Local-Area Walkability and Socioeconomic Disparities of Cardiovascular Disease Mortality in Japan.

abstract：:Background Coronary flow capacity (CFC), which is a categorical assessment based on the combination of hyperemic coronary flow and coronary flow reserve (CFR), has been introduced as a comprehensive assessment of the coronary circulation to overcome the limitations of CFR alone. The aim of this study was to quantify c...

journal_title：Journal of the American Heart Association

authors： Murai T,Stegehuis VE,van de Hoef TP,Wijntjens GWM,Hoshino M,Kanaji Y,Sugiyama T,Hamaya R,Nijjer SS,de Waard GA,Echavarria-Pinto M,Knaapen P,Meuwissen M,Davies JE,van Royen N,Escaned J,Siebes M,Kirkeeide RL,Gould KL,

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:The time-sensitive hazard of perioperative cardiac troponin T (cTnT) elevation and whether long-term mortality differs by mechanism of myocardial injury are poorly understood. METHODS AND RESULTS:In this observational study of 12 882 patients who underwent noncardiac vascular surgery, patients were assessed...

journal_title：Journal of the American Heart Association

authors： Reed GW,Horr S,Young L,Clevenger J,Malik U,Ellis SG,Lincoff AM,Nissen SE,Menon V

更新日期：2017-06-06 00:00:00

abstract：:Background Impaired heart rate variability (HRV) is associated with increased mortality in sinus rhythm. However, HRV has not been systematically assessed in patients with atrial fibrillation (AF). We hypothesized that parameters of HRV may be predictive of cardiovascular death in patients with AF. Methods and Results...

journal_title：Journal of the American Heart Association

authors： Hämmerle P,Eick C,Blum S,Schlageter V,Bauer A,Rizas KD,Eken C,Coslovsky M,Aeschbacher S,Krisai P,Meyre P,Vesin JM,Rodondi N,Moutzouri E,Beer J,Moschovitis G,Kobza R,Di Valentino M,Corino VDA,Laureanti R,Mainardi L

更新日期：2020-08-04 00:00:00

abstract：BACKGROUND:The impact of dispatcher-assisted bystander cardiopulmonary resuscitation (CPR) on neurological outcomes in children is unclear. We investigated whether dispatcher-assisted bystander CPR shows favorable neurological outcomes (Cerebral Performance Category scale 1 or 2) in children with out-of-hospital cardia...

journal_title：Journal of the American Heart Association

authors： Goto Y,Maeda T,Goto Y

更新日期：2014-04-30 00:00:00

abstract：BACKGROUND:Right ventricular (RV) diastolic function is impaired in patients with pulmonary arterial hypertension (PAH). Our previous study showed that elevated cardiomyocyte stiffness and myofilament Ca(2+) sensitivity underlie diastolic dysfunction in PAH. This study investigates protein modifications contributing to...

journal_title：Journal of the American Heart Association

authors： Rain S,Bos Dda S,Handoko ML,Westerhof N,Stienen G,Ottenheijm C,Goebel M,Dorfmüller P,Guignabert C,Humbert M,Bogaard HJ,Remedios CD,Saripalli C,Hidalgo CG,Granzier HL,Vonk-Noordegraaf A,van der Velden J,de Man FS

更新日期：2014-06-03 00:00:00

abstract：:Background Patients with tetralogy of Fallot ( TOF ) remain at risk for cardiovascular events despite successful repair. Some of the current risk stratification tools require advanced imaging and invasive studies, and hence are difficult to apply to routine patient care. A recent study showed that QRS fragmentation ( ...

journal_title：Journal of the American Heart Association

authors： Egbe AC,Miranda WR,Mehra N,Ammash NM,Missula VR,Madhavan M,Deshmukh AJ,Farouk Abdelsamid M,Kothapalli S,Connolly HM

更新日期：2018-12-18 00:00:00

abstract：BACKGROUND:Preeclampsia (PE) is a life-threatening hypertensive disorder of pregnancy associated with autoantibodies, termed AT1-AA, that activate the AT1 angiotensin receptor. Although the pathogenic nature of these autoantibodies has been extensively studied, little is known about the molecular cause of their generat...

journal_title：Journal of the American Heart Association

authors： Liu C,Luo R,Elliott SE,Wang W,Parchim NF,Iriyama T,Daugherty PS,Blackwell SC,Sibai BM,Kellems RE,Xia Y

更新日期：2015-12-16 00:00:00

abstract：BACKGROUND:Lower levels of circulating progenitor cells (PCs) reflect impaired endogenous regenerative capacity and are associated with aging, vascular disease, and poor outcomes. Whether biologic sex and sex hormones influence PC numbers remains a subject of controversy. We sought to determine sex differences in circu...

journal_title：Journal of the American Heart Association

authors： Topel ML,Hayek SS,Ko YA,Sandesara PB,Samman Tahhan A,Hesaroieh I,Mahar E,Martin GS,Waller EK,Quyyumi AA

更新日期：2017-10-03 00:00:00

abstract：:Background Bleeding is a common, morbid, and costly complication of percutaneous coronary intervention. While bleeding avoidance strategies ( BAS ) are effective, they are used paradoxically less in patients at high risk of bleeding. Whether a patient-centered approach to specifically increase the risk-concordant use ...

journal_title：Journal of the American Heart Association

authors： Amin AP,Miller S,Rahn B,Caruso M,Pierce A,Sorensen K,Kurz H,Zajarias A,Bach R,Singh J,Lasala JM,Kulkarni H,Crimmins-Reda P

更新日期：2018-11-06 00:00:00

abstract：:Background Some, but not all, studies report associations between shift work and hypertension, suggesting that particular subgroups may be at risk. We examined moderating effects of sleep duration and circadian preference on the relationship between shift work and new blood pressure (BP) medicine use at follow-up. Met...

journal_title：Journal of the American Heart Association

authors： Riegel B,Daus M,Lozano AJ,Malone SK,Patterson F,Hanlon AL

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:Conflicting findings of the association between serum uric acid (UA) and stroke have been reported in both men and women, and it is unclear whether this association was different between men and women. We preformed this meta-analysis to assess the sex-specific effect of serum UA on the risk of stroke and its...

journal_title：Journal of the American Heart Association

authors： Zhong C,Zhong X,Xu T,Xu T,Zhang Y

更新日期：2017-03-29 00:00:00

abstract：:Background Type 2 diabetes mellitus is closely associated with metabolic risk factors that all contribute to impairment of the left ventricle. The implications of having type 2 diabetes mellitus with well-controlled metabolic risk factors compared to an increasing burden of uncontrolled metabolic risk factors on left ...

journal_title：Journal of the American Heart Association

authors： Jørgensen PG,Jensen MT,Biering-Sørensen T,Mogelvang R,Fritz-Hansen T,Vilsbøll T,Rossing P,Jensen JS

更新日期：2018-10-02 00:00:00

abstract：BACKGROUND:We examined the role of menopause on cardiac dimensions and function and assessed the efficacy of exercise training before and after menopause. METHODS AND RESULTS:Two groups of healthy premenopausal (n=36, 49.4±0.3 years) and postmenopausal (n=37, 53.5±0.5 years) women with no history of cardiovascular dis...

journal_title：Journal of the American Heart Association

authors： Egelund J,Jørgensen PG,Mandrup CM,Fritz-Hansen T,Stallknecht B,Bangsbo J,Nyberg M,Hellsten Y

更新日期：2017-08-18 00:00:00

abstract：BACKGROUND:Whether heart rate upon discharge following hospitalization for heart failure is associated with long-term adverse outcomes and whether this association differs between patients with sinus rhythm (SR) and atrial fibrillation (AF) have not been well studied. METHODS AND RESULTS:We conducted a retrospective c...

journal_title：Journal of the American Heart Association

authors： Laskey WK,Alomari I,Cox M,Schulte PJ,Zhao X,Hernandez AF,Heidenreich PA,Eapen ZJ,Yancy C,Bhatt DL,Fonarow GC,AHA Get With The Guidelines®‐Heart Failure Program.

更新日期：2015-04-22 00:00:00

abstract：BACKGROUND:Atherosclerosis is a chronic inflammatory disorder whose development is inversely correlated with high-density lipoprotein concentration. Current therapies involve pharmaceuticals that significantly elevate plasma high-density lipoprotein cholesterol concentrations. Our studies were conducted to investigate ...

journal_title：Journal of the American Heart Association

authors： Kaul S,Xu H,Zabalawi M,Maruko E,Fulp BE,Bluemn T,Brzoza-Lewis KL,Gerelus M,Weerasekera R,Kallinger R,James R,Zhang YS,Thomas MJ,Sorci-Thomas MG

更新日期：2016-11-07 00:00:00

abstract：BACKGROUND:Although several risk factors for acute kidney injury (AKI) have been identified, early detection of AKI in acute decompensated heart failure patients remains a challenge. The aim of this study was to develop and validate a risk score for early prediction of AKI in acute decompensated heart failure patients....

journal_title：Journal of the American Heart Association

authors： Zhou LZ,Yang XB,Guan Y,Xu X,Tan MT,Hou FF,Chen PY

更新日期：2016-11-16 00:00:00

abstract：BACKGROUND:Ischemic stroke is a major cause of death and disability in the world. A major ischemic stroke subtype, large-vessel ischemic stroke (large artery atherosclerosis; LAA), has been shown to have some genetic components in individuals of European ancestry. However, it is not clear whether the genetic predisposi...

journal_title：Journal of the American Heart Association

authors： Lee TH,Ko TM,Chen CH,Lee MT,Chang YJ,Chang CH,Huang KL,Chang TY,Lee JD,Chang KC,Yang JT,Wen MS,Wang CY,Chen YT,Hsieh CS,Chou SY,Liu YM,Chen HW,Liao HT,Wang CW,Chen SP,Lu LS,Chen YT,Wu JY

更新日期：2016-03-29 00:00:00

abstract：BACKGROUND:The 2005 Bethesda Conference Guidelines advise patients with long QT syndrome against competitive sports. We assessed cardiac event rates during competitive and recreational sports, and daily activities among treated long QT syndrome patients. METHODS AND RESULTS:Long QT syndrome patients aged ≥4 years trea...

journal_title：Journal of the American Heart Association

authors： Chambers KD,Beausejour Ladouceur V,Alexander ME,Hylind RJ,Bevilacqua L,Mah DY,Bezzerides V,Triedman JK,Walsh EP,Abrams DJ

更新日期：2017-09-21 00:00:00

abstract：BACKGROUND:Platelet activation can lead to enhanced oxidative stress, inflammatory response, and endothelial dysfunction. To quantify the effects of platelet inhibition on endothelial function, we assessed platelet activity of healthy persons before and after clopidogrel administration and evaluated its effects on endo...

journal_title：Journal of the American Heart Association

authors： Salimi S,Lewis JP,Yerges-Armstrong LM,Mitchell BD,Saeed F,O'Connell JR,Perry JA,Ryan KA,Shuldiner AR,Parsa A

更新日期：2016-10-31 00:00:00

abstract：BACKGROUND:The volume-outcome relationship associated with intensive care unit (ICU) experience with managing acute myocardial infarction (AMI) remains inadequately understood. METHODS AND RESULTS:Within a multicenter clinical ICU database, we identified patients with a primary ICU admission diagnosis of AMI between 2...

journal_title：Journal of the American Heart Association

authors： Stolker JM,Badawi O,Spertus JA,Nasir A,Kennedy KF,Harris IH,Franey CS,Hsu VD,Ripple GR,Howell GH,Lem VM,Chan PS

更新日期：2015-06-11 00:00:00

abstract：:Background Recently, direct oral anticoagulants have been introduced for venous thromboembolism (VTE), which might change the management strategies of VTE. However, there have been limited data on the current real-world practice pattern for VTE in Asian countries. Methods and Results The JROAD-DPC (Japanese Registry o...

journal_title：Journal of the American Heart Association

authors： Yamashita Y,Morimoto T,Yoshikawa Y,Yaku H,Sumita Y,Nakai M,Ono K,Kimura T

更新日期：2020-01-21 00:00:00

abstract：:Background Hydrogen sulfide (H2S) is an important endogenous physiological signaling molecule and exerts protective properties in the cardiovascular system. Cystathionine γ-lyase (CSE), 1 of 3 H2S producing enzyme, is predominantly localized in the vascular endothelium. However, the regulation of CSE in vascular endot...

journal_title：Journal of the American Heart Association

authors： Xia H,Li Z,Sharp TE 3rd,Polhemus DJ,Carnal J,Moles KH,Tao YX,Elrod J,Pfeilschifter J,Beck KF,Lefer DJ

更新日期：2020-10-20 00:00:00

abstract：:Background Although PAR-1 (protease-activated receptor-1) exerts important functions in the pathophysiology of the cardiovascular system, the role of PAR-1 signaling in heart failure development remains largely unknown. We tested the hypothesis that PAR-1 signaling inhibition has protective effects on the progression ...

journal_title：Journal of the American Heart Association

authors： Yokono Y,Hanada K,Narita M,Tatara Y,Kawamura Y,Miura N,Kitayama K,Nakata M,Nozaka M,Kato T,Kudo N,Tsushima M,Toyama Y,Itoh K,Tomita H

更新日期：2020-06-16 00:00:00

abstract：BACKGROUND:Experimental studies demonstrate that high aortic pressure in late systole relative to early systole causes greater myocardial remodeling and dysfunction, for any given absolute peak systolic pressure. METHODS AND RESULTS:We tested the hypothesis that late systolic hypertension, defined as the ratio of late...

journal_title：Journal of the American Heart Association

authors： Chirinos JA,Segers P,Duprez DA,Brumback L,Bluemke DA,Zamani P,Kronmal R,Vaidya D,Ouyang P,Townsend RR,Jacobs DR Jr

更新日期：2015-03-03 00:00:00

abstract：BACKGROUND:Perioperative antiplatelet agents potentially increase bleeding after non-ST-segment elevation (NSTE) acute coronary syndromes (ACS). The protease-activated receptor 1 antagonist vorapaxar reduced cardiovascular events and was associated with increased bleeding versus placebo in NSTE ACS, but its efficacy an...

journal_title：Journal of the American Heart Association

authors： van Diepen S,Tricoci P,Podder M,Westerhout CM,Aylward PE,Held C,Van de Werf F,Strony J,Wallentin L,Moliterno DJ,White HD,Mahaffey KW,Harrington RA,Armstrong PW

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:Stroke is a leading cause of death in the world. In >80% of strokes, the initial acute phase of ischemic injury is due to the occlusion of a blood vessel resulting in severe focal hypoperfusion, excitotoxicity, and oxidative damage. Interferon-β (IFNβ), a cytokine with immunomodulatory properties, was approv...

journal_title：Journal of the American Heart Association

authors： Kuo PC,Scofield BA,Yu IC,Chang FL,Ganea D,Yen JH

更新日期：2016-01-08 00:00:00

abstract：BACKGROUND:Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co-occur, we hypothesized that there may be shared genetic risk factors for IAs, AAAs, and TAAs. METHODS AND RESULTS:We performed a...

journal_title：Journal of the American Heart Association

authors： van 't Hof FN,Ruigrok YM,Lee CH,Ripke S,Anderson G,de Andrade M,Baas AF,Blankensteijn JD,Böttinger EP,Bown MJ,Broderick J,Bijlenga P,Carrell DS,Crawford DC,Crosslin DR,Ebeling C,Eriksson JG,Fornage M,Foroud T,von Un

更新日期：2016-07-14 00:00:00

abstract：BACKGROUND:Multiple studies have shown that an NO-induced activation of vascular smooth muscle BK channels contributes to the NO-evoked dilation in many blood vessels. In vivo, NO is released continuously. NO attenuates vessel constrictions and, therefore, exerts an anticontractile effect. It is unknown whether the ant...

journal_title：Journal of the American Heart Association

authors： Schmid J,Müller B,Heppeler D,Gaynullina D,Kassmann M,Gagov H,Mladenov M,Gollasch M,Schubert R

更新日期：2018-03-24 00:00:00

abstract：:Background Duchenne muscular dystrophy (DMD) is a neuromuscular disorder caused by mutations within the dystrophin gene. DMD is characterized by progressive skeletal muscle degeneration and atrophy and progressive cardiomyopathy. It has been observed the severity of cardiomyopathy varies in patients with DMD. Methods ...

journal_title：Journal of the American Heart Association

authors： Jiang X,Shao Y,Araj FG,Amin AA,Greenberg BM,Drazner MH,Xing C,Mammen PPA

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Although choline metabolism has been associated with atherosclerotic heart disease, less research attention has been paid to the associations of choline and its oxidative metabolite betaine with cardiac arrhythmias. METHODS AND RESULTS:We evaluated associations of plasma concentrations and dietary intakes o...

journal_title：Journal of the American Heart Association

authors： Zuo H,Svingen GFT,Tell GS,Ueland PM,Vollset SE,Pedersen ER,Ulvik A,Meyer K,Nordrehaug JE,Nilsen DWT,Bønaa KH,Nygård O

更新日期：2018-04-12 00:00:00