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Growth hormone variants: a potential avenue for a better diagnostic characterization of growth hormone deficiency in children.

Abstract：

:Human GH (hGH) is a heterogeneous protein hormone consisting of several isoforms. This heterogeneity is the consequence of multiple hGH genes, mRNA splicing, post-translational modifications, and peripheral metabolism, and it represents one important reason for the disparity among GH assay results from different laboratories. However, other factors are involved: a) interference from endogenous GH binding proteins; b) different specificities of anti- GH (monoclonal and polyclonal) antibodies; c) different matrix effects among the calibrators; d) the use of different calibrators. The measurement of GH levels in response to provocative testing is an essential part of the diagnosis of GH deficiency. For this purpose, an accurate, reproducible and universally valid GH measurement would be highly desirable, but, despite a huge number of efforts in clinical biochemistry, this goal remains elusive.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Rigamonti AE,Bozzola M,Banfi G,Meazza C,Müller EE,Cella SG

doi

10.3275/8647

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

937-44

issue

10

eissn

0391-4097

issn

1720-8386

pii

8647

journal_volume

35

pub_type

杂志文章,评审

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