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Catecholaminergic interactions in the regulation of thyrotropin (TSH) secretion in man.

Abstract：

:The TSH responses to the catecholamine depleting agent monoiodotyrosine (1 g po) and the dopamine receptor blocking drug metoclopramide (10 mg po) have been compared in euthyroid and hypothyroid subjects. Both drugs lead to a prompt and significant rise in TSH levels (peak values at 60-75 min) which is very much greater in hypothyroid than euthyroid subjects. The findings lend further support to the inhibitory role of dopamine in the control of TSH release in man, since TSH release follows either dopamine depletion with monoiodotyrosine or dopamine receptor blockade with metoclopramide.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Scanlon MF,Rodriguez-Arnao MD,Pourmand M,Shale DJ,Weightman DR,Lewis M,Hall R

doi

10.1007/BF03348238

subject

Has Abstract

pub_date

1980-04-01 00:00:00

pages

125-9

issue

2

eissn

0391-4097

issn

1720-8386

journal_volume

3

pub_type

杂志文章

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