak and to establish quarantine measures. We evaluated the clinical performance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV...
journal_title:Annals of laboratory medicinepub_type: 杂志文章
doi:10.3343/alm.2022.42.1.71
更新日期:2022-01-01 00:00:00
abstract::The distribution of antibiotic resistance genes (ARGs) has been intensively studied in large-scale wastewater treatment plants and livestock sources. However, small-scale decentralized sewage treatment facilities must also be explored due to their possible direct exposure to residents. In this study, six wastewater tr...
journal_title:Frontiers of environmental science & engineeringpub_type: 杂志文章
doi:10.1007/s11783-021-1469-4
更新日期:2022-01-01 00:00:00
abstract::The mechanisms of the transplantation of neural stem cells (NSCs) in the treatment of Alzheimer's disease remain poorly understood. In this study, NSCs were transplanted into the hippocampal CA1 region of the rTg (tau P301L) 4510 mouse model, a tauopathy model that is thought to reflect the tau pathology associated wi...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.314324
更新日期:2022-01-01 00:00:00
abstract::Mechanisms of homeostatic plasticity promote compensatory changes of cellular excitability in response to chronic changes in the network activity. This type of plasticity is essential for the maintenance of brain circuits and is involved in the regulation of neural regeneration and the progress of neurodegenerative di...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.314283
更新日期:2022-01-01 00:00:00
abstract::The authors investigated the effects of respite-active music (i.e., music used for active recovery in between high-intensity exercise bouts) on psychological and psychophysiological outcomes. Participants (N = 24) made four laboratory visits for a habituation, medium- and fast-tempo music conditions, and a no-music co...
journal_title:Journal of sport & exercise psychologypub_type: 杂志文章
doi:10.1123/jsep.2019-0335
更新日期:2021-12-30 00:00:00
abstract::Structurally diverse piperazine-based compounds hybrid with thiadiazole, isatin or with sulfur/nitrogen, functionalities were synthesized. The structures of the new compounds were established based on their spectral data and elemental analysis. The physicochemical, bioactivity scores and pharmacokinetic behavior of al...
journal_title:Journal of molecular structurepub_type: 杂志文章
doi:10.1016/j.molstruc.2021.131020
更新日期:2021-12-05 00:00:00
abstract::Purpose: War metaphors are omnipresent in public and medical discourse on cancer . If some studies suggest that cancer patients may view their experiences as afight, few studies focus on the metaphors that patients create from their subjective experiences. The aim was to better understand the experience of four women ...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1971597
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Given the pressure on modern healthcare systems, eHealth can offer valuable opportunities. However, understanding the potential and challenges of eHealth in daily practice can be challenging for many general practitioners (GPs) and their staff. OBJECTIVES:To critically appraise five widely used eHealth appl...
journal_title:The European journal of general practicepub_type: 杂志文章
doi:10.1080/13814788.2021.1962845
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Acute lymphoblastic leukaemia (ALL) is often characterized by broad clinical and biological heterogeneity, as well as recurrent genetic aberrations. Despite remarkable improvements in the treatment outcome in paediatric ALL over the past several decades, it remains a leading cause of morbidity and mortality ...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1970217
更新日期:2021-12-01 00:00:00
abstract::Hybridisation is an important evolutionary mechanism to bring about novel phenotypes and may produce new hybrids with advantageous combinations of traits of industrial importance. Within the Saccharomyces genus, Saccharomyces jurei is a newly discovered species and its biotechnological potential has not yet been fully...
journal_title:Food microbiologypub_type: 杂志文章
doi:10.1016/j.fm.2021.103838
更新日期:2021-12-01 00:00:00
abstract::Purpose: Current study looked into caregiving process of those dealing with family members suffering from Parkinson's disease, within the changing social milieu in India. It aimed to understand the experiential and existential impact on the lifeworld of caregivers.Method: Narrative interviews of 10 female caregivers r...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1967263
更新日期:2021-12-01 00:00:00
abstract::There is some evidence supporting an association between Cullin-5 (CUL5) and cancer, but no research using pan-cancer analysis has been conducted previously. We therefore investigated the oncogenic role of CUL5 in 33 tumors from the Gene Expression Omnibus and The Cancer Genome Atlas databases. Many cancers reduce CUL...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1940042
更新日期:2021-12-01 00:00:00
abstract::Heat stress in poultry is deleterious to productive performance. Chlorogenic acid (CGA) exerts antibacterial, anti-inflammatory, and antioxidant properties. This study was conducted to evaluate the effects of dietary supplemental CGA on the intestinal health and cecal microbiota composition of young hens challenged wi...
journal_title:Animal science journal = Nihon chikusan Gakkaihopub_type: 杂志文章
doi:10.1111/asj.13619
更新日期:2021-12-01 00:00:00
abstract::This study aims to investigate the morphology and distribution of mitochondria, spindles, and chromosomes in oocytes of aged mice and examine the effects of SRT1720 on oocyte maturation. C57BL/6J mice were divided into young (4-8 weeks) and aged groups (48-52 weeks). In vitro maturation media contained (0.05, 0.1, and...
journal_title:Animal science journal = Nihon chikusan Gakkaihopub_type: 杂志文章
doi:10.1111/asj.13608
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Immunoglobulin A nephropathy (IgAN) is the most common cause of glomerulonephritis worldwide, and the optimal approach to its treatment remains a significant challenge. METHODS:We did a prospective, randomized, open-labeled, multicenter, controlled trial, comprised of 3-month run-in, 12-month treatment, and...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1963775
更新日期:2021-12-01 00:00:00
abstract::Most populations around the world are ageing. The proportion of older adults in the population is larger and is growing more rapidly in rural communities than in urban areas. Longevity increases the risk of frailty. Our aim was to explore how single-living frail older adults experience living with frailty in everyday ...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2021.1957569
更新日期:2021-12-01 00:00:00
abstract:...
journal_title:Channels (Austin, Tex.)pub_type: 杂志文章
doi:10.1080/19336950.2021.1961459
更新日期:2021-12-01 00:00:00
abstract::The chronic inflammation operates as one of the critical causes of cervical cancer. Activation of HMGB1/RAGE axis could induce the inflammation and lead to multiple types of cancer. However, whether the HMGB1/RAGE axis could affect the development of cervical cancer by regulating the inflammation is unclear. Here, we ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1957750
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Atherosclerotic renal artery stenosis (ARAS) is frequently related to ischemic nephropathy, secondary hypertension, and end-stage renal failure. Thus, this study aimed to explore whether certain circulating long noncoding RNAs (lncRNAs) may be used as potential specific ARAS biomarkers. METHODS:In the prese...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1956537
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Rosai-Dorfman disease (RDD) is a benign and rare non-Langerhans cell histiocytic proliferative disorder. Laryngeal involvement is an unusual site of extranodal involvement of RDD. Laryngeal RDD can cause life-threatening airway obstruction that requires effective control of the disease. In this...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2021.1941552
更新日期:2021-12-01 00:00:00
abstract::Psychological distress scale is highly recommended for cancer patients' care. Several psychological scales have been implemented in cancer outpatient clinics. However, the use of the psychological distress scale, particularly distress thermometer (DT), in the inpatient has not been reported. In this study, we report t...
journal_title:The Libyan journal of medicinepub_type: 杂志文章
doi:10.1080/19932820.2021.1957199
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:The roots of Tagetes lucida Cav. (Asteraceae) have antioxidant and antimicrobial properties. OBJECTIVE:This study aimed to examine the hepatoprotective effects of T. lucida roots ethanol extract (TLRE) using carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. MATERIALS AND METHODS:The active ingredien...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1949024
更新日期:2021-12-01 00:00:00
abstract::Coronavirus disease (COVID-19) has forced the urgent lockdown of schools and colleges worldwide. To ensure the continuity of education a shift from traditional teaching to e-learning was required. This study aims to identify factors that affect students' satisfaction and continued intention towards e-learning. A quest...
journal_title:Medical education onlinepub_type: 杂志文章
doi:10.1080/10872981.2021.1961348
更新日期:2021-12-01 00:00:00
abstract::Gastrointestinal microbiota play a key role in the nutrients digestion and hence maintaining animal health and welfare. The diet offered to the animals in captivity may differ considerably from that on natural pastures. In a stabled maintenance system, horses have a limited choice of habitat and feed. Time spend for f...
journal_title:Animal science journal = Nihon chikusan Gakkaihopub_type: 杂志文章
doi:10.1111/asj.13603
更新日期:2021-12-01 00:00:00
abstract::Digital rectal examination (DRE) is routinely performed as part of a urology clinical assessment in patients with a clinical suspicion of prostate cancer. An abnormal DRE or a raised prostate specific antigen (PSA) level are part of the criteria for primary care referral to secondary care due to a suspicion of prostat...
journal_title:The aging male : the official journal of the International Society for the Study of the Aging Malepub_type: 杂志文章
doi:10.1080/13685538.2020.1786047
更新日期:2021-12-01 00:00:00
abstract:INTRODUCTION:Prognosis of survivors from cardiac arrest is generally poor. Acute kidney injury (AKI) is a common finding in these patients. In general, AKI is well characterized as a marker of adverse outcome. In-hospital cardiac arrest (IHCA) represents a special subset of cardiac arrest scenarios with differential pr...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1956538
更新日期:2021-12-01 00:00:00
abstract::Extracellular vesicles (EVs) are nano-sized vesicles secreted actively by numeorus cells and have fundamental roles in intercellular communication through shuttling functional RNAs. This study sets out to elucidate the role of microRNA-26a (miR-26a) shuttled by EVs derived from adipose-derived mesenchymal stem cells (...
journal_title:Adipocytepub_type: 杂志文章
doi:10.1080/21623945.2021.1938829
更新日期:2021-12-01 00:00:00
abstract::Traumatic tracheal stenosis (TS) is a serious respiratory disease characterized by hyperplasia of airway granulation. Plumbagin (PLB) is a natural naphthoquinone component with anti-fibrotic properties. This research aimed to explore the roles of PLB in alleviating TS and the underlying mechanisms. For in vitro studie...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1954580
更新日期:2021-12-01 00:00:00
abstract::In this paper, a progressive global perception and local polishing (PCPLP) network is proposed to automatically segment the COVID-19-caused pneumonia infections in computed tomography (CT) images. The proposed PCPLP follows an encoder-decoder architecture. Particularly, the encoder is implemented as a computationally ...
journal_title:Pattern recognitionpub_type: 杂志文章
doi:10.1016/j.patcog.2021.108168
更新日期:2021-12-01 00:00:00