Inhibition of Platelets by Clopidogrel Suppressed Ang II-Induced Vascular Inflammation, Oxidative Stress, and Remodeling.

abstract：:Background Prior reports indicate that the effect of P2Y12 inhibitors may be different in East Asian patients ("East Asian paradox"); therefore, understanding the outcomes associated with potent P2Y12 inhibitors in different populations is clinically important. Methods and Results In this observational cohort study us...

journal_title：Journal of the American Heart Association

authors： Yun JE,Kim YJ,Park JJ,Kim S,Park K,Cho MS,Nam GB,Park DW

更新日期：2019-07-16 00:00:00

abstract：BACKGROUND:Diabetes mellitus (DM) is a major risk factor for cardiovascular events. We aimed to investigate the coronary plaque phenotype of diabetic patients who presented with acute coronary syndromes by optical coherence tomography. METHODS AND RESULTS:A total of 322 patients with acute coronary syndromes who under...

journal_title：Journal of the American Heart Association

authors： Sugiyama T,Yamamoto E,Bryniarski K,Xing L,Fracassi F,Lee H,Jang IK

更新日期：2018-07-13 00:00:00

abstract：BACKGROUND:Recent studies have shown that plasma levels of the biologically inactive prohormone for brain natriuretic peptide (proBNP) are increased in patients with heart failure. This can contribute to a reduction in the effectiveness of circulating BNP and exacerbate heart failure progression. The precise mechanisms...

journal_title：Journal of the American Heart Association

authors： Nakagawa Y,Nishikimi T,Kuwahara K,Fujishima A,Oka S,Tsutamoto T,Kinoshita H,Nakao K,Cho K,Inazumi H,Okamoto H,Nishida M,Kato T,Fukushima H,Yamashita JK,Wijnen WJ,Creemers EE,Kangawa K,Minamino N,Nakao K,Kimura T

更新日期：2017-02-10 00:00:00

abstract：:Background Recent publications reached conflicting conclusions about the cost-effectiveness of left atrial appendage closure (LAAC) with the Watchman device (Boston Scientific, Marlborough, MA) for stroke risk reduction in nonvalvular atrial fibrillation (AF). This analysis sought to assess the cost-effectiveness of L...

journal_title：Journal of the American Heart Association

authors： Reddy VY,Akehurst RL,Gavaghan MB,Amorosi SL,Holmes DR Jr

更新日期：2019-07-02 00:00:00

abstract：:Background There are limited data about cardiac resynchronization therapy (CRT) in adult congenital heart disease. We aimed to assess early and late outcomes of CRT among patients with adult congenital heart disease. Methods and Results We retrospectively studied 54 patients with adult congenital heart disease (median...

journal_title：Journal of the American Heart Association

authors： Yin Y,Dimopoulos K,Shimada E,Lascelles K,Griffiths S,Wong T,Gatzoulis MA,Babu-Narayan SV,Li W

更新日期：2019-11-05 00:00:00

abstract：:Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) have shown their beneficial effects on cardiovascular outcomes and multiple cardiovascular risk factors, including hypertension. However, the mechanism of blood pressure (BP)-lowering effects of thes...

journal_title：Journal of the American Heart Association

authors： Hu M,Cai X,Yang W,Zhang S,Nie L,Ji L

更新日期：2020-04-07 00:00:00

abstract：:Background Cardiac hypertrophy has been recognized as an important independent risk factor for the development of heart failure and increases the risk of cardiac morbidity and mortality. A disintegrin and metalloprotease 23 (ADAM23), a member of ADAM family, is involved in cancer and neuronal differentiation. Although...

journal_title：Journal of the American Heart Association

authors： Xiang M,Luo H,Wu J,Ren L,Ding X,Wu C,Chen J,Chen S,Zhang H,Yu L,Zou Y,Xu H,Ye P,Chen M,Xia J

更新日期：2018-09-18 00:00:00

abstract：:See Article by Fudim et al. ...

journal_title：Journal of the American Heart Association

authors： Bozkurt B

更新日期：2018-12-18 00:00:00

abstract：:Background Hyperoxia during cardiopulmonary resuscitation (CPR) may lead to oxidative injury from mitochondrial-derived reactive oxygen species, despite guidelines recommending 1.0 inspired oxygen during CPR. We hypothesized exposure to 1.0 inspired oxygen during CPR would result in cerebral hyperoxia, higher mitochon...

journal_title：Journal of the American Heart Association

authors： Marquez AM,Morgan RW,Ko T,Landis WP,Hefti MM,Mavroudis CD,McManus MJ,Karlsson M,Starr J,Roberts AL,Lin Y,Nadkarni V,Licht DJ,Berg RA,Sutton RM,Kilbaugh TJ

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:Although a stroke event often leads to work disability, diagnoses behind work disability before and after stroke are largely unknown. We examined the pre-event and postevent trends in diagnosis-specific work disability among patients of working age. METHODS AND RESULTS:We included all new nonfatal stroke ev...

journal_title：Journal of the American Heart Association

authors： Lallukka T,Ervasti J,Lundström E,Mittendorfer-Rutz E,Friberg E,Virtanen M,Alexanderson K

更新日期：2018-01-04 00:00:00

abstract：:Background To determine if accelerometer measured sedentary behavior (SED), light-intensity physical activity (LPA), and moderate-to-vigorous-intensity physical activity (MVPA) in midlife is prospectively associated with cognitive function. Methods and Results Participants were 1970 adults enrolled in the CARDIA (Coro...

journal_title：Journal of the American Heart Association

authors： Whitaker KM,Zhang D,Pettee Gabriel K,Ahrens M,Sternfeld B,Sidney S,Jacobs DR Jr,Palta P,Yaffe K

更新日期：2021-01-20 00:00:00

abstract：:Background Patients presenting to hospitals during non-weekday hours experience worse outcomes, often attributed to reduced staffing. The American Heart Association International Stroke Conference ( ISC ) is well attended by stroke clinicians. We sought to determine whether patients with acute ischemic stroke ( AIS ) ...

journal_title：Journal of the American Heart Association

authors： Messé SR,Mullen MT,Cox M,Fonarow GC,Smith EE,Saver JL,Reeves MJ,Bhatt DL,Matsouaka R,Schwamm LH

更新日期：2018-11-06 00:00:00

abstract：:Background In the 2000s, adults with HIV had a higher risk for atherosclerotic cardiovascular disease (ASCVD) compared with those without HIV. There is uncertainty if this excess risk still exists in the United States given changes in antiretroviral therapies and increased statin use. Methods and Results We compared t...

journal_title：Journal of the American Heart Association

authors： Rosenson RS,Hubbard D,Monda KL,Reading SR,Chen L,Dluzniewski PJ,Burkholder GA,Muntner P,Colantonio LD

更新日期：2020-01-07 00:00:00

abstract：:Background Red blood cell (RBC) transfusion and erythropoiesis-stimulating agent administration are cornerstones of clinical practice, yet concerns exist as to potential increased risk of thrombotic events. This study aims to identify RBC traits most relevant to venous thromboembolism (VTE) and assess their geneticall...

journal_title：Journal of the American Heart Association

authors： Luo S,Au Yeung SL,Zuber V,Burgess S,Schooling CM

更新日期：2020-07-21 00:00:00

abstract：:Background Turner syndrome ( TS ) is the most common sex chromosome abnormality in women and is associated with increased morbidity and mortality. We describe long-term outcomes in a large cohort of patients with TS . Methods and Results Retrospective review of patients with TS followed at Mayo Clinic Rochester from 1...

journal_title：Journal of the American Heart Association

authors： Fuchs MM,Attenhofer Jost C,Babovic-Vuksanovic D,Connolly HM,Egbe A

更新日期：2019-06-04 00:00:00

abstract：BACKGROUND:Although automated external defibrillators (AEDs) have contributed to a better survival of out-of-hospital cardiac arrests, there have been reports of their malfunctioning. We investigated the diagnostic accuracy of commercially available AEDs using surface ECGs of ventricular fibrillation (VF), ventricular ...

journal_title：Journal of the American Heart Association

authors： Nishiyama T,Nishiyama A,Negishi M,Kashimura S,Katsumata Y,Kimura T,Nishiyama N,Tanimoto Y,Aizawa Y,Mitamura H,Fukuda K,Takatsuki S

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Our previous randomized controlled trial demonstrated cardiorespiratory protection by remote ischemic preconditioning (RIPC) in children before cardiac surgery. However, the impact of RIPC on myocardial prosurvival intracellular signaling remains unknown in cyanosis. RIPC may augment phosphorylated protein s...

journal_title：Journal of the American Heart Association

authors： Pepe S,Liaw NY,Hepponstall M,Sheeran FL,Yong MS,d'Udekem Y,Cheung MM,Konstantinov IE

更新日期：2013-05-10 00:00:00

abstract：BACKGROUND:The p.Gln554X mutation in desmocollin-2 (DSC2) is prevalent in ≈10% of the Hutterite population. While the homozygous mutation causes severe biventricular arrhythmogenic right ventricular cardiomyopathy, the phenotypic features and prognosis of heterozygotes remain incompletely understood. METHODS AND RESUL...

journal_title：Journal of the American Heart Association

authors： Wong JA,Duff HJ,Yuen T,Kolman L,Exner DV,Weeks SG,Gerull B

更新日期：2014-12-11 00:00:00

abstract：BACKGROUND:Transcatheter pulmonary valve implantation is approved for the treatment of dysfunctional right ventricle to pulmonary artery conduits. However, the literature is limited because of a small patient population, and it does not reflect changing procedural practice patterns over the last decade. METHODS AND RE...

journal_title：Journal of the American Heart Association

authors： Chatterjee A,Bajaj NS,McMahon WS,Cribbs MG,White JS,Mukherjee A,Law MA

更新日期：2017-08-04 00:00:00

abstract：:Background Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide-ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients. Methods and Results TTS patients from the International Takotsubo Registry we...

journal_title：Journal of the American Heart Association

authors： Jurisic S,Gili S,Cammann VL,Kato K,Szawan KA,D'Ascenzo F,Jaguszewski M,Bossone E,Citro R,Sarcon A,Napp LC,Franke J,Noutsias M,Knorr M,Heiner S,Burgdorf C,Koenig W,Pott A,Kherad B,Rajan L,Michels G,Pfister R,Cu

更新日期：2019-11-05 00:00:00

abstract：:Background Antazoline mesylate represents an antihistamine capable of rapid and safe cardioversion of atrial fibrillation, yet evidence concerning its efficacy in comparison to other medications is insufficient. The study aimed to evaluate the success rate and safety of pharmacological cardioversion of atrial fibrilla...

journal_title：Journal of the American Heart Association

authors： Wybraniec MT,Wróbel W,Wilkosz K,Wrona K,Bula K,Mizia-Stec K

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:Patients with heart failure with preserved ejection fraction (HFpEF) exhibit a range of cardiovascular phenotypic profiles modified by several common comorbidities. In particular, patients with HFpEF tend to be older; however, it is unclear whether the effects of cardiovascular aging per se modify the expres...

journal_title：Journal of the American Heart Association

authors： Nanayakkara S,Haykowsky M,Mariani J,Van Empel V,Maeder MT,Vizi D,Kaye DM

更新日期：2017-09-22 00:00:00

abstract：BACKGROUND:Insulin resistance, characterized by hyperinsulinemia and normal or elevated serum glucose, is an established precursor to diabetes and cardiovascular disease. Despite fasting serum C-peptide levels being an accurate and stable marker of endogenous insulin production used in patients with diabetes, it is unk...

journal_title：Journal of the American Heart Association

authors： Patel N,Taveira TH,Choudhary G,Whitlatch H,Wu WC

更新日期：2012-12-01 00:00:00

abstract：:Background Higher fibroblast growth factor-23 ( FGF -23) levels are associated with incident heart failure ( HF ) in MESA (the Multiethnic Study of Atherosclerosis). FGF -23 is also associated with left ventricular hypertrophy. Whether the FGF -23 association with HF is similar for heart failure with reduced ejection ...

journal_title：Journal of the American Heart Association

authors： Almahmoud MF,Soliman EZ,Bertoni AG,Kestenbaum B,Katz R,Lima JAC,Ouyang P,Miller PE,Michos ED,Herrington DM

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:Contemporary rates of oral anticoagulant (OAC) therapy and associated outcomes among patients undergoing percutaneous coronary intervention (PCI) have been poorly described. METHODS AND RESULTS:Using data from an integrated health care system from 2009 to 2014, we identified patients on OACs within 30 days ...

journal_title：Journal of the American Heart Association

authors： Secemsky EA,Butala NM,Kartoun U,Mahmood S,Wasfy JH,Kennedy KF,Shaw SY,Yeh RW

更新日期：2016-10-17 00:00:00

abstract：BACKGROUND:History of gestational diabetes mellitus (GDM) increases lifetime risk of type 2 diabetes (DM) and the metabolic syndrome (MetS), which increase risk of cardiovascular disease. It is unclear, however, whether GDM increases risk of early atherosclerosis independent of pre-pregnancy obesity and subsequent meta...

journal_title：Journal of the American Heart Association

authors： Gunderson EP,Chiang V,Pletcher MJ,Jacobs DR,Quesenberry CP,Sidney S,Lewis CE

更新日期：2014-03-12 00:00:00

abstract：BACKGROUND:Glycosylated proteins partake in multiple cellular processes including inflammation. We hypothesized that GlycA, a novel biomarker of protein glycan N-acetyl groups, is related to incident cardiovascular disease (CVD), and we compared it with high-sensitivity C-reactive protein (hsCRP). METHODS AND RESULTS:...

journal_title：Journal of the American Heart Association

authors： Akinkuolie AO,Buring JE,Ridker PM,Mora S

更新日期：2014-09-23 00:00:00

abstract：BACKGROUND:Preeclampsia (PE) is a life-threatening hypertensive disorder of pregnancy associated with autoantibodies, termed AT1-AA, that activate the AT1 angiotensin receptor. Although the pathogenic nature of these autoantibodies has been extensively studied, little is known about the molecular cause of their generat...

journal_title：Journal of the American Heart Association

authors： Liu C,Luo R,Elliott SE,Wang W,Parchim NF,Iriyama T,Daugherty PS,Blackwell SC,Sibai BM,Kellems RE,Xia Y

更新日期：2015-12-16 00:00:00

abstract：BACKGROUND:Identifying the best markers to judge the adequacy of lipid-lowering treatment is increasingly important for coronary heart disease (CHD) prevention given that several novel, potent lipid-lowering therapies are in development. Reductions in LDL-C, non-HDL-C, or apoB can all be used but which most closely rel...

journal_title：Journal of the American Heart Association

authors： Thanassoulis G,Williams K,Ye K,Brook R,Couture P,Lawler PR,de Graaf J,Furberg CD,Sniderman A

更新日期：2014-04-14 00:00:00

abstract：BACKGROUND:Regression of left ventricular (LV) hypertrophy (LVH) has been a goal in clinical trials. This study tests the external validity of results of clinical trials on LVH regression using a large registry from a tertiary care center, to identify phenotypes less likely to achieve regression of LVH. METHODS AND RE...

journal_title：Journal of the American Heart Association

authors： Lønnebakken MT,Izzo R,Mancusi C,Gerdts E,Losi MA,Canciello G,Giugliano G,De Luca N,Trimarco B,de Simone G

更新日期：2017-03-08 00:00:00