当前位置： SCI文献检索 > Journal of the American Heart Association期刊下所有文献 > Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes Mellitus in Mice.

Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes Mellitus in Mice.

Abstract：

:Background Tetrahydrobiopterin is a cofactor of endothelial NO synthase ( eNOS ), which is critical to embryonic heart development. We aimed to study the effects of sapropterin (Kuvan), an orally active synthetic form of tetrahydrobiopterin on eNOS uncoupling and congenital heart defects ( CHD s) induced by pregestational diabetes mellitus in mice. Methods and Results Adult female mice were induced to pregestational diabetes mellitus by streptozotocin and bred with normal male mice to produce offspring. Pregnant mice were treated with sapropterin or vehicle during gestation. CHD s were identified by histological analysis. Cell proliferation, eNOS dimerization, and reactive oxygen species production were assessed in the fetal heart. Pregestational diabetes mellitus results in a spectrum of CHD s in their offspring. Oral treatment with sapropterin in the diabetic dams significantly decreased the incidence of CHD s from 59% to 27%, and major abnormalities, such as atrioventricular septal defect and double-outlet right ventricle, were absent in the sapropterin-treated group. Lineage tracing reveals that pregestational diabetes mellitus results in decreased commitment of second heart field progenitors to the outflow tract, endocardial cushions, and ventricular myocardium of the fetal heart. Notably, decreased cell proliferation and cardiac transcription factor expression induced by maternal diabetes mellitus were normalized with sapropterin treatment. Furthermore, sapropterin administration in the diabetic dams increased eNOS dimerization and lowered reactive oxygen species levels in the fetal heart. Conclusions Sapropterin treatment in the diabetic mothers improves eNOS coupling, increases cell proliferation, and prevents the development of CHD s in the offspring. Thus, sapropterin may have therapeutic potential in preventing CHD s in pregestational diabetes mellitus.

journal_name

J Am Heart Assoc

journal_title

Journal of the American Heart Association

authors

Engineer A,Saiyin T,Lu X,Kucey AS,Urquhart BL,Drysdale TA,Norozi K,Feng Q

doi

10.1161/JAHA.118.009624

subject

Has Abstract

pub_date

2018-11-06 00:00:00

pages

e009624

issue

21

issn

2047-9980

journal_volume

7

pub_type

杂志文章

相关文献

Journal of the American Heart Association文献大全
  • Extracellular Vesicles Promote Arteriogenesis in Chronically Ischemic Myocardium in the Setting of Metabolic Syndrome.

    abstract：:Background Ischemic heart disease continues to be a leading cause of mortality in patients. Extracellular vesicles (EVs) provide a potential for treatment that may induce collateral vessel growth to increase myocardial perfusion. Methods and Results Nineteen male Yorkshire pigs were given a high-fat diet for 4 weeks, ...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.119.012617

    authors： Scrimgeour LA,Potz BA,Aboul Gheit A,Shi G,Stanley M,Zhang Z,Sodha NR,Ahsan N,Abid MR,Sellke FW

    更新日期：2019-08-06 00:00:00

  • Beverage Consumption and Longitudinal Changes in Lipoprotein Concentrations and Incident Dyslipidemia in US Adults: The Framingham Heart Study.

    abstract：:Background Limited data are available on the prospective relationship between beverage consumption and plasma lipid and lipoprotein concentrations. Two major sources of sugar in the US diet are sugar-sweetened beverages (SSBs) and 100% fruit juices. Low-calorie sweetened beverages are common replacements. Methods and ...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.119.014083

    authors： Haslam DE,Peloso GM,Herman MA,Dupuis J,Lichtenstein AH,Smith CE,McKeown NM

    更新日期：2020-03-03 00:00:00

  • Mobile Health Access and Use Among Individuals With or At Risk for Cardiovascular Disease: 2018 Health Information National Trends Survey (HINTS).

    abstract：:Background Mobile health (mHealth) technologies can deliver interventions to prevent and manage cardiovascular disease (CVD), but mHealth uptake among those with or at risk for CVD remains incompletely explored. Therefore, in this group, we assessed the prevalence of mHealth access and usage, and the association betwe...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.119.014390

    authors： Shan R,Ding J,Plante TB,Martin SS

    更新日期：2019-12-17 00:00:00

  • Plasma Inflammatory Markers and the Risk of Developing Hypertension in Men.

    abstract：BACKGROUND:Several cross-sectional, but few prospective, studies suggest that inflammation may be involved in the development of hypertension. We examined markers of inflammation-high-sensitivity C-reactive protein, interleukin-6, and soluble intercellular adhesion molecule-1-and a marker of fibrinolysis, D-dimer, for ...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,随机对照试验

    doi：10.1161/JAHA.115.001802

    authors： Sesso HD,Jiménez MC,Wang L,Ridker PM,Buring JE,Gaziano JM

    更新日期：2015-09-21 00:00:00

  • Carotid Atherosclerosis Detected by Ultrasonography: A National Cross-Sectional Study.

    abstract：BACKGROUND:Carotid atherosclerosis (CA) is a reflector of generalized atherosclerosis that is associated with systemic vascular disease. Data are limited on the epidemiology of carotid lesions in a large, nationally representative population sample. We aimed to evaluate the prevalence of CA detected by carotid ultrason...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究

    doi：10.1161/JAHA.118.008701

    authors： Wang X,Li W,Song F,Wang L,Fu Q,Cao S,Gan Y,Zhang W,Yue W,Yan F,Shi W,Wang X,Zhang H,Zhang H,Wang Z,Lu Z

    更新日期：2018-04-05 00:00:00

  • Identification of PTCSC3 as a Novel Locus for Large-Vessel Ischemic Stroke: A Genome-Wide Association Study.

    abstract：BACKGROUND:Ischemic stroke is a major cause of death and disability in the world. A major ischemic stroke subtype, large-vessel ischemic stroke (large artery atherosclerosis; LAA), has been shown to have some genetic components in individuals of European ancestry. However, it is not clear whether the genetic predisposi...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究

    doi：10.1161/JAHA.115.003003

    authors： Lee TH,Ko TM,Chen CH,Lee MT,Chang YJ,Chang CH,Huang KL,Chang TY,Lee JD,Chang KC,Yang JT,Wen MS,Wang CY,Chen YT,Hsieh CS,Chou SY,Liu YM,Chen HW,Liao HT,Wang CW,Chen SP,Lu LS,Chen YT,Wu JY

    更新日期：2016-03-29 00:00:00

  • Clinical Significance of Postinfarct Fever in ST-Segment Elevation Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study.

    abstract：BACKGROUND:Little is known about causality and pathological mechanism underlying association of postinfarct fever with myocardial injury in patients with ST-segment elevation myocardial infarction. METHODS AND RESULTS:In 276 patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocar...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.117.005687

    authors： Jang WJ,Yang JH,Song YB,Chun WJ,Oh JH,Park YH,Lee MR,Hwang JK,Hwang JW,Hahn JY,Choi SH,Lee SC,Choe YH,Gwon HC

    更新日期：2017-04-24 00:00:00

  • Effect of Vegan Fecal Microbiota Transplantation on Carnitine- and Choline-Derived Trimethylamine-N-Oxide Production and Vascular Inflammation in Patients With Metabolic Syndrome.

    abstract：BACKGROUND:Intestinal microbiota have been found to be linked to cardiovascular disease via conversion of the dietary compounds choline and carnitine to the atherogenic metabolite TMAO (trimethylamine-N-oxide). Specifically, a vegan diet was associated with decreased plasma TMAO levels and nearly absent TMAO production...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,随机对照试验

    doi：10.1161/JAHA.117.008342

    authors： Smits LP,Kootte RS,Levin E,Prodan A,Fuentes S,Zoetendal EG,Wang Z,Levison BS,Cleophas MCP,Kemper EM,Dallinga-Thie GM,Groen AK,Joosten LAB,Netea MG,Stroes ESG,de Vos WM,Hazen SL,Nieuwdorp M

    更新日期：2018-03-26 00:00:00

  • A novel protein glycan biomarker and future cardiovascular disease events.

    abstract：BACKGROUND:Glycosylated proteins partake in multiple cellular processes including inflammation. We hypothesized that GlycA, a novel biomarker of protein glycan N-acetyl groups, is related to incident cardiovascular disease (CVD), and we compared it with high-sensitivity C-reactive protein (hsCRP). METHODS AND RESULTS:...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,随机对照试验

    doi：10.1161/JAHA.114.001221

    authors： Akinkuolie AO,Buring JE,Ridker PM,Mora S

    更新日期：2014-09-23 00:00:00

  • Risk Factors and Timing of Acute Myocardial Infarction Associated With Pregnancy: Insights From the National Inpatient Sample.

    abstract：:Background Pregnancy increases the risk of acute myocardial infarction (AMI). The purpose of this study was to examine timing and risk factors for AMI in pregnancy and poor outcome. Methods and Results National Inpatient Sample (2003-2015) was screened in pregnancy, labor and delivery, and postpartum. There were 11 29...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.120.016623

    authors： Balgobin CA,Zhang X,Lima FV,Avila C,Parikh PB,Yang J,Stergiopoulos K

    更新日期：2020-11-03 00:00:00

  • Interferon-β Modulates Inflammatory Response in Cerebral Ischemia.

    abstract：BACKGROUND:Stroke is a leading cause of death in the world. In >80% of strokes, the initial acute phase of ischemic injury is due to the occlusion of a blood vessel resulting in severe focal hypoperfusion, excitotoxicity, and oxidative damage. Interferon-β (IFNβ), a cytokine with immunomodulatory properties, was approv...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.115.002610

    authors： Kuo PC,Scofield BA,Yu IC,Chang FL,Ganea D,Yen JH

    更新日期：2016-01-08 00:00:00

  • Association of Neighborhood Race and Income With Survival After Out-of-Hospital Cardiac Arrest.

    abstract：:Background For individuals with an out-of-hospital cardiac arrest (OHCA), survival may be influenced by the neighborhood in which the arrest occurs. Methods and Results Within the national CARES (Cardiac Arrest Registry to Enhance Survival) registry, we identified 169 502 patients with OHCA from 2013 to 2017. On the b...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究

    doi：10.1161/JAHA.119.014178

    authors： Chan PS,McNally B,Vellano K,Tang Y,Spertus JA

    更新日期：2020-02-18 00:00:00

  • Incidence and Predictors of Complications During Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation.

    abstract：BACKGROUND:Cryoballoon pulmonary vein isolation (PVI) has emerged as an alternative to radiofrequency PVI for atrial fibrillation (AF). Data are lacking to define the rates and predictors of complications, particularly phrenic nerve injury (PNI). METHODS AND RESULTS:We evaluated a single-center prospective registry of...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.116.003724

    authors： Guhl EN,Siddoway D,Adelstein E,Bazaz R,Mendenhall GS,Nemec J,Saba S,Schwartzman D,Voigt A,Wang NC,Jain SK

    更新日期：2016-07-21 00:00:00

  • Cardiovascular and mortality risk of apparent resistant hypertension in women with suspected myocardial ischemia: a report from the NHLBI-sponsored WISE Study.

    abstract：BACKGROUND:Women are more likely than men to develop resistant hypertension, which is associated with excess risk of major adverse outcomes; however, the impact of resistant hypertension in women with ischemia has not been explicitly studied. In this Women's Ischemia Syndrome Evaluation (WISE) analysis, we assessed lon...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究

    doi：10.1161/JAHA.113.000660

    authors： Smith SM,Huo T,Delia Johnson B,Bittner V,Kelsey SF,Vido Thompson D,Noel Bairey Merz C,Pepine CJ,Cooper-Dehoff RM

    更新日期：2014-02-28 00:00:00

  • Late systolic central hypertension as a predictor of incident heart failure: the Multi-ethnic Study of Atherosclerosis.

    abstract：BACKGROUND:Experimental studies demonstrate that high aortic pressure in late systole relative to early systole causes greater myocardial remodeling and dysfunction, for any given absolute peak systolic pressure. METHODS AND RESULTS:We tested the hypothesis that late systolic hypertension, defined as the ratio of late...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究

    doi：10.1161/JAHA.114.001335

    authors： Chirinos JA,Segers P,Duprez DA,Brumback L,Bluemke DA,Zamani P,Kronmal R,Vaidya D,Ouyang P,Townsend RR,Jacobs DR Jr

    更新日期：2015-03-03 00:00:00

  • MicroRNA-26a Protects the Heart Against Hypertension-Induced Myocardial Fibrosis.

    abstract：:Background Hypertensive myocardial fibrosis (MF) is characterized by excessive deposition of extracellular matrix and cardiac fibroblast proliferation, which can lead to heart failure, malignant arrhythmia, and sudden death. In recent years, with the deepening of research, microRNAs have been found to have an importan...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.120.017970

    authors： Zhang W,Wang Q,Feng Y,Chen X,Yang L,Xu M,Wang X,Li W,Niu X,Gao D

    更新日期：2020-09-15 00:00:00

  • Low Nasal NO in Congenital Heart Disease With Systemic Right Ventricle and Postcardiac Transplantation.

    abstract：BACKGROUND:NO bioavailability has not been systematically examined in congenital heart disease (CHD). To assess NO in patients with CHD, we measured nasal NO (nNO) generated by the nasal epithelia, given blood NO is difficult to measure (half-life, <2 ms). Given NO's role in hemodynamic regulation and the association o...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.117.007447

    authors： Adams PS,Zahid M,Khalifa O,Feingold B,Lo CW

    更新日期：2017-12-06 00:00:00

  • The impact of lifecourse socioeconomic position on cardiovascular disease events in African Americans: the Jackson Heart Study.

    abstract：BACKGROUND:Few studies have examined the impact of lifecourse socioeconomic position (SEP) on cardiovascular disease (CVD) risk among African Americans. METHODS AND RESULTS:We used data from the Jackson Heart Study (JHS) to examine the associations of multiple measures of lifecourse SEP with CVD events in a large coho...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.114.001553

    authors： Gebreab SY,Diez Roux AV,Brenner AB,Hickson DA,Sims M,Subramanyam M,Griswold ME,Wyatt SB,James SA

    更新日期：2015-05-27 00:00:00

  • Bleeding Complications in Anticoagulated Patients With Atrial Fibrillation and Sepsis: A Propensity-Weighted Cohort Study.

    abstract：BACKGROUND:Sepsis may adversely affect bleeding risk in anticoagulated patients with atrial fibrillation (AF), but the impact of warfarin treatment in such patients is poorly described. This registry-based nationwide cohort study examined safety of oral anticoagulant treatment (OAC) in patients with preexisting AF who ...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究

    doi：10.1161/JAHA.117.007453

    authors： Søgaard M,Skjøth F,Kjældgaard JN,Lip GYH,Larsen TB

    更新日期：2017-11-09 00:00:00

  • Interaction of Left Ventricular Size and Sex on Outcome of Cardiac Resynchronization Therapy Among Patients With a Narrow QRS Duration in the EchoCRT Trial.

    abstract：BACKGROUND:Longer QRS duration (QRSd) improves, but increased left ventricular (LV) end-diastolic volume (LVEDV) reduces, efficacy of cardiac resynchronization therapy (CRT). QRSd/LVEDV ratios differ between sexes. We hypothesized that in the EchoCRT (Echocardiography Guided Cardiac Resynchronization Therapy) trial enr...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1161/JAHA.118.009592

    authors： Varma N,Sogaard P,Bax JJ,Abraham WT,Borer JS,Dickstein K,Singh JP,Gras D,Holzmeister J,Brugada J,Ruschitzka F

    更新日期：2018-05-27 00:00:00

  • Dipeptidyl Peptidase-4 Inhibition Potentiates Stimulated Growth Hormone Secretion and Vasodilation in Women.

    abstract：BACKGROUND:Diminished growth hormone (GH) is associated with impaired endothelial function and fibrinolysis. GH-releasing hormone is the primary stimulus for GH secretion and a substrate of dipeptidyl peptidase-4. We tested the hypothesis that dipeptidyl peptidase-4 inhibition with sitagliptin increases stimulated GH s...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,随机对照试验

    doi：10.1161/JAHA.117.008000

    authors： Wilson JR,Brown NJ,Nian H,Yu C,Bidlingmaier M,Devin JK

    更新日期：2018-02-25 00:00:00

  • Association Between Stroke Risk and Metformin Use in Hemodialysis Patients With Diabetes Mellitus: A Nested Case-Control Study.

    abstract：BACKGROUND:Metformin use reduces the incidence and severity of stroke in patients with type 2 diabetes mellitus (DM). The benefits of metformin for stroke have not been examined in hemodialysis patients with DM. METHODS AND RESULTS:Using the National Health Insurance Research Database, we identified 17 760 patients wi...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究

    doi：10.1161/JAHA.117.007611

    authors： Chien LN,Chou CL,Chen HH,Kao CC,Lin YC,Wu YL,Chen JS,Chen LY,Fang TC

    更新日期：2017-11-16 00:00:00

  • Elevated Wall Tension Leads to Reduced miR-133a in the Thoracic Aorta by Exosome Release.

    abstract：:Background Reduced miR-133a was previously found to be associated with thoracic aortic ( TA ) dilation, as seen in aneurysm disease. Because wall tension increases with vessel diameter (Law of Laplace), this study tested the hypothesis that elevated tension led to the reduction of miR-133a in the TA . Methods and Resu...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.118.010332

    authors： Akerman AW,Blanding WM,Stroud RE,Nadeau EK,Mukherjee R,Ruddy JM,Zile MR,Ikonomidis JS,Jones JA

    更新日期：2019-01-08 00:00:00

  • Optimal Lifestyle Components in Young Adulthood Are Associated With Maintaining the Ideal Cardiovascular Health Profile Into Middle Age.

    abstract：BACKGROUND:Middle-aged adults with ideal blood pressure, cholesterol, and glucose levels exhibit substantially lower cardiovascular mortality than those with unfavorable levels. Four healthy lifestyle components-optimal body weight, diet, physical activity, and not smoking-are recommended for cardiovascular health (CVH...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究

    doi：10.1161/JAHA.115.002048

    authors： Gooding HC,Shay CM,Ning H,Gillman MW,Chiuve SE,Reis JP,Allen NB,Lloyd-Jones DM

    更新日期：2015-10-29 00:00:00

  • Pregnancy Loss and Carotid Intima-Media Thickness in Mexican Women.

    abstract：BACKGROUND:Cardiovascular disease in women often develops without conventional risk factors. Prenatal loss is a common pregnancy outcome that may result in physiological changes can increase the potential future risk of cardiovascular disease. Insufficient information exists regarding the impact of pregnancy loss on ea...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.117.007582

    authors： Hartasanchez SA,Flores-Torres M,Monge A,Yunes E,Rodriguez B,Cantu-Brito C,Colaci D,Lamadrid-Figueroa H,Lopez-Ridaura R,Lajous M

    更新日期：2018-01-13 00:00:00

  • Long-Term Clinical Outcomes Following Revascularization in High-Risk Coronary Anatomy Patients With Stable Ischemic Heart Disease.

    abstract：:Background The ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) trial failed to show a reduction in hard clinical end points with an early invasive strategy in stable ischemic heart disease (SIHD). However, the influence of left main disease and high-risk coronary...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.120.018104

    authors： Bainey KR,Alemayehu W,Welsh RC,Kumar A,King SB 3rd,Kirtane AJ

    更新日期：2021-01-05 00:00:00

  • Stroke Ready Intervention: Community Engagement to Decrease Prehospital Delay.

    abstract：BACKGROUND:Time-limited acute stroke treatments are underused, primarily due to prehospital delay. One approach to decreasing prehospital delay is to increase stroke preparedness, the ability to recognize stroke, and the intention to immediately call emergency medical services, through community engagement with high-ri...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.116.003331

    authors： Skolarus LE,Zimmerman MA,Bailey S,Dome M,Murphy JB,Kobrossi C,Dombrowski SU,Burke JF,Morgenstern LB

    更新日期：2016-05-20 00:00:00

  • Sex Differences in Circulating Progenitor Cells.

    abstract：BACKGROUND:Lower levels of circulating progenitor cells (PCs) reflect impaired endogenous regenerative capacity and are associated with aging, vascular disease, and poor outcomes. Whether biologic sex and sex hormones influence PC numbers remains a subject of controversy. We sought to determine sex differences in circu...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.117.006245

    authors： Topel ML,Hayek SS,Ko YA,Sandesara PB,Samman Tahhan A,Hesaroieh I,Mahar E,Martin GS,Waller EK,Quyyumi AA

    更新日期：2017-10-03 00:00:00

  • Effects of Preoperative Statin on Acute Kidney Injury After Off-Pump Coronary Artery Bypass Grafting.

    abstract：:Background Although many patients with coronary artery disease are using statins before off-pump coronary artery bypass grafting ( OPCAB ) following current guidelines, recent studies have raised concerns regarding adverse effects of preoperative statins on postoperative kidney function. We evaluated the effects of pr...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.118.010892

    authors： Park J,Lee JH,Kim KA,Lee SH,Lee YT,Kim WS,Min JJ

    更新日期：2019-04-02 00:00:00

  • Association Between Intensive Care Unit Usage and Long-Term Medication Adherence, Mortality, and Readmission Among Initially Stable Patients With Non-ST-Segment-Elevation Myocardial Infarction.

    abstract：:Background Hospitals in the United States vary in their use of intensive care units (ICUs) for hemodynamically stable patients with non-ST-segment-elevation myocardial infarction (NSTEMI). The association between ICU use and long-term outcomes after NSTEMI is unknown. Methods and Results Using data from the National C...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.119.015179

    authors： Fanaroff AC,Chen AY,van Diepen S,Peterson ED,Wang TY

    更新日期：2020-03-17 00:00:00