Circulating microparticles carry a functional endothelial nitric oxide synthase that is decreased in patients with endothelial dysfunction.

abstract：:Background Both elemental metals and particulate air pollution have been reported to influence adult blood pressure (BP). The aim of this study is to examine which elemental components of particle mass with diameter ≤2.5 μm (PM2.5) are responsible for previously reported associations between PM2.5 and neonatal BP. Met...

journal_title：Journal of the American Heart Association

authors： Zanobetti A,Coull BA,Luttmann-Gibson H,van Rossem L,Rifas-Shiman SL,Kloog I,Schwartz JD,Oken E,Bobb JF,Koutrakis P,Gold DR

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:Elevated serum phosphorus might aggravate the effect of hypertension on mortality. The objective of this study was to examine the joint effect of hypertension and serum phosphorus on the risk of mortality. METHODS AND RESULTS:A large prospective (n=15 833), population-based cohort of participants from the N...

journal_title：Journal of the American Heart Association

authors： Vart P,Nigatu YT,Jaglan A,van Zon SK,Shafique K

更新日期：2015-05-20 00:00:00

abstract：BACKGROUND:Vascular complications and abnormal platelet function contribute to morbidity and mortality in diabetes mellitus. We hypothesized that the Rho-related GTPase protein, Rac1, can influence both endothelial and platelet function and might represent a potential novel therapeutic target in diabetes mellitus. MET...

journal_title：Journal of the American Heart Association

authors： Schiattarella GG,Carrizzo A,Ilardi F,Damato A,Ambrosio M,Madonna M,Trimarco V,Marino M,De Angelis E,Settembrini S,Perrino C,Trimarco B,Esposito G,Vecchione C

更新日期：2018-04-06 00:00:00

abstract：BACKGROUND:Patients with heart failure with preserved ejection fraction (HFpEF) exhibit a range of cardiovascular phenotypic profiles modified by several common comorbidities. In particular, patients with HFpEF tend to be older; however, it is unclear whether the effects of cardiovascular aging per se modify the expres...

journal_title：Journal of the American Heart Association

authors： Nanayakkara S,Haykowsky M,Mariani J,Van Empel V,Maeder MT,Vizi D,Kaye DM

更新日期：2017-09-22 00:00:00

abstract：:Background Turner syndrome ( TS ) is the most common sex chromosome abnormality in women and is associated with increased morbidity and mortality. We describe long-term outcomes in a large cohort of patients with TS . Methods and Results Retrospective review of patients with TS followed at Mayo Clinic Rochester from 1...

journal_title：Journal of the American Heart Association

authors： Fuchs MM,Attenhofer Jost C,Babovic-Vuksanovic D,Connolly HM,Egbe A

更新日期：2019-06-04 00:00:00

abstract：:Background Although radiofrequency catheter ablation is the current state-of-the-art treatment for ventricular tachyarrhythmias, it has limited success for several reasons, including insufficient lesion depth, prolonged inflammation with subsequent recurrence, and thromboembolisms due to myoendocardial thermal injury....

journal_title：Journal of the American Heart Association

authors： Morosawa S,Yamamoto H,Hirano M,Amamizu H,Uzuka H,Ohyama K,Hasebe Y,Nakano M,Fukuda K,Takayama K,Shimokawa H

更新日期：2019-01-22 00:00:00

abstract：:Background A combination of clinical and electrocardiographic risk factors is used for risk stratification in Brugada syndrome. In this study, we tested the hypothesis that the incorporation of latent variables between variables using nonnegative matrix factorization can improve risk stratification compared with logis...

journal_title：Journal of the American Heart Association

authors： Tse G,Zhou J,Lee S,Liu T,Bazoukis G,Mililis P,Wong ICK,Chen C,Xia Y,Kamakura T,Aiba T,Kusano K,Zhang Q,Letsas KP

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND:Renal denervation has no validated marker of procedural success. We hypothesized that successful renal denervation would reduce renal sympathetic nerve signaling demonstrated by attenuation of α-1-adrenoceptor-mediated autotransfusion during the Valsalva maneuver. METHODS AND RESULTS:In this substudy of the...

journal_title：Journal of the American Heart Association

authors： Saxena M,Shour T,Shah M,Wolff CB,Julu POO,Kapil V,Collier DJ,Ng FL,Gupta A,Balawon A,Pheby J,Zak A,Rull G,O'Brien B,Schmieder RE,Lobo MD

更新日期：2018-06-12 00:00:00

abstract：:Background There are spatial disparities in cardiovascular disease (CVD) mortality related to area-level socioeconomic status (SES) disadvantage, but little is known about the spatial distribution of CVD mortality according to built environment factors. We examined joint associations of neighborhood walkability attrib...

journal_title：Journal of the American Heart Association

authors： Koohsari MJ,Nakaya T,Hanibuchi T,Shibata A,Ishii K,Sugiyama T,Owen N,Oka K

更新日期：2020-06-16 00:00:00

abstract：:Background There are no risk scores designed specifically for mortality risk prediction in unselected cardiac intensive care unit (CICU) patients. We sought to develop a novel CICU-specific risk score for prediction of hospital mortality using variables available at the time of CICU admission. Methods and Results A da...

journal_title：Journal of the American Heart Association

authors： Jentzer JC,Anavekar NS,Bennett C,Murphree DH,Keegan MT,Wiley B,Morrow DA,Murphy JG,Bell MR,Barsness GW

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Recent trends of hospitalizations and in-hospital mortality are not well defined in sarcoidosis. We examined aforementioned trends and prevalence of cardiovascular manifestations and explored rates of implantable cardioverter-defibrillator implantation in hospitalizations with sarcoidosis. METHODS AND RESUL...

journal_title：Journal of the American Heart Association

authors： Patel N,Kalra R,Doshi R,Arora H,Bajaj NS,Arora G,Arora P

更新日期：2018-01-22 00:00:00

abstract：BACKGROUND:In 2013 the Minnesota Resuscitation Consortium developed an organized approach for the management of patients resuscitated from shockable rhythms to gain early access to the cardiac catheterization laboratory (CCL) in the metro area of Minneapolis-St. Paul. METHODS AND RESULTS:Eleven hospitals with 24/7 per...

journal_title：Journal of the American Heart Association

authors： Garcia S,Drexel T,Bekwelem W,Raveendran G,Caldwell E,Hodgson L,Wang Q,Adabag S,Mahoney B,Frascone R,Helmer G,Lick C,Conterato M,Baran K,Bart B,Bachour F,Roh S,Panetta C,Stark R,Haugland M,Mooney M,Wesley K,Yan

更新日期：2016-01-07 00:00:00

abstract：:Background The current study aims to validate the accuracy of 3-dimensional speckle-tracking echocardiography (3D-STE) in evaluating biventricular functions against the accuracy of cardiac magnetic resonance (CMR) and to explore the comprehensive characteristics and normal values for 3D-biventricular functions in tran...

journal_title：Journal of the American Heart Association

authors： Lv Q,Sun W,Wang J,Wu C,Li H,Shen X,Liang B,Dong N,Li Y,Zhang L,Xie M

更新日期：2020-05-18 00:00:00

abstract：BACKGROUND:We sought to characterize growth between birth and age 3 years in infants with hypoplastic left heart syndrome who underwent the Norwood procedure. METHODS AND RESULTS:We performed a secondary analysis using the Single Ventricle Reconstruction Trial database after excluding patients <37 weeks gestation (N=4...

journal_title：Journal of the American Heart Association

authors： Burch PT,Gerstenberger E,Ravishankar C,Hehir DA,Davies RR,Colan SD,Sleeper LA,Newburger JW,Clabby ML,Williams IA,Li JS,Uzark K,Cooper DS,Lambert LM,Pemberton VL,Pike NA,Anderson JB,Dunbar-Masterson C,Khaikin S,Zyble

更新日期：2014-06-23 00:00:00

abstract：:Background Detection of flow reserve ( FR ) by dobutamine stress echocardiography is used for risk stratification in low-gradient aortic stenosis ( AS ). Prognostic significance of dobutamine stress echocardiography in the transcatheter aortic valve replacement era is unclear. We aimed to assess the current relevance ...

journal_title：Journal of the American Heart Association

authors： Sato K,Sankaramangalam K,Kandregula K,Bullen JA,Kapadia SR,Krishnaswamy A,Mick S,Rodriguez LL,Grimm RA,Menon V,Desai MY,Svensson LG,Griffin BP,Popović ZB

更新日期：2019-03-19 00:00:00

abstract：:Background Hyperkalemia can be harmful, but the effect of correcting hyperkalemia is sparsely studied. We used nationwide data to examine hyperkalemia follow-up in patients with hypertension. Methods and Results We identified 7620 patients with hypertension, who had the first plasma potassium measurement ≥4.7 mmol/L (...

journal_title：Journal of the American Heart Association

authors： Krogager ML,Søgaard P,Torp-Pedersen C,Bøggild H,Gislason G,Kragholm K

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:Though left ventricular mass (LVM) predicts cardiovascular events (CVD) and mortality in African Americans, limited data exists on factors contributing to change in LVM and its prognostic significance. We hypothesized that baseline blood pressure (BP) and body mass index (BMI) and change in these variables o...

journal_title：Journal of the American Heart Association

authors： Fox ER,Musani SK,Samdarshi TE,Taylor JK,Beard WL,Sarpong DF,Xanthakis V,McClendon EE,Liebson PR,Skelton TN,Butler KR,Mosley TH,Taylor H,Vasan RS

更新日期：2015-02-05 00:00:00

abstract：BACKGROUND:Diabetes mellitus (DM) is a major risk factor for cardiovascular events. We aimed to investigate the coronary plaque phenotype of diabetic patients who presented with acute coronary syndromes by optical coherence tomography. METHODS AND RESULTS:A total of 322 patients with acute coronary syndromes who under...

journal_title：Journal of the American Heart Association

authors： Sugiyama T,Yamamoto E,Bryniarski K,Xing L,Fracassi F,Lee H,Jang IK

更新日期：2018-07-13 00:00:00

abstract：:Background The digital transformation of medical data provides opportunities to perform digital population health surveillance and identify people inadequately managed in usual care. We leveraged the electronic health records of a large health system to identify patients with markedly elevated blood pressure and chara...

journal_title：Journal of the American Heart Association

authors： Lu Y,Huang C,Mahajan S,Schulz WL,Nasir K,Spatz ES,Krumholz HM

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Insulin resistance, characterized by hyperinsulinemia and normal or elevated serum glucose, is an established precursor to diabetes and cardiovascular disease. Despite fasting serum C-peptide levels being an accurate and stable marker of endogenous insulin production used in patients with diabetes, it is unk...

journal_title：Journal of the American Heart Association

authors： Patel N,Taveira TH,Choudhary G,Whitlatch H,Wu WC

更新日期：2012-12-01 00:00:00

abstract：:Background Antazoline mesylate represents an antihistamine capable of rapid and safe cardioversion of atrial fibrillation, yet evidence concerning its efficacy in comparison to other medications is insufficient. The study aimed to evaluate the success rate and safety of pharmacological cardioversion of atrial fibrilla...

journal_title：Journal of the American Heart Association

authors： Wybraniec MT,Wróbel W,Wilkosz K,Wrona K,Bula K,Mizia-Stec K

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:Ischemic stroke is a major cause of death and disability in the world. A major ischemic stroke subtype, large-vessel ischemic stroke (large artery atherosclerosis; LAA), has been shown to have some genetic components in individuals of European ancestry. However, it is not clear whether the genetic predisposi...

journal_title：Journal of the American Heart Association

authors： Lee TH,Ko TM,Chen CH,Lee MT,Chang YJ,Chang CH,Huang KL,Chang TY,Lee JD,Chang KC,Yang JT,Wen MS,Wang CY,Chen YT,Hsieh CS,Chou SY,Liu YM,Chen HW,Liao HT,Wang CW,Chen SP,Lu LS,Chen YT,Wu JY

更新日期：2016-03-29 00:00:00

abstract：BACKGROUND:Intramyocardial injection of mesenchymal stem cells (MSCs) in chronic ischemic cardiomyopathy is associated with reverse remodeling in experimental models and humans. Here, we tested the hypothesis that allogeneic MSC therapy drives ventricular remodeling by producing durable and progressive scar size reduct...

journal_title：Journal of the American Heart Association

authors： Williams AR,Suncion VY,McCall F,Guerra D,Mather J,Zambrano JP,Heldman AW,Hare JM

更新日期：2013-05-17 00:00:00

abstract：BACKGROUND:Few studies have evaluated the association between secondhand smoke (SHS) and subclinical cardiovascular disease among ethnically diverse populations. This study assesses the impact of SHS on inflammation and atherosclerosis (carotid intima-media thickness, coronary artery calcification, and peripheral arter...

journal_title：Journal of the American Heart Association

authors： Jones MR,Magid HS,Al-Rifai M,McEvoy JW,Kaufman JD,Hinckley Stukovsky KD,Szklo M,Polak J,Burke GL,Post WS,Blaha MJ,Navas-Acien A

更新日期：2016-12-19 00:00:00

abstract：BACKGROUND:Identifying the best markers to judge the adequacy of lipid-lowering treatment is increasingly important for coronary heart disease (CHD) prevention given that several novel, potent lipid-lowering therapies are in development. Reductions in LDL-C, non-HDL-C, or apoB can all be used but which most closely rel...

journal_title：Journal of the American Heart Association

authors： Thanassoulis G,Williams K,Ye K,Brook R,Couture P,Lawler PR,de Graaf J,Furberg CD,Sniderman A

更新日期：2014-04-14 00:00:00

abstract：:Background Past reports suggested that total-body irradiation at 0.5 to 1.0 Gy could be responsible for atherosclerosis. Peripheral artery disease ( PAD ) is a manifestation of systematic atherosclerosis. Whether the consequences of a low-to-moderate dose of radiation include increased risk of PAD remains to be determ...

journal_title：Journal of the American Heart Association

authors： Takahashi I,Cologne J,Haruta D,Yamada M,Takahashi T,Misumi M,Fujiwara S,Matsumoto M,Kihara Y,Hida A,Ohishi W

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Cryoballoon pulmonary vein isolation (PVI) has emerged as an alternative to radiofrequency PVI for atrial fibrillation (AF). Data are lacking to define the rates and predictors of complications, particularly phrenic nerve injury (PNI). METHODS AND RESULTS:We evaluated a single-center prospective registry of...

journal_title：Journal of the American Heart Association

authors： Guhl EN,Siddoway D,Adelstein E,Bazaz R,Mendenhall GS,Nemec J,Saba S,Schwartzman D,Voigt A,Wang NC,Jain SK

更新日期：2016-07-21 00:00:00

abstract：BACKGROUND:The intersection of heart failure (HF) and atrial fibrillation (AF) is common, but the burden of AF among black patients with HF is poorly characterized. We sought to determine the prevalence of AF, characteristics, in-hospital outcomes, and warfarin use associated with AF in patients hospitalized with HF as...

journal_title：Journal of the American Heart Association

authors： Thomas KL,Piccini JP,Liang L,Fonarow GC,Yancy CW,Peterson ED,Hernandez AF,Get With the Guidelines Steering Committee and Hospitals.

更新日期：2013-09-26 00:00:00

abstract：BACKGROUND:DPP4 (Dipeptidyl peptidase-4)-GLP-1 (glucagon-like peptide-1) and its receptor (GLP-1R) axis has been involved in several intracellular signaling pathways. The Adrβ3 (β3-adrenergic receptor)/CXCL12 (C-X-C motif chemokine 12) signal was required for the hematopoiesis. We investigated the novel molecular requi...

journal_title：Journal of the American Heart Association

authors： Zhu E,Hu L,Wu H,Piao L,Zhao G,Inoue A,Kim W,Yu C,Xu W,Bando YK,Li X,Lei Y,Hao CN,Takeshita K,Kim WS,Okumura K,Murohara T,Kuzuya M,Cheng XW

更新日期：2017-07-14 00:00:00

abstract：:Background In the 2000s, adults with HIV had a higher risk for atherosclerotic cardiovascular disease (ASCVD) compared with those without HIV. There is uncertainty if this excess risk still exists in the United States given changes in antiretroviral therapies and increased statin use. Methods and Results We compared t...

journal_title：Journal of the American Heart Association

authors： Rosenson RS,Hubbard D,Monda KL,Reading SR,Chen L,Dluzniewski PJ,Burkholder GA,Muntner P,Colantonio LD

更新日期：2020-01-07 00:00:00