Development and Validation of a Risk Score for Prediction of Acute Kidney Injury in Patients With Acute Decompensated Heart Failure: A Prospective Cohort Study in China.

abstract：BACKGROUND:Multiple studies have shown that an NO-induced activation of vascular smooth muscle BK channels contributes to the NO-evoked dilation in many blood vessels. In vivo, NO is released continuously. NO attenuates vessel constrictions and, therefore, exerts an anticontractile effect. It is unknown whether the ant...

journal_title：Journal of the American Heart Association

authors： Schmid J,Müller B,Heppeler D,Gaynullina D,Kassmann M,Gagov H,Mladenov M,Gollasch M,Schubert R

更新日期：2018-03-24 00:00:00

abstract：:Background Early discontinuation of P2Y12 antagonists post-percutaneous coronary intervention may increase risk of stent thrombosis or nonstent recurrent myocardial infarction. Our aims were to (1) analyze the early discontinuation rate of P2Y12 antagonists post-percutaneous coronary intervention, (2) explore factors ...

journal_title：Journal of the American Heart Association

authors： Harris DE,Lacey A,Akbari A,Obaid DR,Smith DA,Jenkins GH,Barry JP,Gravenor MB,Halcox JP

更新日期：2019-11-05 00:00:00

abstract：:Background Coronary artery disease is the primary etiology for sudden cardiac arrest in adults, but potential differences in the incidence and utility of invasive coronary testing between resuscitated men and women have not been extensively evaluated. Our aim was to characterize angiographic similarities and differenc...

journal_title：Journal of the American Heart Association

authors： May T,Skinner K,Unger B,Mooney M,Patel N,Dupont A,McPherson J,McMullan P,Nielsen N,Seder DB,Kern KB

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Although choline metabolism has been associated with atherosclerotic heart disease, less research attention has been paid to the associations of choline and its oxidative metabolite betaine with cardiac arrhythmias. METHODS AND RESULTS:We evaluated associations of plasma concentrations and dietary intakes o...

journal_title：Journal of the American Heart Association

authors： Zuo H,Svingen GFT,Tell GS,Ueland PM,Vollset SE,Pedersen ER,Ulvik A,Meyer K,Nordrehaug JE,Nilsen DWT,Bønaa KH,Nygård O

更新日期：2018-04-12 00:00:00

abstract：:Background The objectives of the present study were (1) to evaluate the echocardiographic prognostic factors associated with improved left ventricular (LV) systolic function after aortic valve replacement, and (2) to compare the long-term outcomes after aortic valve replacement in chronic aortic regurgitation (AR) pat...

journal_title：Journal of the American Heart Association

authors： Kim MS,Kim JH,Joo HC,Lee S,Youn YN,Lee SH

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:Hispanic persons represent a heterogeneous and growing population of any race with origins in Mexico, the Caribbean, Central America, South America, or other Spanish-speaking countries. Previous studies have documented variation in cardiovascular risk and outcomes among Hispanic subgroups. Few studies have i...

journal_title：Journal of the American Heart Association

authors： Rodriguez F,Hastings KG,Hu J,Lopez L,Cullen M,Harrington RA,Palaniappan LP

更新日期：2017-12-13 00:00:00

abstract：BACKGROUND:Regression of left ventricular (LV) hypertrophy (LVH) has been a goal in clinical trials. This study tests the external validity of results of clinical trials on LVH regression using a large registry from a tertiary care center, to identify phenotypes less likely to achieve regression of LVH. METHODS AND RE...

journal_title：Journal of the American Heart Association

authors： Lønnebakken MT,Izzo R,Mancusi C,Gerdts E,Losi MA,Canciello G,Giugliano G,De Luca N,Trimarco B,de Simone G

更新日期：2017-03-08 00:00:00

abstract：BACKGROUND:Although automated external defibrillators (AEDs) have contributed to a better survival of out-of-hospital cardiac arrests, there have been reports of their malfunctioning. We investigated the diagnostic accuracy of commercially available AEDs using surface ECGs of ventricular fibrillation (VF), ventricular ...

journal_title：Journal of the American Heart Association

authors： Nishiyama T,Nishiyama A,Negishi M,Kashimura S,Katsumata Y,Kimura T,Nishiyama N,Tanimoto Y,Aizawa Y,Mitamura H,Fukuda K,Takatsuki S

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Oxidative stress is implicated in the etiology of coronary heart disease (CHD). New measures to capture oxidative stress are warranted. Fluorescent oxidation products (FlOPs) can be measured in plasma and have been shown to reflect levels of oxidative stress and to predict risk of CHD in men over 6 years of ...

journal_title：Journal of the American Heart Association

authors： Jensen MK,Wang Y,Rimm EB,Townsend MK,Willett W,Wu T

更新日期：2013-10-08 00:00:00

abstract：:See Article Lee et al. ...

journal_title：Journal of the American Heart Association

authors： Hanna P,Zhu C,Rajendran PS,Shivkumar K

更新日期：2019-05-21 00:00:00

abstract：:Background Current approaches fail to separate patients at high versus low risk for ventricular arrhythmias owing to overreliance on a snapshot left ventricular ejection fraction measure. We used statistical machine learning to identify important cardiac imaging and time-varying risk predictors. Methods and Results Th...

journal_title：Journal of the American Heart Association

authors： Wu KC,Wongvibulsin S,Tao S,Ashikaga H,Stillabower M,Dickfeld TM,Marine JE,Weiss RG,Tomaselli GF,Zeger SL

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Recent literature suggests that blood pressure variability (BPV) predicts outcome beyond blood pressure level (BPL) and that antihypertensive drug classes differentially influence BPV. We compared calcium channel blockers, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockade for effect...

journal_title：Journal of the American Heart Association

authors： Asayama K,Ohkubo T,Hanazawa T,Watabe D,Hosaka M,Satoh M,Yasui D,Staessen JA,Imai Y,Hypertensive Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED‐BP) Study Investigators.

更新日期：2016-03-23 00:00:00

abstract：:Background Evidence suggests that enlarged perivascular spaces (PVSs) may represent a marker for cerebral small-vessel disease. We investigated whether vascular risk factors are correlated with visible PVS in older adults. Methods and Results This population-based study included 530 participants (age ≥60 years) who we...

journal_title：Journal of the American Heart Association

authors： Laveskog A,Wang R,Vetrano DL,Bronge L,Wahlund LO,Qiu C

更新日期：2020-08-18 00:00:00

abstract：:Background In statin trials, men and women derived similar relative risk reductions in cardiovascular events per 39 mg/ dL low-density lipoprotein cholesterol ( LDL -C) reduction. We explored whether lower LDL -C levels and greater LDL -C percentage reductions than those achieved with statins are associated with reduc...

journal_title：Journal of the American Heart Association

authors： Vallejo-Vaz AJ,Ginsberg HN,Davidson MH,Eckel RH,Cannon CP,Lee LV,Bessac L,Pordy R,Letierce A,Ray KK

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:Epinephrine administered during cardiopulmonary resuscitation (CPR) is associated with severe post-resuscitation myocardial dysfunction. We previously demonstrated that therapeutic hypothermia reduced the severity of post-resuscitation myocardial dysfunction caused by epinephrine; however, the relationship b...

journal_title：Journal of the American Heart Association

authors： Wang W,Hua T,Li H,Wu X,Bradley J,Peberdy MA,Ornato JP,Tang W

更新日期：2018-03-23 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate whether the association between baseline cardiovascular health (CVH) and incident cardiovascular disease differs according to coronary heart disease (CHD) and stroke subtypes, and to assess the mediating effect of inflammatory and hemostatic blood biomarkers. METHODS...

journal_title：Journal of the American Heart Association

authors： Gaye B,Tafflet M,Arveiler D,Montaye M,Wagner A,Ruidavets JB,Kee F,Evans A,Amouyel P,Ferrieres J,Empana JP

更新日期：2017-10-17 00:00:00

abstract：:Background Among people with lower extremity peripheral artery disease, obesity is associated with faster functional decline than normal weight. The association of weight loss with functional decline in peripheral artery disease is unknown. Methods and Results Adults with an ankle-brachial index <0.90 were identified ...

journal_title：Journal of the American Heart Association

authors： Polonsky TS,Tian L,Zhang D,Bazzano LA,Criqui MH,Ferrucci L,Guralnik JM,Kibbe MR,Leeuwenburgh C,Sufit RL,McDermott MM

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:Contemporary rates of oral anticoagulant (OAC) therapy and associated outcomes among patients undergoing percutaneous coronary intervention (PCI) have been poorly described. METHODS AND RESULTS:Using data from an integrated health care system from 2009 to 2014, we identified patients on OACs within 30 days ...

journal_title：Journal of the American Heart Association

authors： Secemsky EA,Butala NM,Kartoun U,Mahmood S,Wasfy JH,Kennedy KF,Shaw SY,Yeh RW

更新日期：2016-10-17 00:00:00

abstract：BACKGROUND:The impact of dispatcher-assisted bystander cardiopulmonary resuscitation (CPR) on neurological outcomes in children is unclear. We investigated whether dispatcher-assisted bystander CPR shows favorable neurological outcomes (Cerebral Performance Category scale 1 or 2) in children with out-of-hospital cardia...

journal_title：Journal of the American Heart Association

authors： Goto Y,Maeda T,Goto Y

更新日期：2014-04-30 00:00:00

abstract：:Background It is uncertain whether there is an association between left ventricular (LV) ejection fraction ( LVEF ) or LV wall motion abnormality and embolic stroke of undetermined source ( ESUS ). Methods and Results We performed a retrospective, cross-sectional study of patients with acute ischemic stroke enrolled i...

journal_title：Journal of the American Heart Association

authors： Ramasamy S,Yaghi S,Salehi Omran S,Lerario MP,Devereux R,Okin PM,Gupta A,Navi BB,Kamel H,Merkler AE

更新日期：2019-05-07 00:00:00

abstract：:Background Aerobic exercise capacity is inversely associated with cardiovascular and all-cause mortality in men and women without coronary artery disease (CAD); however, a higher amount of vigorous exercise is associated with a J-shaped relationship in CAD patients. Therefore, the optimal type and amount of exercise f...

journal_title：Journal of the American Heart Association

authors： Malik A,Kanduri JS,Asbeutah AAA,Khraishah H,Shen C,Welty FK

更新日期：2020-04-07 00:00:00

abstract：:Background We examined the prevalence of high burdens and barriers to care among adults with heart disease treatment. Methods and Results The participants were aged 18 to 64 years from the Medical Expenditure Panel Survey-Household Component (MEPS-HC) for 2010-2015. High burden is out-of-pocket spending on care and in...

journal_title：Journal of the American Heart Association

authors： Bernard D,Fang Z

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:Diminished growth hormone (GH) is associated with impaired endothelial function and fibrinolysis. GH-releasing hormone is the primary stimulus for GH secretion and a substrate of dipeptidyl peptidase-4. We tested the hypothesis that dipeptidyl peptidase-4 inhibition with sitagliptin increases stimulated GH s...

journal_title：Journal of the American Heart Association

authors： Wilson JR,Brown NJ,Nian H,Yu C,Bidlingmaier M,Devin JK

更新日期：2018-02-25 00:00:00

abstract：BACKGROUND:The liver X receptors (LXRs; α/β) are nuclear receptors known to regulate cholesterol homeostasis and the production of select hematopoietic populations. The objective of this study was to determine the importance of LXRs and a high-fat high-cholesterol diet on global hematopoiesis, with special emphasis on ...

journal_title：Journal of the American Heart Association

authors： Rasheed A,Tsai R,Cummins CL

更新日期：2018-05-08 00:00:00

abstract：:Background Acute type A aortic dissection presents with abrupt onset of pain that requires emergency surgery. However, minimal research exists on posttraumatic stress disorder (PTSD) in survivors. We aimed to quantify the prevalence and describe characteristics of PTSD in patients following dissection. Methods and Res...

journal_title：Journal of the American Heart Association

authors： Pasadyn SR,Roselli EE,Artis AS,Pasadyn CL,Phelan D,Hurley K,Desai MY,Blackstone EH

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:Microparticles (MPs) are circulating membrane particles of less than a micrometer in diameter shed from endothelial and blood cells. Recent literature suggests that MPs are not just functionally inert cell debris but may possess biological functions and mediate the communication between vascular cells. As a ...

journal_title：Journal of the American Heart Association

authors： Horn P,Cortese-Krott MM,Amabile N,Hundsdörfer C,Kröncke KD,Kelm M,Heiss C

更新日期：2012-12-31 00:00:00

abstract：:Background Sex differences in outcome have been reported in patients with congenital long QT syndrome. We aimed to report on the incidence of time-dependent life-threatening events in male and female patients with long QT syndrome with an implantable cardioverter defibrillator (ICD). Methods and Results A total of 60 ...

journal_title：Journal of the American Heart Association

authors： Younis A,Aktas MK,Rosero S,Kutyifa V,Polonsky B,McNitt S,Sotoodehnia N,Kudenchuk P,Rea TD,Arking DE,Goldenberg I,Zareba W

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Neuregulin-1β (NRG-1β) is a growth factor critical for cardiac development and repair with therapeutic potential for heart failure. We previously showed that the glial growth factor 2 (GGF2) isoform of NRG-1β improves cardiac function in rodents after myocardial infarction (MI), but its efficacy in a large a...

journal_title：Journal of the American Heart Association

authors： Galindo CL,Kasasbeh E,Murphy A,Ryzhov S,Lenihan S,Ahmad FA,Williams P,Nunnally A,Adcock J,Song Y,Harrell FE,Tran TL,Parry TJ,Iaci J,Ganguly A,Feoktistov I,Stephenson MK,Caggiano AO,Sawyer DB,Cleator JH

更新日期：2014-10-23 00:00:00

abstract：BACKGROUND:Serum bicarbonate varies over time in chronic kidney disease (CKD) patients, and this variability may portend poor cardiovascular outcomes. The aim of this study was to conduct a time-updated longitudinal analysis to evaluate the association of serum bicarbonate with long-term clinical outcomes: heart failur...

journal_title：Journal of the American Heart Association

authors： Dobre M,Yang W,Pan Q,Appel L,Bellovich K,Chen J,Feldman H,Fischer MJ,Ham LL,Hostetter T,Jaar BG,Kallem RR,Rosas SE,Scialla JJ,Wolf M,Rahman M,CRIC Study Investigators.

更新日期：2015-04-20 00:00:00

abstract：BACKGROUND:Respiratory muscle weakness contributes to exercise intolerance in patients with heart failure with a preserved ejection fraction (HFpEF)-a condition characterized by multiple comorbidities with few proven treatments. We aimed, therefore, to provide novel insight into the underlying diaphragmatic alterations...

journal_title：Journal of the American Heart Association

authors： Bowen TS,Brauer D,Rolim NPL,Bækkerud FH,Kricke A,Ormbostad Berre AM,Fischer T,Linke A,da Silva GJ,Wisloff U,Adams V

更新日期：2017-10-24 00:00:00