Abstract：
:Mechanisms of homeostatic plasticity promote compensatory changes of cellular excitability in response to chronic changes in the network activity. This type of plasticity is essential for the maintenance of brain circuits and is involved in the regulation of neural regeneration and the progress of neurodegenerative disorders. One of the most studied homeostatic processes is synaptic scaling, where global synaptic adjustments take place to restore the neuronal firing rate to a physiological range by the modulation of synaptic receptors, neurotransmitters, and morphology. However, despite the comprehensive literature on the electrophysiological properties of homeostatic scaling, less is known about the structural adjustments that occur in the synapses and dendritic tree. In this study, we performed a meta-analysis of articles investigating the effects of chronic network excitation (synaptic downscaling) or inhibition (synaptic upscaling) on the dendritic spine density of neurons. Our results indicate that spine density is consistently reduced after protocols that induce synaptic scaling, independent of the intervention type. Then, we discuss the implication of our findings to the current knowledge on the morphological changes induced by homeostatic plasticity.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Moulin TC,Rayêe D,Schiöth HBdoi
10.4103/1673-5374.314283keywords:
["chronic inhibition","chronic stimulation","dendritic spines","downscaling","excitability","homeostatic plasticity","spine density","synaptic scaling","upscaling"]subject
Has Abstractpub_date
2022-01-01 00:00:00pages
20-24issue
1eissn
1673-5374issn
1876-7958pii
NeuralRegenRes_2022_17_1_20_314283journal_volume
17pub_type
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