Trends in Consent for Clinical Trials in Cardiovascular Disease.

abstract：BACKGROUND:In 2013 the Minnesota Resuscitation Consortium developed an organized approach for the management of patients resuscitated from shockable rhythms to gain early access to the cardiac catheterization laboratory (CCL) in the metro area of Minneapolis-St. Paul. METHODS AND RESULTS:Eleven hospitals with 24/7 per...

journal_title：Journal of the American Heart Association

authors： Garcia S,Drexel T,Bekwelem W,Raveendran G,Caldwell E,Hodgson L,Wang Q,Adabag S,Mahoney B,Frascone R,Helmer G,Lick C,Conterato M,Baran K,Bart B,Bachour F,Roh S,Panetta C,Stark R,Haugland M,Mooney M,Wesley K,Yan

更新日期：2016-01-07 00:00:00

abstract：BACKGROUND:Treatment decisions for aortic valve replacement (AVR) should be sensitive to patient preferences. However, we lack knowledge of patient preferences and how to obtain them. METHODS AND RESULTS:We assessed the mortality risk patients were willing to accept when undergoing AVR by using the Standard Gamble met...

journal_title：Journal of the American Heart Association

authors： Hussain AI,Garratt AM,Brunborg C,Aakhus S,Gullestad L,Pettersen KI

更新日期：2016-03-18 00:00:00

abstract：BACKGROUND:The 4-variable risk score from University of California, Los Angeles (UCLA) demonstrated superior discrimination in advanced heart failure, compared to established risk scores. However, the model has not been externally validated, and its suitability as a selection tool for heart transplantation (HT) and lef...

journal_title：Journal of the American Heart Association

authors： Sartipy U,Goda A,Mancini DM,Lund LH

更新日期：2014-06-06 00:00:00

abstract：BACKGROUND:The postnatal development of myofibrillar mechanics, a major determinant of heart function, is unknown in pediatric patients with tetralogy of Fallot and related structural heart defects. We therefore determined the mechanical properties of myofibrils isolated from right ventricular tissue samples from such ...

journal_title：Journal of the American Heart Association

authors： Elhamine F,Iorga B,Krüger M,Hunger M,Eckhardt J,Sreeram N,Bennink G,Brockmeier K,Pfitzer G,Stehle R

更新日期：2016-06-27 00:00:00

abstract：:Background Stroke and thromboembolic events may still occur in "clinically low-risk" atrial fibrillation (AF) patients as categorized by CHA2DS2-VASc score. Our aim was to assess the proportion of "clinically low-risk" patients using a nongender CHA2DS2-VASc (ie, CHA2DS2-VA) score of 0 to 1 among patients who experien...

journal_title：Journal of the American Heart Association

authors： Shin SY,Han SJ,Kim JS,Im SI,Shim J,Ahn J,Lee EM,Park YM,Kim JH,Lip GYH,Lim HE

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:A cohort study found that 9/11-related environmental exposures and posttraumatic stress disorder increased self-reported cardiovascular disease risk. We attempted to replicate these findings using objectively defined cardiovascular disease hospitalizations in the same cohort. METHODS AND RESULTS:Data for ad...

journal_title：Journal of the American Heart Association

authors： Jordan HT,Stellman SD,Morabia A,Miller-Archie SA,Alper H,Laskaris Z,Brackbill RM,Cone JE

更新日期：2013-10-24 00:00:00

abstract：:Background Normal-flow, low-gradient severe aortic stenosis (NF-LG-SAS), defined by aortic valve area <1 cm2, mean gradient <40 mm Hg, and indexed stroke volume >35 mL/m2, is the most prevalent form of low-gradient aortic stenosis (AS). However, the true severity of AS and the management of NF-LG-SAS are controversial...

journal_title：Journal of the American Heart Association

authors： Chadha G,Bohbot Y,Rusinaru D,Maréchaux S,Tribouilloy C

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:In-stent hyperplasia (ISH) may develop in regions of low endothelial shear stress (ESS), but the relationship between the magnitude of low ESS, the extent of ISH, and subsequent clinical events has not been investigated. METHODS AND RESULTS:We assessed the association of poststent ESS with neointimal ISH an...

journal_title：Journal of the American Heart Association

authors： Shishido K,Antoniadis AP,Takahashi S,Tsuda M,Mizuno S,Andreou I,Papafaklis MI,Coskun AU,O'Brien C,Feldman CL,Saito S,Edelman ER,Stone PH

更新日期：2016-09-14 00:00:00

abstract：BACKGROUND:Transcatheter pulmonary valve implantation is approved for the treatment of dysfunctional right ventricle to pulmonary artery conduits. However, the literature is limited because of a small patient population, and it does not reflect changing procedural practice patterns over the last decade. METHODS AND RE...

journal_title：Journal of the American Heart Association

authors： Chatterjee A,Bajaj NS,McMahon WS,Cribbs MG,White JS,Mukherjee A,Law MA

更新日期：2017-08-04 00:00:00

abstract：:Background Although PAR-1 (protease-activated receptor-1) exerts important functions in the pathophysiology of the cardiovascular system, the role of PAR-1 signaling in heart failure development remains largely unknown. We tested the hypothesis that PAR-1 signaling inhibition has protective effects on the progression ...

journal_title：Journal of the American Heart Association

authors： Yokono Y,Hanada K,Narita M,Tatara Y,Kawamura Y,Miura N,Kitayama K,Nakata M,Nozaka M,Kato T,Kudo N,Tsushima M,Toyama Y,Itoh K,Tomita H

更新日期：2020-06-16 00:00:00

abstract：:Background Aging is associated with a modest decline in ankle-brachial index (ABI); however, the underpinnings of this decline are not fully understood. The greater systolic ankle than brachial blood pressure, a normal ABI implies, is partially attributed to lower central than peripheral arterial stiffness. Hence, we ...

journal_title：Journal of the American Heart Association

authors： Oberdier MT,Morrell CH,Lakatta EG,Ferrucci L,AlGhatrif M

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:Levels of LDL (low-density lipoprotein) cholesterol in the population are declining, and increasing attention is being focused on residual lipid-related pathways of atherosclerotic cardiovascular disease risk beyond LDL cholesterol. Among individuals with low (<130 mg/dL) LDL cholesterol, we undertook detail...

journal_title：Journal of the American Heart Association

authors： Lawler PR,Akinkuolie AO,Chu AY,Shah SH,Kraus WE,Craig D,Padmanabhan L,Glynn RJ,Ridker PM,Chasman DI,Mora S

更新日期：2017-07-21 00:00:00

abstract：BACKGROUND:Coronary heart disease and peripheral arterial disease (PAD) affect different vascular territories. Supplementing baseline findings with assays from stored serum, we compared their 20-year predictors. METHODS AND RESULTS:We randomly recruited 15 737 disease-free men and women aged 30 to 75 years across Scot...

journal_title：Journal of the American Heart Association

authors： Tunstall-Pedoe H,Peters SAE,Woodward M,Struthers AD,Belch JJF

更新日期：2017-09-18 00:00:00

abstract：BACKGROUND:Tissue Doppler index E/e' is used clinically and in multidisciplinary research for estimation of left ventricular filling pressure (LVFP) and diastolic dysfunction (DD)/heart failure with preserved ejection fraction (HFpEF). Its diagnostic accuracy is not well studied. METHODS AND RESULTS:From the PubMed, S...

journal_title：Journal of the American Heart Association

authors： Sharifov OF,Schiros CG,Aban I,Denney TS,Gupta H

更新日期：2016-01-25 00:00:00

abstract：:Background Patients presenting to hospitals during non-weekday hours experience worse outcomes, often attributed to reduced staffing. The American Heart Association International Stroke Conference ( ISC ) is well attended by stroke clinicians. We sought to determine whether patients with acute ischemic stroke ( AIS ) ...

journal_title：Journal of the American Heart Association

authors： Messé SR,Mullen MT,Cox M,Fonarow GC,Smith EE,Saver JL,Reeves MJ,Bhatt DL,Matsouaka R,Schwamm LH

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Hospital procedures have been associated with cognitive change in older patients. This study aimed to document the prevalence of mild cognitive impairment in individuals undergoing left heart catheterization (LHC) before the procedure and the incidence of cognitive decline to 3 months afterwards. METHODS AN...

journal_title：Journal of the American Heart Association

authors： Scott DA,Evered L,Maruff P,MacIsaac A,Maher S,Silbert BS

更新日期：2018-03-10 00:00:00

abstract：:Background Accurate assessments of sodium intake in children are important for the early prevention of cardiovascular disease. There is currently no accurate simple and feasible sodium intake approach for children. This study intends to validate the accuracy of 24-hour urinary sodium excretion (UNaV) estimation in chi...

journal_title：Journal of the American Heart Association

authors： Peng Y,Zhang Y,Li K,Liu L,Zhang S,Peng X

更新日期：2020-01-07 00:00:00

abstract：:Background Quantitative flow ratio ( QFR ) has a high diagnostic accuracy in assessing functional stenoses relevance, as judged by fractional flow reserve ( FFR ). However, its diagnostic performance has not been thoroughly evaluated using instantaneous wave-free ratio ( iFR ) or coronary flow reserve as the reference...

journal_title：Journal of the American Heart Association

authors： Hwang D,Choi KH,Lee JM,Mejía-Rentería H,Kim J,Park J,Rhee TM,Jeon KH,Lee HJ,Kim HK,Park TK,Yang JH,Song YB,Shin ES,Nam CW,Kwak JJ,Doh JH,Hahn JY,Choi JH,Choi SH,Escaned J,Koo BK,Gwon HC

更新日期：2019-04-16 00:00:00

abstract：:Background Systemic innate immune priming is a recognized sequela of post-ischemic neuroinflammation and contributor to delayed neurodegeneration. Given mounting evidence linking acute stroke with reactive lung inflammation, we asked whether enhanced expression of the endogenous antioxidant extracellular superoxide di...

journal_title：Journal of the American Heart Association

authors： Mai N,Miller-Rhodes K,Prifti V,Kim M,O'Reilly MA,Halterman MW

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Fatty acids constitute the critical components of cell structure and function, and dysregulation of fatty acid composition may exert diverging vascular effects including proliferation, migration, and differentiation of vascular smooth muscle cells (VSMCs). However, direct evidence for this hypothesis has bee...

journal_title：Journal of the American Heart Association

authors： Sunaga H,Matsui H,Anjo S,Syamsunarno MR,Koitabashi N,Iso T,Matsuzaka T,Shimano H,Yokoyama T,Kurabayashi M

更新日期：2016-11-23 00:00:00

abstract：BACKGROUND:There is increasing evidence implicating atrial mitochondrial dysfunction in the pathogenesis of atrial fibrillation. In this study, we explored whether alogliptin, a dipeptidyl peptidase-4 inhibitor, can prevent mitochondrial dysfunction and atrial remodeling in a diabetic rabbit model. METHODS AND RESULTS...

journal_title：Journal of the American Heart Association

authors： Zhang X,Zhang Z,Zhao Y,Jiang N,Qiu J,Yang Y,Li J,Liang X,Wang X,Tse G,Li G,Liu T

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND:The increased adverse cardiac events in women undergoing coronary artery bypass grafting are multifactorial and may include clinical, psychosocial, and biological factors. Potential contributing biological factors could include vascular hyperreactivity of the internal mammary artery (IMA) to endogenous vasoc...

journal_title：Journal of the American Heart Association

authors： Lamin V,Jaghoori A,Jakobczak R,Stafford I,Heresztyn T,Worthington M,Edwards J,Viana F,Stuklis R,Wilson DP,Beltrame JF

更新日期：2018-07-09 00:00:00

abstract：:Background We aimed to determine the change in treatment strategies and times to treatment over the first 5 years of the Mission: Lifeline program. Methods and Results We assessed pre- and in-hospital care and outcomes from 2008 to 2012 for patients with ST -segment-elevation myocardial infarction at US hospitals, usi...

journal_title：Journal of the American Heart Association

authors： Granger CB,Bates ER,Jollis JG,Antman EM,Nichol G,O'Connor RE,Gregory T,Roettig ML,Peng SA,Ellrodt G,Henry TD,French WJ,Jacobs AK

更新日期：2019-01-08 00:00:00

abstract：:Background Among people with lower extremity peripheral artery disease, obesity is associated with faster functional decline than normal weight. The association of weight loss with functional decline in peripheral artery disease is unknown. Methods and Results Adults with an ankle-brachial index <0.90 were identified ...

journal_title：Journal of the American Heart Association

authors： Polonsky TS,Tian L,Zhang D,Bazzano LA,Criqui MH,Ferrucci L,Guralnik JM,Kibbe MR,Leeuwenburgh C,Sufit RL,McDermott MM

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:Genome-wide association studies identified ADAMTS7 as a risk locus for coronary artery disease (CAD). Functional studies suggest that ADAMTS7 may promote cellular processes in atherosclerosis. We sought to examine the association between genetic variation at ADAMTS7 and measures of atherosclerosis using hist...

journal_title：Journal of the American Heart Association

authors： Chan K,Pu X,Sandesara P,Poston RN,Simpson IA,Quyyumi AA,Ye S,Patel RS

更新日期：2017-10-31 00:00:00

abstract：BACKGROUND:Perioperative antiplatelet agents potentially increase bleeding after non-ST-segment elevation (NSTE) acute coronary syndromes (ACS). The protease-activated receptor 1 antagonist vorapaxar reduced cardiovascular events and was associated with increased bleeding versus placebo in NSTE ACS, but its efficacy an...

journal_title：Journal of the American Heart Association

authors： van Diepen S,Tricoci P,Podder M,Westerhout CM,Aylward PE,Held C,Van de Werf F,Strony J,Wallentin L,Moliterno DJ,White HD,Mahaffey KW,Harrington RA,Armstrong PW

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:This study aimed to determine the relationship of statin therapy and cardiovascular risk factors to changes in atherosclerosis in the carotid artery. METHODS AND RESULTS:Carotid magnetic resonance imaging was used to evaluate 106 hyperlipidemic participants at baseline and after 12 months of 3-hydroxy-3-met...

journal_title：Journal of the American Heart Association

authors： Sandfort V,Lai S,Ahlman MA,Mallek M,Liu S,Sibley CT,Turkbey EB,Lima JA,Bluemke DA

更新日期：2016-07-13 00:00:00

abstract：BACKGROUND:Sleep disordered breathing in children is associated with increased blood flow velocity and sympathetic overactivity. Sympathetic overactivity results in peripheral vasoconstriction and reduced systemic vascular compliance, which increases blood flow velocity during systole. Augmented blood flow velocity is ...

journal_title：Journal of the American Heart Association

authors： Kontos A,Lushington K,Martin J,Schwarz Q,Green R,Wabnitz D,Xu X,M Sokoya E,Willoughby S,Baumert M,Ferrante A,La Forgia M,Kennedy D

更新日期：2017-07-17 00:00:00

abstract：:Background The management of the cardiorenal syndrome in advanced heart failure is challenging, and the role of inotropic drugs has not been fully defined. Our aim was to compare the renal effects of levosimendan versus dobutamine in patients with heart failure and renal impairment. Methods and Results In a randomized...

journal_title：Journal of the American Heart Association

authors： Lannemyr L,Ricksten SE,Rundqvist B,Andersson B,Bartfay SE,Ljungman C,Dahlberg P,Bergh N,Hjalmarsson C,Gilljam T,Bollano E,Karason K

更新日期：2018-08-21 00:00:00

abstract：BACKGROUND:Diabetes is associated with coronary arteriolar endothelial dysfunction. We investigated the role of the small/intermediate (SK(Ca)/IK(Ca)) conductance of calcium-activated potassium channels in diabetes-related endothelial dysfunction. METHODS AND RESULTS:Coronary arterioles (80 to 150 μm in diameter) were...

journal_title：Journal of the American Heart Association

authors： Liu Y,Xie A,Singh AK,Ehsan A,Choudhary G,Dudley S,Sellke FW,Feng J

更新日期：2015-08-24 00:00:00