ADAM23 in Cardiomyocyte Inhibits Cardiac Hypertrophy by Targeting FAK - AKT Signaling.

abstract：BACKGROUND:Left ventricular noncompaction (LVNC) has since been classified as a primary genetic cardiomyopathy, but the genetic basis is not fully evaluated. The aim of the present study was to identify the genetic spectrum using next-generation sequencing and to evaluate genotype-phenotype correlations in LVNC patient...

journal_title：Journal of the American Heart Association

authors： Wang C,Hata Y,Hirono K,Takasaki A,Ozawa SW,Nakaoka H,Saito K,Miyao N,Okabe M,Ibuki K,Nishida N,Origasa H,Yu X,Bowles NE,Ichida F,for LVNC Study Collaborators.

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:A prior randomized controlled trial of social media exposure at Circulation determined that social media did not increase 30-day page views. Whether insufficient social media intensity contributed to these results is uncertain. METHODS AND RESULTS:Original article manuscripts were randomized to social media...

journal_title：Journal of the American Heart Association

authors： Fox CS,Gurary EB,Ryan J,Bonaca M,Barry K,Loscalzo J,Massaro J

更新日期：2016-04-27 00:00:00

abstract：BACKGROUND:Cardiac fibrosis occurs because of disruption of the extracellular matrix network leading to myocardial dysfunction. Angiotensin II has been implicated in the development of cardiac fibrosis. Recently, microRNAs have been identified as an attractive target for therapeutic intervention in cardiac pathologies;...

journal_title：Journal of the American Heart Association

authors： Li L,Bounds KR,Chatterjee P,Gupta S

更新日期：2017-11-07 00:00:00

abstract：:[This corrects the article DOI: 10.1161/JAHA.117.005967.]. ...

journal_title：Journal of the American Heart Association

authors：

更新日期：2017-12-23 00:00:00

abstract：BACKGROUND:Despite variations in the prevalence of cardiovascular disease and related risk factors among US Hispanic/Latino adults of diverse backgrounds, there is little information on whether disparities exist in the use of medications for the primary and secondary prevention of cardiovascular disease. We examined th...

journal_title：Journal of the American Heart Association

authors： Qato DM,Lee TA,Durazo-Arvizu R,Wu D,Wilder J,Reina SA,Cai J,Gonzalez F 2nd,Talavera GA,Ostfeld RJ,Daviglus ML

更新日期：2016-03-30 00:00:00

abstract：BACKGROUND:Impaired generation and signaling of nitric oxide (NO) contribute substantially to cardiovascular (CV) risk (CVR) associated with hypertension, hyperlipidemia, and diabetes mellitus. In our rapidly aging society, advanced age is, in itself, a consistent and independent CVR factor. Many processes involved in ...

journal_title：Journal of the American Heart Association

authors： Sverdlov AL,Ngo DT,Chan WP,Chirkov YY,Horowitz JD

更新日期：2014-08-18 00:00:00

abstract：:Background Muscular dystrophy (MD) causes a progressive cardiomyopathy characterized by diffuse fibrosis, arrhythmia, heart failure, and early death. Activation of the thromboxane-prostanoid receptor (TPr) increases calcium transients in cardiomyocytes and is proarrhythmic and profibrotic. We hypothesized that TPr act...

journal_title：Journal of the American Heart Association

authors： West JD,Galindo CL,Kim K,Shin JJ,Atkinson JB,Macias-Perez I,Pavliv L,Knollmann BC,Soslow JH,Markham LW,Carrier EJ

更新日期：2019-11-05 00:00:00

abstract：:Background There are limited data about cardiac resynchronization therapy (CRT) in adult congenital heart disease. We aimed to assess early and late outcomes of CRT among patients with adult congenital heart disease. Methods and Results We retrospectively studied 54 patients with adult congenital heart disease (median...

journal_title：Journal of the American Heart Association

authors： Yin Y,Dimopoulos K,Shimada E,Lascelles K,Griffiths S,Wong T,Gatzoulis MA,Babu-Narayan SV,Li W

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:The incidence of abdominal aortic aneurysms (AAAs) will significantly increase during the next decade. Novel biomarkers, besides diameter, are needed for a better characterization of aneurysms and the estimation of the risk of rupture. Fibrin is a key protein in the formation of focal hematoma associated wit...

journal_title：Journal of the American Heart Association

authors： Botnar RM,Brangsch J,Reimann C,Janssen CHP,Razavi R,Hamm B,Makowski MR

更新日期：2018-05-30 00:00:00

abstract：BACKGROUND:Although clinical trials have proved that statin can be used prophylactically against cardiovascular events, the direct effects of statin on plaque development are not well understood. We generated low-density lipoprotein receptor knockout (LDLR(-/-)) pigs to study the effects of early statin administration ...

journal_title：Journal of the American Heart Association

authors： Li Y,Fuchimoto D,Sudo M,Haruta H,Lin QF,Takayama T,Morita S,Nochi T,Suzuki S,Sembon S,Nakai M,Kojima M,Iwamoto M,Hashimoto M,Yoda S,Kunimoto S,Hiro T,Matsumoto T,Mitsumata M,Sugitani M,Saito S,Hirayama A,Onish

更新日期：2016-04-18 00:00:00

abstract：:Background Several lipid-lowering therapies reduce CRP (C-reactive protein) independently of LDL-C (low-density lipoprotein cholesterol) reduction, but the association between CRP parameters and benefits from more-intensive LDL-C lowering is inconclusive. We aimed to determine whether the benefits of more- versus less...

journal_title：Journal of the American Heart Association

authors： Zhang XL,Lan RF,Zhang XW,Xu W,Wang L,Kang LN,Xu B

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Platelet activation can lead to enhanced oxidative stress, inflammatory response, and endothelial dysfunction. To quantify the effects of platelet inhibition on endothelial function, we assessed platelet activity of healthy persons before and after clopidogrel administration and evaluated its effects on endo...

journal_title：Journal of the American Heart Association

authors： Salimi S,Lewis JP,Yerges-Armstrong LM,Mitchell BD,Saeed F,O'Connell JR,Perry JA,Ryan KA,Shuldiner AR,Parsa A

更新日期：2016-10-31 00:00:00

abstract：:Background Obesity is a precursor to heart failure with preserved ejection fraction. Biomarkers that identify preclinical metabolic heart disease ( MHD ) in young obese patients would help identify high-risk individuals for heart failure prevention strategies. We assessed the predictive value of GAL3 (galectin-3), FST...

journal_title：Journal of the American Heart Association

authors： Gopal DM,Ayalon N,Wang YC,Siwik D,Sverdlov A,Donohue C,Perez A,Downing J,Apovian C,Silva V,Panagia M,Kolachalama V,Ho JE,Liang CS,Gokce N,Colucci WS

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:Bypass grafting remains the standard of care for coronary artery disease and severe lower extremity ischemia. Efficacy is limited by poor long-term venous graft patency secondary to intimal hyperplasia (IH) caused by venous injury upon exposure to arterial pressure. We investigate whether photochemical tissu...

journal_title：Journal of the American Heart Association

authors： Goldstone RN,McCormack MC,Khan SI,Salinas HM,Meppelink A,Randolph MA,Watkins MT,Redmond RW,Austen WG Jr

更新日期：2016-07-27 00:00:00

abstract：BACKGROUND:Beta-blockers (BB) are recommended in secondary prevention of acute myocardial infarction (AMI), but adherence to prescription medication is a recognized problem. Most literature on the consequences of poor adherence to prescribed BB is limited by the possibility of "healthy adherer bias" and better-designed...

journal_title：Journal of the American Heart Association

authors： Di Bartolomeo S,Marino M,Guastaroba P,Valent F,De Palma R

更新日期：2015-01-07 00:00:00

abstract：:Background Ticagrelor reduces ischaemic end points in acute coronary syndromes. However, outcomes of ticagrelor versus clopidogrel in real-world patients with acute coronary syndromes treated with percutaneous coronary intervention (PCI) remain unclear. We sought to examine whether treatment with ticagrelor is superio...

journal_title：Journal of the American Heart Association

authors： Völz S,Petursson P,Odenstedt J,Ioanes D,Haraldsson I,Angerås O,Dworeck C,Hirlekar G,Myredal A,Albertsson P,Råmunddal T,Redfors B,Omerovic E

更新日期：2020-07-21 00:00:00

abstract：:Background Mortality is increased following a hospitalization for decompensated heart failure (HF), during which diuretics are usually intensified. It is unclear how risk is affected after outpatient intensification of diuretic therapy for HF. Methods and Results From nationwide administrative registers, we identified...

journal_title：Journal of the American Heart Association

authors： Madelaire C,Gustafsson F,Stevenson LW,Kristensen SL,Køber L,Andersen J,D'Souza M,Biering-Sørensen T,Andersson C,Torp-Pedersen C,Gislason G,Schou M

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:Extracorporeal cardiopulmonary resuscitation (ECPR) is widely proposed for the treatment of refractory cardiac arrest. It should be associated with coronary angiography if coronary artery disease is suspected. However, the prioritization of care remains unclear in this situation. Our goal was to determine wh...

journal_title：Journal of the American Heart Association

authors： Hutin A,Lamhaut L,Lidouren F,Kohlhauer M,Mongardon N,Carli P,Berdeaux A,Ghaleh B,Tissier R

更新日期：2016-12-22 00:00:00

abstract：:Background We systematically reviewed trials comparing different reperfusion strategies for ST-segment-elevation myocardial infarction and used multivariate network meta-analysis to compare outcomes across these strategies. Methods and Results We identified 31 contemporary trials in which patients with ST-segment-elev...

journal_title：Journal of the American Heart Association

authors： Fazel R,Joseph TI,Sankardas MA,Pinto DS,Yeh RW,Kumbhani DJ,Nallamothu BK

更新日期：2020-06-16 00:00:00

abstract：BACKGROUND:MYBPC3 dysfunctions have been proven to induce dilated cardiomyopathy, hypertrophic cardiomyopathy, and/or left ventricular noncompaction; however, the genotype-phenotype correlation between MYBPC3 and restrictive cardiomyopathy (RCM) has not been established. The newly developed next-generation sequencing m...

journal_title：Journal of the American Heart Association

authors： Wu W,Lu CX,Wang YN,Liu F,Chen W,Liu YT,Han YC,Cao J,Zhang SY,Zhang X

更新日期：2015-07-10 00:00:00

abstract：:Background For individuals with an out-of-hospital cardiac arrest (OHCA), survival may be influenced by the neighborhood in which the arrest occurs. Methods and Results Within the national CARES (Cardiac Arrest Registry to Enhance Survival) registry, we identified 169 502 patients with OHCA from 2013 to 2017. On the b...

journal_title：Journal of the American Heart Association

authors： Chan PS,McNally B,Vellano K,Tang Y,Spertus JA

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is a common, growing, and costly medical condition. We aimed to evaluate the impact of a management algorithm for symptomatic AF that used an emergency department observation unit on hospital admission rates and patient outcomes. METHODS AND RESULTS:This retrospective cohort study c...

journal_title：Journal of the American Heart Association

authors： Bellew SD,Bremer ML,Kopecky SL,Lohse CM,Munger TM,Robelia PM,Smars PA

更新日期：2016-02-08 00:00:00

abstract：:Background Coronary flow capacity (CFC), which is a categorical assessment based on the combination of hyperemic coronary flow and coronary flow reserve (CFR), has been introduced as a comprehensive assessment of the coronary circulation to overcome the limitations of CFR alone. The aim of this study was to quantify c...

journal_title：Journal of the American Heart Association

authors： Murai T,Stegehuis VE,van de Hoef TP,Wijntjens GWM,Hoshino M,Kanaji Y,Sugiyama T,Hamaya R,Nijjer SS,de Waard GA,Echavarria-Pinto M,Knaapen P,Meuwissen M,Davies JE,van Royen N,Escaned J,Siebes M,Kirkeeide RL,Gould KL,

更新日期：2020-07-21 00:00:00

abstract：:Background Meta-analyses are expected to follow a standardized process, and thus, they have become highly formulaic, although there is little evidence that such regimentation yields high-quality results. Methods and Results This article describes the results of a critical examination of 14 published meta-analyses of c...

journal_title：Journal of the American Heart Association

authors： Packer M

更新日期：2019-11-05 00:00:00

abstract：:Background Both genetic and nongenetic factors can predispose individuals to cardiovascular risk. Finding ways to alter these predispositions is important for cardiovascular disease prevention. Methods and Results We used a novel whole-genome approach to estimate the genetic and nongenetic effects on-and hence their p...

journal_title：Journal of the American Heart Association

authors： Zhou X,van der Werf J,Carson-Chahhoud K,Ni G,McGrath J,Hyppönen E,Lee SH

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:We aimed to determine how single and combination antihypertensive therapy alters risk for diabetes mellitus (DM).Thiazide diuretics (TD), β blockers (BB), and renin-angiotensin system blockers (RASB) impact DM risk while calcium channel blockers (CCB) are neutral. DM risk associated with combinations is uncl...

journal_title：Journal of the American Heart Association

authors： Cooper--DeHoff RM,Bird ST,Nichols GA,Delaney JA,Winterstein AG

更新日期：2013-06-10 00:00:00

abstract：:Background Unruptured intracerebral aneurysm wall enhancement (AWE) on vessel wall magnetic resonance imaging scans may be a promising predictor for rupture-prone intracerebral aneurysms. However, the pathophysiology of AWE remains unclear. To this end, the association between AWE and histopathological changes was ass...

journal_title：Journal of the American Heart Association

authors： Zhong W,Su W,Li T,Tan X,Chen C,Wang Q,Wang D,Su W,Wang Y

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Epidemiology of myocarditis in childhood is largely unknown. Men are known to have a higher incidence of myocarditis than women in adults aged <50 years, but whether this is true by sex in pediatric age groups is unknown. We set out to study the occurrence and potential sex differences of myocarditis in a ge...

journal_title：Journal of the American Heart Association

authors： Arola A,Pikkarainen E,Sipilä JO,Pykäri J,Rautava P,Kytö V

更新日期：2017-11-18 00:00:00

abstract：BACKGROUND:Extracellular fluid (ECF) excess is an independent predictor of cardiovascular morbidity in patients undergoing dialysis. This study aimed to investigate the relationship between ECF status, which is affected by renal function, and coronary artery calcification (CAC), which is a marker of cardiovascular dise...

journal_title：Journal of the American Heart Association

authors： Park S,Lee CJ,Jhee JH,Yun HR,Kim H,Jung SY,Kee YK,Yoon CY,Park JT,Kim HC,Han SH,Kang SW,Park S,Yoo TH

更新日期：2018-06-30 00:00:00

abstract：:Background Increased vagal modulation is a mechanism that may partially explain the protective effect of healthy lifestyles. However, it is unclear how healthy lifestyles relate to vagal regulation longitudinally. We prospectively examined associations between a comprehensive measure of 4 important lifestyle factors a...

journal_title：Journal of the American Heart Association

authors： Jandackova VK,Scholes S,Britton A,Steptoe A

更新日期：2019-10-01 00:00:00