Endothelial Cell Cystathionine γ-Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury.

abstract：BACKGROUND:Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a key role in removing toxic aldehydes. Deficient variant ALDH2*2 genotype is prevalent in up to 40% of the East Asians and reported to be associated with acute myocardial infarction (AMI). To elucidate the mechanisms underlying the association of ALDH2*2 ...

journal_title：Journal of the American Heart Association

authors： Mizuno Y,Hokimoto S,Harada E,Kinoshita K,Nakagawa K,Yoshimura M,Ogawa H,Yasue H

更新日期：2016-05-06 00:00:00

abstract：BACKGROUND:Galectin-3 may play a role in cardiac and noncardiac fibrosis, and elevated circulating levels of this protein predict adverse outcomes in patients with heart failure who do not have congenital heart disease. We investigated galectin-3 in adults with single-ventricle Fontan circulation, patients who are pron...

journal_title：Journal of the American Heart Association

authors： Opotowsky AR,Baraona F,Owumi J,Loukas B,Singh MN,Valente AM,Wu F,Cheng S,Veldtman G,Rimm EB,Landzberg MJ

更新日期：2016-01-11 00:00:00

abstract：:Background Dietary micronutrient deficiencies have been shown to predict event-free survival in other countries but have not been examined in patients with heart failure living in the United States. The purpose of this study was to determine whether number of dietary micronutrient deficiencies in patients with heart f...

journal_title：Journal of the American Heart Association

authors： Lennie TA,Andreae C,Rayens MK,Song EK,Dunbar SB,Pressler SJ,Heo S,Kim J,Moser DK

更新日期：2018-09-04 00:00:00

abstract：:Background This study examined the association between ideal cardiovascular health ( CVH ) and the retinal microvasculature in midadulthood. Methods and Results The Cardiovascular Risk in Young Finns Study included children from 5 Finnish University cities, who were chosen randomly from the national population registe...

journal_title：Journal of the American Heart Association

authors： Campbell MD,Laitinen TT,Hughes A,Pahkala K,Juonala M,Kähönen M,Wong TY,Lehtimäki T,Hutri-Kähönen N,Raitakari OT,Tapp RJ

更新日期：2018-10-16 00:00:00

abstract：:Background The "healthy obese" hypothesis suggests the risks associated with excess adiposity are reduced in those with higher muscle quality (mass/strength). Alternative possibilities include loss of muscle quality as people become unwell (reverse causality) or unmeasured confounding. Methods and Results We conducted...

journal_title：Journal of the American Heart Association

authors： Farmer RE,Mathur R,Schmidt AF,Bhaskaran K,Fatemifar G,Eastwood SV,Finan C,Denaxas S,Smeeth L,Chaturvedi N

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:Epidemiological evidence suggests a cardioprotective role of α-linolenic acid (ALA), a plant-derived ω-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a...

journal_title：Journal of the American Heart Association

authors： Sala-Vila A,Guasch-Ferré M,Hu FB,Sánchez-Tainta A,Bulló M,Serra-Mir M,López-Sabater C,Sorlí JV,Arós F,Fiol M,Muñoz MA,Serra-Majem L,Martínez JA,Corella D,Fitó M,Salas-Salvadó J,Martínez-González MA,Estruch R,Ros E,P

更新日期：2016-01-26 00:00:00

abstract：:Background Myocardial infarction (MI) size is a key predictor of prognosis in post-MI patients. Cardiovascular magnetic resonance (CMR) is the gold standard test for MI quantification, but the ECG is less expensive and more widely available. We sought to quantify the relationship between ECG markers and cardiovascular...

journal_title：Journal of the American Heart Association

authors： Lee DC,Albert CM,Narula D,Kadish AH,Panicker GK,Wu E,Schaechter A,Pester J,Chatterjee NA,Cook NR,Goldberger JJ

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:Whether heart rate upon discharge following hospitalization for heart failure is associated with long-term adverse outcomes and whether this association differs between patients with sinus rhythm (SR) and atrial fibrillation (AF) have not been well studied. METHODS AND RESULTS:We conducted a retrospective c...

journal_title：Journal of the American Heart Association

authors： Laskey WK,Alomari I,Cox M,Schulte PJ,Zhao X,Hernandez AF,Heidenreich PA,Eapen ZJ,Yancy C,Bhatt DL,Fonarow GC,AHA Get With The Guidelines®‐Heart Failure Program.

更新日期：2015-04-22 00:00:00

abstract：BACKGROUND:Hispanic persons represent a heterogeneous and growing population of any race with origins in Mexico, the Caribbean, Central America, South America, or other Spanish-speaking countries. Previous studies have documented variation in cardiovascular risk and outcomes among Hispanic subgroups. Few studies have i...

journal_title：Journal of the American Heart Association

authors： Rodriguez F,Hastings KG,Hu J,Lopez L,Cullen M,Harrington RA,Palaniappan LP

更新日期：2017-12-13 00:00:00

abstract：:Background Patients undergoing lead extraction for infected devices have worse outcomes compared with those with noninfected devices. We assessed predictors of in-hospital mortality and procedure-related major adverse events (MAEs) in a large cohort undergoing lead extraction. Methods and Results Deidentified hospital...

journal_title：Journal of the American Heart Association

authors： Aleong RG,Zipse MM,Tompkins C,Aftab M,Varosy P,Sauer W,Kao D

更新日期：2020-04-07 00:00:00

abstract：:Background Cardiology has advanced guideline development and quality measurement. Recognizing the substantial benefits of guideline-directed medical therapy, this study aims to measure and explain apparent deviations in heart failure ( HF ) guideline adherence by clinicians at hospital discharge and describe any impac...

journal_title：Journal of the American Heart Association

authors： Gilstrap LG,Stevenson LW,Small R,Parambi R,Hamershock R,Greenberg J,Carr C,Ghazinouri R,Rathman L,Han E,Mehra MR,Desai AS

更新日期：2018-08-07 00:00:00

abstract：BACKGROUND:Ischemic stroke is a major cause of death and disability in the world. A major ischemic stroke subtype, large-vessel ischemic stroke (large artery atherosclerosis; LAA), has been shown to have some genetic components in individuals of European ancestry. However, it is not clear whether the genetic predisposi...

journal_title：Journal of the American Heart Association

authors： Lee TH,Ko TM,Chen CH,Lee MT,Chang YJ,Chang CH,Huang KL,Chang TY,Lee JD,Chang KC,Yang JT,Wen MS,Wang CY,Chen YT,Hsieh CS,Chou SY,Liu YM,Chen HW,Liao HT,Wang CW,Chen SP,Lu LS,Chen YT,Wu JY

更新日期：2016-03-29 00:00:00

abstract：:Background We evaluated a community-engaged stroke preparedness intervention that aimed to increase early hospital arrival and emergency medical services (EMS) utilization among patients with stroke in the South Side of Chicago, Illinois. Methods and Results We compared change in early hospital arrival (<3 hours from ...

journal_title：Journal of the American Heart Association

authors： Prabhakaran S,Richards CT,Kwon S,Wymore E,Song S,Eisenstein A,Brown J,Kandula NR,Mason M,Beckstrom H,Washington KV,Aggarwal NT

更新日期：2020-09-15 00:00:00

abstract：:Background The purpose of this study was to determine whether the presence of antegrade blood flow was related to stroke subtype in patients with acute intracranial large artery occlusion. Methods and Results The prospectively collected data for consecutive patients who had occlusion of the unilateral M1 segment of th...

journal_title：Journal of the American Heart Association

authors： Zhang M,Chen Z,Xu J,Gong X,Shi F,Lou M

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Sedentary behaviors have been directly associated with all-cause mortality. However, little is known about different types of sedentary behaviors in relation to overall mortality. Our objective was to assess the association between different sedentary behaviors and all-cause mortality. METHODS AND RESULTS:I...

journal_title：Journal of the American Heart Association

authors： Basterra-Gortari FJ,Bes-Rastrollo M,Gea A,Núñez-Córdoba JM,Toledo E,Martínez-González MÁ

更新日期：2014-06-25 00:00:00

abstract：BACKGROUND:The geometric organization of myocytes in the ventricular wall comprises the structural underpinnings of cardiac mechanical function. Cardiac myosin binding protein-C (MYBPC3) is a sarcomeric protein, for which phosphorylation modulates myofilament binding, sarcomere morphology, and myocyte alignment in the ...

journal_title：Journal of the American Heart Association

authors： Taylor EN,Hoffman MP,Barefield DY,Aninwene GE 2nd,Abrishamchi AD,Lynch TL 4th,Govindan S,Osinska H,Robbins J,Sadayappan S,Gilbert RJ

更新日期：2016-03-15 00:00:00

abstract：:Background Ischemic heart disease continues to be a leading cause of mortality in patients. Extracellular vesicles (EVs) provide a potential for treatment that may induce collateral vessel growth to increase myocardial perfusion. Methods and Results Nineteen male Yorkshire pigs were given a high-fat diet for 4 weeks, ...

journal_title：Journal of the American Heart Association

authors： Scrimgeour LA,Potz BA,Aboul Gheit A,Shi G,Stanley M,Zhang Z,Sodha NR,Ahsan N,Abid MR,Sellke FW

更新日期：2019-08-06 00:00:00

abstract：:Background Malnutrition is one of the most important comorbidities in patients with heart failure with preserved ejection fraction. We recently reported the prognostic significance of serum cholinesterase level and superior predictive power of cholinesterase level to other objective nutritional indices such as the con...

journal_title：Journal of the American Heart Association

authors： Seo M,Yamada T,Tamaki S,Hikoso S,Yasumura Y,Higuchi Y,Nakagawa Y,Uematsu M,Abe H,Fuji H,Mano T,Nakatani D,Fukunami M,Sakata Y

更新日期：2020-01-07 00:00:00

abstract：BACKGROUND:Perioperative antiplatelet agents potentially increase bleeding after non-ST-segment elevation (NSTE) acute coronary syndromes (ACS). The protease-activated receptor 1 antagonist vorapaxar reduced cardiovascular events and was associated with increased bleeding versus placebo in NSTE ACS, but its efficacy an...

journal_title：Journal of the American Heart Association

authors： van Diepen S,Tricoci P,Podder M,Westerhout CM,Aylward PE,Held C,Van de Werf F,Strony J,Wallentin L,Moliterno DJ,White HD,Mahaffey KW,Harrington RA,Armstrong PW

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:Recent studies have shown improving survival after cardiac arrest. However, data regarding sex-based disparities in treatment and outcomes after cardiac arrest are limited. METHODS AND RESULTS:We performed a retrospective analysis of all patients suffering cardiac arrest between 2003 and 2012 using the Nati...

journal_title：Journal of the American Heart Association

authors： Kim LK,Looser P,Swaminathan RV,Horowitz J,Friedman O,Shin JH,Minutello RM,Bergman G,Singh H,Wong SC,Feldman DN

更新日期：2016-06-22 00:00:00

abstract：BACKGROUND:This study aimed to determine the relationship of statin therapy and cardiovascular risk factors to changes in atherosclerosis in the carotid artery. METHODS AND RESULTS:Carotid magnetic resonance imaging was used to evaluate 106 hyperlipidemic participants at baseline and after 12 months of 3-hydroxy-3-met...

journal_title：Journal of the American Heart Association

authors： Sandfort V,Lai S,Ahlman MA,Mallek M,Liu S,Sibley CT,Turkbey EB,Lima JA,Bluemke DA

更新日期：2016-07-13 00:00:00

abstract：BACKGROUND:Clinical guidelines recommend using predicted atherosclerotic cardiovascular disease (ASCVD) risk to inform treatment decisions. The objective was to compare the contribution of changes in modifiable risk factors versus aging to the development of high 10-year predicted ASCVD risk. METHODS AND RESULTS:A pro...

journal_title：Journal of the American Heart Association

authors： Bress AP,Colantonio LD,Booth JN 3rd,Spruill TM,Ravenell J,Butler M,Shallcross AJ,Seals SR,Reynolds K,Ogedegbe G,Shimbo D,Muntner P

更新日期：2017-02-08 00:00:00

abstract：:Background Tetrahydrobiopterin is a cofactor of endothelial NO synthase ( eNOS ), which is critical to embryonic heart development. We aimed to study the effects of sapropterin (Kuvan), an orally active synthetic form of tetrahydrobiopterin on eNOS uncoupling and congenital heart defects ( CHD s) induced by pregestati...

journal_title：Journal of the American Heart Association

authors： Engineer A,Saiyin T,Lu X,Kucey AS,Urquhart BL,Drysdale TA,Norozi K,Feng Q

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Metropolitan versus nonmetropolitan status and area median income may independently affect care for and outcomes of acute coronary syndromes. We sought to determine whether location of care modifies the association among area income, receipt of cardiac catheterization, and mortality following an acute corona...

journal_title：Journal of the American Heart Association

authors： Fabreau GE,Leung AA,Southern DA,James MT,Knudtson ML,Ghali WA,Ayanian JZ

更新日期：2016-02-23 00:00:00

abstract：:Background We aim to generate a line of "universal donor" human induced pluripotent stem cells (hi PSC s) that are nonimmunogenic and, therefore, can be used to derive cell products suitable for allogeneic transplantation. Methods and Results hi PSC s carrying knockout mutations for 2 key components (β2 microglobulin ...

journal_title：Journal of the American Heart Association

authors： Mattapally S,Pawlik KM,Fast VG,Zumaquero E,Lund FE,Randall TD,Townes TM,Zhang J

更新日期：2018-12-04 00:00:00

abstract：:Background Young women with coronary artery disease ( CAD ), a group with high psychosocial burden, were previously shown to have higher levels of interleukin-6 ( IL -6) compared with men of similar age. We sought to examine IL -6 response to acute stress in CAD patients across sex and age, and contrast results to hea...

journal_title：Journal of the American Heart Association

authors： Sullivan S,Hammadah M,Wilmot K,Ramadan R,Pearce BD,Shah A,Kaseer B,Gafeer MM,Lima BB,Kim JH,Ward L,Ko YA,Lewis TT,Hankus A,Elon L,Li L,Bremner JD,Raggi P,Quyyumi A,Vaccarino V

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Metformin use reduces the incidence and severity of stroke in patients with type 2 diabetes mellitus (DM). The benefits of metformin for stroke have not been examined in hemodialysis patients with DM. METHODS AND RESULTS:Using the National Health Insurance Research Database, we identified 17 760 patients wi...

journal_title：Journal of the American Heart Association

authors： Chien LN,Chou CL,Chen HH,Kao CC,Lin YC,Wu YL,Chen JS,Chen LY,Fang TC

更新日期：2017-11-16 00:00:00

abstract：:Background Neurocognitive impairment is a common complication of congenital heart disease (CHD) as well as acquired cardiovascular disease. Data are limited on neurocognitive function in adults with CHD (ACHD). Methods and Results A total of 1020 individuals with mild-to-moderate ACHD and 497 987 individuals without A...

journal_title：Journal of the American Heart Association

authors： Perrotta ML,Saha P,Zawadzki R,Beidelman M,Ingelsson E,Lui GK,Priest JR

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Accumulated research has shown that the older adult brain is significantly more vulnerable to stroke than the young adult brain. Although recent evidence in young adult rats demonstrates that single-whisker stimulation can result in complete protection from ischemic damage after permanent middle cerebral art...

journal_title：Journal of the American Heart Association

authors： Lay CC,Davis MF,Chen-Bee CH,Frostig RD

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:It is uncertain whether sex and race affect thrombogenicity in patients with coronary artery disease. We evaluated the effects of sex and race on thrombogenicity in patients with coronary artery disease treated with aspirin. METHODS AND RESULTS:Patients on aspirin therapy for 1 week or longer with known or ...

journal_title：Journal of the American Heart Association

authors： Lev EI,Bliden KP,Jeong YH,Pandya S,Kang K,Franzese C,Tantry US,Gurbel PA

更新日期：2014-10-20 00:00:00