Early and Late Effects of Cardiac Resynchronization Therapy in Adult Congenital Heart Disease.

abstract：:Background Tetrahydrobiopterin is a cofactor of endothelial NO synthase ( eNOS ), which is critical to embryonic heart development. We aimed to study the effects of sapropterin (Kuvan), an orally active synthetic form of tetrahydrobiopterin on eNOS uncoupling and congenital heart defects ( CHD s) induced by pregestati...

journal_title：Journal of the American Heart Association

authors： Engineer A,Saiyin T,Lu X,Kucey AS,Urquhart BL,Drysdale TA,Norozi K,Feng Q

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Acute end points of catheter ablation for ventricular tachycardia (VT) remain incompletely defined. The aim of this study is to identify causes for failure in patients with structural heart disease and to assess the relation of this acute outcome to longer-term management and outcomes. METHODS AND RESULTS:F...

journal_title：Journal of the American Heart Association

authors： Tokuda M,Kojodjojo P,Tung S,Tedrow UB,Nof E,Inada K,Koplan BA,Michaud GF,John RM,Epstein LM,Stevenson WG

更新日期：2013-05-31 00:00:00

abstract：:Background Laboratory studies demonstrate glucose-insulin-potassium (GIK) as a potent cardioprotective intervention, but clinical trials have yielded mixed results, likely because of varying formulas and timing of GIK treatment and different clinical settings. This study sought to evaluate the effects of modified GIK ...

journal_title：Journal of the American Heart Association

authors： Zhao K,Zhang Y,Li J,Cui Q,Zhao R,Chen W,Liu J,Zhao B,Wan Y,Ma XL,Yu S,Yi D,Gao F

更新日期：2020-03-17 00:00:00

abstract：BACKGROUND:Intracerebral hemorrhage (ICH) carries high risk for short-term mortality. We sought to identify race-specific predictors of mortality in ICH patients. METHODS AND RESULTS:We used 2 databases, the Johns Hopkins clinical stroke database and the Nationwide Inpatient Sample (NIS). We included 226 patients with...

journal_title：Journal of the American Heart Association

authors： Faigle R,Marsh EB,Llinas RH,Urrutia VC,Gottesman RF

更新日期：2016-08-16 00:00:00

abstract：BACKGROUND:The American Heart Association (AHA) recently developed the Cardiovascular Health Index (CVHI), a health metric consisting of 7 modifiable risk factors. The relationship of the CVHI with preclinical markers, such as carotid intima-media thickness (CIMT) has not been assessed. METHODS:We examined 490 male mo...

journal_title：Journal of the American Heart Association

authors： Kulshreshtha A,Goyal A,Veledar E,McClellan W,Judd S,Eufinger SC,Bremner JD,Goldberg J,Vaccarino V

更新日期：2014-01-02 00:00:00

abstract：BACKGROUND:Obesity is closely associated with various cardiovascular diseases (CVDs). Adipose tissue inflammation and perturbation of adipokine secretion may contribute to the pathogenesis of CVD. This study aimed to evaluate whether the 2 most abundant adipokines, adipocyte-fatty acid binding protein (A-FABP) and adip...

journal_title：Journal of the American Heart Association

authors： Chow WS,Tso AW,Xu A,Yuen MM,Fong CH,Lam TH,Lo SV,Tse HF,Woo YC,Yeung CY,Cheung BM,Lam KS

更新日期：2013-01-15 00:00:00

abstract：BACKGROUND:MYBPC3 dysfunctions have been proven to induce dilated cardiomyopathy, hypertrophic cardiomyopathy, and/or left ventricular noncompaction; however, the genotype-phenotype correlation between MYBPC3 and restrictive cardiomyopathy (RCM) has not been established. The newly developed next-generation sequencing m...

journal_title：Journal of the American Heart Association

authors： Wu W,Lu CX,Wang YN,Liu F,Chen W,Liu YT,Han YC,Cao J,Zhang SY,Zhang X

更新日期：2015-07-10 00:00:00

abstract：BACKGROUND:The atherosclerosis cardiovascular disease (ASCVD) Pooled Cohort risk equations have shown different calibration across US populations with varied levels of social deprivation. METHODS AND RESULTS:We analyzed the calibration and discrimination of the Pooled Cohort risk equations by social deprivation status...

journal_title：Journal of the American Heart Association

authors： Colantonio LD,Richman JS,Carson AP,Lloyd-Jones DM,Howard G,Deng L,Howard VJ,Safford MM,Muntner P,Goff DC Jr

更新日期：2017-03-17 00:00:00

abstract：:Background Pregnancy increases the risk of acute myocardial infarction (AMI). The purpose of this study was to examine timing and risk factors for AMI in pregnancy and poor outcome. Methods and Results National Inpatient Sample (2003-2015) was screened in pregnancy, labor and delivery, and postpartum. There were 11 29...

journal_title：Journal of the American Heart Association

authors： Balgobin CA,Zhang X,Lima FV,Avila C,Parikh PB,Yang J,Stergiopoulos K

更新日期：2020-11-03 00:00:00

abstract：:Background Atrial fibrillation (AF) is associated with cognitive decline. Whether left atrial enlargement (LAE), a critical substrate for AF, is also associated is less well established. Therefore, we assessed the association of LAE and AF with cognitive decline in the ARIC-NCS (Atherosclerosis Risk in Communities Neu...

journal_title：Journal of the American Heart Association

authors： Zhang MJ,Norby FL,Lutsey PL,Mosley TH,Cogswell RJ,Konety SH,Chao TF,Shah AM,Solomon SD,Alonso A,Chen LY

更新日期：2019-12-03 00:00:00

abstract：:Background Although PAR-1 (protease-activated receptor-1) exerts important functions in the pathophysiology of the cardiovascular system, the role of PAR-1 signaling in heart failure development remains largely unknown. We tested the hypothesis that PAR-1 signaling inhibition has protective effects on the progression ...

journal_title：Journal of the American Heart Association

authors： Yokono Y,Hanada K,Narita M,Tatara Y,Kawamura Y,Miura N,Kitayama K,Nakata M,Nozaka M,Kato T,Kudo N,Tsushima M,Toyama Y,Itoh K,Tomita H

更新日期：2020-06-16 00:00:00

abstract：:Background Infants with critical congenital heart disease (CCHD) are more likely to be small for gestational age (SGA) or born to mothers with maternal placental syndrome. The objective of this study was to investigate the relationship between maternal placental syndrome, SGA, and gestational age (GA) on 1-year mortal...

journal_title：Journal of the American Heart Association

authors： Steurer MA,Peyvandi S,Baer RJ,Oltman SP,Chambers CD,Norton ME,Ryckman KK,Moon-Grady AJ,Keller RL,Shiboski SC,Jelliffe-Pawlowski LL

更新日期：2019-11-19 00:00:00

abstract：:See Article Shah et al. ...

journal_title：Journal of the American Heart Association

authors： Winniford MD

更新日期：2019-06-04 00:00:00

abstract：BACKGROUND:Recent studies have shown improving survival after cardiac arrest. However, data regarding sex-based disparities in treatment and outcomes after cardiac arrest are limited. METHODS AND RESULTS:We performed a retrospective analysis of all patients suffering cardiac arrest between 2003 and 2012 using the Nati...

journal_title：Journal of the American Heart Association

authors： Kim LK,Looser P,Swaminathan RV,Horowitz J,Friedman O,Shin JH,Minutello RM,Bergman G,Singh H,Wong SC,Feldman DN

更新日期：2016-06-22 00:00:00

abstract：BACKGROUND:The presence and implications of abnormal arterial stiffness, a potential independent predictor of outcomes, in community-dwelling treated hypertensives is unknown. Furthermore, limited data exist regarding the risk of cardiovascular disease (CVD) associated with arterial stiffness across the entire range of...

journal_title：Journal of the American Heart Association

authors： Niiranen TJ,Kalesan B,Hamburg NM,Benjamin EJ,Mitchell GF,Vasan RS

更新日期：2016-10-26 00:00:00

abstract：BACKGROUND:The intersection of heart failure (HF) and atrial fibrillation (AF) is common, but the burden of AF among black patients with HF is poorly characterized. We sought to determine the prevalence of AF, characteristics, in-hospital outcomes, and warfarin use associated with AF in patients hospitalized with HF as...

journal_title：Journal of the American Heart Association

authors： Thomas KL,Piccini JP,Liang L,Fonarow GC,Yancy CW,Peterson ED,Hernandez AF,Get With the Guidelines Steering Committee and Hospitals.

更新日期：2013-09-26 00:00:00

abstract：BACKGROUND:Intravascular imaging can facilitate chronic total occlusion (CTO) percutaneous coronary intervention. METHODS AND RESULTS:We examined the frequency of use and outcomes of intravascular imaging among 619 CTO percutaneous coronary interventions performed between 2012 and 2015 at 7 US centers. Mean age was 65...

journal_title：Journal of the American Heart Association

authors： Karacsonyi J,Alaswad K,Jaffer FA,Yeh RW,Patel M,Bahadorani J,Karatasakis A,Danek BA,Doing A,Grantham JA,Karmpaliotis D,Moses JW,Kirtane A,Parikh M,Ali Z,Lombardi WL,Kandzari DE,Lembo N,Garcia S,Wyman MR,Alame A,

更新日期：2016-08-20 00:00:00

abstract：BACKGROUND:Insulin resistance, characterized by hyperinsulinemia and normal or elevated serum glucose, is an established precursor to diabetes and cardiovascular disease. Despite fasting serum C-peptide levels being an accurate and stable marker of endogenous insulin production used in patients with diabetes, it is unk...

journal_title：Journal of the American Heart Association

authors： Patel N,Taveira TH,Choudhary G,Whitlatch H,Wu WC

更新日期：2012-12-01 00:00:00

abstract：:Background Recent studies have raised concerns about the reduced efficacy of citalopram when used concurrently with proton pump inhibitors. The aim of this study was to evaluate the associations between clinical use of citalopram and omeprazole and the risk of sudden cardiac arrest (SCA) in an Asian population. Method...

journal_title：Journal of the American Heart Association

authors： Wu WT,Tsai CT,Chou YC,Ku PM,Chen YC,You SL,Hung CF,Sun CA

更新日期：2019-10-15 00:00:00

abstract：:Background Cardiogenic shock ( CS ) following acute myocardial infarction ( AMI ) portends a poor prognosis. Both venoarterial extracorporeal membrane oxygenation ( VA - ECMO ) and a percutaneous ventricular assist device ( pVAD ) provide hemodynamic support for patients with CS, but little is known about the best dev...

journal_title：Journal of the American Heart Association

authors： Garan AR,Takeda K,Salna M,Vandenberge J,Doshi D,Karmpaliotis D,Kirtane AJ,Takayama H,Kurlansky P

更新日期：2019-05-07 00:00:00

abstract：:Background We aim to generate a line of "universal donor" human induced pluripotent stem cells (hi PSC s) that are nonimmunogenic and, therefore, can be used to derive cell products suitable for allogeneic transplantation. Methods and Results hi PSC s carrying knockout mutations for 2 key components (β2 microglobulin ...

journal_title：Journal of the American Heart Association

authors： Mattapally S,Pawlik KM,Fast VG,Zumaquero E,Lund FE,Randall TD,Townes TM,Zhang J

更新日期：2018-12-04 00:00:00

abstract：:Background Informed consent for acute myocardial infarction and stroke research is challenging. Time for enrollment decisions is limited, patients and family are usually stressed, and being asked to participate in research is often unexpected. Despite these barriers, patients and surrogates have reported a preference ...

journal_title：Journal of the American Heart Association

authors： Scicluna VM,Goldkind SF,Mitchell AR,Pentz RD,Speight CD,Silbergleit R,Dickert NW

更新日期：2019-11-19 00:00:00

abstract：:Background The Institute of Medicine has called for actions to understand and target sex-related differences in care and outcomes for out-of-hospital cardiac arrest patients. We assessed changes in bystander and first-responder interventions and outcomes for males versus females after statewide efforts to improve card...

journal_title：Journal of the American Heart Association

authors： Malta Hansen C,Kragholm K,Dupre ME,Pearson DA,Tyson C,Monk L,Rea TD,Starks MA,Nelson D,Jollis JG,McNally B,Corbett CM,Granger CB

更新日期：2018-09-18 00:00:00

abstract：:Background Sepsis is the overwhelming host response to infection leading to shock and multiple organ dysfunction. Cardiovascular complications greatly increase sepsis-associated mortality. Although murine models are routinely used for preclinical studies, the benefit of using genetically engineered mice in sepsis is c...

journal_title：Journal of the American Heart Association

authors： Hoffman M,Kyriazis ID,Lucchese AM,de Lucia C,Piedepalumbo M,Bauer M,Schulze PC,Bonios MJ,Koch WJ,Drosatos K

更新日期：2019-05-21 00:00:00

abstract：BACKGROUND:Peripheral arterial disease (PAD) shares several risk factors with atrial fibrillation (AF), and persons with PAD have an increased risk of stroke. It is unclear if PAD is associated with an increased risk for AF and whether this potential association explains the increased risk of stroke observed in those w...

journal_title：Journal of the American Heart Association

authors： O'Neal WT,Efird JT,Nazarian S,Alonso A,Heckbert SR,Soliman EZ

更新日期：2014-11-17 00:00:00

abstract：:Background Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy. Current guidelines endorse management in expert centers, but patient socioeconomic status can affect access to specialty care. The effect of socioeconomic status and specialty care access on HCM outcomes has not been examined. Me...

journal_title：Journal of the American Heart Association

authors： Thomas A,Papoutsidakis N,Spatz E,Testani J,Soucier R,Chou J,Ahmad T,Darr U,Hu X,Li F,Chen ME,Bellumkonda L,Sumathipala A,Jacoby D

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a key role in removing toxic aldehydes. Deficient variant ALDH2*2 genotype is prevalent in up to 40% of the East Asians and reported to be associated with acute myocardial infarction (AMI). To elucidate the mechanisms underlying the association of ALDH2*2 ...

journal_title：Journal of the American Heart Association

authors： Mizuno Y,Hokimoto S,Harada E,Kinoshita K,Nakagawa K,Yoshimura M,Ogawa H,Yasue H

更新日期：2016-05-06 00:00:00

abstract：BACKGROUND:Adults with repaired coarctation of the aorta (CoA) have reduced long-term survival compared with the general population. This study aimed to determine whether CoA is independently associated with premature ischemic and hemorrhagic stroke in the contemporary era. METHODS AND RESULTS:This was a cross-section...

journal_title：Journal of the American Heart Association

authors： Pickard SS,Gauvreau K,Gurvitz M,Gagne JJ,Opotowsky AR,Jenkins KJ,Prakash A

更新日期：2018-06-01 00:00:00

abstract：:Background There are no risk scores designed specifically for mortality risk prediction in unselected cardiac intensive care unit (CICU) patients. We sought to develop a novel CICU-specific risk score for prediction of hospital mortality using variables available at the time of CICU admission. Methods and Results A da...

journal_title：Journal of the American Heart Association

authors： Jentzer JC,Anavekar NS,Bennett C,Murphree DH,Keegan MT,Wiley B,Morrow DA,Murphy JG,Bell MR,Barsness GW

更新日期：2019-09-03 00:00:00

abstract：:Congenital heart disease is the most common congenital defect observed in newborns. Within the spectrum of congenital heart disease are left-sided obstructive lesions (LSOLs), which include hypoplastic left heart syndrome, aortic stenosis, bicuspid aortic valve, coarctation of the aorta, and interrupted aortic arch. T...

journal_title：Journal of the American Heart Association

authors： Parker LE,Landstrom AP

更新日期：2021-01-19 00:00:00