microRNA-26a shuttled by extracellular vesicles secreted from adipose-derived mesenchymal stem cells reduce neuronal damage through KLF9-mediated regulation of TRAF2/KLF2 axis.

abstract：:Orexin A (OX) is a small excitatory neuropeptide hormone that stimulates feeding, wakefulness and energy expenditure via a pair of G-coupled protein receptors, namely orexin receptor-1 (OXR1) and orexin receptor-2 (OXR2). OX-deficient mice are sensitive to obesity despite being hypophagic. The obesogenic effect of OX-...

journal_title：Adipocyte

authors： Sellayah D,Sikder D

更新日期：2012-01-01 00:00:00

abstract：:Cardiotrophin-1 (CT-1) is a member of the gp130 family of cytokines. In a recent study we examined the metabolic features of ct-1 null mice and the effects on body composition, glucose and lipid metabolism of acute and chronic administration of recombinant CT-1. Our data revealed that CT-1 is a key regulator of energy...

journal_title：Adipocyte

authors： Moreno-Aliaga MJ,Romero-Lozano MA,Castaño D,Prieto J,Bustos M

更新日期：2012-04-01 00:00:00

abstract：:Angiopoietin-like 4 (Angptl4) is a secreted protein modulating triacylglycerol homeostasis. Its transcription is induced by glucocorticoids, which act to elevate circulating Angptl4 levels during fasting. In investigating the role of Angptl4 in glucocorticoid action, we identified that in addition to its known ability...

journal_title：Adipocyte

authors： Koliwad SK,Gray NE,Wang JC

更新日期：2012-07-01 00:00:00

abstract：:Brown adipose tissue (BAT), an important endocrine organ long known for thermogenesis and energy consumption, has received much attention in recent years for its potential to combat obesity. In general, BAT can enhance metabolism and improve overall health. Our recent work demonstrates the ability of embryonic BAT tra...

journal_title：Adipocyte

authors： Gunawardana SC

更新日期：2012-10-01 00:00:00

abstract：:Epigenetics generates a considerable interest in the field of research on complex traits, including obesity and diabetes. Recently, we reported a number of epipolymorphisms in the placental leptin and adiponectin genes associated with maternal hyperglycemia during pregnancy. Our results suggest that DNA methylation co...

journal_title：Adipocyte

authors： Houde AA,Hivert MF,Bouchard L

更新日期：2013-01-01 00:00:00

abstract：:In tumors, cross talk between malignant and non-malignant cells (stroma) influences tumor growth, angiogenesis and metastasis. Stromal cells in tumors typically include vascular cells, fibroblasts and a heterogeneous population of inflammatory cells. Adipocytes may also be present. Adipose tissue is perhaps the least ...

journal_title：Adipocyte

authors： Wagner M,Dudley AC

更新日期：2013-04-01 00:00:00

abstract：:Dedifferentiated fat cells (DFAT cells) are derived from lipid-containing (mature) adipocytes, which possess the ability to symmetrically or asymmetrically proliferate, replicate, and redifferentiate/transdifferentiate. Robust cell isolation and downstream culture methods are needed to isolate large numbers of DFAT ce...

journal_title：Adipocyte

authors： Wei S,Du M,Jiang Z,Duarte MS,Fernyhough-Culver M,Albrecht E,Will K,Zan L,Hausman GJ,Elabd EM,Bergen WG,Basu U,Dodson MV

更新日期：2013-07-01 00:00:00

abstract：:ZBED6 was identified as a transcription factor that affects muscle mass and fat deposition in pigs. Mechanisms mediating effects on fat mass are unclear. The objective was to determine the effect of ZBED6 mRNA knockdown on 3T3-L1 preadipocyte differentiation and gene expression. Differentiation was associated with inc...

journal_title：Adipocyte

authors： Zhang W,Cline MA,Liu D,Gilbert ER

更新日期：2013-10-01 00:00:00

abstract：:Obesity-associated insulin resistance is accompanied by an alteration in the Th1/Th2 balance in adipose tissue. T-bet (Tbx21) is an immune cell transcription factor originally described as the master regulator of Th1 cell development, although is now recognized to have a role in both the adaptive and innate immune sys...

journal_title：Adipocyte

authors： Stolarczyk E,Lord GM,Howard JK

更新日期：2014-01-01 00:00:00

abstract：:Obesity is a major public health concern and a strong risk factor for insulin resistance, type 2 diabetes mellitus (T2DM), and cardiovascular disease. The last two decades have seen a reconsideration of the role of white adipose tissue (WAT) in whole body metabolism and insulin action. Adipose tissue-derived cytokines...

journal_title：Adipocyte

authors： Knights AJ,Funnell AP,Pearson RC,Crossley M,Bell-Anderson KS

更新日期：2014-04-01 00:00:00

abstract：:There are many unanswered questions related to the heterogeneity of adipose tissue depots and the paucity of their function, development, and organization at the cellular level. Much effort has been directed at studying white adipose tissue (WAT), the driver of obesity and the associated metabolic disease. In recent y...

journal_title：Adipocyte

authors： Kolonin MG

更新日期：2014-04-01 00:00:00

abstract：:Obesity-associated insulin resistance has long been linked to both increased adipocyte oxidative stress as well as the presence of inflammatory changes in adipose tissue, including the infiltration and activation of tissue-resident macrophages. In order to investigate the connections between obesity-associated oxidati...

journal_title：Adipocyte

authors： Frohnert BI,Bernlohr DA

更新日期：2014-07-01 00:00:00

abstract：:Circulating adipokines are associated with physiological and pathophysiological processes in both obesity and pregnancy. Obesity in pregnancy increases the risk of pregnancy complications and the majority of research uses body mass index (BMI) to assess fatness. Specific fat compartments are associated with obesity-in...

journal_title：Adipocyte

authors： Ozias MK,Li S,Hull HR,Brooks WM,Carlson SE

更新日期：2014-10-30 00:00:00

abstract：:The revelation of leptin action mechanisms has led to various attempts to establish the association of polymorphisms in the leptin gene with obesity-related phenotypes. But, outcomes have been contradicting, which made the information on the role of the leptin gene in regulating the mechanism of pathophysiology of obe...

journal_title：Adipocyte

authors： Dasgupta S,Salman M,Siddalingaiah LB,Lakshmi GL,Xaviour D,Sreenath J

更新日期：2014-12-20 00:00:00

abstract：:With adipose-derived stem cells being in the focus of research in regenerative medicine, the need arises for fast reliable cultivation protocols. We have tested the cultivation of human adipose-derived stem cells in endothelial cell growth medium prior to induction and differentiation, against the long-established use...

journal_title：Adipocyte

authors： Storck K,Ell J,Regn S,Rittler-Ungetüm B,Mayer H,Schantz T,Müller D,Buchberger M

更新日期：2015-01-20 00:00:00

abstract：:Fat grafting popularity continues to rise among plastic surgeons. As a soft tissue filler, adipose tissue had many desirable attributes: it is easy to obtain, autologous, and may reintegrate into recipient sites. However, fat grafting is clinically plagued by unpredictable resorption rates, thus there is much interest...

journal_title：Adipocyte

authors： Gause TM 2nd,Kling RE,Sivak WN,Marra KG,Rubin JP,Kokai LE

更新日期：2014-12-10 00:00:00

abstract：:The adipose cell-size distribution is a quantitative characterization of adipose tissue morphology. At a population level, the adipose cell-size distribution is insulin-sensitivity dependent, and the observed correlation between obesity and insulin resistance is believed to play a key role in the metabolic syndrome. C...

journal_title：Adipocyte

authors： Li Y,Gaillard JR,McLaughlin T,Sørensen TIa,Periwal V

更新日期：2015-04-21 00:00:00

abstract：:Obesity and diabetes are major health concerns worldwide. Western diets, often calorically rich, paired with sedentary habits are driving the current worldwide epidemic of pediatric and adult obesity. In addition, age related energy imbalances lead to increased adiposity and metabolic disorders later in life, making t...

journal_title：Adipocyte

authors： Ma X,Xu L,Mueller E

更新日期：2015-05-07 00:00:00

abstract：:Chronic, low level treatment with a carbon monoxide releasing molecule (CO-RM), CORM-A1, has been shown to prevent the development of obesity in response to a high fat diet. The objective of this study was to test the hypothesis that chronic, low level treatment with this CO-RM can reverse established obesity via a me...

journal_title：Adipocyte

authors： Hosick PA,AlAmodi AA,Hankins MW,Stec DE

更新日期：2015-08-07 00:00:00

abstract：:Adipose tissue fatty acid storage varies according to sex, adipose tissue depot and degree of fat gain. However, the mechanism(s) for these variations is not completely understood. We recently published findings based on the glycerol 3-phosphate acyltransferase (GPAT) enzyme activity assay we optimized for use with hu...

journal_title：Adipocyte

authors： Morgan-Bathke M,Chen L,Oberschneider E,Harteneck D,Jensen MD

更新日期：2015-07-17 00:00:00

abstract：:Obesity has reached epidemic proportions, leading to severe associated pathologies such as insulin resistance, cardiovascular disease, cancer and type 2 diabetes. Adipose tissue has become crucial due to its involvement in the pathogenesis of obesity-induced insulin resistance, and traditionally white adipose tissue h...

journal_title：Adipocyte

authors： Calderon-Dominguez M,Mir JF,Fucho R,Weber M,Serra D,Herrero L

更新日期：2015-12-10 00:00:00

abstract：:Adipose tissue is classified as either white (WAT) or brown (BAT) and differs not only by anatomical location but also in function. WAT is the main source of stored energy and releases fatty acids in times of energy demand, whereas BAT plays a role in regulating non-shivering thermogenesis and oxidizes fatty acids rel...

journal_title：Adipocyte

authors： Ramos SV,Turnbull PC,MacPherson RE

更新日期：2016-03-10 00:00:00

abstract：:The adipocyte-derived hormone adiponectin mediates beneficial cardiometabolic effects, and hypoadiponectinemia is a biomarker for increased metabolic and cardiovascular risk. Indeed, circulating adiponectin decreases in obesity and insulin-resistance, likely because of impaired production from white adipose tissue (WA...

journal_title：Adipocyte

authors： Scheller EL,Burr AA,MacDougald OA,Cawthorn WP

更新日期：2016-03-22 00:00:00

abstract：:To assess whether there is any clinical significance for determining the normal range of subcutaneous abdominal fat area, we compared fat area with insulin sensitivity. Visceral and subcutaneous abdominal fat area the L4-L5 thoracic level was determined by computed tomography (CT). Plasma glucose and insulin levels we...

journal_title：Adipocyte

authors： Niijima K,Shimoda Y,Saito T,Yamada E,Niijima Y,Okada S,Yamada M

更新日期：2016-09-27 00:00:00

abstract：:Predictors of weight loss responses are not well-defined. We hypothesized that adipose tissue phenotypic features related to remodeling would be associated with bariatric surgery weight loss responses. Visceral and subcutaneous adipose tissues collected from patients during bariatric surgery were studied with flow cyt...

journal_title：Adipocyte

authors： Muir LA,Baker NA,Washabaugh AR,Neeley CK,Flesher CG,DelProposto JB,Geletka LM,Ghaferi AA,Finks JF,Singer K,Varban OA,Lumeng CN,O'Rourke RW

更新日期：2017-04-03 00:00:00

abstract：:A major focus of biogerontology is elucidating the role(s) of the endocrine system in aging and the accumulation of age-related diseases. Endocrine control of mammalian longevity was first reported in Ames dwarf (Prop1df) mice, which are long-lived due to a recessive Prop1 loss-of-function mutation resulting in defici...

journal_title：Adipocyte

authors： Darcy J,McFadden S,Bartke A

更新日期：2017-04-03 00:00:00

abstract：:Human adipose-derived stem cells (ASC) have been shown to differentiate into mature adipocytes and to play an important role in creating the vasculature, necessary for white adipose tissue to function. To study the stimulatory capacity of ASC on endothelial progenitor cells we used a commercially available co-culture ...

journal_title：Adipocyte

authors： Ell J,Regn S,Buchberger AM,von Bomhard A,Stark T,Schantz JT,Storck K

更新日期：2017-01-02 00:00:00

abstract：:Understanding development and maintenance of beige adipocytes provide exciting insights in establishing novel therapies against obesity and obesity-associated disorders. Lysine-specific demethylase 1 (Lsd1) is an epigenetic eraser required for differentiation and function of adipocytes. Lsd1 is involved in early commi...

journal_title：Adipocyte

authors： Duteil D,Tosic M,Schüle R

更新日期：2017-10-02 00:00:00

abstract：:Obesity-associated low-grade inflammation underlies insulin resistance and associated metabolic comorbidities, such as type 2 diabetes (T2D) and nonalcoholic fatty liver disease. Excessive ectopic fat deposition in obesity causes disorders of energy homeostasis and low-grade chronic inflammation in metabolic tissues. ...

journal_title：Adipocyte

authors： Xu L,Ota T

更新日期：2018-01-01 00:00:00

abstract：:Stromal/stem cell differentiation is controlled by a vast array of regulatory mechanisms. Included within these are methods of mRNA gene regulation that occur at the level of epigenetic, transcriptional, and/or posttranscriptional modifications. Current studies that evaluate the posttranscriptional regulation of mRNA ...

journal_title：Adipocyte

authors： Martin EC,Qureshi AT,Llamas CB,Burow ME,King AG,Lee OC,Dasa V,Freitas MA,Forsberg JA,Elster EA,Davis TA,Gimble JM

更新日期：2018-01-01 00:00:00