当前位置： SCI文献检索 > Journal of the American Heart Association期刊下所有文献 > Extracellular Vesicles Promote Arteriogenesis in Chronically Ischemic Myocardium in the Setting of Metabolic Syndrome.

Extracellular Vesicles Promote Arteriogenesis in Chronically Ischemic Myocardium in the Setting of Metabolic Syndrome.

Abstract：

:Background Ischemic heart disease continues to be a leading cause of mortality in patients. Extracellular vesicles (EVs) provide a potential for treatment that may induce collateral vessel growth to increase myocardial perfusion. Methods and Results Nineteen male Yorkshire pigs were given a high-fat diet for 4 weeks, then underwent placement of an ameroid constrictor on the left circumflex artery to induce chronic myocardial ischemia. Two weeks later, the pigs received either intramyocardial vehicle (n=6), EVs (high-fat diet with myocardial EV injection [HVM]; n=8), or HVM and calpain inhibition (n=5). Five weeks later, myocardial function, perfusion, coronary vascular density, and cell signaling were examined. Perfusion in the collateral-dependent myocardium was increased during rapid ventricular pacing in the HVM group in both nonischemic (P=0.04) and ischemic areas of the ventricle (P=0.05). Cardiac output and stroke volume were significantly improved in the HVM group compared with the control group during ventricular pacing (P=0.006). Increased arteriolar density was seen in the HVM group in both nonischemic and ischemic myocardium (P=0.003 for both). However, no significant changes in the capillary density were observed between the control, HVM, and HVM and calpain inhibition groups (P=0.07). The group that received EVs with oral calpain inhibition had neither increased vessel density (P>0.99) nor improvement in blood flow or cardiac function (P=0.48) when compared with the control group. Conclusions These findings suggest that EVs promote angiogenesis in areas of chronic myocardial ischemia and improve cardiac function under conditions of diet-induced metabolic syndrome.

journal_name

J Am Heart Assoc

journal_title

Journal of the American Heart Association

authors

Scrimgeour LA,Potz BA,Aboul Gheit A,Shi G,Stanley M,Zhang Z,Sodha NR,Ahsan N,Abid MR,Sellke FW

doi

10.1161/JAHA.119.012617

subject

Has Abstract

pub_date

2019-08-06 00:00:00

pages

e012617

issue

15

issn

2047-9980

journal_volume

8

pub_type

杂志文章

相关文献

Journal of the American Heart Association文献大全
  • Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia.

    abstract：:Background Hyperhomocysteinemia is a risk factor for ischemic stroke; however, a targeted treatment strategy is lacking partly because of limited understanding of the causal role of homocysteine in cerebrovascular pathogenesis. Methods and Results In a genetic model of cystathionine beta synthase (CBS) deficiency, we ...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.119.013368

    authors： Gu SX,Sonkar VK,Katare PB,Kumar R,Kruger WD,Arning E,Bottiglieri T,Lentz SR,Dayal S

    更新日期：2020-02-18 00:00:00

  • Stroke in Adults With Coarctation of the Aorta: A National Population-Based Study.

    abstract：BACKGROUND:Adults with repaired coarctation of the aorta (CoA) have reduced long-term survival compared with the general population. This study aimed to determine whether CoA is independently associated with premature ischemic and hemorrhagic stroke in the contemporary era. METHODS AND RESULTS:This was a cross-section...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究

    doi：10.1161/JAHA.118.009072

    authors： Pickard SS,Gauvreau K,Gurvitz M,Gagne JJ,Opotowsky AR,Jenkins KJ,Prakash A

    更新日期：2018-06-01 00:00:00

  • Enigmatic ectopic fat: prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese population.

    abstract：BACKGROUND:Fatty infiltration of the pancreas is an enigmatic manifestation of ectopic fat deposition in obesity. Studies have shown that pancreatic lipid accumulation interferes with insulin secretion in humans. However, the prevalence of fatty pancreas and its associated factors in the general population remain uncle...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.113.000297

    authors： Wang CY,Ou HY,Chen MF,Chang TC,Chang CJ

    更新日期：2014-02-26 00:00:00

  • Fludrocortisone Is Associated With a Higher Risk of All-Cause Hospitalizations Compared With Midodrine in Patients With Orthostatic Hypotension.

    abstract：BACKGROUND:Orthostatic hypotension causes ≈80 000 hospitalizations per year in the United States. Treatments for orthostatic hypotension include fludrocortisone, a mineralocorticoid analog that promotes sodium reabsorption; and midodrine, an α-1 adrenergic agonist that is a direct vasoconstrictor. Although both medicat...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.117.006848

    authors： Grijalva CG,Biaggioni I,Griffin MR,Shibao CA

    更新日期：2017-10-12 00:00:00

  • Impact of Statin Therapy on Clinical Outcome in Patients With Coronary Spasm.

    abstract：BACKGROUND:Statin therapy reduces the risk of cardiovascular events in patients with obstructive coronary artery disease. The aim of the present study was to determine the effects of statins on the prognosis of patients with coronary vasospastic angina (VSA) free of significant atherosclerotic stenosis. METHODS AND RE...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.116.003426

    authors： Ishii M,Kaikita K,Sato K,Yamanaga K,Miyazaki T,Akasaka T,Tabata N,Arima Y,Sueta D,Sakamoto K,Yamamoto E,Tsujita K,Yamamuro M,Kojima S,Soejima H,Hokimoto S,Matsui K,Ogawa H

    更新日期：2016-05-20 00:00:00

  • Obstructive and Central Sleep Apnea and the Risk of Incident Atrial Fibrillation in a Community Cohort of Men and Women.

    abstract：BACKGROUND:Previous studies have documented a high prevalence of atrial fibrillation (AF) in individuals with obstructive sleep apnea (OSA). Central sleep apnea (CSA) has been associated with AF in patients with heart failure. However, data from prospective cohorts are sparse and few studies have distinguished the asso...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.116.004500

    authors： Tung P,Levitzky YS,Wang R,Weng J,Quan SF,Gottlieb DJ,Rueschman M,Punjabi NM,Mehra R,Bertisch S,Benjamin EJ,Redline S

    更新日期：2017-07-01 00:00:00

  • Toll-Like Receptor (TLR)4 and MyD88 are Essential for Atheroprotection by Peritoneal B1a B Cells.

    abstract：BACKGROUND:We previously identified peritoneal B1a cells that secrete natural IgM as a key atheroprotective B cell subset. However, the molecules that activate atheroprotective B1a cells are unknown. Here, we investigated whether Toll-like receptors (TLRs) TLR2, TLR4, and TLR9 expressed by B1a cells are required for Ig...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.115.002947

    authors： Hosseini H,Li Y,Kanellakis P,Tay C,Cao A,Liu E,Peter K,Tipping P,Toh BH,Bobik A,Kyaw T

    更新日期：2016-11-14 00:00:00

  • Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase/Krüppel-Like Factor 4 (AMPK/KLF4) Signaling.

    abstract：BACKGROUND:Fatty acids constitute the critical components of cell structure and function, and dysregulation of fatty acid composition may exert diverging vascular effects including proliferation, migration, and differentiation of vascular smooth muscle cells (VSMCs). However, direct evidence for this hypothesis has bee...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.116.004014

    authors： Sunaga H,Matsui H,Anjo S,Syamsunarno MR,Koitabashi N,Iso T,Matsuzaka T,Shimano H,Yokoyama T,Kurabayashi M

    更新日期：2016-11-23 00:00:00

  • Interaction of Left Ventricular Size and Sex on Outcome of Cardiac Resynchronization Therapy Among Patients With a Narrow QRS Duration in the EchoCRT Trial.

    abstract：BACKGROUND:Longer QRS duration (QRSd) improves, but increased left ventricular (LV) end-diastolic volume (LVEDV) reduces, efficacy of cardiac resynchronization therapy (CRT). QRSd/LVEDV ratios differ between sexes. We hypothesized that in the EchoCRT (Echocardiography Guided Cardiac Resynchronization Therapy) trial enr...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1161/JAHA.118.009592

    authors： Varma N,Sogaard P,Bax JJ,Abraham WT,Borer JS,Dickstein K,Singh JP,Gras D,Holzmeister J,Brugada J,Ruschitzka F

    更新日期：2018-05-27 00:00:00

  • Development of Human-Like Advanced Coronary Plaques in Low-Density Lipoprotein Receptor Knockout Pigs and Justification for Statin Treatment Before Formation of Atherosclerotic Plaques.

    abstract：BACKGROUND:Although clinical trials have proved that statin can be used prophylactically against cardiovascular events, the direct effects of statin on plaque development are not well understood. We generated low-density lipoprotein receptor knockout (LDLR(-/-)) pigs to study the effects of early statin administration ...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.115.002779

    authors： Li Y,Fuchimoto D,Sudo M,Haruta H,Lin QF,Takayama T,Morita S,Nochi T,Suzuki S,Sembon S,Nakai M,Kojima M,Iwamoto M,Hashimoto M,Yoda S,Kunimoto S,Hiro T,Matsumoto T,Mitsumata M,Sugitani M,Saito S,Hirayama A,Onish

    更新日期：2016-04-18 00:00:00

  • Risk of Stroke in Patients With Ocular Arterial Occlusive Disorders: A Retrospective Canadian Study.

    abstract：:Background Monocular vision loss, attributed to either central retinal artery occlusion ( CRAO ), branch retinal artery occlusion ( BRAO ), or ocular ischemic syndrome ( OIS ), is thought to be associated with an increased prevalence of cerebral infarcts. However, there is a paucity of data substantiating this. We aim...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究

    doi：10.1161/JAHA.118.010509

    authors： Avery MB,Magal I,Kherani A,Mitha AP

    更新日期：2019-02-05 00:00:00

  • Predictive Value of 18F-Sodium Fluoride Positron Emission Tomography in Detecting High-Risk Coronary Artery Disease in Combination With Computed Tomography.

    abstract：:Background Application of 18F-sodium fluoride (18F-NaF) positron emission tomography ( PET ) to coronary artery disease has attracted interest. We investigated the utility of 18F-NaF uptake for predicting coronary events and evaluated the combined use of coronary computed tomography (CT) angiography ( CCTA ) and 18F-N...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.118.010224

    authors： Kitagawa T,Yamamoto H,Nakamoto Y,Sasaki K,Toshimitsu S,Tatsugami F,Awai K,Hirokawa Y,Kihara Y

    更新日期：2018-10-16 00:00:00

  • Pharmacodynamic Comparison of Ticagrelor Monotherapy Versus Ticagrelor and Aspirin in Patients After Percutaneous Coronary Intervention: The TEMPLATE (Ticagrelor Monotherapy and Platelet Reactivity) Randomized Controlled Trial.

    abstract：:Background To assess differences in platelet inhibition during ticagrelor monotherapy (TIC) or dual therapy with ticagrelor and aspirin (TIC+ASP) in patients after percutaneous coronary intervention using a comprehensive panel of functional tests. Methods and Results In a single-center parallel group, open label, rand...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.120.016495

    authors： Johnson TW,Baos S,Collett L,Hutchinson JL,Nkau M,Molina M,Aungraheeta R,Reilly-Stitt C,Bowles R,Reeves BC,Rogers CA,Mundell SJ,Baumbach A,Mumford AD

    更新日期：2020-12-15 00:00:00

  • Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysms: A Histopathological Evaluation.

    abstract：:Background Unruptured intracerebral aneurysm wall enhancement (AWE) on vessel wall magnetic resonance imaging scans may be a promising predictor for rupture-prone intracerebral aneurysms. However, the pathophysiology of AWE remains unclear. To this end, the association between AWE and histopathological changes was ass...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.120.018633

    authors： Zhong W,Su W,Li T,Tan X,Chen C,Wang Q,Wang D,Su W,Wang Y

    更新日期：2021-01-19 00:00:00

  • Lower On-Treatment Low-Density Lipoprotein Cholesterol and Major Adverse Cardiovascular Events in Women and Men: Pooled Analysis of 10 ODYSSEY Phase 3 Alirocumab Trials.

    abstract：:Background In statin trials, men and women derived similar relative risk reductions in cardiovascular events per 39 mg/ dL low-density lipoprotein cholesterol ( LDL -C) reduction. We explored whether lower LDL -C levels and greater LDL -C percentage reductions than those achieved with statins are associated with reduc...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1161/JAHA.118.009221

    authors： Vallejo-Vaz AJ,Ginsberg HN,Davidson MH,Eckel RH,Cannon CP,Lee LV,Bessac L,Pordy R,Letierce A,Ray KK

    更新日期：2018-09-18 00:00:00

  • One-Year Mortality After Intensification of Outpatient Diuretic Therapy.

    abstract：:Background Mortality is increased following a hospitalization for decompensated heart failure (HF), during which diuretics are usually intensified. It is unclear how risk is affected after outpatient intensification of diuretic therapy for HF. Methods and Results From nationwide administrative registers, we identified...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.119.016010

    authors： Madelaire C,Gustafsson F,Stevenson LW,Kristensen SL,Køber L,Andersen J,D'Souza M,Biering-Sørensen T,Andersson C,Torp-Pedersen C,Gislason G,Schou M

    更新日期：2020-07-21 00:00:00

  • Assessment of a University of California, Los Angeles 4-variable risk score for advanced heart failure.

    abstract：BACKGROUND:The 4-variable risk score from University of California, Los Angeles (UCLA) demonstrated superior discrimination in advanced heart failure, compared to established risk scores. However, the model has not been externally validated, and its suitability as a selection tool for heart transplantation (HT) and lef...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.114.000998

    authors： Sartipy U,Goda A,Mancini DM,Lund LH

    更新日期：2014-06-06 00:00:00

  • Implantable Ventricular Assist Device Use and Outcomes in People With End-Stage Renal Disease.

    abstract：BACKGROUND:People with end-stage renal disease (ESRD) are at risk for advanced heart failure, but little is known about use and outcomes of durable mechanical circulatory support in this setting. We examined use and outcomes of implantable ventricular assist devices (VADs) in a national ESRD cohort. METHODS AND RESULT...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.118.008664

    authors： Walther CP,Niu J,Winkelmayer WC,Cheema FH,Nair AP,Morgan JA,Fedson SE,Deswal A,Navaneethan SD

    更新日期：2018-07-06 00:00:00

  • Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress.

    abstract：BACKGROUND:The amino acid response (AAR) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control nonderepressible 2. In addition to mobilizing amino acids, the AAR broadly affects gene and protein expression in a variety of pathways and elicits antifi...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.116.004453

    authors： Qin P,Arabacilar P,Bernard RE,Bao W,Olzinski AR,Guo Y,Lal H,Eisennagel SH,Platchek MC,Xie W,Del Rosario J,Nayal M,Lu Q,Roethke T,Schnackenberg CG,Wright F,Quaile MP,Halsey WS,Hughes AM,Sathe GM,Livi GP,Kirkpatri

    更新日期：2017-05-09 00:00:00

  • Longitudinal assessment of growth in hypoplastic left heart syndrome: results from the single ventricle reconstruction trial.

    abstract：BACKGROUND:We sought to characterize growth between birth and age 3 years in infants with hypoplastic left heart syndrome who underwent the Norwood procedure. METHODS AND RESULTS:We performed a secondary analysis using the Single Ventricle Reconstruction Trial database after excluding patients <37 weeks gestation (N=4...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,随机对照试验

    doi：10.1161/JAHA.114.000079

    authors： Burch PT,Gerstenberger E,Ravishankar C,Hehir DA,Davies RR,Colan SD,Sleeper LA,Newburger JW,Clabby ML,Williams IA,Li JS,Uzark K,Cooper DS,Lambert LM,Pemberton VL,Pike NA,Anderson JB,Dunbar-Masterson C,Khaikin S,Zyble

    更新日期：2014-06-23 00:00:00

  • Long-Term Outcomes in Patients With Turner Syndrome: A 68-Year Follow-Up.

    abstract：:Background Turner syndrome ( TS ) is the most common sex chromosome abnormality in women and is associated with increased morbidity and mortality. We describe long-term outcomes in a large cohort of patients with TS . Methods and Results Retrospective review of patients with TS followed at Mayo Clinic Rochester from 1...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.118.011501

    authors： Fuchs MM,Attenhofer Jost C,Babovic-Vuksanovic D,Connolly HM,Egbe A

    更新日期：2019-06-04 00:00:00

  • Safety and Effectiveness of Contemporary P2Y12 Inhibitors in an East Asian Population With Acute Coronary Syndrome: A Nationwide Population-Based Cohort Study.

    abstract：:Background Prior reports indicate that the effect of P2Y12 inhibitors may be different in East Asian patients ("East Asian paradox"); therefore, understanding the outcomes associated with potent P2Y12 inhibitors in different populations is clinically important. Methods and Results In this observational cohort study us...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.119.012078

    authors： Yun JE,Kim YJ,Park JJ,Kim S,Park K,Cho MS,Nam GB,Park DW

    更新日期：2019-07-16 00:00:00

  • Diagnostic Accuracy of Commercially Available Automated External Defibrillators.

    abstract：BACKGROUND:Although automated external defibrillators (AEDs) have contributed to a better survival of out-of-hospital cardiac arrests, there have been reports of their malfunctioning. We investigated the diagnostic accuracy of commercially available AEDs using surface ECGs of ventricular fibrillation (VF), ventricular ...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.115.002465

    authors： Nishiyama T,Nishiyama A,Negishi M,Kashimura S,Katsumata Y,Kimura T,Nishiyama N,Tanimoto Y,Aizawa Y,Mitamura H,Fukuda K,Takatsuki S

    更新日期：2015-12-01 00:00:00

  • Early and Late Effects of Cardiac Resynchronization Therapy in Adult Congenital Heart Disease.

    abstract：:Background There are limited data about cardiac resynchronization therapy (CRT) in adult congenital heart disease. We aimed to assess early and late outcomes of CRT among patients with adult congenital heart disease. Methods and Results We retrospectively studied 54 patients with adult congenital heart disease (median...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.119.012744

    authors： Yin Y,Dimopoulos K,Shimada E,Lascelles K,Griffiths S,Wong T,Gatzoulis MA,Babu-Narayan SV,Li W

    更新日期：2019-11-05 00:00:00

  • Reperfusion and Time to Presentation in Women: Too Little Too Late.

    abstract：:See Editorial by Cenko et al. ...

    journal_title：Journal of the American Heart Association

    pub_type： 评论,社论

    doi：10.1161/JAHA.118.011835

    authors： Pande AN,Jacobs AK

    更新日期：2019-02-19 00:00:00

  • A Wide and Specific Spectrum of Genetic Variants and Genotype-Phenotype Correlations Revealed by Next-Generation Sequencing in Patients with Left Ventricular Noncompaction.

    abstract：BACKGROUND:Left ventricular noncompaction (LVNC) has since been classified as a primary genetic cardiomyopathy, but the genetic basis is not fully evaluated. The aim of the present study was to identify the genetic spectrum using next-generation sequencing and to evaluate genotype-phenotype correlations in LVNC patient...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.117.006210

    authors： Wang C,Hata Y,Hirono K,Takasaki A,Ozawa SW,Nakaoka H,Saito K,Miyao N,Okabe M,Ibuki K,Nishida N,Origasa H,Yu X,Bowles NE,Ichida F,for LVNC Study Collaborators.

    更新日期：2017-08-30 00:00:00

  • Associations of Accelerometer-Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk Factors: The CARDIA Study.

    abstract：:Background Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity; however, existing studies are limited by cross-sectional study designs. Methods and Results Participants were 1922 adults fr...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究

    doi：10.1161/JAHA.118.010212

    authors： Whitaker KM,Pettee Gabriel K,Buman MP,Pereira MA,Jacobs DR Jr,Reis JP,Gibbs BB,Carnethon MR,Staudenmayer J,Sidney S,Sternfeld B

    更新日期：2019-01-08 00:00:00

  • Clinical Significance of Postinfarct Fever in ST-Segment Elevation Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study.

    abstract：BACKGROUND:Little is known about causality and pathological mechanism underlying association of postinfarct fever with myocardial injury in patients with ST-segment elevation myocardial infarction. METHODS AND RESULTS:In 276 patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocar...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.117.005687

    authors： Jang WJ,Yang JH,Song YB,Chun WJ,Oh JH,Park YH,Lee MR,Hwang JK,Hwang JW,Hahn JY,Choi SH,Lee SC,Choe YH,Gwon HC

    更新日期：2017-04-24 00:00:00

  • Phospholipase Cγ1 Mediates Intima Formation Through Akt-Notch1 Signaling Independent of the Phospholipase Activity.

    abstract：BACKGROUND:Vascular smooth muscle cell proliferation, migration, and dedifferentiation are critical for vascular diseases. Recently, it was demonstrated that Notch receptors have opposing effects on intima formation after vessel injury. Therefore, it is important to investigate the specific regulatory pathways that act...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.117.005537

    authors： Jiang D,Zhuang J,Peng W,Lu Y,Liu H,Zhao Q,Chi C,Li X,Zhu G,Xu X,Yan C,Xu Y,Ge J,Pang J

    更新日期：2017-07-11 00:00:00

  • Novel Phenotype-Genotype Correlations of Restrictive Cardiomyopathy With Myosin-Binding Protein C (MYBPC3) Gene Mutations Tested by Next-Generation Sequencing.

    abstract：BACKGROUND:MYBPC3 dysfunctions have been proven to induce dilated cardiomyopathy, hypertrophic cardiomyopathy, and/or left ventricular noncompaction; however, the genotype-phenotype correlation between MYBPC3 and restrictive cardiomyopathy (RCM) has not been established. The newly developed next-generation sequencing m...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.115.001879

    authors： Wu W,Lu CX,Wang YN,Liu F,Chen W,Liu YT,Han YC,Cao J,Zhang SY,Zhang X

    更新日期：2015-07-10 00:00:00