Fast desensitization of acetylcholine receptors induced by a spider toxin.

abstract：:Neurotransmitter and hormone regulation of cellular function can result from a concomitant stimulation of different signaling pathways. Signaling cascades are strongly regulated during disease and are often targeted by commonly used drugs. Crosstalk of different signaling pathways can have profound effects on the regu...

journal_title：Channels (Austin, Tex.)

authors： Lopes CM,Remon JI,Matavel A,Sui JL,Keselman I,Medei E,Shen Y,Rosenhouse-Dantsker A,Rohacs T,Logothetis DE

更新日期：2007-03-01 00:00:00

abstract：:Studies suggest that Ktr/Trk/HKT-type transporters have evolved from multiple gene fusions of simple K(+) channels of the KcsA type into proteins that span the membrane at least eight times. Several positively charged residues are present in the eighth transmembrane segment, M2(D), in the transporters but not K(+) cha...

journal_title：Channels (Austin, Tex.)

authors： Kato N,Akai M,Zulkifli L,Matsuda N,Kato Y,Goshima S,Hazama A,Yamagami M,Guy HR,Uozumi N

更新日期：2007-05-01 00:00:00

abstract：:mu-Conotoxin GIIIA (mu-CTX) is a high-affinity ligand for the outer vestibule of selected isoforms of the voltage-gated Na(+) channel. The detailed bases for the toxin's high affinity binding and isoform selectivity are unclear. The outer vestibule is lined by four pore-forming (P) loops, each with an acidic residue n...

journal_title：Channels (Austin, Tex.)

authors： Choudhary G,Aliste MP,Tieleman DP,French RJ,Dudley SC Jr

更新日期：2007-09-01 00:00:00

abstract：:Phosphatidylinositol bisphosphate (PIP(2)) is the most abundant phosphoinositide in the plasma membrane of cells and its interaction with many ion channel proteins has proven to be a critical factor enabling ion channel gating. All members of the inwardly rectifying potassium (Kir) channel family depend on PIP(2) for ...

journal_title：Channels (Austin, Tex.)

authors： Jin T,Sui JL,Rosenhouse-Dantsker A,Chan KW,Jan LY,Logothetis DE

更新日期：2008-01-01 00:00:00

abstract：:Recent evidence strongly suggests that both central and peripheral T-type Ca(2+) channels enhance somatic and visceral nociceptive inputs, as well as that regulation of T-type Ca(2+) channel function can result in significant changes of pain threshold in a variety of animal models. Therefore, T-type Ca(2+) channels in...

journal_title：Channels (Austin, Tex.)

authors： Todorovic SM,Jevtovic-Todorovic V

更新日期：2007-07-01 00:00:00

abstract：The KcsA potassium channel from Streptomyces lividans is one of the most actively studied ion channels. However, there are still unresolved issues about its gating mechanism in vivo because the channel is only activated by highly acidic intracellular pH, meaning that it will be mostly inactive in its host environment. ...

journal_title：Channels (Austin, Tex.)

authors： Paynter JJ,Sarkies P,Andres-Enguix I,Tucker SJ

更新日期：2008-11-01 00:00:00

abstract：A channelopathy mutation in segment IIS6 of Ca(V)1.4 (I745T) has been shown to cause severe visual impairment by shifting the activation and inactivation curves to more hyperpolarized voltages and slowing activation and inactivation kinetics. A similar gating phenotype is caused by the corresponding mutation, I781T, in...

journal_title：Channels (Austin, Tex.)

authors： Stary A,Kudrnac M,Beyl S,Hohaus A,Timin EN,Wolschann P,Guy HR,Hering S

更新日期：2008-05-01 00:00:00

abstract：:Extracellular acidification regulates the biophysical properties of many voltage-gated potassium channels. Most often acidic pH reduces peak current and enhances current decay during depolarization. Here we review recent data from single channel and voltage clamp fluorimetry studies, which suggest that these two effec...

journal_title：Channels (Austin, Tex.)

authors： Claydon TW,Kehl SJ,Fedida D

更新日期：2008-03-01 00:00:00

abstract：:Numerous structurally and functionally unrelated drugs block the hERG potassium channel. HERG channels are involved in cardiac action potential repolarization, and reduced function of hERG lengthens ventricular action potentials, prolongs the QT interval in an electrocardiogram, and increases the risk for potentially ...

journal_title：Channels (Austin, Tex.)

authors： Priest BT,Bell IM,Garcia ML

更新日期：2008-03-01 00:00:00

abstract：:P2X(7) receptors are non-selective cation channels gated by extracellular ATP. Prolonged stimulation of the P2X(7) receptor leads to an increase in cell permeability, cytokine release and apoptosis/necrosis. Application of PIP(2) to inside-out patches strongly activated all homomeric members of the P2X receptor family...

journal_title：Channels (Austin, Tex.)

authors： Zhao Q,Yang M,Ting AT,Logothetis DE

更新日期：2007-01-01 00:00:00

abstract：:The annual meeting of the French Ion Channels Society, held on the Mediterranean coast of France, is aimed at gathering the international scientific community working on various aspects of ion channels. In this report of the 19th edition of the meeting, held in September 2008, we summarize selected symposia on aspects...

journal_title：Channels (Austin, Tex.)

authors： Bichet D,Duranton C,Hirbec H,Kellenberger S,Mérot J,Ulmann L,Van Coppenolle F

更新日期：2009-01-01 00:00:00

abstract：:Alternative splicing is known to generate multiple functionally distinct calcium channel variants that exhibit unique spatial and temporal expression patterns. In humans, naturally occurring mutations in genes encoding calcium channel pore forming alpha(1)-subunits are associated with several severe hereditary disorde...

journal_title：Channels (Austin, Tex.)

authors： Adams PJ,Garcia E,David LS,Mulatz KJ,Spacey SD,Snutch TP

更新日期：2009-03-01 00:00:00

abstract：:Depolarization-induced entry of divalent ions into skeletal muscle has been attributed to a process termed Excitation-Coupled Ca(2+) Entry (ECCE), which is hypothesized to require the interaction of the ryanodine receptor (RyR1), the L-type Ca(2+) channel (DHPR) and another unidentified cation channel. Thus, ECCE is a...

journal_title：Channels (Austin, Tex.)

authors： Bannister RA,Beam KG

更新日期：2009-07-01 00:00:00

abstract：:Somatodendritic A-type (I(A)) voltage-gated K(+) (K(V)) channels are key regulators of neuronal excitability, functioning to control action potential waveforms, repetitive firing and the responses to synaptic inputs. Rapidly activating and inactivating somatodendritic I(A) channels are encoded by K(V)4 alpha subunits ...

journal_title：Channels (Austin, Tex.)

authors： Marionneau C,LeDuc RD,Rohrs HW,Link AJ,Townsend RR,Nerbonne JM

更新日期：2009-07-01 00:00:00

abstract：:Voltage-activated Ca(2+) channels comprise complexes of a pore-forming Ca(V)alpha(1) and auxiliary subunits Ca(V)beta, Ca(V)alpha(2)delta and sometimes Ca(V)gamma. The intracellular Ca(V)beta subunit assists in trafficking and surface expression of the Ca(V)alpha(1) subunit and can modulate biophysical properties of t...

journal_title：Channels (Austin, Tex.)

authors： Kuhn S,Knirsch M,Rüttiger L,Kasperek S,Winter H,Freichel M,Flockerzi V,Knipper M,Engel J

更新日期：2009-09-01 00:00:00

abstract：:Purkinje neurons fire spontaneous action potentials at ∼50 spikes/sec and generate more than 100 spikes/sec during cerebellum-mediated behaviors. Many voltage-gated channels, including Ca channels, can inactivate and/or facilitate with repeated stimulation, raising the question of how these channels respond to regular...

journal_title：Channels (Austin, Tex.)

authors： Benton MD,Raman IM

更新日期：2009-11-01 00:00:00

abstract：:Direct binding of cGMP or cAMP to tetrameric cyclic nucleotide-gated (CNG) channels will normally promote the open (conductive) conformation. However, the catfish CNGA2 subtype exhibits bimodal agonism, whereby open probability (P(o)) increases with initial cGMP binding events ("pro" action) but decreases with subsequ...

journal_title：Channels (Austin, Tex.)

authors： Chan KS,Young EC

更新日期：2009-11-01 00:00:00

abstract：:The SecY channel serves to transport proteins across the bacterial inner membrane. The closed channel is impermeable to small molecules by means of a plug domain and a hydrophobic pore, consisting of six conserved isoleucine residues. The substitution of these isoleucines by asparagine leads to the selective conductan...

journal_title：Channels (Austin, Tex.)

authors： Dalal K,Bao H,Duong F

更新日期：2010-03-01 00:00:00

abstract：:The Na(+)-Ca(2+) exchanger (NCX) is a plasma membrane protein particularly abundant in cardiomyocytes where it plays a prominent role in Ca(2+) extrusion. In addition to being transported, cytoplasmic Ca(2+) and Na(+) regulate NCX activity by activating and inhibiting ion transport, respectively. There are two Ca(2+) ...

journal_title：Channels (Austin, Tex.)

authors： Ottolia M,Nicoll DA,John S,Philipson KD

更新日期：2010-05-01 00:00:00

abstract：:Ca(V)2.2 voltage-gated calcium channels play a key role in the gating of transmitter release at presynaptic terminals. Recently we used mass spectrometry (MS) to analyze the protein complex associated with Ca(V)2.2 in purified presynaptic terminal membranes. A number of known and new Ca(V)2.2-associated proteins were ...

journal_title：Channels (Austin, Tex.)

authors： Gardezi SR,Taylor P,Stanley EF

更新日期：2010-01-01 00:00:00

abstract：:Membrane currents and resting potential of isolated primary mouse articular chondrocytes maintained in monolayer cell culture for 1-9 days were recorded using patch clamp methods. Quantitative RT-PCR showed that the most abundantly expressed transcript of voltage-gated K(+) channels was for K(V)1.6, and immunological ...

journal_title：Channels (Austin, Tex.)

authors： Clark RB,Hatano N,Kondo C,Belke DD,Brown BS,Kumar S,Votta BJ,Giles WR

更新日期：2010-05-01 00:00:00

abstract：:Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmogenic disease that manifests as syncope or sudden death during high adrenergic tone in the absence of structural heart defects. It is primarily caused by mutations in the cardiac ryanodine receptor (RyR2). The mechanism by which these mutation...

journal_title：Channels (Austin, Tex.)

authors： Jiang D,Jones PP,Davis DR,Gow R,Green MS,Birnie DH,Chen SR,Gollob MH

更新日期：2010-07-01 00:00:00

abstract：:K(V)1.2 is a potassium channel protein whose electrophysiological properties, including an oxygen sensing response, are modulated by auxiliary beta subunits. The beta subunits are homologous to oxidoreductases, supporting a hypothesis that the coupling of the two subunits helps connect the redox state of the cell to t...

journal_title：Channels (Austin, Tex.)

authors： Natarajan S,Mashl RJ,Jakobsson E

更新日期：2010-09-01 00:00:00

abstract：:Our interest was drawn to the I-II loop of Cav3 channels for two reasons:  one, transfer of the I-II loop from a high voltage-activated channel (Cav2.2) to a low voltage-activated channel (Cav3.1) unexpectedly produced an ultra-low voltage activated channel; and two, sequence variants of the I-II loop found in childho...

journal_title：Channels (Austin, Tex.)

authors： Perez-Reyes E

更新日期：2010-11-01 00:00:00

abstract：:The regulation of intracellular Ca (2+) is essential for cardiomyocyte function, and alterations in proteins that regulate Ca (2+) influx have dire consequences in the diseased heart. Low voltage-activated, T-type Ca (2+) channels are one pathway of Ca (2+) entry that is regulated according to developmental stage and ...

journal_title：Channels (Austin, Tex.)

authors： Cribbs L

更新日期：2010-11-01 00:00:00

abstract：:The effects of anesthetics and analgesics on ion channels have been the subject of intense research since recent reports of direct actions of anesthetic molecules on ion channel proteins.  It is now known that ligand-gated channels, particularly γ-amino-butyric acid (GABAA) and N-methyl-D-aspartate (NMDA) receptors, p...

journal_title：Channels (Austin, Tex.)

authors： Orestes P,Todorovic SM

更新日期：2010-11-01 00:00:00

abstract：:Four glutamate residues residing at corresponding positions within the four conserved membrane-spanning repeats of L-type Ca(2+) channels are important structural determinants for the passage of Ca(2+) across the selectivity filter. Mutation of the critical glutamate in Repeat III in the a 1S subunit of the skeletal L...

journal_title：Channels (Austin, Tex.)

authors： Bannister RA,Beam KG

更新日期：2011-05-01 00:00:00

abstract：:The type II secretion system (T2SS) is a large macromolecular complex spanning the inner and outer membranes of many gram-negative bacteria. The T2SS is responsible for the secretion of virulence factors such as cholera toxin (CT) and heat-labile enterotoxin (LT) from Vibrio cholerae and enterotoxigenic Escherichia co...

journal_title：Channels (Austin, Tex.)

authors： Reichow SL,Korotkov KV,Gonen M,Sun J,Delarosa JR,Hol WG,Gonen T

更新日期：2011-05-01 00:00:00

abstract：:Mechanisms underlying K(v)4 (Shal type) potassium channel macroscopic (open state) inactivation and recovery are unknown, as are mechanisms by which KChIP2 isoforms modulate these two processes. In a recent study (Xenopus oocytes, 2 microelectrode voltage clamp) we demonstrated that: i) Partial deletion of the K(v)4.3...

journal_title：Channels (Austin, Tex.)

authors： Hovind LJ,Campbell DL

更新日期：2011-05-01 00:00:00

abstract：:Invertebrate L-type calcium channel, LCa(v) 1, isolated from the pond snail Lymnaea stagnalis is nearly indistinguishable from mammalian Ca(v) 1.2 (α1C) calcium channel in biophysical characteristics observed in vitro. These L-type channels are likely constrained within a narrow range of biophysical parameters to perf...

journal_title：Channels (Austin, Tex.)

authors： Senatore A,Boone A,Lam S,Dawson TF,Zhorov B,Spafford JD

更新日期：2011-03-01 00:00:00