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The association of plasma free amino acids with liver enzymes in Type 2 diabetic patients.

Abstract：

BACKGROUND:Elevated γ-glutamyl transpeptidase (GGT) and alanine aminotransferase (ALT) could predict the risk of Type 2 diabetes (T2D), but the reason for their elevation was unclear. GGT and ALT mediated the metabolism of many amino acids (AA). Up to now, it was not investigated whether abnormal AA concentration was associated with elevated liver enzymes. AIM:This study was to investigate the status of AA in T2D and their relationship with liver enzymes. SUBJECTS AND METHODS:A total of 132 T2D patients and 137 healthy controls were recruited. Plasma free AA were measured by high-performance liquid chromatography. The contribution of individual AA to liver enzymes was assessed by stepwise linear regression. RESULTS:a) The levels of alanine, valine, leucine, isoleucine, phenylalanine, tyrosine, methionine, glutamate, and lysine were higher while the level of glycine was lower in T2D than in controls (all p<0.01). b) Glutamate contributed to GGT in T2D, and its contribution was even greater than that of waist circumference. Leucine, lysine, and glutamate contributed to ALT. CONCLUSION:There were significant differences in plasma AA profile between T2D and controls. Abnormal AA might contribute to elevated liver enzymes. The interaction between AA, liver enzymes, and the risk of T2D should be further investigated by prospective studies.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Chen T,Zhang X,Long Y,Yu H,Ran X,Gao Y,Lu H,Xie X,Chen X,Ren Y,Shi J,Tian H

doi

10.3275/8059

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

772-5

issue

8

eissn

0391-4097

issn

1720-8386

pii

8059

journal_volume

35

pub_type

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