The Ever-Humbling Challenge of Peripheral Artery Disease Treatment Seen Across the Sexes.

abstract：:Background The aim of the present study was to investigate the efficacy and safety of antiplatelet (aspirin plus cilostazol) dual therapy for patients with noncardioembolic stroke within 48 hours of symptom onset. Methods and Results The ADS (Acute Aspirin Plus Cilostazol Dual Therapy for Non-Cardiogenic Stroke Patien...

journal_title：Journal of the American Heart Association

authors： Aoki J,Iguchi Y,Urabe T,Yamagami H,Todo K,Fujimoto S,Idomari K,Kaneko N,Iwanaga T,Terasaki T,Tanaka R,Yamamoto N,Tsujino A,Nomura K,Abe K,Uno M,Okada Y,Matsuoka H,Yamagata S,Yamamoto Y,Yonehara T,Inoue T,Yagit

更新日期：2019-08-06 00:00:00

abstract：:Background Recent publications reached conflicting conclusions about the cost-effectiveness of left atrial appendage closure (LAAC) with the Watchman device (Boston Scientific, Marlborough, MA) for stroke risk reduction in nonvalvular atrial fibrillation (AF). This analysis sought to assess the cost-effectiveness of L...

journal_title：Journal of the American Heart Association

authors： Reddy VY,Akehurst RL,Gavaghan MB,Amorosi SL,Holmes DR Jr

更新日期：2019-07-02 00:00:00

abstract：:Background The majority of studies evaluating cardiorespiratory fitness ( CRF ) as a cardiovascular risk factor use cardiovascular mortality and not cardiovascular disease events as the primary end point, and generally do not include women. The aim of this study was to investigate the association of estimated CRF ( eC...

journal_title：Journal of the American Heart Association

authors： Shigdel R,Dalen H,Sui X,Lavie CJ,Wisløff U,Ernstsen L

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Transcatheter pulmonary valve implantation is approved for the treatment of dysfunctional right ventricle to pulmonary artery conduits. However, the literature is limited because of a small patient population, and it does not reflect changing procedural practice patterns over the last decade. METHODS AND RE...

journal_title：Journal of the American Heart Association

authors： Chatterjee A,Bajaj NS,McMahon WS,Cribbs MG,White JS,Mukherjee A,Law MA

更新日期：2017-08-04 00:00:00

abstract：BACKGROUND:Obesity is causally associated with atherosclerosis, and adipose tissue (AT)-derived exosomes may be implicated in the metabolic complications of obesity. However, the precise role of AT-exosomes in atherogenesis remains unclear. We herein aimed to assess the effect of AT-exosomes on macrophage foam cell for...

journal_title：Journal of the American Heart Association

authors： Xie Z,Wang X,Liu X,Du H,Sun C,Shao X,Tian J,Gu X,Wang H,Tian J,Yu B

更新日期：2018-03-03 00:00:00

abstract：BACKGROUND:Ticagrelor is a P2Y12 receptor inhibitor used in acute coronary syndromes to reduce platelet activity and to decrease thrombus formation. Ticagrelor is associated with a reduction in mortality incremental to that observed with clopidogrel, potentially related to its non-antiplatelet effects. Evidence from an...

journal_title：Journal of the American Heart Association

authors： Pelletier-Galarneau M,Hunter CRRN,Ascah KJ,Beanlands RSB,Dwivedi G,deKemp RA,Chow BJW,Ruddy TD

更新日期：2017-05-02 00:00:00

abstract：:Background Public health policies reflect concerns that certain fruit sources may not have the intended benefits and that vegetables should be preferred to fruit. We assessed the relation of fruit and vegetable sources with cardiovascular outcomes using a systematic review and meta-analysis of prospective cohort studi...

journal_title：Journal of the American Heart Association

authors： Zurbau A,Au-Yeung F,Blanco Mejia S,Khan TA,Vuksan V,Jovanovski E,Leiter LA,Kendall CWC,Jenkins DJA,Sievenpiper JL

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Women have high rates of peripheral artery disease (PAD) despite fewer cardiovascular disease (CVD) risk factors, compared to men. We sought to determine the gender-specific prevalence of low ankle brachial index (ABI) and the relationship to C-reactive protein (CRP) levels and CVD risk factors in the Life L...

journal_title：Journal of the American Heart Association

authors： Hiramoto JS,Katz R,Weisman S,Conte M

更新日期：2014-03-13 00:00:00

abstract：:Background Young women with coronary artery disease ( CAD ), a group with high psychosocial burden, were previously shown to have higher levels of interleukin-6 ( IL -6) compared with men of similar age. We sought to examine IL -6 response to acute stress in CAD patients across sex and age, and contrast results to hea...

journal_title：Journal of the American Heart Association

authors： Sullivan S,Hammadah M,Wilmot K,Ramadan R,Pearce BD,Shah A,Kaseer B,Gafeer MM,Lima BB,Kim JH,Ward L,Ko YA,Lewis TT,Hankus A,Elon L,Li L,Bremner JD,Raggi P,Quyyumi A,Vaccarino V

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:We previously identified peritoneal B1a cells that secrete natural IgM as a key atheroprotective B cell subset. However, the molecules that activate atheroprotective B1a cells are unknown. Here, we investigated whether Toll-like receptors (TLRs) TLR2, TLR4, and TLR9 expressed by B1a cells are required for Ig...

journal_title：Journal of the American Heart Association

authors： Hosseini H,Li Y,Kanellakis P,Tay C,Cao A,Liu E,Peter K,Tipping P,Toh BH,Bobik A,Kyaw T

更新日期：2016-11-14 00:00:00

abstract：:Background Sex differences in outcome have been reported in patients with congenital long QT syndrome. We aimed to report on the incidence of time-dependent life-threatening events in male and female patients with long QT syndrome with an implantable cardioverter defibrillator (ICD). Methods and Results A total of 60 ...

journal_title：Journal of the American Heart Association

authors： Younis A,Aktas MK,Rosero S,Kutyifa V,Polonsky B,McNitt S,Sotoodehnia N,Kudenchuk P,Rea TD,Arking DE,Goldenberg I,Zareba W

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Epidemiology of myocarditis in childhood is largely unknown. Men are known to have a higher incidence of myocarditis than women in adults aged <50 years, but whether this is true by sex in pediatric age groups is unknown. We set out to study the occurrence and potential sex differences of myocarditis in a ge...

journal_title：Journal of the American Heart Association

authors： Arola A,Pikkarainen E,Sipilä JO,Pykäri J,Rautava P,Kytö V

更新日期：2017-11-18 00:00:00

abstract：BACKGROUND:Decreased arterial elasticity is a risk factor for several cardiovascular outcomes. Longitudinal data on the effect of physical activity in youth on adult arterial elasticity are limited. The aim of this study was to determine the long-term effects of physical activity in children and young adults on carotid...

journal_title：Journal of the American Heart Association

authors： Pälve KS,Pahkala K,Magnussen CG,Koivistoinen T,Juonala M,Kähönen M,Lehtimäki T,Rönnemaa T,Viikari JS,Raitakari OT

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:Different sleep-disordered breathing (SDB) phenotypes, including coexisting obstructive and central sleep apnea (OSA-CSA), have not yet been characterized in a large sample of patients with heart failure and reduced ejection fraction (HFrEF) receiving guideline-based therapies. Therefore, the aim of the pres...

journal_title：Journal of the American Heart Association

authors： Arzt M,Oldenburg O,Graml A,Erdmann E,Teschler H,Wegscheider K,Suling A,Woehrle H,SchlaHF Investigators.

更新日期：2017-11-29 00:00:00

abstract：BACKGROUND:We aimed to determine how single and combination antihypertensive therapy alters risk for diabetes mellitus (DM).Thiazide diuretics (TD), β blockers (BB), and renin-angiotensin system blockers (RASB) impact DM risk while calcium channel blockers (CCB) are neutral. DM risk associated with combinations is uncl...

journal_title：Journal of the American Heart Association

authors： Cooper--DeHoff RM,Bird ST,Nichols GA,Delaney JA,Winterstein AG

更新日期：2013-06-10 00:00:00

abstract：BACKGROUND:Statin therapy reduces the risk of cardiovascular events in patients with obstructive coronary artery disease. The aim of the present study was to determine the effects of statins on the prognosis of patients with coronary vasospastic angina (VSA) free of significant atherosclerotic stenosis. METHODS AND RE...

journal_title：Journal of the American Heart Association

authors： Ishii M,Kaikita K,Sato K,Yamanaga K,Miyazaki T,Akasaka T,Tabata N,Arima Y,Sueta D,Sakamoto K,Yamamoto E,Tsujita K,Yamamuro M,Kojima S,Soejima H,Hokimoto S,Matsui K,Ogawa H

更新日期：2016-05-20 00:00:00

abstract：BACKGROUND:Although automated external defibrillators (AEDs) have contributed to a better survival of out-of-hospital cardiac arrests, there have been reports of their malfunctioning. We investigated the diagnostic accuracy of commercially available AEDs using surface ECGs of ventricular fibrillation (VF), ventricular ...

journal_title：Journal of the American Heart Association

authors： Nishiyama T,Nishiyama A,Negishi M,Kashimura S,Katsumata Y,Kimura T,Nishiyama N,Tanimoto Y,Aizawa Y,Mitamura H,Fukuda K,Takatsuki S

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Metformin use reduces the incidence and severity of stroke in patients with type 2 diabetes mellitus (DM). The benefits of metformin for stroke have not been examined in hemodialysis patients with DM. METHODS AND RESULTS:Using the National Health Insurance Research Database, we identified 17 760 patients wi...

journal_title：Journal of the American Heart Association

authors： Chien LN,Chou CL,Chen HH,Kao CC,Lin YC,Wu YL,Chen JS,Chen LY,Fang TC

更新日期：2017-11-16 00:00:00

abstract：:Background Myocardial infarction (MI) size is a key predictor of prognosis in post-MI patients. Cardiovascular magnetic resonance (CMR) is the gold standard test for MI quantification, but the ECG is less expensive and more widely available. We sought to quantify the relationship between ECG markers and cardiovascular...

journal_title：Journal of the American Heart Association

authors： Lee DC,Albert CM,Narula D,Kadish AH,Panicker GK,Wu E,Schaechter A,Pester J,Chatterjee NA,Cook NR,Goldberger JJ

更新日期：2020-02-04 00:00:00

abstract：:Background Recently, direct oral anticoagulants have been introduced for venous thromboembolism (VTE), which might change the management strategies of VTE. However, there have been limited data on the current real-world practice pattern for VTE in Asian countries. Methods and Results The JROAD-DPC (Japanese Registry o...

journal_title：Journal of the American Heart Association

authors： Yamashita Y,Morimoto T,Yoshikawa Y,Yaku H,Sumita Y,Nakai M,Ono K,Kimura T

更新日期：2020-01-21 00:00:00

abstract：:Background This study examined the association between ideal cardiovascular health ( CVH ) and the retinal microvasculature in midadulthood. Methods and Results The Cardiovascular Risk in Young Finns Study included children from 5 Finnish University cities, who were chosen randomly from the national population registe...

journal_title：Journal of the American Heart Association

authors： Campbell MD,Laitinen TT,Hughes A,Pahkala K,Juonala M,Kähönen M,Wong TY,Lehtimäki T,Hutri-Kähönen N,Raitakari OT,Tapp RJ

更新日期：2018-10-16 00:00:00

abstract：:Background The objectives of the present study were (1) to evaluate the echocardiographic prognostic factors associated with improved left ventricular (LV) systolic function after aortic valve replacement, and (2) to compare the long-term outcomes after aortic valve replacement in chronic aortic regurgitation (AR) pat...

journal_title：Journal of the American Heart Association

authors： Kim MS,Kim JH,Joo HC,Lee S,Youn YN,Lee SH

更新日期：2020-12-15 00:00:00

abstract：:Background Previous studies have reported an association between the timing of menarche and cardiovascular disease ( CVD ). However, emerging studies have not examined the timing of menarche in relation to role of estrogen over a lifetime and major adverse cardiac events ( MACE ). Methods and Results A total of 648 wo...

journal_title：Journal of the American Heart Association

authors： Lee JJ,Cook-Wiens G,Johnson BD,Braunstein GD,Berga SL,Stanczyk FZ,Pepine CJ,Bairey Merz CN,Shufelt CL

更新日期：2019-06-18 00:00:00

abstract：:Background Normal-flow, low-gradient severe aortic stenosis (NF-LG-SAS), defined by aortic valve area <1 cm2, mean gradient <40 mm Hg, and indexed stroke volume >35 mL/m2, is the most prevalent form of low-gradient aortic stenosis (AS). However, the true severity of AS and the management of NF-LG-SAS are controversial...

journal_title：Journal of the American Heart Association

authors： Chadha G,Bohbot Y,Rusinaru D,Maréchaux S,Tribouilloy C

更新日期：2019-10-01 00:00:00

abstract：:Background The 2017 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines lowered the threshold of blood pressure (BP) for hypertension to 130/80 mm Hg. However, the clinical significance of isolated diastolic hypertension (IDH) according to the cutoff value of the 2017 ACC/AHA guidelines wa...

journal_title：Journal of the American Heart Association

authors： Kaneko H,Itoh H,Yotsumoto H,Kiriyama H,Kamon T,Fujiu K,Morita K,Michihata N,Jo T,Takeda N,Morita H,Yasunaga H,Komuro I

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Fatty acids constitute the critical components of cell structure and function, and dysregulation of fatty acid composition may exert diverging vascular effects including proliferation, migration, and differentiation of vascular smooth muscle cells (VSMCs). However, direct evidence for this hypothesis has bee...

journal_title：Journal of the American Heart Association

authors： Sunaga H,Matsui H,Anjo S,Syamsunarno MR,Koitabashi N,Iso T,Matsuzaka T,Shimano H,Yokoyama T,Kurabayashi M

更新日期：2016-11-23 00:00:00

abstract：:Background The interrelationships among the different stages of impaired glucose metabolism, insulin resistance, and hypertension are not fully understood. Methods and Results We investigated the impact of insulin resistance, plasma glucose, and serum immunoreactive insulin levels on hypertension in 19 166 participant...

journal_title：Journal of the American Heart Association

authors： Sasaki N,Ozono R,Higashi Y,Maeda R,Kihara Y

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGB) reduces obesity-associated comorbidities and cardiovascular mortality. RYGB improves endothelial dysfunction, reducing c-Jun N-terminal kinase (JNK) vascular phosphorylation. JNK activation links obesity with insulin resistance and endothelial dysfunction. Herein, we examined ...

journal_title：Journal of the American Heart Association

authors： Doytcheva P,Bächler T,Tarasco E,Marzolla V,Engeli M,Pellegrini G,Stivala S,Rohrer L,Tona F,Camici GG,Vanhoutte PM,Matter CM,Lutz TA,Lüscher TF,Osto E

更新日期：2017-11-14 00:00:00

abstract：BACKGROUND:Dyslipidemia is a major risk factor for cardiovascular events. The prognostic importance of lipoproteins in patients with atrial fibrillation is not well understood. We aimed to explore the association between apolipoprotein A1 (ApoA1) and B (ApoB) and cardiovascular events in patients with atrial fibrillati...

journal_title：Journal of the American Heart Association

authors： Pol T,Held C,Westerbergh J,Lindbäck J,Alexander JH,Alings M,Erol C,Goto S,Halvorsen S,Huber K,Hanna M,Lopes RD,Ruzyllo W,Granger CB,Hijazi Z

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Single-electrode ablation of the main renal artery for renal sympathetic denervation showed mixed blood pressure (BP)-lowering effects. Further improvement of the technique seems crucial to optimize effectiveness of the procedure. Because sympathetic nerve fibers are closer to the lumen in the distal part of...

journal_title：Journal of the American Heart Association

authors： Fengler K,Ewen S,Höllriegel R,Rommel KP,Kulenthiran S,Lauder L,Cremers B,Schuler G,Linke A,Böhm M,Mahfoud F,Lurz P

更新日期：2017-08-10 00:00:00