Acute failure of catheter ablation for ventricular tachycardia due to structural heart disease: causes and significance.

Abstract:

BACKGROUND:Acute end points of catheter ablation for ventricular tachycardia (VT) remain incompletely defined. The aim of this study is to identify causes for failure in patients with structural heart disease and to assess the relation of this acute outcome to longer-term management and outcomes. METHODS AND RESULTS:From 2002 to 2010, 518 consecutive patients (84% male, 62 ± 14 years) with structural heart disease underwent a first ablation procedure for sustained VT at our institution. Acute ablation failure was defined as persistent inducibility of a clinical VT. Acute ablation failure was seen in 52 (10%) patients. Causes for failure were: intramural free wall VT in 13 (25%), deep septal VT in 9 (17%), decision not to ablate due to proximity to the bundle of His, left phrenic nerve, or a coronary artery in 3 (6%), and endocardial ablation failure with inability or decision not to attempt to access the epicardium in 27 (52%) patients. In multivariable analysis, ablation failure was an independent predictor of mortality (hazard ratio 2.010, 95% CI 1.147 to 3.239, P=0.004) and VT recurrence (hazard ratio 2.385, 95% CI 1.642 to 3.466, P<0.001). CONCLUSIONS:With endocardial or epicardial ablation, or both, acute ablation failure was seen in 10% of patients, largely due to anatomic factors. Persistence of a clinical VT is associated with recurrence and comparatively higher mortality.

journal_name

J Am Heart Assoc

authors

Tokuda M,Kojodjojo P,Tung S,Tedrow UB,Nof E,Inada K,Koplan BA,Michaud GF,John RM,Epstein LM,Stevenson WG

doi

10.1161/JAHA.113.000072

subject

Has Abstract

pub_date

2013-05-31 00:00:00

pages

e000072

issue

3

issn

2047-9980

pii

2/3/e000072

journal_volume

2

pub_type

杂志文章
  • Pregnancy Loss and Carotid Intima-Media Thickness in Mexican Women.

    abstract:BACKGROUND:Cardiovascular disease in women often develops without conventional risk factors. Prenatal loss is a common pregnancy outcome that may result in physiological changes can increase the potential future risk of cardiovascular disease. Insufficient information exists regarding the impact of pregnancy loss on ea...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.117.007582

    authors: Hartasanchez SA,Flores-Torres M,Monge A,Yunes E,Rodriguez B,Cantu-Brito C,Colaci D,Lamadrid-Figueroa H,Lopez-Ridaura R,Lajous M

    更新日期:2018-01-13 00:00:00

  • Improving Care of STEMI in the United States 2008 to 2012.

    abstract::Background We aimed to determine the change in treatment strategies and times to treatment over the first 5 years of the Mission: Lifeline program. Methods and Results We assessed pre- and in-hospital care and outcomes from 2008 to 2012 for patients with ST -segment-elevation myocardial infarction at US hospitals, usi...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,多中心研究

    doi:10.1161/JAHA.118.008096

    authors: Granger CB,Bates ER,Jollis JG,Antman EM,Nichol G,O'Connor RE,Gregory T,Roettig ML,Peng SA,Ellrodt G,Henry TD,French WJ,Jacobs AK

    更新日期:2019-01-08 00:00:00

  • Epigenomic Assessment of Cardiovascular Disease Risk and Interactions With Traditional Risk Metrics.

    abstract::Background Epigenome-wide association studies for cardiometabolic risk factors have discovered multiple loci associated with incident cardiovascular disease (CVD). However, few studies have sought to directly optimize a predictor of CVD risk. Furthermore, it is challenging to train multivariate models across multiple ...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.119.015299

    authors: Westerman K,Fernández-Sanlés A,Patil P,Sebastiani P,Jacques P,Starr JM,J Deary I,Liu Q,Liu S,Elosua R,DeMeo DL,Ordovás JM

    更新日期:2020-04-21 00:00:00

  • Identification of PTCSC3 as a Novel Locus for Large-Vessel Ischemic Stroke: A Genome-Wide Association Study.

    abstract:BACKGROUND:Ischemic stroke is a major cause of death and disability in the world. A major ischemic stroke subtype, large-vessel ischemic stroke (large artery atherosclerosis; LAA), has been shown to have some genetic components in individuals of European ancestry. However, it is not clear whether the genetic predisposi...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,多中心研究

    doi:10.1161/JAHA.115.003003

    authors: Lee TH,Ko TM,Chen CH,Lee MT,Chang YJ,Chang CH,Huang KL,Chang TY,Lee JD,Chang KC,Yang JT,Wen MS,Wang CY,Chen YT,Hsieh CS,Chou SY,Liu YM,Chen HW,Liao HT,Wang CW,Chen SP,Lu LS,Chen YT,Wu JY

    更新日期:2016-03-29 00:00:00

  • Retrospective Analysis of Clinical Genetic Testing in Pediatric Primary Dilated Cardiomyopathy: Testing Outcomes and the Effects of Variant Reclassification.

    abstract::Background Genetic testing in pediatric primary dilated cardiomyopathy (DCM) patients has identified numerous disease-causing variants, but few studies have evaluated genetic testing outcomes in this population in the context of patient and familial clinical data or assessed the clinical implications of temporal chang...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.120.016195

    authors: Quiat D,Witkowski L,Zouk H,Daly KP,Roberts AE

    更新日期:2020-06-02 00:00:00

  • Mean Dietary Salt Intake in Urban and Rural Areas in India: A Population Survey of 1395 Persons.

    abstract:BACKGROUND:The scientific evidence base in support of population-wide salt reduction is strong, but current high-quality data about salt intake levels in India are mostly absent. This project sought to estimate daily salt consumption levels in selected communities of Delhi and Haryana in north India and Andhra Pradesh ...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.116.004547

    authors: Johnson C,Mohan S,Rogers K,Shivashankar R,Thout SR,Gupta P,He FJ,MacGregor GA,Webster J,Krishnan A,Maulik PK,Reddy KS,Prabhakaran D,Neal B

    更新日期:2017-01-06 00:00:00

  • Cardiovascular Outcomes Associated With Clinical Use of Citalopram and Omeprazole: A Nationwide Population-Based Cohort Study.

    abstract::Background Recent studies have raised concerns about the reduced efficacy of citalopram when used concurrently with proton pump inhibitors. The aim of this study was to evaluate the associations between clinical use of citalopram and omeprazole and the risk of sudden cardiac arrest (SCA) in an Asian population. Method...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,多中心研究

    doi:10.1161/JAHA.118.011607

    authors: Wu WT,Tsai CT,Chou YC,Ku PM,Chen YC,You SL,Hung CF,Sun CA

    更新日期:2019-10-15 00:00:00

  • Effect of bromocriptine-QR (a quick-release formulation of bromocriptine mesylate) on major adverse cardiovascular events in type 2 diabetes subjects.

    abstract:BACKGROUND:Bromocriptine-QR (a quick-release formulation of bromocriptine mesylate), a dopamine D2 receptor agonist, is a US Food and Drug Administrration-approved treatment for type 2 diabetes mellitus (T2DM). A 3070-subject randomized trial demonstrated a significant, 40% reduction in relative risk among bromocriptin...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/JAHA.112.002279

    authors: Gaziano JM,Cincotta AH,Vinik A,Blonde L,Bohannon N,Scranton R

    更新日期:2012-10-01 00:00:00

  • Extracardial Vasculopathy After Kawasaki Disease: A Long-Term Follow-up Study.

    abstract:BACKGROUND:Kawasaki disease (KD) is a pediatric vasculitis with coronary artery aneurysm (CAA) as a major complication. Controversy exists about cardiovascular risk later in life. The aim of our study was to evaluate whether KD patients are at increased risk, as assessed by carotid intima-media thickness (cIMT). METHO...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.116.003414

    authors: Dietz SM,Tacke CE,de Groot E,Kuipers IM,Hutten BA,Kuijpers TW,Dutch Kawasaki Study Groupten BergeMaartjeBiezeveldMaarten H.BruijnMartijnDelemarreLuçan C.DolmanKoert M.FilippiniLuc H.P.M.HendriksTomMaingay‐VisserDianne A.P.G.F.NoordzijJeroen

    更新日期:2016-07-05 00:00:00

  • Distinct Aspects of Left Ventricular Mechanical Function Are Differentially Associated With Cardiovascular Outcomes and All-Cause Mortality in the Community.

    abstract:BACKGROUND:There are few data relating novel measures of left ventricular (LV) mechanical function to cardiovascular disease (CVD) outcomes in the community. Whether distinct components of LV mechanical function provide information regarding risk for different CVD outcomes is unclear. METHODS AND RESULTS:We used speck...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.115.002071

    authors: Cheng S,McCabe EL,Larson MG,Merz AA,Osypiuk E,Lehman BT,Stantchev P,Aragam J,Solomon SD,Benjamin EJ,Vasan RS

    更新日期:2015-10-27 00:00:00

  • Impact of Ideal Cardiovascular Health in Childhood on the Retinal Microvasculature in Midadulthood: Cardiovascular Risk in Young Finns Study.

    abstract::Background This study examined the association between ideal cardiovascular health ( CVH ) and the retinal microvasculature in midadulthood. Methods and Results The Cardiovascular Risk in Young Finns Study included children from 5 Finnish University cities, who were chosen randomly from the national population registe...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,多中心研究

    doi:10.1161/JAHA.118.009487

    authors: Campbell MD,Laitinen TT,Hughes A,Pahkala K,Juonala M,Kähönen M,Wong TY,Lehtimäki T,Hutri-Kähönen N,Raitakari OT,Tapp RJ

    更新日期:2018-10-16 00:00:00

  • Remote Ischemic Perconditioning to Reduce Reperfusion Injury During Acute ST-Segment-Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Remote ischemic conditioning (RIC) is a noninvasive therapeutic strategy that uses brief cycles of blood pressure cuff inflation and deflation to protect the myocardium against ischemia-reperfusion injury. The objective of this systematic review was to determine the impact of RIC on myocardial salvage index,...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,meta分析,评审

    doi:10.1161/JAHA.117.005522

    authors: McLeod SL,Iansavichene A,Cheskes S

    更新日期:2017-05-17 00:00:00

  • A Wide and Specific Spectrum of Genetic Variants and Genotype-Phenotype Correlations Revealed by Next-Generation Sequencing in Patients with Left Ventricular Noncompaction.

    abstract:BACKGROUND:Left ventricular noncompaction (LVNC) has since been classified as a primary genetic cardiomyopathy, but the genetic basis is not fully evaluated. The aim of the present study was to identify the genetic spectrum using next-generation sequencing and to evaluate genotype-phenotype correlations in LVNC patient...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.117.006210

    authors: Wang C,Hata Y,Hirono K,Takasaki A,Ozawa SW,Nakaoka H,Saito K,Miyao N,Okabe M,Ibuki K,Nishida N,Origasa H,Yu X,Bowles NE,Ichida F,for LVNC Study Collaborators.

    更新日期:2017-08-30 00:00:00

  • Hospital Factors Associated With Interhospital Transfer Destination for Stroke in the Northeast United States.

    abstract::Background We aimed to determine if there is an association between hospital quality and the likelihood of a given hospital being a preferred transfer destination for stroke patients. Methods and Results Data from Medicare claims identified acute ischemic stroke transferred between 394 northeast US hospitals from 2007...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.118.011575

    authors: Zachrison KS,Onnela JP,Reeves MJ,Hernandez A,Camargo CA Jr,Zhao X,Matsouaka RA,Goldstein JN,Metlay JP,Schwamm LH

    更新日期:2020-01-07 00:00:00

  • Leveraging the Electronic Health Records for Population Health: A Case Study of Patients With Markedly Elevated Blood Pressure.

    abstract::Background The digital transformation of medical data provides opportunities to perform digital population health surveillance and identify people inadequately managed in usual care. We leveraged the electronic health records of a large health system to identify patients with markedly elevated blood pressure and chara...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.119.015033

    authors: Lu Y,Huang C,Mahajan S,Schulz WL,Nasir K,Spatz ES,Krumholz HM

    更新日期:2020-04-07 00:00:00

  • Burden of Uncontrolled Metabolic Risk Factors and Left Ventricular Structure and Function in Patients With Type 2 Diabetes Mellitus.

    abstract::Background Type 2 diabetes mellitus is closely associated with metabolic risk factors that all contribute to impairment of the left ventricle. The implications of having type 2 diabetes mellitus with well-controlled metabolic risk factors compared to an increasing burden of uncontrolled metabolic risk factors on left ...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,多中心研究

    doi:10.1161/JAHA.118.008856

    authors: Jørgensen PG,Jensen MT,Biering-Sørensen T,Mogelvang R,Fritz-Hansen T,Vilsbøll T,Rossing P,Jensen JS

    更新日期:2018-10-02 00:00:00

  • Erratum: Twenty-Year Predictors of Peripheral Arterial Disease Compared With Coronary Heart Disease in the Scottish Heart Health Extended Cohort (SHHEC).

    abstract::[This corrects the article DOI: 10.1161/JAHA.117.005967.]. ...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,已发布勘误

    doi:10.1161/JAHA.117.004215

    authors:

    更新日期:2017-12-23 00:00:00

  • Incorporating Latent Variables Using Nonnegative Matrix Factorization Improves Risk Stratification in Brugada Syndrome.

    abstract::Background A combination of clinical and electrocardiographic risk factors is used for risk stratification in Brugada syndrome. In this study, we tested the hypothesis that the incorporation of latent variables between variables using nonnegative matrix factorization can improve risk stratification compared with logis...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.119.012714

    authors: Tse G,Zhou J,Lee S,Liu T,Bazoukis G,Mililis P,Wong ICK,Chen C,Xia Y,Kamakura T,Aiba T,Kusano K,Zhang Q,Letsas KP

    更新日期:2020-11-17 00:00:00

  • Effects of Inhibition of Nitric Oxide Synthase on Muscular Arteries During Exercise: Nitric Oxide Does Not Contribute to Vasodilation During Exercise or in Recovery.

    abstract::Background Basal release of nitric oxide (NO) from the vascular endothelium regulates the tone of muscular arteries and resistance vasculature. Effects of NO on muscular arteries could be particularly important during exercise when shear stress may stimulate increased NO synthesis. Methods and Results We investigated ...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.119.013849

    authors: O'Gallagher K,Shabeeh H,Munir S,Roomi A,Jiang B,Guilcher A,Brett S,Chowienczyk P

    更新日期:2020-08-18 00:00:00

  • Interferon-β Modulates Inflammatory Response in Cerebral Ischemia.

    abstract:BACKGROUND:Stroke is a leading cause of death in the world. In >80% of strokes, the initial acute phase of ischemic injury is due to the occlusion of a blood vessel resulting in severe focal hypoperfusion, excitotoxicity, and oxidative damage. Interferon-β (IFNβ), a cytokine with immunomodulatory properties, was approv...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.115.002610

    authors: Kuo PC,Scofield BA,Yu IC,Chang FL,Ganea D,Yen JH

    更新日期:2016-01-08 00:00:00

  • Complete Revascularization by Percutaneous Coronary Intervention for Patients With ST-Segment-Elevation Myocardial Infarction and Multivessel Coronary Artery Disease: An Updated Meta-Analysis of Randomized Trials.

    abstract::Background For patients with ST-segment-elevation myocardial infarction (STEMI) and multivessel coronary artery disease, the optimal treatment of the non-infarct-related artery has been controversial. This up-to-date meta-analysis focusing on individual clinical end points was performed to further evaluate the benefit...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.119.015263

    authors: Ahmad Y,Howard JP,Arnold A,Prasad M,Seligman H,Cook CM,Warisawa T,Shun-Shun M,Ali Z,Parikh MA,Al-Lamee R,Sen S,Francis D,Moses JW,Leon MB,Stone GW,Karmpaliotis D

    更新日期:2020-06-16 00:00:00

  • Sex Differences in Long-Term Survival After Major Cardiac Surgery: A Population-Based Cohort Study.

    abstract::Background Little attention has been paid to the importance of sex in the long-term prognosis of patients undergoing cardiac surgery. Methods and Results We conducted a retrospective cohort study of Ontario residents, aged ≥40 years, who underwent coronary artery bypass grafting (CABG) and/or aortic, mitral, or tricus...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.119.013260

    authors: Johnston A,Mesana TG,Lee DS,Eddeen AB,Sun LY

    更新日期:2019-09-03 00:00:00

  • Pulmonary vascular and right ventricular reserve in patients with normalized resting hemodynamics after pulmonary endarterectomy.

    abstract:BACKGROUND:Patients with normalized mean pulmonary artery pressure (mPAP) after pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH) do not always regain normal exercise capacity. We evaluated right ventricular function, its interaction with both pulsatile and resistive afterload, an...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.114.001602

    authors: Claessen G,La Gerche A,Dymarkowski S,Claus P,Delcroix M,Heidbuchel H

    更新日期:2015-03-23 00:00:00

  • Obstructive and Central Sleep Apnea and the Risk of Incident Atrial Fibrillation in a Community Cohort of Men and Women.

    abstract:BACKGROUND:Previous studies have documented a high prevalence of atrial fibrillation (AF) in individuals with obstructive sleep apnea (OSA). Central sleep apnea (CSA) has been associated with AF in patients with heart failure. However, data from prospective cohorts are sparse and few studies have distinguished the asso...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.116.004500

    authors: Tung P,Levitzky YS,Wang R,Weng J,Quan SF,Gottlieb DJ,Rueschman M,Punjabi NM,Mehra R,Bertisch S,Benjamin EJ,Redline S

    更新日期:2017-07-01 00:00:00

  • Sample Size in Clinical Cardioprotection Trials Using Myocardial Salvage Index, Infarct Size, or Biochemical Markers as Endpoint.

    abstract:BACKGROUND:Cardiac magnetic resonance (CMR) can quantify myocardial infarct (MI) size and myocardium at risk (MaR), enabling assessment of myocardial salvage index (MSI). We assessed how MSI impacts the number of patients needed to reach statistical power in relation to MI size alone and levels of biochemical markers i...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/JAHA.115.002708

    authors: Engblom H,Heiberg E,Erlinge D,Jensen SE,Nordrehaug JE,Dubois-Randé JL,Halvorsen S,Hoffmann P,Koul S,Carlsson M,Atar D,Arheden H

    更新日期:2016-03-09 00:00:00

  • Coronary vasomotor response to intracoronary acetylcholine injection, clinical features, and long-term prognosis in 873 consecutive patients with coronary spasm: analysis of a single-center study over 20 years.

    abstract:BACKGROUND:The aim of this study was to elucidate the correlation between angiographic coronary vasomotor responses to intracoronary acetylcholine (ACh) injection, clinical features, and long-term prognosis in patients with vasospastic angina (VSA). METHODS AND RESULTS:This is a retrospective, observational, single-ce...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.113.000227

    authors: Sato K,Kaikita K,Nakayama N,Horio E,Yoshimura H,Ono T,Ohba K,Tsujita K,Kojima S,Tayama S,Hokimoto S,Matsui K,Sugiyama S,Yamabe H,Ogawa H

    更新日期:2013-07-15 00:00:00

  • Cardiovascular disease hospitalizations in relation to exposure to the September 11, 2001 World Trade Center disaster and posttraumatic stress disorder.

    abstract:BACKGROUND:A cohort study found that 9/11-related environmental exposures and posttraumatic stress disorder increased self-reported cardiovascular disease risk. We attempted to replicate these findings using objectively defined cardiovascular disease hospitalizations in the same cohort. METHODS AND RESULTS:Data for ad...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.113.000431

    authors: Jordan HT,Stellman SD,Morabia A,Miller-Archie SA,Alper H,Laskaris Z,Brackbill RM,Cone JE

    更新日期:2013-10-24 00:00:00

  • A novel protein glycan biomarker and future cardiovascular disease events.

    abstract:BACKGROUND:Glycosylated proteins partake in multiple cellular processes including inflammation. We hypothesized that GlycA, a novel biomarker of protein glycan N-acetyl groups, is related to incident cardiovascular disease (CVD), and we compared it with high-sensitivity C-reactive protein (hsCRP). METHODS AND RESULTS:...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/JAHA.114.001221

    authors: Akinkuolie AO,Buring JE,Ridker PM,Mora S

    更新日期:2014-09-23 00:00:00

  • Out-of-Hospital Cardiac Arrest in Patients With and Without Psychiatric Disorders: Differences in Use of Coronary Angiography, Coronary Revascularization, and Implantable Cardioverter-Defibrillator and Survival.

    abstract::Background Healthcare disparities for psychiatric patients are common. Whether these inequalities apply to postresuscitation management in out-of-hospital cardiac arrest (OHCA) is unknown. We investigated differences in in-hospital cardiovascular procedures following OHCA between patients with and without psychiatric ...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.119.012708

    authors: Barcella CA,Mohr GH,Kragholm KH,Gerds TA,Jensen SE,Polcwiartek C,Wissenberg M,Lippert FK,Torp-Pedersen C,Kessing LV,Gislason GH,Søndergaard KB

    更新日期:2019-08-20 00:00:00

  • Trends in Diagnosis-Specific Work Disability Before and After Stroke: A Longitudinal Population-Based Study in Sweden.

    abstract:BACKGROUND:Although a stroke event often leads to work disability, diagnoses behind work disability before and after stroke are largely unknown. We examined the pre-event and postevent trends in diagnosis-specific work disability among patients of working age. METHODS AND RESULTS:We included all new nonfatal stroke ev...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章

    doi:10.1161/JAHA.117.006991

    authors: Lallukka T,Ervasti J,Lundström E,Mittendorfer-Rutz E,Friberg E,Virtanen M,Alexanderson K

    更新日期:2018-01-04 00:00:00