Abstract:
:Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) have shown their beneficial effects on cardiovascular outcomes and multiple cardiovascular risk factors, including hypertension. However, the mechanism of blood pressure (BP)-lowering effects of these agents has not been elucidated. This study aims to evaluate the effect of hemoglobin A1c reduction or body weight reduction with GLP-1RA treatment and SGLT2i treatment on BP changes in patients with type 2 diabetes mellitus. Methods and Results Studies were identified by a search of MEDLINE, EMBASE, and the Cochrane Central Register until June 2019. Meta-regression analysis was performed to evaluate the association between hemoglobin A1c reduction or body weight reduction and changes of BP. A total of 184 trials were included. Both GLP-1RA and SGLT2i led to significant reductions in systolic BP (weighted mean difference, -2.856 and -4.331 mm Hg, respectively; P<0.001 for both) and diastolic BP (weighted mean difference, -0.898 and -2.279 mm Hg, respectively; P<0.001 for both). For both drug classes, hemoglobin A1c reduction was not independently associated with systolic BP reduction or diastolic BP reduction. In GLP-1RA treatment, weight reduction was positively associated with systolic BP reduction and diastolic BP reduction (β=0.821 and β=0.287, respectively; P<0.001 for both). In SGLT2i treatment, weight loss was significantly associated with systolic BP reduction (β=0.820; P=0.001) but was not associated with diastolic BP reduction. Conclusions Treatment with GLP-1RA and SGLT2i led to significant reductions in BP in patients with type 2 diabetes mellitus. Weight reduction was significantly and independently associated with BP reductions in GLP-1RA treatment and SGLT2i treatment.
journal_name
J Am Heart Assocjournal_title
Journal of the American Heart Associationauthors
Hu M,Cai X,Yang W,Zhang S,Nie L,Ji Ldoi
10.1161/JAHA.119.015323subject
Has Abstractpub_date
2020-04-07 00:00:00pages
e015323issue
7issn
2047-9980journal_volume
9pub_type
杂志文章abstract:BACKGROUND:Treatment decisions for aortic valve replacement (AVR) should be sensitive to patient preferences. However, we lack knowledge of patient preferences and how to obtain them. METHODS AND RESULTS:We assessed the mortality risk patients were willing to accept when undergoing AVR by using the Standard Gamble met...
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pub_type: 杂志文章
doi:10.1161/JAHA.115.002828
更新日期:2016-03-18 00:00:00
abstract::The primary goal of the initial ECG evaluation of every wide complex tachycardia is to determine whether the tachyarrhythmia has a ventricular or supraventricular origin. The answer to this question drives immediate patient care decisions, ensuing clinical workup, and long-term management strategies. Thus, the importa...
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更新日期:2016-08-20 00:00:00
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doi:10.1161/JAHA.118.011346
更新日期:2019-08-06 00:00:00
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更新日期:2013-02-22 00:00:00
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更新日期:2012-08-29 00:00:00
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pub_type: 杂志文章
doi:10.1161/JAHA.118.010664
更新日期:2019-02-05 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-08-16 00:00:00
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更新日期:2017-08-10 00:00:00
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更新日期:2014-05-08 00:00:00
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journal_title:Journal of the American Heart Association
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更新日期:2014-10-20 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2021-01-18 00:00:00