Patients With Acute Ischemic Stroke Who Receive Brain Magnetic Resonance Imaging Demonstrate Favorable In-Hospital Outcomes.

abstract：:Background The ODYSSEY OUTCOMES (Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome) trial demonstrated that alirocumab reduced major cardiovascular events. However, because of the hierarchical testing strategy used for the multiple outcomes examined, the observed reduction in all-cause mortality was...

journal_title：Journal of the American Heart Association

authors： Labos C,Brophy JM,Sniderman A,Thanassoulis G

更新日期：2019-10-15 00:00:00

abstract：:Background Young women with coronary artery disease ( CAD ), a group with high psychosocial burden, were previously shown to have higher levels of interleukin-6 ( IL -6) compared with men of similar age. We sought to examine IL -6 response to acute stress in CAD patients across sex and age, and contrast results to hea...

journal_title：Journal of the American Heart Association

authors： Sullivan S,Hammadah M,Wilmot K,Ramadan R,Pearce BD,Shah A,Kaseer B,Gafeer MM,Lima BB,Kim JH,Ward L,Ko YA,Lewis TT,Hankus A,Elon L,Li L,Bremner JD,Raggi P,Quyyumi A,Vaccarino V

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Troponin-T elevation is seen commonly in sepsis and septic shock patients admitted to the intensive care unit. We sought to evaluate the role of admission and serial troponin-T testing in the prognostication of these patients. METHODS AND RESULTS:This was a retrospective cohort study from 2007 to 2014 on pa...

journal_title：Journal of the American Heart Association

authors： Vallabhajosyula S,Sakhuja A,Geske JB,Kumar M,Poterucha JT,Kashyap R,Kashani K,Jaffe AS,Jentzer JC

更新日期：2017-09-09 00:00:00

abstract：BACKGROUND:Kawasaki disease (KD) is a pediatric vasculitis with coronary artery aneurysm (CAA) as a major complication. Controversy exists about cardiovascular risk later in life. The aim of our study was to evaluate whether KD patients are at increased risk, as assessed by carotid intima-media thickness (cIMT). METHO...

journal_title：Journal of the American Heart Association

authors： Dietz SM,Tacke CE,de Groot E,Kuipers IM,Hutten BA,Kuijpers TW,Dutch Kawasaki Study Groupten BergeMaartjeBiezeveldMaarten H.BruijnMartijnDelemarreLuçan C.DolmanKoert M.FilippiniLuc H.P.M.HendriksTomMaingay‐VisserDianne A.P.G.F.NoordzijJeroen

更新日期：2016-07-05 00:00:00

abstract：:Background Cardiology has advanced guideline development and quality measurement. Recognizing the substantial benefits of guideline-directed medical therapy, this study aims to measure and explain apparent deviations in heart failure ( HF ) guideline adherence by clinicians at hospital discharge and describe any impac...

journal_title：Journal of the American Heart Association

authors： Gilstrap LG,Stevenson LW,Small R,Parambi R,Hamershock R,Greenberg J,Carr C,Ghazinouri R,Rathman L,Han E,Mehra MR,Desai AS

更新日期：2018-08-07 00:00:00

abstract：BACKGROUND:DPP4 (Dipeptidyl peptidase-4)-GLP-1 (glucagon-like peptide-1) and its receptor (GLP-1R) axis has been involved in several intracellular signaling pathways. The Adrβ3 (β3-adrenergic receptor)/CXCL12 (C-X-C motif chemokine 12) signal was required for the hematopoiesis. We investigated the novel molecular requi...

journal_title：Journal of the American Heart Association

authors： Zhu E,Hu L,Wu H,Piao L,Zhao G,Inoue A,Kim W,Yu C,Xu W,Bando YK,Li X,Lei Y,Hao CN,Takeshita K,Kim WS,Okumura K,Murohara T,Kuzuya M,Cheng XW

更新日期：2017-07-14 00:00:00

abstract：:Background Informed consent for acute myocardial infarction and stroke research is challenging. Time for enrollment decisions is limited, patients and family are usually stressed, and being asked to participate in research is often unexpected. Despite these barriers, patients and surrogates have reported a preference ...

journal_title：Journal of the American Heart Association

authors： Scicluna VM,Goldkind SF,Mitchell AR,Pentz RD,Speight CD,Silbergleit R,Dickert NW

更新日期：2019-11-19 00:00:00

abstract：BACKGROUND:Previous studies have suggested that n-3 polyunsaturated fatty acids (n-3 PUFAs) have antiarrhythmic effects on atrial fibrillation (AF). We aimed to assess the effects of therapy with n-3 PUFAs on the incidence of recurrent AF and on postoperative AF. METHODS AND RESULTS:Electronic searches were conducted ...

journal_title：Journal of the American Heart Association

authors： Mariani J,Doval HC,Nul D,Varini S,Grancelli H,Ferrante D,Tognoni G,Macchia A

更新日期：2013-02-19 00:00:00

abstract：:Background Angiotensin II type 1 receptor ( AT 1R) autoantibody ( AT 1- AA ) was first identified as a causative factor in preeclampsia. Unlike physiological ligand angiotensin II (Ang II ), AT 1- AA can induce vasoconstriction in a sustained manner, causing a series of adverse effects, such as vascular injury and poo...

journal_title：Journal of the American Heart Association

authors： Bian J,Lei J,Yin X,Wang P,Wu Y,Yang X,Wang L,Zhang S,Liu H,Fu MLX

更新日期：2019-03-19 00:00:00

abstract：BACKGROUND:NO bioavailability has not been systematically examined in congenital heart disease (CHD). To assess NO in patients with CHD, we measured nasal NO (nNO) generated by the nasal epithelia, given blood NO is difficult to measure (half-life, <2 ms). Given NO's role in hemodynamic regulation and the association o...

journal_title：Journal of the American Heart Association

authors： Adams PS,Zahid M,Khalifa O,Feingold B,Lo CW

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:Increased platelet aggregation during antiplatelet therapy may predict cardiovascular events in patients with coronary artery disease. The majority of these patients receive aspirin monotherapy. We aimed to investigate whether high platelet-aggregation levels predict cardiovascular events in stable coronary ...

journal_title：Journal of the American Heart Association

authors： Larsen SB,Grove EL,Neergaard-Petersen S,Würtz M,Hvas AM,Kristensen SD

更新日期：2017-08-05 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea is associated with high blood pressure. The magnitude of blood pressure effects from sleep apnea treatment is unclear. We aimed to determine the effect of mandibular advancement device therapy on ambulatory nighttime and daytime blood pressure in women and men with daytime sleepiness ...

journal_title：Journal of the American Heart Association

authors： Rietz H,Franklin KA,Carlberg B,Sahlin C,Marklund M

更新日期：2018-06-21 00:00:00

abstract：:Background Mobile health (mHealth) technologies can deliver interventions to prevent and manage cardiovascular disease (CVD), but mHealth uptake among those with or at risk for CVD remains incompletely explored. Therefore, in this group, we assessed the prevalence of mHealth access and usage, and the association betwe...

journal_title：Journal of the American Heart Association

authors： Shan R,Ding J,Plante TB,Martin SS

更新日期：2019-12-17 00:00:00

abstract：:Background The role of platelets in the development of vascular inflammation and endothelial dysfunction in the pathogenesis of hypertension is well established at this time. Aspirin is known to relieve pain, decrease fever, reduce inflammation, impair platelet aggregation, and prevent clotting, yet its effect in the ...

journal_title：Journal of the American Heart Association

authors： Jiang X,Liu X,Liu X,Wu X,Jose PA,Liu M,Yang Z

更新日期：2020-01-07 00:00:00

abstract：:Background Detection of flow reserve ( FR ) by dobutamine stress echocardiography is used for risk stratification in low-gradient aortic stenosis ( AS ). Prognostic significance of dobutamine stress echocardiography in the transcatheter aortic valve replacement era is unclear. We aimed to assess the current relevance ...

journal_title：Journal of the American Heart Association

authors： Sato K,Sankaramangalam K,Kandregula K,Bullen JA,Kapadia SR,Krishnaswamy A,Mick S,Rodriguez LL,Grimm RA,Menon V,Desai MY,Svensson LG,Griffin BP,Popović ZB

更新日期：2019-03-19 00:00:00

abstract：:Background A vegetarian diet (VD) may reduce future cardiovascular risk in patients with ischemic heart disease. Methods and Results A randomized crossover study was conducted in subjects with ischemic heart disease, assigned to 4-week intervention periods of isocaloric VD and meat diet (MD) with individually designed...

journal_title：Journal of the American Heart Association

authors： Djekic D,Shi L,Brolin H,Carlsson F,Särnqvist C,Savolainen O,Cao Y,Bäckhed F,Tremaroli V,Landberg R,Frøbert O

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:Elevated serum phosphorus might aggravate the effect of hypertension on mortality. The objective of this study was to examine the joint effect of hypertension and serum phosphorus on the risk of mortality. METHODS AND RESULTS:A large prospective (n=15 833), population-based cohort of participants from the N...

journal_title：Journal of the American Heart Association

authors： Vart P,Nigatu YT,Jaglan A,van Zon SK,Shafique K

更新日期：2015-05-20 00:00:00

abstract：:Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) have shown their beneficial effects on cardiovascular outcomes and multiple cardiovascular risk factors, including hypertension. However, the mechanism of blood pressure (BP)-lowering effects of thes...

journal_title：Journal of the American Heart Association

authors： Hu M,Cai X,Yang W,Zhang S,Nie L,Ji L

更新日期：2020-04-07 00:00:00

abstract：:Background Action potential alternans can induce ventricular tachyarrhythmias and manifest on the surface ECG as T-wave alternans (TWA) and QRS alternans (QRSA). We sought to evaluate microvolt QRSA in cardiomyopathy patients in relation to TWA and ventricular tachyarrhythmia outcomes. Methods and Results Prospectivel...

journal_title：Journal of the American Heart Association

authors： Suszko A,Nayyar S,Labos C,Nanthakumar K,Pinter A,Crystal E,Chauhan VS

更新日期：2020-09-01 00:00:00

abstract：:Background Healthcare resource utilization is substantial for single-ventricle cardiac defects ( SVCD ), with effort commencing at time of fetal diagnosis through staged surgical palliation. We sought to characterize and identify variables that influence resource utilization for SVCD from fetal diagnosis through death...

journal_title：Journal of the American Heart Association

authors： Zielonka B,Snarr BS,Liu MY,Zhang X,Mascio CE,Fuller S,Gaynor JW,Spray TL,Rychik J

更新日期：2019-06-04 00:00:00

abstract：BACKGROUND:A higher milk consumption may be associated with a lower stroke risk. We conducted a comprehensive systematic review and dose-response meta-analysis of milk and other dairy products in relation to stroke risk. METHODS AND RESULTS:Through a systematic literature search, prospective cohort studies of dairy fo...

journal_title：Journal of the American Heart Association

authors： de Goede J,Soedamah-Muthu SS,Pan A,Gijsbers L,Geleijnse JM

更新日期：2016-05-20 00:00:00

abstract：BACKGROUND:Single-electrode ablation of the main renal artery for renal sympathetic denervation showed mixed blood pressure (BP)-lowering effects. Further improvement of the technique seems crucial to optimize effectiveness of the procedure. Because sympathetic nerve fibers are closer to the lumen in the distal part of...

journal_title：Journal of the American Heart Association

authors： Fengler K,Ewen S,Höllriegel R,Rommel KP,Kulenthiran S,Lauder L,Cremers B,Schuler G,Linke A,Böhm M,Mahfoud F,Lurz P

更新日期：2017-08-10 00:00:00

abstract：BACKGROUND:Clinical guidelines recommend using predicted atherosclerotic cardiovascular disease (ASCVD) risk to inform treatment decisions. The objective was to compare the contribution of changes in modifiable risk factors versus aging to the development of high 10-year predicted ASCVD risk. METHODS AND RESULTS:A pro...

journal_title：Journal of the American Heart Association

authors： Bress AP,Colantonio LD,Booth JN 3rd,Spruill TM,Ravenell J,Butler M,Shallcross AJ,Seals SR,Reynolds K,Ogedegbe G,Shimbo D,Muntner P

更新日期：2017-02-08 00:00:00

abstract：:Background Kidney function decreases during the lifetime, and this decline is a powerful predictor of both kidney and cardiovascular outcomes. Statins lower cardiovascular risk, which may relate to beneficial effects on kidney function. We studied whether atorvastatin influences kidney function decline and assessed th...

journal_title：Journal of the American Heart Association

authors： Vogt L,Bangalore S,Fayyad R,Melamed S,Hovingh GK,DeMicco DA,Waters DD

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Treatment decisions for aortic valve replacement (AVR) should be sensitive to patient preferences. However, we lack knowledge of patient preferences and how to obtain them. METHODS AND RESULTS:We assessed the mortality risk patients were willing to accept when undergoing AVR by using the Standard Gamble met...

journal_title：Journal of the American Heart Association

authors： Hussain AI,Garratt AM,Brunborg C,Aakhus S,Gullestad L,Pettersen KI

更新日期：2016-03-18 00:00:00

abstract：BACKGROUND:Optimal thromboprophylaxis after cardiac surgery is uncertain. This systematic review aimed to define the incidence and risk factors for deep vein thrombosis (DVT), fatal and nonfatal pulmonary embolism (PE), and assess whether venous thromboembolism (VTE) prophylaxis was effective in reducing VTE without co...

journal_title：Journal of the American Heart Association

authors： Ho KM,Bham E,Pavey W

更新日期：2015-10-26 00:00:00

abstract：BACKGROUND:Transcription of the myristoylated alanine-rich C kinase substrate (MARCKS) is upregulated in animal models of intimal hyperplasia. MARCKS knockdown inhibits vascular smooth muscle cell (VSMC) migration in vitro; however, the mechanism is as yet unknown. We sought to elucidate the mechanism of MARCKS-mediate...

journal_title：Journal of the American Heart Association

authors： Yu D,Makkar G,Strickland DK,Blanpied TA,Stumpo DJ,Blackshear PJ,Sarkar R,Monahan TS

更新日期：2015-10-08 00:00:00

abstract：:Background Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity; however, existing studies are limited by cross-sectional study designs. Methods and Results Participants were 1922 adults fr...

journal_title：Journal of the American Heart Association

authors： Whitaker KM,Pettee Gabriel K,Buman MP,Pereira MA,Jacobs DR Jr,Reis JP,Gibbs BB,Carnethon MR,Staudenmayer J,Sidney S,Sternfeld B

更新日期：2019-01-08 00:00:00

abstract：:Background The purpose of this study was to determine whether the presence of antegrade blood flow was related to stroke subtype in patients with acute intracranial large artery occlusion. Methods and Results The prospectively collected data for consecutive patients who had occlusion of the unilateral M1 segment of th...

journal_title：Journal of the American Heart Association

authors： Zhang M,Chen Z,Xu J,Gong X,Shi F,Lou M

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Cardiac magnetic resonance (CMR) can quantify myocardial infarct (MI) size and myocardium at risk (MaR), enabling assessment of myocardial salvage index (MSI). We assessed how MSI impacts the number of patients needed to reach statistical power in relation to MI size alone and levels of biochemical markers i...

journal_title：Journal of the American Heart Association

authors： Engblom H,Heiberg E,Erlinge D,Jensen SE,Nordrehaug JE,Dubois-Randé JL,Halvorsen S,Hoffmann P,Koul S,Carlsson M,Atar D,Arheden H

更新日期：2016-03-09 00:00:00