Rac1 Modulates Endothelial Function and Platelet Aggregation in Diabetes Mellitus.

abstract：BACKGROUND:Postoperative thrombocytopenia has been reported to be correlated with adverse events, but the prognostic value of baseline thrombocytopenia is unclear. This study was undertaken to evaluate the relationship between preoperative thrombocytopenia and adverse outcomes in patients with rheumatic heart disease w...

journal_title：Journal of the American Heart Association

authors： Wei XB,Jiang L,Liu YH,Feng D,He PC,Chen JY,Tan N,Yu DQ

更新日期：2017-12-04 00:00:00

abstract：:Background The management of the cardiorenal syndrome in advanced heart failure is challenging, and the role of inotropic drugs has not been fully defined. Our aim was to compare the renal effects of levosimendan versus dobutamine in patients with heart failure and renal impairment. Methods and Results In a randomized...

journal_title：Journal of the American Heart Association

authors： Lannemyr L,Ricksten SE,Rundqvist B,Andersson B,Bartfay SE,Ljungman C,Dahlberg P,Bergh N,Hjalmarsson C,Gilljam T,Bollano E,Karason K

更新日期：2018-08-21 00:00:00

abstract：:Background Infants with critical congenital heart disease (CCHD) are more likely to be small for gestational age (SGA) or born to mothers with maternal placental syndrome. The objective of this study was to investigate the relationship between maternal placental syndrome, SGA, and gestational age (GA) on 1-year mortal...

journal_title：Journal of the American Heart Association

authors： Steurer MA,Peyvandi S,Baer RJ,Oltman SP,Chambers CD,Norton ME,Ryckman KK,Moon-Grady AJ,Keller RL,Shiboski SC,Jelliffe-Pawlowski LL

更新日期：2019-11-19 00:00:00

abstract：:Background Sepsis is the overwhelming host response to infection leading to shock and multiple organ dysfunction. Cardiovascular complications greatly increase sepsis-associated mortality. Although murine models are routinely used for preclinical studies, the benefit of using genetically engineered mice in sepsis is c...

journal_title：Journal of the American Heart Association

authors： Hoffman M,Kyriazis ID,Lucchese AM,de Lucia C,Piedepalumbo M,Bauer M,Schulze PC,Bonios MJ,Koch WJ,Drosatos K

更新日期：2019-05-21 00:00:00

abstract：:Background Patients with a Fontan circulation achieve lower peak heart rates ( HR ) during exercise. Whether this impaired chronotropic response reflects pathology of the sinoatrial node or is a consequence of altered cardiac hemodynamics is uncertain. We evaluated the adequacy of HR acceleration throughout exercise r...

journal_title：Journal of the American Heart Association

authors： Claessen G,La Gerche A,Van De Bruaene A,Claeys M,Willems R,Dymarkowski S,Bogaert J,Claus P,Budts W,Heidbuchel H,Gewillig M

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Increasing evidence has suggested that major depression (MD) is associated with an increased risk of ischemic heart disease (IHD). We examined this association in Chinese adults using data from the China Kadoorie Biobank study. METHODS AND RESULTS:Over 0.5 million adults aged 30 to 79 years were followed fr...

journal_title：Journal of the American Heart Association

authors： Liu N,Pan XF,Yu C,Lv J,Guo Y,Bian Z,Yang L,Chen Y,Wu T,Chen Z,Pan A,Li L,China Kadoorie Biobank Collaborative Group.

更新日期：2016-12-21 00:00:00

abstract：:Background Increased vagal modulation is a mechanism that may partially explain the protective effect of healthy lifestyles. However, it is unclear how healthy lifestyles relate to vagal regulation longitudinally. We prospectively examined associations between a comprehensive measure of 4 important lifestyle factors a...

journal_title：Journal of the American Heart Association

authors： Jandackova VK,Scholes S,Britton A,Steptoe A

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Multiple studies have shown that an NO-induced activation of vascular smooth muscle BK channels contributes to the NO-evoked dilation in many blood vessels. In vivo, NO is released continuously. NO attenuates vessel constrictions and, therefore, exerts an anticontractile effect. It is unknown whether the ant...

journal_title：Journal of the American Heart Association

authors： Schmid J,Müller B,Heppeler D,Gaynullina D,Kassmann M,Gagov H,Mladenov M,Gollasch M,Schubert R

更新日期：2018-03-24 00:00:00

abstract：:Background Limited data are available on mid-range ejection fraction (mrEF) patients with dilated cardiomyopathy. We sought to define the characteristics, evolution, and long-term prognosis of dilated cardiomyopathy patients with mrEF at diagnosis. Methods and Results We analyzed all dilated cardiomyopathy patients co...

journal_title：Journal of the American Heart Association

authors： Gentile P,Merlo M,Cannatà A,Gobbo M,Artico J,Stolfo D,Gigli M,Ramani F,Barbati G,Pinamonti B,Sinagra G

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:The ventricular fibrillation amplitude spectral area (AMSA) predicts whether an electrical shock could terminate ventricular fibrillation and prompt return of spontaneous circulation. We hypothesized that AMSA can guide more precise timing for effective shock delivery during cardiopulmonary resuscitation. M...

journal_title：Journal of the American Heart Association

authors： Aiello S,Perez M,Cogan C,Baetiong A,Miller SA,Radhakrishnan J,Kaufman CL,Gazmuri RJ

更新日期：2017-11-04 00:00:00

abstract：:Background Myocarditis attributable to immune checkpoint inhibitor (ICI) therapy is a potentially fatal immune-related adverse event. Limited data have suggested an association between baseline and on-treatment absolute lymphocyte count (ALC) and neutrophil/lymphocyte ratio (NLR) and the development of other immune-re...

journal_title：Journal of the American Heart Association

authors： Drobni ZD,Zafar A,Zubiri L,Zlotoff DA,Alvi RM,Lee C,Hartmann S,Gilman HK,Villani AC,Nohria A,Groarke JD,Sullivan RJ,Reynolds KL,Zhang L,Neilan TG

更新日期：2020-12-01 00:00:00

abstract：:Background The objectives of the present study were (1) to evaluate the echocardiographic prognostic factors associated with improved left ventricular (LV) systolic function after aortic valve replacement, and (2) to compare the long-term outcomes after aortic valve replacement in chronic aortic regurgitation (AR) pat...

journal_title：Journal of the American Heart Association

authors： Kim MS,Kim JH,Joo HC,Lee S,Youn YN,Lee SH

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:Neuregulin-1β (NRG-1β) is a growth factor critical for cardiac development and repair with therapeutic potential for heart failure. We previously showed that the glial growth factor 2 (GGF2) isoform of NRG-1β improves cardiac function in rodents after myocardial infarction (MI), but its efficacy in a large a...

journal_title：Journal of the American Heart Association

authors： Galindo CL,Kasasbeh E,Murphy A,Ryzhov S,Lenihan S,Ahmad FA,Williams P,Nunnally A,Adcock J,Song Y,Harrell FE,Tran TL,Parry TJ,Iaci J,Ganguly A,Feoktistov I,Stephenson MK,Caggiano AO,Sawyer DB,Cleator JH

更新日期：2014-10-23 00:00:00

abstract：BACKGROUND:There are few data relating novel measures of left ventricular (LV) mechanical function to cardiovascular disease (CVD) outcomes in the community. Whether distinct components of LV mechanical function provide information regarding risk for different CVD outcomes is unclear. METHODS AND RESULTS:We used speck...

journal_title：Journal of the American Heart Association

authors： Cheng S,McCabe EL,Larson MG,Merz AA,Osypiuk E,Lehman BT,Stantchev P,Aragam J,Solomon SD,Benjamin EJ,Vasan RS

更新日期：2015-10-27 00:00:00

abstract：BACKGROUND:Excess accumulation of abdominal subcutaneous (SAT) and visceral adipose tissue (VAT) is associated with adverse levels of adipokines and cardiovascular disease risk. Whether fat quality is associated with adipokines has not been firmly established. This study examined the association between abdominal SAT a...

journal_title：Journal of the American Heart Association

authors： Lee JJ,Pedley A,Hoffmann U,Massaro JM,Keaney JF Jr,Vasan RS,Fox CS

更新日期：2016-02-29 00:00:00

abstract：BACKGROUND:Microvascular injury (MVI) after primary percutaneous coronary intervention for ST-elevation myocardial infarction (STEMI) is a major determinant of adverse clinical outcome. Experimental data indicate an impact of hypercholesterolemia on MVI; however, there is a lack of clinical studies confirming this rela...

journal_title：Journal of the American Heart Association

authors： Reindl M,Reinstadler SJ,Feistritzer HJ,Theurl M,Basic D,Eigler C,Holzknecht M,Mair J,Mayr A,Klug G,Metzler B

更新日期：2017-10-10 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging of carotid plaque can aid in stroke risk stratification in patients with carotid stenosis. However, the prevalence of complicated carotid plaque in patients with cryptogenic stroke is uncertain, especially as assessed by plaque imaging techniques routinely included in acute stroke ...

journal_title：Journal of the American Heart Association

authors： Gupta A,Gialdini G,Lerario MP,Baradaran H,Giambrone A,Navi BB,Marshall RS,Iadecola C,Kamel H

更新日期：2015-06-15 00:00:00

abstract：BACKGROUND:Although automated external defibrillators (AEDs) have contributed to a better survival of out-of-hospital cardiac arrests, there have been reports of their malfunctioning. We investigated the diagnostic accuracy of commercially available AEDs using surface ECGs of ventricular fibrillation (VF), ventricular ...

journal_title：Journal of the American Heart Association

authors： Nishiyama T,Nishiyama A,Negishi M,Kashimura S,Katsumata Y,Kimura T,Nishiyama N,Tanimoto Y,Aizawa Y,Mitamura H,Fukuda K,Takatsuki S

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Cardiovascular clinical trials depend on patient enrollment. Enrollment rates appear inadequate, but little is known about how frequently patients accept or decline offers of enrollment. The objective of this study was to assess trends and predictors of patient acceptance of offers to enroll in clinical tria...

journal_title：Journal of the American Heart Association

authors： Kerkhoff LA,Butler J,Kelkar AA,Shore S,Speight CD,Wall LK,Dickert NW

更新日期：2016-06-17 00:00:00

abstract：:Background Genetic testing in pediatric primary dilated cardiomyopathy (DCM) patients has identified numerous disease-causing variants, but few studies have evaluated genetic testing outcomes in this population in the context of patient and familial clinical data or assessed the clinical implications of temporal chang...

journal_title：Journal of the American Heart Association

authors： Quiat D,Witkowski L,Zouk H,Daly KP,Roberts AE

更新日期：2020-06-02 00:00:00

abstract：BACKGROUND:The impact of the 2013 American College of Cardiology/American Heart Association cholesterol guidelines on statin eligibility in individuals otherwise destined to experience cardiovascular disease (CVD) events is unclear. METHODS AND RESULTS:We analyzed a prospective cohort of consecutive ST-segment elevati...

journal_title：Journal of the American Heart Association

authors： Miedema MD,Garberich RF,Schnaidt LJ,Peterson E,Strauss C,Sharkey S,Knickelbine T,Newell MC,Henry TD

更新日期：2017-04-12 00:00:00

abstract：BACKGROUND:Workforce experts predict a future shortage of cardiologists that is expected to impact rural areas more severely than urban areas. However, there is little research on how rural patients are currently served through clinical outreach. This study examines the impact of cardiology outreach in Iowa, a state wi...

journal_title：Journal of the American Heart Association

authors： Gruca TS,Pyo TH,Nelson GC

更新日期：2016-06-30 00:00:00

abstract：:Background Sex differences in the management of cardiovascular disease have been reported in secondary care. We conducted a systematic review with meta-analysis of systematically investigated sex differences in cardiovascular medication prescription among patients at high risk or with established cardiovascular diseas...

journal_title：Journal of the American Heart Association

authors： Zhao M,Woodward M,Vaartjes I,Millett ERC,Klipstein-Grobusch K,Hyun K,Carcel C,Peters SAE

更新日期：2020-06-02 00:00:00

abstract：:Background A previous study reported histologic abnormalities in the pulmonary artery ( PA ) of patients with tetralogy of Fallot ( TOF ). However, the potential effect of these anatomical findings on PA vascular function has not been studied. We hypothesized that TOF patients had abnormal PA vascular function, and th...

journal_title：Journal of the American Heart Association

authors： Egbe AC,Anavekar NS,Connolly HM

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:A high consumption of omega-3 long-chain polyunsaturated fatty acids, and particularly docosahexaenoic acid (DHA), has been suggested to reduce the risk of cardiovascular disease (CVD). However, while DHA supplementation may have benefits for secondary prevention, few studies have investigated the role of DH...

journal_title：Journal of the American Heart Association

authors： Singhal A,Lanigan J,Storry C,Low S,Birbara T,Lucas A,Deanfield J

更新日期：2013-07-01 00:00:00

abstract：:Background Higher fibroblast growth factor-23 ( FGF -23) levels are associated with incident heart failure ( HF ) in MESA (the Multiethnic Study of Atherosclerosis). FGF -23 is also associated with left ventricular hypertrophy. Whether the FGF -23 association with HF is similar for heart failure with reduced ejection ...

journal_title：Journal of the American Heart Association

authors： Almahmoud MF,Soliman EZ,Bertoni AG,Kestenbaum B,Katz R,Lima JAC,Ouyang P,Miller PE,Michos ED,Herrington DM

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:Epinephrine administered during cardiopulmonary resuscitation (CPR) is associated with severe post-resuscitation myocardial dysfunction. We previously demonstrated that therapeutic hypothermia reduced the severity of post-resuscitation myocardial dysfunction caused by epinephrine; however, the relationship b...

journal_title：Journal of the American Heart Association

authors： Wang W,Hua T,Li H,Wu X,Bradley J,Peberdy MA,Ornato JP,Tang W

更新日期：2018-03-23 00:00:00

abstract：BACKGROUND:Peripheral arterial disease (PAD) shares several risk factors with atrial fibrillation (AF), and persons with PAD have an increased risk of stroke. It is unclear if PAD is associated with an increased risk for AF and whether this potential association explains the increased risk of stroke observed in those w...

journal_title：Journal of the American Heart Association

authors： O'Neal WT,Efird JT,Nazarian S,Alonso A,Heckbert SR,Soliman EZ

更新日期：2014-11-17 00:00:00

abstract：BACKGROUND:The 4-variable risk score from University of California, Los Angeles (UCLA) demonstrated superior discrimination in advanced heart failure, compared to established risk scores. However, the model has not been externally validated, and its suitability as a selection tool for heart transplantation (HT) and lef...

journal_title：Journal of the American Heart Association

authors： Sartipy U,Goda A,Mancini DM,Lund LH

更新日期：2014-06-06 00:00:00

abstract：:Background The interrelationships among the different stages of impaired glucose metabolism, insulin resistance, and hypertension are not fully understood. Methods and Results We investigated the impact of insulin resistance, plasma glucose, and serum immunoreactive insulin levels on hypertension in 19 166 participant...

journal_title：Journal of the American Heart Association

authors： Sasaki N,Ozono R,Higashi Y,Maeda R,Kihara Y

更新日期：2020-04-07 00:00:00