Sex Differences in Long-Term Survival After Major Cardiac Surgery: A Population-Based Cohort Study.

abstract：:Background Limited data are available on mid-range ejection fraction (mrEF) patients with dilated cardiomyopathy. We sought to define the characteristics, evolution, and long-term prognosis of dilated cardiomyopathy patients with mrEF at diagnosis. Methods and Results We analyzed all dilated cardiomyopathy patients co...

journal_title：Journal of the American Heart Association

authors： Gentile P,Merlo M,Cannatà A,Gobbo M,Artico J,Stolfo D,Gigli M,Ramani F,Barbati G,Pinamonti B,Sinagra G

更新日期：2019-09-03 00:00:00

abstract：:Background Many patients use opioids for nonmalignant pain, and opioid use in the general population has been associated with poor long-term outcomes. The use of high-risk medications, including opioid analgesics, may increase the risk of unplanned healthcare utilization. Methods and Results We performed a nested eval...

journal_title：Journal of the American Heart Association

authors： Liberman JS,Samuels LR,Goggins K,Kripalani S,Roumie CL,VICS (Vanderbilt Inpatient Cohort Study).

更新日期：2019-02-05 00:00:00

abstract：:Background The ODYSSEY OUTCOMES (Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome) trial demonstrated that alirocumab reduced major cardiovascular events. However, because of the hierarchical testing strategy used for the multiple outcomes examined, the observed reduction in all-cause mortality was...

journal_title：Journal of the American Heart Association

authors： Labos C,Brophy JM,Sniderman A,Thanassoulis G

更新日期：2019-10-15 00:00:00

abstract：:Despite numerous advances in the prevention and treatment of atherosclerosis, cardiovascular disease remains a leading cause of morbidity and mortality. Novel and inexpensive interventions that can contribute to the primary and secondary prevention of cardiovascular disease are of interest. Numerous studies have repor...

journal_title：Journal of the American Heart Association

authors： Levine GN,Lange RA,Bairey-Merz CN,Davidson RJ,Jamerson K,Mehta PK,Michos ED,Norris K,Ray IB,Saban KL,Shah T,Stein R,Smith SC Jr,American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nur

更新日期：2017-09-28 00:00:00

abstract：BACKGROUND:Many patients requiring a pacemaker have persistent hypertension with systolic blood pressures above recommended levels. We evaluated a pacemaker-based Programmable Hypertension Control (PHC) therapy that uses a sequence of variably timed shorter and longer atrioventricular intervals. METHODS AND RESULTS:Pa...

journal_title：Journal of the American Heart Association

authors： Neuzil P,Merkely B,Erglis A,Marinskis G,de Groot JR,Schmidinger H,Rodriguez Venegas M,Voskuil M,Sturmberger T,Petru J,Jongejan N,Aichinger J,Kamzola G,Aidietis A,Gellér L,Mraz T,Osztheimer I,Mika Y,Evans S,Burkhoff

更新日期：2017-12-23 00:00:00

abstract：BACKGROUND:Novel therapies aimed at modulating the autonomic nervous system, including thoracic epidural anesthesia (TEA), have been shown in small case series to be beneficial in treating medically refractory ventricular tachycardia (VT) storm. However, it is not clear when these options should be considered. We revie...

journal_title：Journal of the American Heart Association

authors： Do DH,Bradfield J,Ajijola OA,Vaseghi M,Le J,Rahman S,Mahajan A,Nogami A,Boyle NG,Shivkumar K

更新日期：2017-10-27 00:00:00

abstract：:Background Detection of flow reserve ( FR ) by dobutamine stress echocardiography is used for risk stratification in low-gradient aortic stenosis ( AS ). Prognostic significance of dobutamine stress echocardiography in the transcatheter aortic valve replacement era is unclear. We aimed to assess the current relevance ...

journal_title：Journal of the American Heart Association

authors： Sato K,Sankaramangalam K,Kandregula K,Bullen JA,Kapadia SR,Krishnaswamy A,Mick S,Rodriguez LL,Grimm RA,Menon V,Desai MY,Svensson LG,Griffin BP,Popović ZB

更新日期：2019-03-19 00:00:00

abstract：:Background There are limited data about cardiac resynchronization therapy (CRT) in adult congenital heart disease. We aimed to assess early and late outcomes of CRT among patients with adult congenital heart disease. Methods and Results We retrospectively studied 54 patients with adult congenital heart disease (median...

journal_title：Journal of the American Heart Association

authors： Yin Y,Dimopoulos K,Shimada E,Lascelles K,Griffiths S,Wong T,Gatzoulis MA,Babu-Narayan SV,Li W

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:Vascular proliferative diseases such as atherosclerosis are inflammatory disorders involving multiple cell types including macrophages, lymphocytes, endothelial cells, and smooth muscle cells (SMCs). Although activation of the nuclear factor-κB (NF-κB) pathway in vessels has been shown to be critical for the...

journal_title：Journal of the American Heart Association

authors： Yoshida T,Yamashita M,Horimai C,Hayashi M

更新日期：2013-05-23 00:00:00

abstract：BACKGROUND:Current American Heart Association/American College of Cardiology guidelines recommend the GRACE (Global Registry of Acute Coronary Events) and TIMI (Thrombolysis in Myocardial Infarction) scores to assess myocardial infarction (MI) prognosis. Changes in the epidemiological characteristics of MI and the avai...

journal_title：Journal of the American Heart Association

authors： Gerber Y,Weston SA,Enriquez-Sarano M,Jaffe AS,Manemann SM,Jiang R,Roger VL

更新日期：2017-10-20 00:00:00

abstract：BACKGROUND:Women are more likely than men to develop resistant hypertension, which is associated with excess risk of major adverse outcomes; however, the impact of resistant hypertension in women with ischemia has not been explicitly studied. In this Women's Ischemia Syndrome Evaluation (WISE) analysis, we assessed lon...

journal_title：Journal of the American Heart Association

authors： Smith SM,Huo T,Delia Johnson B,Bittner V,Kelsey SF,Vido Thompson D,Noel Bairey Merz C,Pepine CJ,Cooper-Dehoff RM

更新日期：2014-02-28 00:00:00

abstract：BACKGROUND:The aim of this study was to elucidate the correlation between angiographic coronary vasomotor responses to intracoronary acetylcholine (ACh) injection, clinical features, and long-term prognosis in patients with vasospastic angina (VSA). METHODS AND RESULTS:This is a retrospective, observational, single-ce...

journal_title：Journal of the American Heart Association

authors： Sato K,Kaikita K,Nakayama N,Horio E,Yoshimura H,Ono T,Ohba K,Tsujita K,Kojima S,Tayama S,Hokimoto S,Matsui K,Sugiyama S,Yamabe H,Ogawa H

更新日期：2013-07-15 00:00:00

abstract：:See Article Ramkumar et al. ...

journal_title：Journal of the American Heart Association

authors： Braun JD,Kougias P

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Greater understanding of differences between men and women with coronary heart disease is needed. METHODS AND RESULTS:In this post hoc analysis of the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) trial, we described psychosocial factors, treatments, and outcomes of...

journal_title：Journal of the American Heart Association

authors： Guimarães PO,Granger CB,Stebbins A,Chiswell K,Held C,Hochman JS,Krug-Gourley S,Lonn E,Lopes RD,Stewart RAH,Vinereanu D,Wallentin L,White HD,Hagström E,Danchin N

更新日期：2017-09-14 00:00:00

abstract：BACKGROUND:Metformin use reduces the incidence and severity of stroke in patients with type 2 diabetes mellitus (DM). The benefits of metformin for stroke have not been examined in hemodialysis patients with DM. METHODS AND RESULTS:Using the National Health Insurance Research Database, we identified 17 760 patients wi...

journal_title：Journal of the American Heart Association

authors： Chien LN,Chou CL,Chen HH,Kao CC,Lin YC,Wu YL,Chen JS,Chen LY,Fang TC

更新日期：2017-11-16 00:00:00

abstract：BACKGROUND:Light chain amyloidosis (AL) is associated with high mortality, especially in patients with advanced cardiovascular involvement. It is caused by toxicity of misfolded light chain proteins (LC) in vascular, cardiac, and other tissues. There is no treatment to reverse LC tissue toxicity. We tested the hypothes...

journal_title：Journal of the American Heart Association

authors： Franco DA,Truran S,Weissig V,Guzman-Villanueva D,Karamanova N,Senapati S,Burciu C,Ramirez-Alvarado M,Blancas-Mejia LM,Lindsay S,Hari P,Migrino RQ

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:Bromocriptine-QR (a quick-release formulation of bromocriptine mesylate), a dopamine D2 receptor agonist, is a US Food and Drug Administrration-approved treatment for type 2 diabetes mellitus (T2DM). A 3070-subject randomized trial demonstrated a significant, 40% reduction in relative risk among bromocriptin...

journal_title：Journal of the American Heart Association

authors： Gaziano JM,Cincotta AH,Vinik A,Blonde L,Bohannon N,Scranton R

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:The natural history of coronary artery aneurysms (CAA) after intravenous immunoglobulin (IVIG) treatment in the United States is not well described. We describe the natural history of CAA in US Kawasaki disease (KD) patients and identify factors associated with major adverse cardiac events (MACE) and CAA reg...

journal_title：Journal of the American Heart Association

authors： Friedman KG,Gauvreau K,Hamaoka-Okamoto A,Tang A,Berry E,Tremoulet AH,Mahavadi VS,Baker A,deFerranti SD,Fulton DR,Burns JC,Newburger JW

更新日期：2016-09-15 00:00:00

abstract：BACKGROUND:Women have high rates of peripheral artery disease (PAD) despite fewer cardiovascular disease (CVD) risk factors, compared to men. We sought to determine the gender-specific prevalence of low ankle brachial index (ABI) and the relationship to C-reactive protein (CRP) levels and CVD risk factors in the Life L...

journal_title：Journal of the American Heart Association

authors： Hiramoto JS,Katz R,Weisman S,Conte M

更新日期：2014-03-13 00:00:00

abstract：BACKGROUND:It is unclear whether the incidence of non-valvular atrial fibrillation (NVAF) has been increasing over time. We aimed to provide contemporary estimates of the incidence and case-fatality of NVAF in a well-defined population. METHODS AND RESULTS:We used the computerized databases of the Régie de l'assurance...

journal_title：Journal of the American Heart Association

authors： Renoux C,Patenaude V,Suissa S

更新日期：2014-11-03 00:00:00

abstract：:Background Healthcare resource utilization is substantial for single-ventricle cardiac defects ( SVCD ), with effort commencing at time of fetal diagnosis through staged surgical palliation. We sought to characterize and identify variables that influence resource utilization for SVCD from fetal diagnosis through death...

journal_title：Journal of the American Heart Association

authors： Zielonka B,Snarr BS,Liu MY,Zhang X,Mascio CE,Fuller S,Gaynor JW,Spray TL,Rychik J

更新日期：2019-06-04 00:00:00

abstract：BACKGROUND:The increased adverse cardiac events in women undergoing coronary artery bypass grafting are multifactorial and may include clinical, psychosocial, and biological factors. Potential contributing biological factors could include vascular hyperreactivity of the internal mammary artery (IMA) to endogenous vasoc...

journal_title：Journal of the American Heart Association

authors： Lamin V,Jaghoori A,Jakobczak R,Stafford I,Heresztyn T,Worthington M,Edwards J,Viana F,Stuklis R,Wilson DP,Beltrame JF

更新日期：2018-07-09 00:00:00

abstract：BACKGROUND:Cardiac fibrosis occurs because of disruption of the extracellular matrix network leading to myocardial dysfunction. Angiotensin II has been implicated in the development of cardiac fibrosis. Recently, microRNAs have been identified as an attractive target for therapeutic intervention in cardiac pathologies;...

journal_title：Journal of the American Heart Association

authors： Li L,Bounds KR,Chatterjee P,Gupta S

更新日期：2017-11-07 00:00:00

abstract：:Background We aimed to determine if there is an association between hospital quality and the likelihood of a given hospital being a preferred transfer destination for stroke patients. Methods and Results Data from Medicare claims identified acute ischemic stroke transferred between 394 northeast US hospitals from 2007...

journal_title：Journal of the American Heart Association

authors： Zachrison KS,Onnela JP,Reeves MJ,Hernandez A,Camargo CA Jr,Zhao X,Matsouaka RA,Goldstein JN,Metlay JP,Schwamm LH

更新日期：2020-01-07 00:00:00

abstract：BACKGROUND:Neuregulin-1β (NRG-1β) is a growth factor critical for cardiac development and repair with therapeutic potential for heart failure. We previously showed that the glial growth factor 2 (GGF2) isoform of NRG-1β improves cardiac function in rodents after myocardial infarction (MI), but its efficacy in a large a...

journal_title：Journal of the American Heart Association

authors： Galindo CL,Kasasbeh E,Murphy A,Ryzhov S,Lenihan S,Ahmad FA,Williams P,Nunnally A,Adcock J,Song Y,Harrell FE,Tran TL,Parry TJ,Iaci J,Ganguly A,Feoktistov I,Stephenson MK,Caggiano AO,Sawyer DB,Cleator JH

更新日期：2014-10-23 00:00:00

abstract：:Background A combination of clinical and electrocardiographic risk factors is used for risk stratification in Brugada syndrome. In this study, we tested the hypothesis that the incorporation of latent variables between variables using nonnegative matrix factorization can improve risk stratification compared with logis...

journal_title：Journal of the American Heart Association

authors： Tse G,Zhou J,Lee S,Liu T,Bazoukis G,Mililis P,Wong ICK,Chen C,Xia Y,Kamakura T,Aiba T,Kusano K,Zhang Q,Letsas KP

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND:Although clinical trials have proved that statin can be used prophylactically against cardiovascular events, the direct effects of statin on plaque development are not well understood. We generated low-density lipoprotein receptor knockout (LDLR(-/-)) pigs to study the effects of early statin administration ...

journal_title：Journal of the American Heart Association

authors： Li Y,Fuchimoto D,Sudo M,Haruta H,Lin QF,Takayama T,Morita S,Nochi T,Suzuki S,Sembon S,Nakai M,Kojima M,Iwamoto M,Hashimoto M,Yoda S,Kunimoto S,Hiro T,Matsumoto T,Mitsumata M,Sugitani M,Saito S,Hirayama A,Onish

更新日期：2016-04-18 00:00:00

abstract：BACKGROUND:Treatment decisions for aortic valve replacement (AVR) should be sensitive to patient preferences. However, we lack knowledge of patient preferences and how to obtain them. METHODS AND RESULTS:We assessed the mortality risk patients were willing to accept when undergoing AVR by using the Standard Gamble met...

journal_title：Journal of the American Heart Association

authors： Hussain AI,Garratt AM,Brunborg C,Aakhus S,Gullestad L,Pettersen KI

更新日期：2016-03-18 00:00:00

abstract：:Background Global fractional flow reserve (FFR) (ie, the sum of the FFR values in the 3 major coronary arteries) is a physiologic correlate of global atherosclerotic burden. The objective of the present study was to investigate the value of global FFR in predicting long-term clinical outcome of patients with stable co...

journal_title：Journal of the American Heart Association

authors： Fournier S,Collet C,Xaplanteris P,Zimmermann FM,Toth GG,Tonino PAL,Pijls NHJ,Colaiori I,Di Gioia G,Barbato E,Jüni P,Fearon WF,De Bruyne B

更新日期：2020-12-15 00:00:00

abstract：:Background In statin trials, men and women derived similar relative risk reductions in cardiovascular events per 39 mg/ dL low-density lipoprotein cholesterol ( LDL -C) reduction. We explored whether lower LDL -C levels and greater LDL -C percentage reductions than those achieved with statins are associated with reduc...

journal_title：Journal of the American Heart Association

authors： Vallejo-Vaz AJ,Ginsberg HN,Davidson MH,Eckel RH,Cannon CP,Lee LV,Bessac L,Pordy R,Letierce A,Ray KK

更新日期：2018-09-18 00:00:00