Abstract：
:It is well accepted that mortality in acromegaly is increased because of cardiovascular and respiratory diseases while neoplastic complications account less to mortality. Amongst different cardiovascular complications the most frequent is biventricular hypertrophy, which occurs independently of hypertension and metabolic complications that, in turn, aggravate the cardiomyopathy. Diastolic and systolic dysfunction develops in a variable number of patients, depending on age and disease duration. Other cardiac disorders, such as arrhythmias, valve disease, hypertension, atherosclerosis and endothelial dysfunction have been less characterized but all appear to be present in acromegaly, depicting the so called "acromegalic cardiomyopathy". The best characterized respiratory disease is the sleep apnea. Ventilatory dysfunction recognizes bony changes of thoracic cage and lung overgrowth as relevant pathogenetic factors. Earlier evidences that patients with acromegaly have an increased risk of developing malignancies have become more realistic in recent years. Most studies have reported an increased risk of colonic polyps, which more frequently recur in patients not controlled after treatment. Malignancies in other organs have also been described, but less convincingly than at the gastrointestinal level and are not a main cause of mortality. Bone changes are also feature of the disease. They involve theoretically all bones and, particularly, the appendicular and the axial skeleton. Patients with long-standing disease are more prone to develop degenerative changes. Control of acromegaly by surgery or pharmacotherapy, especially by somatostatin analogs, improves cardiovascular morbidity and sleep apnea. There is still no demonstration that improvement of different complications corresponds a reduction in mortality.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Colao A,Pivonello R,Marzullo P,Auriemma RS,De Martino MC,Ferone D,Lombardi Gkeywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
65-77issue
5 Suppleissn
0391-4097issn
1720-8386journal_volume
28pub_type
杂志文章,评审abstract：:The aim of the study was to determine the main metabolic parameters of 11-beta-hydroxy-androstenedione (11 OHAD) in man. Seven normal subjects were investigated at 1-3 months interval by 2 types of isotope dilution techniques using a tritiated tracer: constant infusion and bolus iv injection. 3H-11 OHAD and 3H-11-beta...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349485
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journal_title：Journal of endocrinological investigation
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journal_title：Journal of endocrinological investigation
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更新日期：1993-12-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
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更新日期：2019-05-01 00:00:00
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journal_title：Journal of endocrinological investigation
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journal_title：Journal of endocrinological investigation
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更新日期：2007-06-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Journal of endocrinological investigation
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更新日期：1985-12-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2011-07-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03343814
更新日期：2001-02-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347659
更新日期：1993-02-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-015-0319-2
更新日期：2016-01-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348787
更新日期：1992-07-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349021
更新日期：1996-10-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.3275/8468
更新日期：2013-01-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
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更新日期：2000-09-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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doi：10.1007/BF03346945
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journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章
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journal_title：Journal of endocrinological investigation
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更新日期：1992-09-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2019-06-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
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更新日期：1992-10-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
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更新日期：2011-10-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
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更新日期：2007-11-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVE:The Merseburg triad (hyperthyroidism, goiter, and orbitopathy) characterizes classical description of Graves' disease (GD). Aim of this observational, longitudinal study was to evaluate the current clinical features of newly diagnosed GD in Italy. MATERIALS AND METHODS:In two Northern Italy centers (Varese a...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-016-0516-7
更新日期：2016-12-01 00:00:00
