Abstract:
PURPOSE:Polycystic ovary syndrome (PCOS) was associated with a number of polymorphisms of genes involved in insulin signaling. So far, they have been studied separately. The aim of this study was to verify the impact of the coexistence of two polymorphisms of insulin signaling. METHODS:One hundred consecutive PCOS women (diagnosed by Rotterdam criteria) and 45 age-matched healthy women were genotyped for two polymorphisms: Gly972Arg of IRS-1 and Lys121Gln of PC-1. Also, they underwent clinical evaluation, blood sampling for measurement of metabolic and hormonal indices, and a 75-g oral glucose tolerance test (OGTT). RESULTS:Comparing PCOS women with controls, the rate of homo-/heterozygosity was significantly greater (50 vs. 24.5%, P = 0.004) for IRS-1 polymorphism, but insignificantly greater (20 vs. 13.3%, P = 0.33) for PC-1 polymorphism. In PCOS women, compared with controls, the genotypes IRS-1 hetero/PC-1 wild type (WT) (36 vs. 17.8%, P = 0.03) and IRS-1 hetero/PC-1 hetero (14 vs. 6.7%, P = 0.20) were overrepresented at the expense of IRS-1 WT/PC-1 WT (44 vs. 68.8%, P = 0.005), while IRS-1 WT/PC-1 hetero was similarly represented (6 vs. 6.7%). Based on genotype, metabolic and hormonal indices changed significantly. For instance, six indices (HOMA-IR, fasting insulin, insulin area under the curve at OGTT, triglycerides, total and calculated free testosterone) were the highest in IRS-1 hetero/PC-1 WT women. CONCLUSIONS:Genetic variations in insulin signaling contribute to the extent and the variability of metabolic and hormonal derangement.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Pappalardo MA,Vita R,Di Bari F,Le Donne M,Trimarchi F,Benvenga Sdoi
10.1007/s40618-016-0569-7subject
Has Abstractpub_date
2017-04-01 00:00:00pages
367-376issue
4eissn
0391-4097issn
1720-8386pii
10.1007/s40618-016-0569-7journal_volume
40pub_type
杂志文章abstract::We herein describe a 40-year-old woman with hyperprolactinemia, an empty sella and two extrasellar intracranial recurrent tumors which were revealed 23 years after the first transfrontal craniotomy and 18 years after the second transfrontal surgery and irradiation to a provable prolactin-producing pituitary macroadeno...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03351046
更新日期:2001-06-01 00:00:00
abstract::Metabolic diseases are associated with chronic low-grade inflammation, which has been indicated as a potential mediator of endothelial dysfunction and cardiovascular disease. Visceral adiposity is thought to be the starting condition of the inflammatory state through the release of inflammatory cytokines, including TN...
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abstract::Two radioimmunological techniques for the measurement of anti-alpha-galactosyl (anti-Gal) antibodies were developed and we demonstrated that this antibody is present in the serum of most untreated patients with Graves' disease, thyroid-associated ophthalmopathy (TAO) and autoimmune thyroiditis. Thyrotropin-binding inh...
journal_title:Journal of endocrinological investigation
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更新日期:1995-11-01 00:00:00
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doi:10.1007/s40618-014-0225-z
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journal_title:Journal of endocrinological investigation
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doi:10.1007/BF03350806
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doi:10.1007/BF03346996
更新日期:1987-12-01 00:00:00
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journal_title:Journal of endocrinological investigation
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
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journal_title:Journal of endocrinological investigation
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更新日期:2011-03-01 00:00:00
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journal_title:Journal of endocrinological investigation
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journal_title:Journal of endocrinological investigation
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journal_title:Journal of endocrinological investigation
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更新日期:2009-12-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract::In healthy pregnant women, the regulation of thyroid function depends upon several factors. Three factors act independently to increase thyroid hormone requirements: 1) the marked increase in the binding capacity of serum due to high TBG levels; 2) the direct stimulation of the thyroid by human chorionic gonadotropin,...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/BF03348861
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journal_title:Journal of endocrinological investigation
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journal_title:Journal of endocrinological investigation
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更新日期:1978-10-01 00:00:00
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journal_title:Journal of endocrinological investigation
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journal_title:Journal of endocrinological investigation
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350794
更新日期:1998-11-01 00:00:00
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journal_title:Journal of endocrinological investigation
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