当前位置： SCI文献检索 > JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION期刊下所有文献 > Effects of ovary suppression by a long-acting GnRH-agonist on circulating GH, insulin-like growth factor I and insulin levels in women with polycystic ovary syndrome.

Effects of ovary suppression by a long-acting GnRH-agonist on circulating GH, insulin-like growth factor I and insulin levels in women with polycystic ovary syndrome.

Abstract：

:Our aim was to investigate the effect of GnRH-agonist (GnRH-a) induced suppression of plasma sex steroids on serum GH, insulin like growth factor-I (IGF-I) and insulin levels after an oral glucose load (OGTT) in women with polycystic ovary syndrome (PCOS). Serum insulin, GH and IGF-I levels during a 75-g 4-h OGTT were measured in 3 nonobese and 7 obese hyperandrogenic women with PCOS and normal glucose tolerance before and after 10 weeks of treatment with the GnRH-a triptorelin (3,75 mg im every 28 days). Basal estrogen and androgen levels were also measured at time 0 of the first and the second OGTT. After the therapy serum estrogens and androgens were significantly suppressed. Body weight remained unchanged. Basal GH significantly increased after the treatment while fasting IGF-I and insulin levels decreased from (mean +/- SE) 349.3 +/- 31.8 to 278.7 +/- 33.2 ng/mL and from 22.4 +/- 4.1 to 18.8 +/- 4.4 microU/mL, respectively. The insulin response to OGTT (area under curve) was also reduced (from 16,017 +/- 2598 to 11,736 +/- 2317 microU/mL/240 min). Our results suggest that the GnRH-a induced suppression of ovary secretion may modify the serum GH and IGF-I levels and the insulin response to an OGTT in women with PCOS.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Tropeano G,Liberale I,Vuolo IP,Barini A,Caroli G,Carfagna P,Menini E

doi

10.1007/BF03346907

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

220-4

issue

4

eissn

0391-4097

issn

1720-8386

journal_volume

20

pub_type

杂志文章

相关文献

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION文献大全
  • Hyperhomocysteinemia: a biochemical link between bone and cardiovascular system diseases?

    abstract：:Homocysteine (HCY) is a sulfur-containing amino acid involved in two metabolic pathways, catalized by cystathionine-B-synthase and methionine synthase, depending on vitamin (vit) B6, B12, and folate levels and enzymatic activity of methylenetetrahydrofolate. High HCY levels (HHCY) are associated with cardiovascular (C...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：

    authors： Petramala L,Acca M,Francucci CM,D'Erasmo E

    更新日期：2009-01-01 00:00:00

  • Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH-releasing peptide, in humans.

    abstract：:Reduced cardiac mass and performances are present in GH deficiency and are counteracted by rhGH replacement. GH and IGF-I possess specific myocardial receptors and have been reported able to exert an acute inotropic effect. Synthetic GH secretagogues (GHS) possess specific pituitary and hypothalamic but even myocardia...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF03343555

    authors： Bisi G,Podio V,Valetto MR,Broglio F,Bertuccio G,Del Rio G,Arvat E,Boghen MF,Deghenghi R,Muccioli G,Ong H,Ghigo E

    更新日期：1999-04-01 00:00:00

  • Uptake of estrone and estrone-3-sulfate by lung of macaca fuscata.

    abstract：:An equimolar mixture of 3H-E1-S2 and 14C-E1 was injected in one shot into the inferior vena cava near the heart of female Japanese monkey. Following the injection, blood was collected from the aortic arch at intervals of 15 s over a period of 10 min. The concentration of radioactivities in the whole blood and serum wa...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03348447

    authors： Sakai C,Yamamoto T,Kitawaki J,Yoshiji S,Yasuda J,Yamaki J,Fujii M,Tsukamoto K,Honjo H,Okada H

    更新日期：1984-10-01 00:00:00

  • Structure-function correlations of growth hormone or/and prolactin-producing pituitary adenomas: an in vitro study with the reverse hemolytic plaque assay.

    abstract：:The purpose of this study was to detect in vitro growth hormone (GH) and prolactin (PRL) secretion from adenomas clinically associated with GH or PRL hypersecretion. The reverse hemolytic plaque assay (RHPA) was applied in order to reveal possible differences among various morphologic adenoma types, and to examine the...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343628

    authors： Thodou E,Kontogeorgos G,Kyrodimou E,Salla H,Ramyar L,Vamvassakis E,Piaditis G,Anagnostopoulos N,Tzanis S,Levedis A,Rologis D,Asa SL

    更新日期：1999-10-01 00:00:00

  • Growth hormone response to physical exercise in growing patients with classic congenital adrenal hyperplasia.

    abstract：:Glucocorticoid over-treatment in children with congenital adrenal hyperplasia (CAH) may suppress GH secretion and growth. Aims of our study were: 1) to evaluate post-exercise GH response in patients affected by CAH due to 21-hydroxylase deficiency, in comparison with a group of healthy subjects; 2) to investigate the ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345770

    authors： Bizzarri C,Ubertini G,Crea F,Colabianchi D,Loche S,Ravà L,Cappa M

    更新日期：2009-12-01 00:00:00

  • Pluripotent stem cells isolated from human amniotic fluid and differentiation into pancreatic beta-cells.

    abstract：:Human amniotic fluid (HAF) contains multipotent stem cells [amniotic fluid-derived stem cells (AFSC)] which can differentiate into a variety of different cell types. Recently, we demonstrated that obestatin, a peptide encoded by the ghrelin gene, exerts anti-apoptotic effects in pancreatic beta-cells and human islets ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345764

    authors： Trovato L,De Fazio R,Annunziata M,Sdei S,Favaro E,Ponti R,Marozio L,Ghigo E,Benedetto C,Granata R

    更新日期：2009-12-01 00:00:00

  • Vitamin D and parameters of calcium homeostasis in inpatients with and without Type 2 diabetes mellitus.

    abstract：AIM:We investigated inpatients with and without Type 2 diabetes mellitus, aged over 60 yr, to compare their vitamin D status and calcium homeostatic parameters. MATERIALS AND METHODS:We studied 140 patients consecutively admitted to our Internal Medicine Unit during the year 2010 (61 from November to April, 79 from Ma...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.3275/8236

    authors： Carnevale V,Inglese M,Annese MA,De Matthaeis A,Santini SA,Frusciante V,Fontana A,Copetti M,Pellegrini F,D'Amico G

    更新日期：2012-10-01 00:00:00

  • A multimodality therapeutic approach in anaplastic thyroid carcinoma: study on 39 patients.

    abstract：:The aim of this study was to investigate the role of multimodality treatment in patients with anaplastic thyroid carcinoma. From 1992 to 1999, 39 consecutive patients with a histologically or cytologically proven anaplastic thyroid carcinoma were referred to the Thyroid Center of Padua General Hospital. There were 28 ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345066

    authors： Busnardo B,Daniele O,Pelizzo MR,Mazzarotto R,Nacamulli D,Devido D,Mian C,Girelli ME

    更新日期：2000-12-01 00:00:00

  • Comparison of histopathological features and prognosis of classical and follicular variant papillary thyroid carcinoma.

    abstract：PURPOSE:To compare the histopathological features and the outcomes of the follicular variant and classical variant of papillary thyroid carcinoma. MATERIAL AND THE METHODS:Demographic data, histopathological features (tumor size, thyroid capsule invasion, extrathyroidal extension, vascular invasion and multicentricity...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-015-0376-6

    authors： Tunca F,Sormaz IC,Iscan Y,Senyurek YG,Terzioglu T

    更新日期：2015-12-01 00:00:00

  • Metabolic and cardiovascular profile in patients with Addison's disease under conventional glucocorticoid replacement.

    abstract：OBJECTIVE:Although two studies have shown that Addison's disease (AD) is still a potentially lethal condition for cardiovascular, malignant, and infectious diseases, a recent retrospective study showed a normal overall mortality rate. Differently from secondary hypoadrenalism, scanty data exist on the role of conventio...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345773

    authors： Giordano R,Marzotti S,Balbo M,Romagnoli S,Marinazzo E,Berardelli R,Migliaretti G,Benso A,Falorni A,Ghigo E,Arvat E

    更新日期：2009-12-01 00:00:00

  • Untreated adult GH deficiency is not associated with the development of metabolic risk factors: a long-term observational study.

    abstract：PURPOSE:Uncertainties exist about the predictors of the severity of the clinical picture of GH deficiency (GHD) syndrome. Aim of the study was to evaluate, in adult patients with GHD, the predictors of the development of hypercholesterolemia, hypertension, diabetes mellitus, and osteoporosis. METHODS:We retrospectivel...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-019-01100-y

    authors： Gasco V,Roncoroni L,Zavattaro M,Bona C,Berton A,Ghigo E,Maccario M,Grottoli S

    更新日期：2020-02-01 00:00:00

  • Expression of natriuretic peptide receptors in human adipose and other tissues.

    abstract：:To characterize natriuretic peptide receptor (NPr) gene expression in human tissues, we cloned portions of the cDNAs codifying for NPr with guanylyl cyclase activity (NPr-A and NPr-B) and without guanylyl cyclase activity (NPr-C). Total RNA was extracted from samples taken at surgery from normal human tissues. NPr-A a...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349021

    authors： Sarzani R,Dessì-Fulgheri P,Paci VM,Espinosa E,Rappelli A

    更新日期：1996-10-01 00:00:00

  • Does computation provide a model for creativity? An epistemological perspective in neuroscience.

    abstract：:In 1939 Alan Turing, a major scholar in the field of mechanical computation, described a system whose computational power was beyond that of a discrete, finite state machine (Turing Machine). The composition of this system was likely the first example of what is now called an hybrid computational system. Since then, d...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：

    authors： Sandri G

    更新日期：2004-01-01 00:00:00

  • Effects of somatostatin in a case of severe hypoglycemia due to nesidioblastosis.

    abstract：:The Authors have studied the effects of somatostatin (SRIF) treatment in an infant affected by hypoglycemia due to nesidioblastosis. During iv infusion with SRIF we observed a marked increase of blood glucose levels; concomitantly insulin secretion was almost completely suppressed. In contrast, during treatment with p...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350454

    authors： Roti E,Ghinelli C,Bandini P,Del Rossi C,Emanuele R,Robuschi G,Gnudi A

    更新日期：1981-04-01 00:00:00

  • Chronobiology of catecholamine excretion in normal and diabetic men.

    abstract：:The adrenomedullary response to stimuli is often elevated in poorly controlled insulin dependent diabetic patients, and it is controversial whether the adrenomedullary hyperactivity induces the suppression of the circadian rhythm of catecholamines. We have studied the urinary excretion of catecholamines in 11 diabetic...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03348628

    authors： Del Rio G,Carani C,Baldini A,Marrama P,Della Casa L

    更新日期：1990-07-01 00:00:00

  • "Madonna of the Pinks" and "Madonna Dell'Impannata": Raphael Sanzio (1483-1520).

    abstract：: ...

    journal_title：Journal of endocrinological investigation

    pub_type： 历史文章,杂志文章

    doi：10.1007/s40618-018-0896-y

    authors： Lazzeri D,Al-Mousawi A,Nicoli F

    更新日期：2018-12-01 00:00:00

  • Erectile dysfunction: symptom or disease?

    abstract：:Erectile dysfunction (ED) has been defined by the National Institute of Health (NIH) as the inability to achieve and/or to maintain an erection for a sufficiently long period of time so as to permit satisfactory sexual intercourse. ED affects millions of men throughout the world and could have a negative influence on ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/BF03350917

    authors： Foresta C,Caretta N,Aversa A,Bettocchi C,Corona G,Mariani S,Rossato M

    更新日期：2004-01-01 00:00:00

  • Further evidence that insulin metabolism is a major determinant of peripheral insulin response to oral glucose in subjects with mild glucose intolerance.

    abstract：:In mild glucose intolerance plasma concentration of C-peptide seems to give an estimate of pancreatic B cell secretion more reliable than plasma insulin itself. In the present study we measured the plasma levels of insulin and C-peptide after oral glucose load in 100 mildly glucose intolerant subjects, focusing our at...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346945

    authors： Bonora E,Zavaroni I,Manicardi V,Coscelli C,Butturini U

    更新日期：1986-10-01 00:00:00

  • Severe systemic complications of acromegaly.

    abstract：:It is well accepted that mortality in acromegaly is increased because of cardiovascular and respiratory diseases while neoplastic complications account less to mortality. Amongst different cardiovascular complications the most frequent is biventricular hypertrophy, which occurs independently of hypertension and metabo...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：

    authors： Colao A,Pivonello R,Marzullo P,Auriemma RS,De Martino MC,Ferone D,Lombardi G

    更新日期：2005-01-01 00:00:00

  • Effect of ethanol infusion on the pituitary-testicular responsiveness to gonadotropin releasing hormone and thyrotropin releasing hormone in normal males and in chronic alcoholics presenting with hypogonadism.

    abstract：:Nine chronic male alcoholics presenting with hypogonadism but without overt liver failure were examined under baseline conditions and after acute injection of gonadotropin releasing hormone (GnRH, 100 micrograms iv) and thyrotropin releasing hormone (TRH, 200 micrograms iv), performed at 60 min of a 3-h infusion of sa...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF03348339

    authors： Bertello P,Gurioli L,Faggiuolo R,Veglio F,Tamagnone C,Angeli A

    更新日期：1983-12-01 00:00:00

  • Corticotropin-releasing factor and adrenal function in major depression.

    abstract：:We investigated ACTH and cortisol responses after ovine CRF injection (1 microgram/kg one bolus) in a group of 11 drug-free patients suffering from major depression. When compared to sex- and age-matched normal controls, our depressed patients showed: Higher ACTH basal values (p less than 0.002); higher cortisol basal...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350921

    authors： Nerozzi D,Bersani G,Melia E,Magnani A,Antonozzi I,Frajese G

    更新日期：1988-11-01 00:00:00

  • Acute keratoconus induced by hypothyroxinemia during pregnancy.

    abstract：:Keratoconus is a bilateral non-inflammatory corneal ectasia with an incidence of approximately 1 per 2000 in the general population. The etiology of keratoconus is multifactorial, although not completely understood. Several clinical observations suggest that thyroid gland dysfunction is associated with keratoconus pat...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345600

    authors： Gatzioufas Z,Thanos S

    更新日期：2008-03-01 00:00:00

  • Medicinal chemistry of somatostatin analogs leading to the DTPA and DOTA conjugates of the multi-receptor-ligand SOM230.

    abstract：:The somatostatin field has been a success story in terms of medicinal chemistry and drug discovery offering a variety of therapeutic opportunities. A rational medicinal chemistry approach capitalising on structure activity relationships has led to the discovery of SOM230, a novel, stable cyclohexapeptide somatostatin ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：

    authors： Lewis I,Albert R,Kneuer R,Pless J,Simeon C,Kerrad S,Hoyer D,Bruns C

    更新日期：2005-01-01 00:00:00

  • Association between emotional and behavioral problems and metabolic control in children and adolescents with Type 1 diabetes.

    abstract：OBJECTIVE:We aimed to investigate the differences in emotional and behavioral problems and to explore the association between the level of psychiatric problems and the metabolic control in Type 1 diabetes. METHODS:The children with Type 1 diabetes (no.=42) and the "healthy" control group (no.=42), their parents and en...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345721

    authors： Akbaş S,Karabekiroğlu K,Ozgen T,Tasdemir G,Karakurt M,Senses A,Böke O,Aydin M

    更新日期：2009-04-01 00:00:00

  • Investigating the effect of testosterone by itself and in combination with letrozole on 1,25-dihydroxy vitamin D and FGF23 in male rats.

    abstract：BACKGROUND:Testosterone deficiency might be associated with vitamin D levels in hypogonadal men, but it is not clear whether testosterone can affect vitamin D and fibroblast growth factor-23 (FGF23), either directly or indirectly via aromatization to estradiol. We aimed to investigate the role of testosterone on vitami...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-018-0875-3

    authors： Saki F,Kasaee SR,Sadeghian F,Koohpeyma F,Omrani GHR

    更新日期：2019-01-01 00:00:00

  • Effect of the somatostatin analog D-Trp8,D-Cys14 on glucose insulin, pancreatic glucagon and growth hormone plasma levels in acromegalics and mild diabetics.

    abstract：:The effect of the somatostatin analog (GHRIH-A) D-Trp8, D-Cys14 on plasma levels of growth hormone, pancreatic glucagon, insulin and glucose was studied in four acromegalic patients and in four maturity-onset mild diabetics. Acromegalics received a bolus iv injection of 25 microgram of GHRIH-A, followed by a continuou...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03348250

    authors： Trovati M,Massara F,Camanni F,Molinatti GM,Lorenzati R,Pagano GF

    更新日期：1980-04-01 00:00:00

  • The triglycerides and glucose index is associated with cardiovascular risk factors in metabolically obese normal-weight subjects.

    abstract：PURPOSE:The aim of this study was to determine whether the triglycerides and glucose (TyG) index is associated with the presence of metabolically obese normal-weight (MONW) phenotype and related cardiovascular risk factors. METHODS:Apparently healthy men and non-pregnant women aged 20-65 years were enrolled in a popul...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-020-01184-x

    authors： Morales-Gurrola G,Simental-Mendía LE,Castellanos-Juárez FX,Salas-Pacheco JM,Guerrero-Romero F

    更新日期：2020-07-01 00:00:00

  • Regulation of mouse placental lactogen secretion by G proteins before midpregnancy.

    abstract：:To determine whether G proteins are involved in the regulation of mouse placental lactogen-I (mPL-I) and/or mPL-II secretion before midpregnancy, mouse placental tissue from day 7 of pregnancy was dispersed with collagenase, cells were fractionated on a percoll gradient, and the purified trophoblast cells were culture...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349006

    authors： Yamaguchi M,Miyake A

    更新日期：1996-09-01 00:00:00

  • Low doses of either intravenously or orally administered arginine are able to enhance growth hormone response to growth hormone releasing hormone in elderly subjects.

    abstract：:Reportedly, the responsiveness of somatotrope cells to GHRH is reduced in elderly humans but it is totally restored by arginine (ARG) which likely acts by inhibiting hypothalamic release of somatostatin. As this effect was observed after infusion of high doses of the amino acid, in this study, we compared the effect o...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF03347695

    authors： Ghigo E,Ceda GP,Valcavi R,Goffi S,Zini M,Mucci M,Valenti G,Cocchi D,Müller EE,Camanni F

    更新日期：1994-02-01 00:00:00

  • Growth hormone treatment in non-growth hormone-deficient short children.

    abstract：:The unlimited availability of GH obtained by recombinant DNA technology has allowed optimization of treatment in GH-deficient (GHD) children. At the same time it has prompted a number of studies in conditions not characterized by GHD such as Turner syndrome, intrauterine growth retardation, chronic renal failure and o...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/BF03345367

    authors： Loche S,Casini MR,Ubertini GM,Cappa M

    更新日期：2005-02-01 00:00:00