Galectin-3 Is Associated With Stage B Metabolic Heart Disease and Pulmonary Hypertension in Young Obese Patients.

abstract：:Background We aimed to determine the change in treatment strategies and times to treatment over the first 5 years of the Mission: Lifeline program. Methods and Results We assessed pre- and in-hospital care and outcomes from 2008 to 2012 for patients with ST -segment-elevation myocardial infarction at US hospitals, usi...

journal_title：Journal of the American Heart Association

authors： Granger CB,Bates ER,Jollis JG,Antman EM,Nichol G,O'Connor RE,Gregory T,Roettig ML,Peng SA,Ellrodt G,Henry TD,French WJ,Jacobs AK

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Depression is known to increase the risk of coronary artery disease, but few studies have evaluated the association between depression and peripheral artery disease (PAD). We examined the association of depression with PAD and evaluated potential mediators of this association. METHODS AND RESULTS:We used da...

journal_title：Journal of the American Heart Association

authors： Grenon SM,Hiramoto J,Smolderen KG,Vittinghoff E,Whooley MA,Cohen BE

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:The presence and implications of abnormal arterial stiffness, a potential independent predictor of outcomes, in community-dwelling treated hypertensives is unknown. Furthermore, limited data exist regarding the risk of cardiovascular disease (CVD) associated with arterial stiffness across the entire range of...

journal_title：Journal of the American Heart Association

authors： Niiranen TJ,Kalesan B,Hamburg NM,Benjamin EJ,Mitchell GF,Vasan RS

更新日期：2016-10-26 00:00:00

abstract：BACKGROUND:Women are more likely than men to develop resistant hypertension, which is associated with excess risk of major adverse outcomes; however, the impact of resistant hypertension in women with ischemia has not been explicitly studied. In this Women's Ischemia Syndrome Evaluation (WISE) analysis, we assessed lon...

journal_title：Journal of the American Heart Association

authors： Smith SM,Huo T,Delia Johnson B,Bittner V,Kelsey SF,Vido Thompson D,Noel Bairey Merz C,Pepine CJ,Cooper-Dehoff RM

更新日期：2014-02-28 00:00:00

abstract：:Background Hypertensive myocardial fibrosis (MF) is characterized by excessive deposition of extracellular matrix and cardiac fibroblast proliferation, which can lead to heart failure, malignant arrhythmia, and sudden death. In recent years, with the deepening of research, microRNAs have been found to have an importan...

journal_title：Journal of the American Heart Association

authors： Zhang W,Wang Q,Feng Y,Chen X,Yang L,Xu M,Wang X,Li W,Niu X,Gao D

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a key role in removing toxic aldehydes. Deficient variant ALDH2*2 genotype is prevalent in up to 40% of the East Asians and reported to be associated with acute myocardial infarction (AMI). To elucidate the mechanisms underlying the association of ALDH2*2 ...

journal_title：Journal of the American Heart Association

authors： Mizuno Y,Hokimoto S,Harada E,Kinoshita K,Nakagawa K,Yoshimura M,Ogawa H,Yasue H

更新日期：2016-05-06 00:00:00

abstract：BACKGROUND:Patients with heart failure with preserved ejection fraction (HFpEF) exhibit a range of cardiovascular phenotypic profiles modified by several common comorbidities. In particular, patients with HFpEF tend to be older; however, it is unclear whether the effects of cardiovascular aging per se modify the expres...

journal_title：Journal of the American Heart Association

authors： Nanayakkara S,Haykowsky M,Mariani J,Van Empel V,Maeder MT,Vizi D,Kaye DM

更新日期：2017-09-22 00:00:00

abstract：:Background The "healthy obese" hypothesis suggests the risks associated with excess adiposity are reduced in those with higher muscle quality (mass/strength). Alternative possibilities include loss of muscle quality as people become unwell (reverse causality) or unmeasured confounding. Methods and Results We conducted...

journal_title：Journal of the American Heart Association

authors： Farmer RE,Mathur R,Schmidt AF,Bhaskaran K,Fatemifar G,Eastwood SV,Finan C,Denaxas S,Smeeth L,Chaturvedi N

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:Short-term exposures to fine (<2.5 μm aerodynamic diameter) ambient particulate-matter (PM) have been related with increased blood pressure (BP) in controlled-human exposure and community-based studies. However, whether coarse (2.5 to 10 μm) PM exposure increases BP is uncertain. Recent observational studies...

journal_title：Journal of the American Heart Association

authors： Bellavia A,Urch B,Speck M,Brook RD,Scott JA,Albetti B,Behbod B,North M,Valeri L,Bertazzi PA,Silverman F,Gold D,Baccarelli AA

更新日期：2013-06-19 00:00:00

abstract：BACKGROUND:Recent trends of hospitalizations and in-hospital mortality are not well defined in sarcoidosis. We examined aforementioned trends and prevalence of cardiovascular manifestations and explored rates of implantable cardioverter-defibrillator implantation in hospitalizations with sarcoidosis. METHODS AND RESUL...

journal_title：Journal of the American Heart Association

authors： Patel N,Kalra R,Doshi R,Arora H,Bajaj NS,Arora G,Arora P

更新日期：2018-01-22 00:00:00

abstract：:Background Blood pressure ( BP ) varies over time within individual patients and across different BP measurement techniques. The effect of different BP targets on concordance between BP measurements is unknown. The goals of this analysis are to evaluate concordance between (1) clinic and ambulatory BP , (2) clinic vis...

journal_title：Journal of the American Heart Association

authors： Ghazi L,Pajewski NM,Rifkin DE,Bates JT,Chang TI,Cushman WC,Glasser SP,Haley WE,Johnson KC,Kostis WJ,Papademetriou V,Rahman M,Simmons DL,Taylor A,Whelton PK,Wright JT,Bhatt UY,Drawz PE

更新日期：2019-07-16 00:00:00

abstract：:Background Normal-flow, low-gradient severe aortic stenosis (NF-LG-SAS), defined by aortic valve area <1 cm2, mean gradient <40 mm Hg, and indexed stroke volume >35 mL/m2, is the most prevalent form of low-gradient aortic stenosis (AS). However, the true severity of AS and the management of NF-LG-SAS are controversial...

journal_title：Journal of the American Heart Association

authors： Chadha G,Bohbot Y,Rusinaru D,Maréchaux S,Tribouilloy C

更新日期：2019-10-01 00:00:00

abstract：:The coronavirus disease 2019 pandemic, caused by severe acute respiratory syndrome coronavirus-2, represents the third human affliction attributed to the highly pathogenic coronavirus in the current century. Because of its highly contagious nature and unprecedented global spread, its aggressive clinical presentation, ...

journal_title：Journal of the American Heart Association

authors： Patel V,Jimenez E,Cornwell L,Tran T,Paniagua D,Denktas AE,Chou A,Hankins SJ,Bozkurt B,Rosengart TK,Jneid H

更新日期：2020-07-07 00:00:00

abstract：:Background Circulating proteins are exposed to vascular endothelial layer and influence their functions. Among them, adipsin is a member of the trypsin family of peptidases and is mainly secreted from adipocytes, monocytes, and macrophages, catalyzing the rate-limiting step of the alternative complement pathway. Howev...

journal_title：Journal of the American Heart Association

authors： Ohtsuki T,Satoh K,Shimizu T,Ikeda S,Kikuchi N,Satoh T,Kurosawa R,Nogi M,Sunamura S,Yaoita N,Omura J,Aoki T,Tatebe S,Sugimura K,Takahashi J,Miyata S,Shimokawa H

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:Statin therapy reduces the risk of cardiovascular events in patients with obstructive coronary artery disease. The aim of the present study was to determine the effects of statins on the prognosis of patients with coronary vasospastic angina (VSA) free of significant atherosclerotic stenosis. METHODS AND RE...

journal_title：Journal of the American Heart Association

authors： Ishii M,Kaikita K,Sato K,Yamanaga K,Miyazaki T,Akasaka T,Tabata N,Arima Y,Sueta D,Sakamoto K,Yamamoto E,Tsujita K,Yamamuro M,Kojima S,Soejima H,Hokimoto S,Matsui K,Ogawa H

更新日期：2016-05-20 00:00:00

abstract：BACKGROUND:Contemporary rates of oral anticoagulant (OAC) therapy and associated outcomes among patients undergoing percutaneous coronary intervention (PCI) have been poorly described. METHODS AND RESULTS:Using data from an integrated health care system from 2009 to 2014, we identified patients on OACs within 30 days ...

journal_title：Journal of the American Heart Association

authors： Secemsky EA,Butala NM,Kartoun U,Mahmood S,Wasfy JH,Kennedy KF,Shaw SY,Yeh RW

更新日期：2016-10-17 00:00:00

abstract：BACKGROUND:The aim of this study was to elucidate the correlation between angiographic coronary vasomotor responses to intracoronary acetylcholine (ACh) injection, clinical features, and long-term prognosis in patients with vasospastic angina (VSA). METHODS AND RESULTS:This is a retrospective, observational, single-ce...

journal_title：Journal of the American Heart Association

authors： Sato K,Kaikita K,Nakayama N,Horio E,Yoshimura H,Ono T,Ohba K,Tsujita K,Kojima S,Tayama S,Hokimoto S,Matsui K,Sugiyama S,Yamabe H,Ogawa H

更新日期：2013-07-15 00:00:00

abstract：BACKGROUND:The scientific evidence base in support of population-wide salt reduction is strong, but current high-quality data about salt intake levels in India are mostly absent. This project sought to estimate daily salt consumption levels in selected communities of Delhi and Haryana in north India and Andhra Pradesh ...

journal_title：Journal of the American Heart Association

authors： Johnson C,Mohan S,Rogers K,Shivashankar R,Thout SR,Gupta P,He FJ,MacGregor GA,Webster J,Krishnan A,Maulik PK,Reddy KS,Prabhakaran D,Neal B

更新日期：2017-01-06 00:00:00

abstract：:Background Prevalence of peripheral artery disease ( PAD ) is significantly higher among blacks as compared with non-Hispanic whites, but the role of cigarette smoking in PAD is understudied in blacks. We aimed to evaluate the relationship between cigarette smoking and PAD in blacks in the (JHS) Jackson Heart Study. M...

journal_title：Journal of the American Heart Association

authors： Clark D 3rd,Cain LR,Blaha MJ,DeFilippis AP,Mentz RJ,Kamimura D,White WB,Butler KR,Robertson RM,Bhatnagar A,Butler J,Correa A,Benjamin EJ,Hall ME

更新日期：2019-02-05 00:00:00

abstract：BACKGROUND:Fatty acids constitute the critical components of cell structure and function, and dysregulation of fatty acid composition may exert diverging vascular effects including proliferation, migration, and differentiation of vascular smooth muscle cells (VSMCs). However, direct evidence for this hypothesis has bee...

journal_title：Journal of the American Heart Association

authors： Sunaga H,Matsui H,Anjo S,Syamsunarno MR,Koitabashi N,Iso T,Matsuzaka T,Shimano H,Yokoyama T,Kurabayashi M

更新日期：2016-11-23 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is a major risk factor for the development of chronic kidney disease. Nuclear factor-κB is a nuclear transcription factor activated post-ischemia, responsible for the transcription of proinflammatory proteins. The role of nuclear factor-κB in the renal fibrosis post-AKI is unknown. ...

journal_title：Journal of the American Heart Association

authors： Johnson FL,Patel NSA,Purvis GSD,Chiazza F,Chen J,Sordi R,Hache G,Merezhko VV,Collino M,Yaqoob MM,Thiemermann C

更新日期：2017-07-03 00:00:00

abstract：:Background Postpericardiotomy syndrome ( PPS ) is a common complication after cardiac surgery. However, large-scale epidemiological studies about the effect of procedure type on the occurrence of PPS and mortality of patients with PPS have not yet been performed. Methods and Results We studied the association of PPS o...

journal_title：Journal of the American Heart Association

authors： Lehto J,Kiviniemi T,Gunn J,Airaksinen J,Rautava P,Kytö V

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:Our previous randomized controlled trial demonstrated cardiorespiratory protection by remote ischemic preconditioning (RIPC) in children before cardiac surgery. However, the impact of RIPC on myocardial prosurvival intracellular signaling remains unknown in cyanosis. RIPC may augment phosphorylated protein s...

journal_title：Journal of the American Heart Association

authors： Pepe S,Liaw NY,Hepponstall M,Sheeran FL,Yong MS,d'Udekem Y,Cheung MM,Konstantinov IE

更新日期：2013-05-10 00:00:00

abstract：BACKGROUND:Obesity is closely associated with various cardiovascular diseases (CVDs). Adipose tissue inflammation and perturbation of adipokine secretion may contribute to the pathogenesis of CVD. This study aimed to evaluate whether the 2 most abundant adipokines, adipocyte-fatty acid binding protein (A-FABP) and adip...

journal_title：Journal of the American Heart Association

authors： Chow WS,Tso AW,Xu A,Yuen MM,Fong CH,Lam TH,Lo SV,Tse HF,Woo YC,Yeung CY,Cheung BM,Lam KS

更新日期：2013-01-15 00:00:00

abstract：BACKGROUND:Intracerebral hemorrhage (ICH) carries high risk for short-term mortality. We sought to identify race-specific predictors of mortality in ICH patients. METHODS AND RESULTS:We used 2 databases, the Johns Hopkins clinical stroke database and the Nationwide Inpatient Sample (NIS). We included 226 patients with...

journal_title：Journal of the American Heart Association

authors： Faigle R,Marsh EB,Llinas RH,Urrutia VC,Gottesman RF

更新日期：2016-08-16 00:00:00

abstract：BACKGROUND:The associations between high-sensitivity troponin I (hsTnI) levels and coronary artery disease (CAD) severity and progression remain unclear. We investigated whether there is an association between hsTnI and angiographic severity and progression of CAD and whether the predictive value of hsTnI level for inc...

journal_title：Journal of the American Heart Association

authors： Samman Tahhan A,Sandesara P,Hayek SS,Hammadah M,Alkhoder A,Kelli HM,Topel M,O'Neal WT,Ghasemzadeh N,Ko YA,Gafeer MM,Abdelhadi N,Choudhary F,Patel K,Beshiri A,Murtagh G,Kim J,Wilson P,Shaw L,Vaccarino V,Epstein SE

更新日期：2018-02-21 00:00:00

abstract：BACKGROUND:Bypass grafting remains the standard of care for coronary artery disease and severe lower extremity ischemia. Efficacy is limited by poor long-term venous graft patency secondary to intimal hyperplasia (IH) caused by venous injury upon exposure to arterial pressure. We investigate whether photochemical tissu...

journal_title：Journal of the American Heart Association

authors： Goldstone RN,McCormack MC,Khan SI,Salinas HM,Meppelink A,Randolph MA,Watkins MT,Redmond RW,Austen WG Jr

更新日期：2016-07-27 00:00:00

abstract：BACKGROUND:Whether heart rate upon discharge following hospitalization for heart failure is associated with long-term adverse outcomes and whether this association differs between patients with sinus rhythm (SR) and atrial fibrillation (AF) have not been well studied. METHODS AND RESULTS:We conducted a retrospective c...

journal_title：Journal of the American Heart Association

authors： Laskey WK,Alomari I,Cox M,Schulte PJ,Zhao X,Hernandez AF,Heidenreich PA,Eapen ZJ,Yancy C,Bhatt DL,Fonarow GC,AHA Get With The Guidelines®‐Heart Failure Program.

更新日期：2015-04-22 00:00:00

abstract：BACKGROUND:Neuregulin-1β (NRG-1β) is a growth factor critical for cardiac development and repair with therapeutic potential for heart failure. We previously showed that the glial growth factor 2 (GGF2) isoform of NRG-1β improves cardiac function in rodents after myocardial infarction (MI), but its efficacy in a large a...

journal_title：Journal of the American Heart Association

authors： Galindo CL,Kasasbeh E,Murphy A,Ryzhov S,Lenihan S,Ahmad FA,Williams P,Nunnally A,Adcock J,Song Y,Harrell FE,Tran TL,Parry TJ,Iaci J,Ganguly A,Feoktistov I,Stephenson MK,Caggiano AO,Sawyer DB,Cleator JH

更新日期：2014-10-23 00:00:00

abstract：:Background Pregnancy increases the risk of acute myocardial infarction (AMI). The purpose of this study was to examine timing and risk factors for AMI in pregnancy and poor outcome. Methods and Results National Inpatient Sample (2003-2015) was screened in pregnancy, labor and delivery, and postpartum. There were 11 29...

journal_title：Journal of the American Heart Association

authors： Balgobin CA,Zhang X,Lima FV,Avila C,Parikh PB,Yang J,Stergiopoulos K

更新日期：2020-11-03 00:00:00