Durable scar size reduction due to allogeneic mesenchymal stem cell therapy regulates whole-chamber remodeling.

abstract：BACKGROUND:Data are limited regarding outcomes of deferred lesions in patients with angiographically insignificant stenosis but low fractional flow reserve (FFR). We investigated the natural history of angiographically insignificant stenosis with low FFR among patients who underwent routine 3-vessel FFR measurement. M...

journal_title：Journal of the American Heart Association

authors： Lee JM,Koo BK,Shin ES,Nam CW,Doh JH,Hu X,Ye F,Chen S,Yang J,Chen J,Tanaka N,Yokoi H,Matsuo H,Takashima H,Shiono Y,Hwang D,Park J,Kim KJ,Akasaka T,Wang J

更新日期：2017-08-22 00:00:00

abstract：BACKGROUND:Long chain acyl-CoA synthetases (ACSL) catalyze long-chain fatty acids (FA) conversion to acyl-CoAs. Temporal ACSL1 inactivation in mouse hearts (Acsl1(H-/-)) impaired FA oxidation and dramatically increased glucose uptake, glucose oxidation, and mTOR activation, resulting in cardiac hypertrophy. We used unb...

journal_title：Journal of the American Heart Association

authors： Schisler JC,Grevengoed TJ,Pascual F,Cooper DE,Ellis JM,Paul DS,Willis MS,Patterson C,Jia W,Coleman RA

更新日期：2015-02-24 00:00:00

abstract：BACKGROUND:There are several mechanisms, including inflammation, oxidative stress and abnormal calcium homeostasis, involved in the pathogenesis of atrial fibrillation. In diabetes mellitus (DM), increased oxidative stress may be attributable to higher xanthine oxidase activity. In this study, we examined the relations...

journal_title：Journal of the American Heart Association

authors： Yang Y,Zhao J,Qiu J,Li J,Liang X,Zhang Z,Zhang X,Fu H,Korantzopoulos P,Letsas KP,Tse G,Li G,Liu T

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea (OSA) is a common condition associated with cardiovascular disease. Its potential effect on progression of subclinical atherosclerosis is not well understood. We tested the hypothesis that self-reported OSA is associated with progression of coronary artery calcium (CAC). We also evalu...

journal_title：Journal of the American Heart Association

authors： Kwon Y,Duprez DA,Jacobs DR,Nagayoshi M,McClelland RL,Shahar E,Budoff M,Redline S,Shea S,Carr JJ,Lutsey PL

更新日期：2014-09-26 00:00:00

abstract：BACKGROUND:Obesity is causally associated with atherosclerosis, and adipose tissue (AT)-derived exosomes may be implicated in the metabolic complications of obesity. However, the precise role of AT-exosomes in atherogenesis remains unclear. We herein aimed to assess the effect of AT-exosomes on macrophage foam cell for...

journal_title：Journal of the American Heart Association

authors： Xie Z,Wang X,Liu X,Du H,Sun C,Shao X,Tian J,Gu X,Wang H,Tian J,Yu B

更新日期：2018-03-03 00:00:00

abstract：:Background Prevalence of peripheral artery disease ( PAD ) is significantly higher among blacks as compared with non-Hispanic whites, but the role of cigarette smoking in PAD is understudied in blacks. We aimed to evaluate the relationship between cigarette smoking and PAD in blacks in the (JHS) Jackson Heart Study. M...

journal_title：Journal of the American Heart Association

authors： Clark D 3rd,Cain LR,Blaha MJ,DeFilippis AP,Mentz RJ,Kamimura D,White WB,Butler KR,Robertson RM,Bhatnagar A,Butler J,Correa A,Benjamin EJ,Hall ME

更新日期：2019-02-05 00:00:00

abstract：:Background This study was performed to characterize the metabolic, functional, and structural cardiac changes in a canine model of radiation-induced heart disease by serial in vivo imaging and ex vivo analyses. Methods and Results Thirty-six dogs were randomly assigned to control or irradiated groups at 3 time points ...

journal_title：Journal of the American Heart Association

authors： Yan R,Li X,Song J,Guo M,Cai H,Wu Z,Wu P,Li L,Yang M,Wang Y,Li S

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging of carotid plaque can aid in stroke risk stratification in patients with carotid stenosis. However, the prevalence of complicated carotid plaque in patients with cryptogenic stroke is uncertain, especially as assessed by plaque imaging techniques routinely included in acute stroke ...

journal_title：Journal of the American Heart Association

authors： Gupta A,Gialdini G,Lerario MP,Baradaran H,Giambrone A,Navi BB,Marshall RS,Iadecola C,Kamel H

更新日期：2015-06-15 00:00:00

abstract：:Background Current approaches fail to separate patients at high versus low risk for ventricular arrhythmias owing to overreliance on a snapshot left ventricular ejection fraction measure. We used statistical machine learning to identify important cardiac imaging and time-varying risk predictors. Methods and Results Th...

journal_title：Journal of the American Heart Association

authors： Wu KC,Wongvibulsin S,Tao S,Ashikaga H,Stillabower M,Dickfeld TM,Marine JE,Weiss RG,Tomaselli GF,Zeger SL

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:The increased adverse cardiac events in women undergoing coronary artery bypass grafting are multifactorial and may include clinical, psychosocial, and biological factors. Potential contributing biological factors could include vascular hyperreactivity of the internal mammary artery (IMA) to endogenous vasoc...

journal_title：Journal of the American Heart Association

authors： Lamin V,Jaghoori A,Jakobczak R,Stafford I,Heresztyn T,Worthington M,Edwards J,Viana F,Stuklis R,Wilson DP,Beltrame JF

更新日期：2018-07-09 00:00:00

abstract：BACKGROUND:Optimal thromboprophylaxis after cardiac surgery is uncertain. This systematic review aimed to define the incidence and risk factors for deep vein thrombosis (DVT), fatal and nonfatal pulmonary embolism (PE), and assess whether venous thromboembolism (VTE) prophylaxis was effective in reducing VTE without co...

journal_title：Journal of the American Heart Association

authors： Ho KM,Bham E,Pavey W

更新日期：2015-10-26 00:00:00

abstract：BACKGROUND:The presence and implications of abnormal arterial stiffness, a potential independent predictor of outcomes, in community-dwelling treated hypertensives is unknown. Furthermore, limited data exist regarding the risk of cardiovascular disease (CVD) associated with arterial stiffness across the entire range of...

journal_title：Journal of the American Heart Association

authors： Niiranen TJ,Kalesan B,Hamburg NM,Benjamin EJ,Mitchell GF,Vasan RS

更新日期：2016-10-26 00:00:00

abstract：:Background Educational attainment is an indicator of socioeconomic status and is inversely associated with coronary artery disease risk. Whether educational attainment level (EAL) among patients with coronary artery disease influences outcomes remains understudied. Methods and Results Patients undergoing cardiac cathe...

journal_title：Journal of the American Heart Association

authors： Kelli HM,Mehta A,Tahhan AS,Liu C,Kim JH,Dong TA,Dhindsa DS,Ghazzal B,Choudhary MK,Sandesara PB,Hayek SS,Topel ML,Alkhoder AA,Martini MA,Sidoti A,Ko YA,Lewis TT,Vaccarino V,Sperling LS,Quyyumi AA

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Although generic medications are approved based on bioequivalence with brand-name medications, there remains substantial concern regarding their clinical effectiveness and safety. Lipitor(®), available as generic atorvastatin, is one of the most commonly prescribed statins. Therefore, we compared the effecti...

journal_title：Journal of the American Heart Association

authors： Jackevicius CA,Tu JV,Krumholz HM,Austin PC,Ross JS,Stukel TA,Koh M,Chong A,Ko DT

更新日期：2016-04-19 00:00:00

abstract：:Background Laboratory studies demonstrate glucose-insulin-potassium (GIK) as a potent cardioprotective intervention, but clinical trials have yielded mixed results, likely because of varying formulas and timing of GIK treatment and different clinical settings. This study sought to evaluate the effects of modified GIK ...

journal_title：Journal of the American Heart Association

authors： Zhao K,Zhang Y,Li J,Cui Q,Zhao R,Chen W,Liu J,Zhao B,Wan Y,Ma XL,Yu S,Yi D,Gao F

更新日期：2020-03-17 00:00:00

abstract：BACKGROUND:Impacts of a single radiofrequency ablation (RFA) on quality of life (QoL) were not well investigated in atrial fibrillation (AF) patients with low stroke risk. METHODS AND RESULTS:Nine hundred AF patients with low CHADS2 score (ie, CHADS2 ≤1) who completed both a baseline and 6-month Atrial Fibrillation Ef...

journal_title：Journal of the American Heart Association

authors： Bai Y,Bai R,Wu JH,Zhang T,Liu N,Shi XB,Liu XY,Liu XH,Du X,Dong JZ,Ma CS

更新日期：2015-09-16 00:00:00

abstract：BACKGROUND:Extracorporeal cardiopulmonary resuscitation (ECPR) is widely proposed for the treatment of refractory cardiac arrest. It should be associated with coronary angiography if coronary artery disease is suspected. However, the prioritization of care remains unclear in this situation. Our goal was to determine wh...

journal_title：Journal of the American Heart Association

authors： Hutin A,Lamhaut L,Lidouren F,Kohlhauer M,Mongardon N,Carli P,Berdeaux A,Ghaleh B,Tissier R

更新日期：2016-12-22 00:00:00

abstract：:Background Hyperoxia during cardiopulmonary resuscitation (CPR) may lead to oxidative injury from mitochondrial-derived reactive oxygen species, despite guidelines recommending 1.0 inspired oxygen during CPR. We hypothesized exposure to 1.0 inspired oxygen during CPR would result in cerebral hyperoxia, higher mitochon...

journal_title：Journal of the American Heart Association

authors： Marquez AM,Morgan RW,Ko T,Landis WP,Hefti MM,Mavroudis CD,McManus MJ,Karlsson M,Starr J,Roberts AL,Lin Y,Nadkarni V,Licht DJ,Berg RA,Sutton RM,Kilbaugh TJ

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:Metabolic syndrome increases risk for atherosclerotic coronary artery disease, and its prevalence increases with increasing age and body mass index. Adults with congenital heart disease (ACHD) are now living longer and accruing coronary artery disease risk factors. However, the prevalence of metabolic syndro...

journal_title：Journal of the American Heart Association

authors： Deen JF,Krieger EV,Slee AE,Arslan A,Arterburn D,Stout KK,Portman MA

更新日期：2016-02-12 00:00:00

abstract：BACKGROUND:The MMP (matrix metalloproteinase) family plays diverse and critical roles in directing vascular wall remodeling in atherosclerosis. Unlike secreted-type MMPs, a member of the membrane-type MMP family, MT1-MMP (membrane-type 1 MMP; MMP14), mediates pericellular extracellular matrix degradation that is indisp...

journal_title：Journal of the American Heart Association

authors： Barnes RH 2nd,Akama T,Öhman MK,Woo MS,Bahr J,Weiss SJ,Eitzman DT,Chun TH

更新日期：2017-07-22 00:00:00

abstract：BACKGROUND:Fatty acids constitute the critical components of cell structure and function, and dysregulation of fatty acid composition may exert diverging vascular effects including proliferation, migration, and differentiation of vascular smooth muscle cells (VSMCs). However, direct evidence for this hypothesis has bee...

journal_title：Journal of the American Heart Association

authors： Sunaga H,Matsui H,Anjo S,Syamsunarno MR,Koitabashi N,Iso T,Matsuzaka T,Shimano H,Yokoyama T,Kurabayashi M

更新日期：2016-11-23 00:00:00

abstract：:Background Platelets play a role in promoting inflammatory responses under several disease conditions. Platelets are activated in hypertensive patients. However, the mechanisms responsible for platelet-mediating vascular inflammation are unknown. The present study investigated the role of platelets in promoting vascul...

journal_title：Journal of the American Heart Association

authors： An X,Jiang G,Cheng C,Lv Z,Liu Y,Wang F

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Treatment decisions for aortic valve replacement (AVR) should be sensitive to patient preferences. However, we lack knowledge of patient preferences and how to obtain them. METHODS AND RESULTS:We assessed the mortality risk patients were willing to accept when undergoing AVR by using the Standard Gamble met...

journal_title：Journal of the American Heart Association

authors： Hussain AI,Garratt AM,Brunborg C,Aakhus S,Gullestad L,Pettersen KI

更新日期：2016-03-18 00:00:00

abstract：:Background Ischemic heart disease continues to be a leading cause of mortality in patients. Extracellular vesicles (EVs) provide a potential for treatment that may induce collateral vessel growth to increase myocardial perfusion. Methods and Results Nineteen male Yorkshire pigs were given a high-fat diet for 4 weeks, ...

journal_title：Journal of the American Heart Association

authors： Scrimgeour LA,Potz BA,Aboul Gheit A,Shi G,Stanley M,Zhang Z,Sodha NR,Ahsan N,Abid MR,Sellke FW

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:Time-limited acute stroke treatments are underused, primarily due to prehospital delay. One approach to decreasing prehospital delay is to increase stroke preparedness, the ability to recognize stroke, and the intention to immediately call emergency medical services, through community engagement with high-ri...

journal_title：Journal of the American Heart Association

authors： Skolarus LE,Zimmerman MA,Bailey S,Dome M,Murphy JB,Kobrossi C,Dombrowski SU,Burke JF,Morgenstern LB

更新日期：2016-05-20 00:00:00

abstract：BACKGROUND:Little is known about causality and pathological mechanism underlying association of postinfarct fever with myocardial injury in patients with ST-segment elevation myocardial infarction. METHODS AND RESULTS:In 276 patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocar...

journal_title：Journal of the American Heart Association

authors： Jang WJ,Yang JH,Song YB,Chun WJ,Oh JH,Park YH,Lee MR,Hwang JK,Hwang JW,Hahn JY,Choi SH,Lee SC,Choe YH,Gwon HC

更新日期：2017-04-24 00:00:00

abstract：BACKGROUND:Fatty infiltration of the pancreas is an enigmatic manifestation of ectopic fat deposition in obesity. Studies have shown that pancreatic lipid accumulation interferes with insulin secretion in humans. However, the prevalence of fatty pancreas and its associated factors in the general population remain uncle...

journal_title：Journal of the American Heart Association

authors： Wang CY,Ou HY,Chen MF,Chang TC,Chang CJ

更新日期：2014-02-26 00:00:00

abstract：BACKGROUND:Cardiac fibrosis occurs because of disruption of the extracellular matrix network leading to myocardial dysfunction. Angiotensin II has been implicated in the development of cardiac fibrosis. Recently, microRNAs have been identified as an attractive target for therapeutic intervention in cardiac pathologies;...

journal_title：Journal of the American Heart Association

authors： Li L,Bounds KR,Chatterjee P,Gupta S

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:Obesity is closely associated with various cardiovascular diseases (CVDs). Adipose tissue inflammation and perturbation of adipokine secretion may contribute to the pathogenesis of CVD. This study aimed to evaluate whether the 2 most abundant adipokines, adipocyte-fatty acid binding protein (A-FABP) and adip...

journal_title：Journal of the American Heart Association

authors： Chow WS,Tso AW,Xu A,Yuen MM,Fong CH,Lam TH,Lo SV,Tse HF,Woo YC,Yeung CY,Cheung BM,Lam KS

更新日期：2013-01-15 00:00:00

abstract：BACKGROUND:Physical activity is of benefit for primary prevention of cardiovascular diseases, but it appears to increase the risk for atrial fibrillation. We aimed to study a cohort of patients following a first stroke in individuals with previous high physical activity, compare them to the general population with resp...

journal_title：Journal of the American Heart Association

authors： Hållmarker U,Åsberg S,Michaëlsson K,Ärnlöv J,Hellberg D,Lindbäck J,Wester P,James S

更新日期：2015-09-24 00:00:00