Impact of Statin Therapy on Clinical Outcome in Patients With Coronary Spasm.

abstract：:Background Quantitative flow ratio ( QFR ) has a high diagnostic accuracy in assessing functional stenoses relevance, as judged by fractional flow reserve ( FFR ). However, its diagnostic performance has not been thoroughly evaluated using instantaneous wave-free ratio ( iFR ) or coronary flow reserve as the reference...

journal_title：Journal of the American Heart Association

authors： Hwang D,Choi KH,Lee JM,Mejía-Rentería H,Kim J,Park J,Rhee TM,Jeon KH,Lee HJ,Kim HK,Park TK,Yang JH,Song YB,Shin ES,Nam CW,Kwak JJ,Doh JH,Hahn JY,Choi JH,Choi SH,Escaned J,Koo BK,Gwon HC

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:Intestinal microbiota have been found to be linked to cardiovascular disease via conversion of the dietary compounds choline and carnitine to the atherogenic metabolite TMAO (trimethylamine-N-oxide). Specifically, a vegan diet was associated with decreased plasma TMAO levels and nearly absent TMAO production...

journal_title：Journal of the American Heart Association

authors： Smits LP,Kootte RS,Levin E,Prodan A,Fuentes S,Zoetendal EG,Wang Z,Levison BS,Cleophas MCP,Kemper EM,Dallinga-Thie GM,Groen AK,Joosten LAB,Netea MG,Stroes ESG,de Vos WM,Hazen SL,Nieuwdorp M

更新日期：2018-03-26 00:00:00

abstract：:Background Stroke and thromboembolic events may still occur in "clinically low-risk" atrial fibrillation (AF) patients as categorized by CHA2DS2-VASc score. Our aim was to assess the proportion of "clinically low-risk" patients using a nongender CHA2DS2-VASc (ie, CHA2DS2-VA) score of 0 to 1 among patients who experien...

journal_title：Journal of the American Heart Association

authors： Shin SY,Han SJ,Kim JS,Im SI,Shim J,Ahn J,Lee EM,Park YM,Kim JH,Lip GYH,Lim HE

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:Diabetes mellitus (DM) is a major risk factor for cardiovascular events. We aimed to investigate the coronary plaque phenotype of diabetic patients who presented with acute coronary syndromes by optical coherence tomography. METHODS AND RESULTS:A total of 322 patients with acute coronary syndromes who under...

journal_title：Journal of the American Heart Association

authors： Sugiyama T,Yamamoto E,Bryniarski K,Xing L,Fracassi F,Lee H,Jang IK

更新日期：2018-07-13 00:00:00

abstract：:Background Hypertensive myocardial fibrosis (MF) is characterized by excessive deposition of extracellular matrix and cardiac fibroblast proliferation, which can lead to heart failure, malignant arrhythmia, and sudden death. In recent years, with the deepening of research, microRNAs have been found to have an importan...

journal_title：Journal of the American Heart Association

authors： Zhang W,Wang Q,Feng Y,Chen X,Yang L,Xu M,Wang X,Li W,Niu X,Gao D

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:Renal denervation has no validated marker of procedural success. We hypothesized that successful renal denervation would reduce renal sympathetic nerve signaling demonstrated by attenuation of α-1-adrenoceptor-mediated autotransfusion during the Valsalva maneuver. METHODS AND RESULTS:In this substudy of the...

journal_title：Journal of the American Heart Association

authors： Saxena M,Shour T,Shah M,Wolff CB,Julu POO,Kapil V,Collier DJ,Ng FL,Gupta A,Balawon A,Pheby J,Zak A,Rull G,O'Brien B,Schmieder RE,Lobo MD

更新日期：2018-06-12 00:00:00

abstract：BACKGROUND:NO bioavailability has not been systematically examined in congenital heart disease (CHD). To assess NO in patients with CHD, we measured nasal NO (nNO) generated by the nasal epithelia, given blood NO is difficult to measure (half-life, <2 ms). Given NO's role in hemodynamic regulation and the association o...

journal_title：Journal of the American Heart Association

authors： Adams PS,Zahid M,Khalifa O,Feingold B,Lo CW

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:Respiratory muscle weakness contributes to exercise intolerance in patients with heart failure with a preserved ejection fraction (HFpEF)-a condition characterized by multiple comorbidities with few proven treatments. We aimed, therefore, to provide novel insight into the underlying diaphragmatic alterations...

journal_title：Journal of the American Heart Association

authors： Bowen TS,Brauer D,Rolim NPL,Bækkerud FH,Kricke A,Ormbostad Berre AM,Fischer T,Linke A,da Silva GJ,Wisloff U,Adams V

更新日期：2017-10-24 00:00:00

abstract：BACKGROUND:Diabetes is associated with coronary arteriolar endothelial dysfunction. We investigated the role of the small/intermediate (SK(Ca)/IK(Ca)) conductance of calcium-activated potassium channels in diabetes-related endothelial dysfunction. METHODS AND RESULTS:Coronary arterioles (80 to 150 μm in diameter) were...

journal_title：Journal of the American Heart Association

authors： Liu Y,Xie A,Singh AK,Ehsan A,Choudhary G,Dudley S,Sellke FW,Feng J

更新日期：2015-08-24 00:00:00

abstract：:Background It has been suggested that endocardial and epicardial ablation of ventricular tachycardia ( VT ) improves outcome in arrhythmogenic right ventricular cardiomyopathy/dysplasia. We investigated our sequential approach for VT ablation in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia i...

journal_title：Journal of the American Heart Association

authors： Mathew S,Saguner AM,Schenker N,Kaiser L,Zhang P,Yashuiro Y,Lemes C,Fink T,Maurer T,Santoro F,Wohlmuth P,Reißmann B,Heeger CH,Tilz R,Wissner E,Rillig A,Metzner A,Kuck KH,Ouyang F

更新日期：2019-03-05 00:00:00

abstract：:Background Catheter ablation is an effective treatment for atrial fibrillation (AF), but high levels of post-procedure inflammation predict adverse clinical events. Ascorbic acid (AA) has shown promise in reducing inflammation but is untested in this population. We sought to test the feasibility, safety, and prelimina...

journal_title：Journal of the American Heart Association

authors： Trankle CR,Puckett L,Swift-Scanlan T,DeWilde C,Priday A,Sculthorpe R,Ellenbogen KA,Fowler A,Koneru JN

更新日期：2020-02-04 00:00:00

abstract：:Background Pharmacists-led medication reviews (MRs) are claimed to be effective for the control of cardiovascular diseases; however, the evidence in the literature is conflicting. The main objective of this meta-analysis was to analyze the impact of pharmacist-led MRs on cardiovascular disease risk factors overall and...

journal_title：Journal of the American Heart Association

authors： Martínez-Mardones F,Fernandez-Llimos F,Benrimoj SI,Ahumada-Canale A,Plaza-Plaza JC,S Tonin F,Garcia-Cardenas V

更新日期：2019-11-19 00:00:00

abstract：:Background Although many patients with coronary artery disease are using statins before off-pump coronary artery bypass grafting ( OPCAB ) following current guidelines, recent studies have raised concerns regarding adverse effects of preoperative statins on postoperative kidney function. We evaluated the effects of pr...

journal_title：Journal of the American Heart Association

authors： Park J,Lee JH,Kim KA,Lee SH,Lee YT,Kim WS,Min JJ

更新日期：2019-04-02 00:00:00

abstract：:Background The interrelationships among the different stages of impaired glucose metabolism, insulin resistance, and hypertension are not fully understood. Methods and Results We investigated the impact of insulin resistance, plasma glucose, and serum immunoreactive insulin levels on hypertension in 19 166 participant...

journal_title：Journal of the American Heart Association

authors： Sasaki N,Ozono R,Higashi Y,Maeda R,Kihara Y

更新日期：2020-04-07 00:00:00

abstract：:Background In statin trials, men and women derived similar relative risk reductions in cardiovascular events per 39 mg/ dL low-density lipoprotein cholesterol ( LDL -C) reduction. We explored whether lower LDL -C levels and greater LDL -C percentage reductions than those achieved with statins are associated with reduc...

journal_title：Journal of the American Heart Association

authors： Vallejo-Vaz AJ,Ginsberg HN,Davidson MH,Eckel RH,Cannon CP,Lee LV,Bessac L,Pordy R,Letierce A,Ray KK

更新日期：2018-09-18 00:00:00

abstract：:Background We systematically reviewed trials comparing different reperfusion strategies for ST-segment-elevation myocardial infarction and used multivariate network meta-analysis to compare outcomes across these strategies. Methods and Results We identified 31 contemporary trials in which patients with ST-segment-elev...

journal_title：Journal of the American Heart Association

authors： Fazel R,Joseph TI,Sankardas MA,Pinto DS,Yeh RW,Kumbhani DJ,Nallamothu BK

更新日期：2020-06-16 00:00:00

abstract：:Background Patients with tetralogy of Fallot ( TOF ) remain at risk for cardiovascular events despite successful repair. Some of the current risk stratification tools require advanced imaging and invasive studies, and hence are difficult to apply to routine patient care. A recent study showed that QRS fragmentation ( ...

journal_title：Journal of the American Heart Association

authors： Egbe AC,Miranda WR,Mehra N,Ammash NM,Missula VR,Madhavan M,Deshmukh AJ,Farouk Abdelsamid M,Kothapalli S,Connolly HM

更新日期：2018-12-18 00:00:00

abstract：:Background Atrial fibrillation (AF) has been shown to be associated with an increased risk of dementia as well as Alzheimer disease in observational studies. Whether this association reflects causal association is still unclear. The purpose of this study was to examine the causal association of AF with Alzheimer disea...

journal_title：Journal of the American Heart Association

authors： Pan Y,Wang Y,Wang Y

更新日期：2020-01-21 00:00:00

abstract：:Background Left ventricular assist devices (LVADs) generate electromagnetic interference that causes high-frequency noise artifacts on 12-lead ECGs. We describe the causes of this interference and potential solutions to aid ECG interpretation in patients with LVAD. Methods and Results Waveform data from ECGs performed...

journal_title：Journal of the American Heart Association

authors： Loring Z,Sen S,Black-Maier E,Atwater BD,Russell SD,DeVore AD,Piccini JP

更新日期：2020-08-18 00:00:00

abstract：:Background Short-term variability of the QT interval (STVQT) has been proposed as a novel electrophysiological marker for the prediction of imminent ventricular arrhythmias in animal models. Our aim is to study whether STVQT can predict imminent ventricular arrhythmias in patients. Methods and Results In 2331 patients...

journal_title：Journal of the American Heart Association

authors： Smoczyńska A,Loen V,Sprenkeler DJ,Tuinenburg AE,Ritsema van Eck HJ,Malik M,Schmidt G,Meine M,Vos MA

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Obesity may increase heart failure risk through cardiac remodeling. Cross-sectional associations between adiposity and cardiac structure and function have been elucidated, but the impact of longitudinal changes in adiposity on cardiac remodeling is less well understood. METHODS AND RESULTS:Participants in t...

journal_title：Journal of the American Heart Association

authors： Wilner B,Garg S,Ayers CR,Maroules CD,McColl R,Matulevicius SA,de Lemos JA,Drazner MH,Peshock R,Neeland IJ

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:Elevated albuminuria as well as an increased serum uric acid concentration is associated with poor cardiovascular outcome. We questioned whether these 2 variables (albuminuria and serum uric concentration) may be interrelated via tubular uric acid reabsorption. METHODS AND RESULTS:Included were 7688 partici...

journal_title：Journal of the American Heart Association

authors： Scheven L,Joosten MM,de Jong PE,Bakker SJ,Gansevoort RT,PREVEND study group.

更新日期：2014-01-01 00:00:00

abstract：:Background Characterizing associations of sleep characteristics with blood-glucose-level factors among blacks may clarify the underlying mechanisms of impaired glucose metabolism and help identify treatment targets to prevent diabetes mellitus in blacks. Methods and Results Cross-sectional analyses were conducted in 7...

journal_title：Journal of the American Heart Association

authors： Yano Y,Gao Y,Johnson DA,Carnethon M,Correa A,Mittleman MA,Sims M,Mostofsky E,Wilson JG,Redline S

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:Right ventricular (RV) diastolic function is impaired in patients with pulmonary arterial hypertension (PAH). Our previous study showed that elevated cardiomyocyte stiffness and myofilament Ca(2+) sensitivity underlie diastolic dysfunction in PAH. This study investigates protein modifications contributing to...

journal_title：Journal of the American Heart Association

authors： Rain S,Bos Dda S,Handoko ML,Westerhof N,Stienen G,Ottenheijm C,Goebel M,Dorfmüller P,Guignabert C,Humbert M,Bogaard HJ,Remedios CD,Saripalli C,Hidalgo CG,Granzier HL,Vonk-Noordegraaf A,van der Velden J,de Man FS

更新日期：2014-06-03 00:00:00

abstract：BACKGROUND:Dyslipidemia is a major risk factor for cardiovascular events. The prognostic importance of lipoproteins in patients with atrial fibrillation is not well understood. We aimed to explore the association between apolipoprotein A1 (ApoA1) and B (ApoB) and cardiovascular events in patients with atrial fibrillati...

journal_title：Journal of the American Heart Association

authors： Pol T,Held C,Westerbergh J,Lindbäck J,Alexander JH,Alings M,Erol C,Goto S,Halvorsen S,Huber K,Hanna M,Lopes RD,Ruzyllo W,Granger CB,Hijazi Z

更新日期：2018-02-01 00:00:00

abstract：:Background A combination of clinical and electrocardiographic risk factors is used for risk stratification in Brugada syndrome. In this study, we tested the hypothesis that the incorporation of latent variables between variables using nonnegative matrix factorization can improve risk stratification compared with logis...

journal_title：Journal of the American Heart Association

authors： Tse G,Zhou J,Lee S,Liu T,Bazoukis G,Mililis P,Wong ICK,Chen C,Xia Y,Kamakura T,Aiba T,Kusano K,Zhang Q,Letsas KP

更新日期：2020-11-17 00:00:00

abstract：:Background Use of inpatient brain magnetic resonance imaging (MRI) in patients with acute ischemic stroke is highly institution dependent and has been associated with increased length and cost of hospital stay. We examined whether inpatient brain MRI in patients with acute ischemic stroke is associated with improved c...

journal_title：Journal of the American Heart Association

authors： Lee H,Yang Y,Liu B,Castro SA,Shi T

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Relevant clinical studies have been small and have not convincingly demonstrated whether the perioperative initiation of beta-blockers should be considered in patients with diabetes mellitus undergoing noncardiac surgery. METHODS AND RESULTS:In this nationwide propensity score-matched study, we included pat...

journal_title：Journal of the American Heart Association

authors： Chen RJ,Chu H,Tsai LW

更新日期：2017-01-10 00:00:00

abstract：:Background Among people with lower extremity peripheral artery disease, obesity is associated with faster functional decline than normal weight. The association of weight loss with functional decline in peripheral artery disease is unknown. Methods and Results Adults with an ankle-brachial index <0.90 were identified ...

journal_title：Journal of the American Heart Association

authors： Polonsky TS,Tian L,Zhang D,Bazzano LA,Criqui MH,Ferrucci L,Guralnik JM,Kibbe MR,Leeuwenburgh C,Sufit RL,McDermott MM

更新日期：2019-07-02 00:00:00

abstract：:Background Higher fibroblast growth factor-23 ( FGF -23) levels are associated with incident heart failure ( HF ) in MESA (the Multiethnic Study of Atherosclerosis). FGF -23 is also associated with left ventricular hypertrophy. Whether the FGF -23 association with HF is similar for heart failure with reduced ejection ...

journal_title：Journal of the American Heart Association

authors： Almahmoud MF,Soliman EZ,Bertoni AG,Kestenbaum B,Katz R,Lima JAC,Ouyang P,Miller PE,Michos ED,Herrington DM

更新日期：2018-09-18 00:00:00