Abstract：
:Patients with simple exogenous obesity are characterized by increased B-endorphin (B-EP) plasma levels, despite normal ACTH and B-Lipotropin (B-LPH). To evaluate the origin of such an hyperendorphinemia, 42 obese patients were submitted to a short overnight dexamethasone suppression test (DST: 1 mg at 23:00 h). Blood samples were taken in basal conditions and 9, and 17 h after DST. The same procedure was applied in 12 healthy, normal weight volunteers. In further five patients, 0.5 mg per 4/die were given. B-EP was measured by radioimmunoassay (RIA) after silicic acid extraction and Sephadex G-75 column chromatography. ACTH and Cortisol were measured by direct IRMA and RIA, respectively. Basal B-EP levels of patients (24.2 +/- 16.5, fmol/ml, M +/- SD) were double than in normal weight controls (10.8 +/- 4.6), while ACTH and cortisol fell in the normal range. ACTH and cortisol were significantly reduced by DST in both patients and controls, while B-EP in patients did not. Cortisol, however, was not suppressed in 7 patients (16%). At 08:00, the suppression of B-EP in controls was 49.0 +/- 18.4%, while in obese patients it was only 21.2 +/- 38.8% (p less than 0.01). However, patients with weight excess below 50% normally suppressed B-EP (41.6 +/- 15.3%), while those with weight excess over 75% did not (11.3 +/- 47.5%). The doubling of dexamethasone intake does not lead to a suppression of plasma B-EP in these last patients. These data indicate the existence of neuroendocrine abnormalities in the hypothalamus-pituitary-adrenal axis of obese patients and suggest that their hyperendorphinemia originates outside the anterior pituitary.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Facchinetti F,Giovannini C,Petraglia F,Barletta C,Comitini G,Genazzani ARdoi
10.1007/BF03350117subject
Has Abstractpub_date
1988-02-01 00:00:00pages
119-23issue
2eissn
0391-4097issn
1720-8386journal_volume
11pub_type
杂志文章abstract：BACKGROUND:Results of circulating Ghrelin levels in hyper- or hypothyroidism are conflicting and only overt thyroid dysfunction has been evaluated. AIM:To evaluate in a large number of patients with thyroid disfunction whether: a) hyper- and hypothyroidism (clinical or subclinical) are associated with variations in bo...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345683
更新日期：2009-01-01 00:00:00
abstract：:The genetic factors determining bone mineral density (BMD) are not well characterized. Many studies have investigated the relationship between the fokI polymorphism of vitamin D receptor (VDR) gene in diverse populations and gender, resulting in conflicting outcomes. Because peak bone mass in men is closely related to...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347571
更新日期：2005-10-01 00:00:00
abstract：:According to recent studies showing the presence of estrogens receptors (ERs) in the human female lower urinary tract, we performed ER and progesterone receptor (PR) assays in fresh frozen and paraffin embedded biopsies taken from the urinary bladder. Fourteen females undergoing endoscopy during staging for gynecologi...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347639
更新日期：1992-11-01 00:00:00
abstract：BACKGROUND:Bone marrow mesenchymal stem cells (MSC) mediate their protection by paracrine mechanism under ischemic conditions and anoxic pre-conditioning (AP) of MSC strongly enhances their survival and regenerative capacity. However, there is no report about the therapeutic potency of MSC transplantation on diabetic c...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345575
更新日期：2008-02-01 00:00:00
abstract：:Typical modifications of cardiovascular activity and water and salt homeostasis throughout female reproductive life are well known. Differences in plasma levels of calcitonin gene-related peptide (CGRP) and atrial natriuretic peptide (ANP) have been observed in conditions characterized by different estrogenic levels, ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347311
更新日期：1998-04-01 00:00:00
abstract：:To analyze the inhibitory effect of hormone replacement therapy (HRT) on bone resorption, we measured urinary excretion of C-telopeptide (CTX) and N-telopeptide (NTX) of type I collagen as new markers of bone resorption and assessed their correlation with bone mineral density, in comparison with urinary pyridinoline (...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347294
更新日期：1998-03-01 00:00:00
abstract：BACKGROUND:Studies from every continent have shown that only around 50% of the patients subjected to thyroid hormone replacement have TSH in the normal range. However, to date, there are no consistent data about Brazil. OBJECTIVES:To evaluate levothyroxine (LT4) replacement treatment in patients with primary hypothyro...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,多中心研究
doi：10.3275/8810
更新日期：2013-07-01 00:00:00
abstract：:Estrogen deficiency in females and androgen deficiency in males may harm periosteal and endosteal apposition, reduce bone size and both cortical and trabecular thickness, modifying in this way the bone structure later in life. To date, few systematic studies on bone mineral density (BMD) and hypogonadism in adolescent...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346513
更新日期：2009-07-01 00:00:00
abstract：:Juvenile Rheumatoid Arthritis (JRA) is frequently associated with osteoporosis. In order to determine if JRA osteoporosis is related to reduced formation or to increased bone resorption or both, serum levels of calcium (Ca), phosphorus (PO4), magnesium (Mg), alkaline phosphatase (ALP), parathormone (PTHi), 25-hydroxyv...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347283
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:To review the proportion of diabetic patients reaching recommended therapeutic goals, as reported in intervention trials and observational studies, and to analyse the factors associated with success or failure in achieving these targets. METHODS:A systematic review and meta-analysis through a Medline and Embas...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s40618-014-0069-6
更新日期：2014-05-01 00:00:00
abstract：:Growth hormone (GH) response to provocative tests was compared in normal short children. Seven of 23 children failed to respond to insulin hypoglycemia. Using insulin hypoglycemia followed by L-dopa only 2 of 23 children did not respond and giving bromocriptine combined with insulin hypoglycemia only 1 of 8 children f...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03351005
更新日期：1984-08-01 00:00:00
abstract：:It has recently been suggested that the classical routine of glucocorticoid administration before and after transsphenoidal surgery (TSS) in Cushing's disease (CD) patients may not be necessary, since it is likely that peritumoral normal corticotrophs are not completely suppressed during this period. We compared the d...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347237
更新日期：2005-06-01 00:00:00
abstract：:Central hypothyroidism (CH) is a rare cause of hypothyroidism characterized by a defect of thyroid hormone production due to an insufficient TSH stimulation. CH can be congenital in the case of genetic defects or acquired in the case of lesions affecting either pituitary or hypothalamus. Diagnosis is usually made on a...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2008-09-01 00:00:00
abstract：:Rats bearing mammosomatotropic tumors have raised insulin but lowered glucose concentrations. To determine if growth hormone (GH) secreted by these tumors causes insulin antagonism, pancreatic suppression tests utilizing infusions (per kg per min) of glucose (8 mg), insulin (200 ng) and somatostatin (1.4 micrograms) f...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346996
更新日期：1987-12-01 00:00:00
abstract：PURPOSE:This study investigated the relationship between seasonal variations in 25-hydroxyvitamin D (25(OH)D) levels and growth in prepubertal children during both the pretreatment year and the first year of GH treatment. METHODS:The study included 249 short prepubertal children with a broad range of GH secretion, GH(...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-015-0360-1
更新日期：2015-12-01 00:00:00
abstract：:The in vivo suppressive effect of glucose and insulin on plasma free fatty acid concentrations was investigated in obese subjects with (n = 6) and without (n = 6) Type 2 (non-insulin-dependent) diabetes mellitus during a 4h-hyperglycemic glucose clamp (about 11.2 mmol/l). Somatostatin was infused (250 micrograms/h) du...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348582
更新日期：1990-01-01 00:00:00
abstract：:Monolayer cultures of medullary thyroid carcinoma (MTC) cells were prepared from 5 patients with familial and 4 with sporadic MTC. Basal calcitonin (CT) release decreased rapidly during 17 days in culture. Addition of extra calcium (2 mmol/l) or dibutyryl cyclic AMP (dBcAMP, 3 mmol/l) increased CT release in all inves...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347169
更新日期：1987-04-01 00:00:00
abstract：:The cause of a poor response to human menopausal gonadotropin (hMG) remains unexplained. To determine whether aromatase activity of cultured granulosa cells obtained from relatively low estradiol (E2) responders (serum E2 < 1000 pg/ml) to hMG therapy differed from that of good responders (E2 > or = 1000 pg/ml), we pro...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03344926
更新日期：1992-09-01 00:00:00
abstract：:The 1865 volume of the "II Morgagni", one of the most important Italian medical journals of the 19th century, presented two important articles, milestones for further scientific studies in the field of sexual differentiation. One was the original description of the "ramified cells" of testicular tubules by E. Sertoli,...
journal_title：Journal of endocrinological investigation
pub_type： 历史文章,杂志文章
doi：10.1007/BF03345329
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND:Adipose tissue has emerged as an important endocrine regulator by secreting hormones referred to as adipokines. Recent studies showed that adipose tissue considerably responds to hypoxia. Although the impact of white adipose tissue on regulative processes is established, the importance of brown adipose tissu...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.3275/7964
更新日期：2012-05-01 00:00:00
abstract：:This study examined the association of depression, anxiety, and stress with Type 2 diabetes (T2DM) in Bahrain, an island-country with a very high prevalence of T2DM. This was a cross-sectional study involving administering Depression Anxiety Stress Scales (DASS)-21 structured depression, anxiety, and stress scale to 1...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345642
更新日期：2008-11-01 00:00:00
abstract：:In mature female rats the administration of testosterone led to a striking reduction of hepatic alcohol dehydrogenase activity, whereas the hepatic microsomal ethanol oxidizing system as well as catalase were both increased in activity under these experimental conditions. Conversely, estradiol left the activities of a...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348330
更新日期：1982-07-01 00:00:00
abstract：:Between 1973 and 1980, 93 patients with Graves' disease underwent subtotal thyroidectomy by the same surgeon (the size of thyroid remnant was 4 g per side). No case of operative mortality, no case of thyroid storm nor of surgical complications occurred. Three months after surgery 40% of patients were euthyroid, 25% ha...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349057
更新日期：1988-05-01 00:00:00
abstract：:The present study investigated whether trophoblast, decidua and fetal membranes express nerve growth factor (NGF) mRNA and peptide. Tissue specimens were collected in the first and third trimester of pregnancy from women undergoing voluntary pregnancy interruption (no.= 6; from 8 to 12 gestational weeks) and from wome...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03344105
更新日期：2006-04-01 00:00:00
abstract：PURPOSE:Spinal cord injury (SCI) affects sexual health of both male and female, but little attention has been given to sexuality of SCI women. Similar to penile erection, vaginal lubrication represents a neurovascular event and then both denervation and vascular damage might contribute to its impairment. Nevertheless, ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-020-01185-w
更新日期：2020-07-01 00:00:00
abstract：:The status of the erythrocyte insulin receptor was investigated prior to and during storage at 4C in acid-citrate dextrose (ACD) solution. The receptors on cells that were obtained from both resting and exercised fasting subjects and stored for up to three days in ACD were unchanged as evaluated by both maximal specif...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347594
更新日期：1983-08-01 00:00:00
abstract：PURPOSE:Polycystic ovary syndrome (PCOS) was associated with a number of polymorphisms of genes involved in insulin signaling. So far, they have been studied separately. The aim of this study was to verify the impact of the coexistence of two polymorphisms of insulin signaling. METHODS:One hundred consecutive PCOS wom...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-016-0569-7
更新日期：2017-04-01 00:00:00
abstract：:Iodine balance during pregnancy and lactation was investigated by measuring iodine concentration in the urine of 11 pregnant women, born and living in a moderately iodine deficient endemic goiter area in Northeastern Sicily, collected during the last week of pregnancy, and between the 5th and 7th day after delivery, a...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348681
更新日期：1992-02-01 00:00:00
abstract：:Human GH (hGH) is a heterogeneous protein hormone consisting of several isoforms. This heterogeneity is the consequence of multiple hGH genes, mRNA splicing, post-translational modifications, and peripheral metabolism, and it represents one important reason for the disparity among GH assay results from different labor...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.3275/8647
更新日期：2012-11-01 00:00:00
abstract：:Aging is related to critical changes of the hypothalamo-pituitary-adrenal function. A decline in serum DHEA levels has been demonstrated in healthy elderly subjects, while ACTH and cortisol concentrations remain at normal values. The purpose of the present study was to investigate the effect of aging on pituitary-adre...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章
doi：10.1007/BF03347325
更新日期：1998-07-01 00:00:00
