Obesity Is Associated With Progression of Atherosclerosis During Statin Treatment.

abstract：BACKGROUND:Acute kidney injury (AKI) following primary percutaneous coronary intervention (pPCI) is frequently interpreted as contrast-induced AKI but may result from other insults. We aimed to determine the causal association of contrast material exposure and the incidence of AKI following pPCI using a control group o...

journal_title：Journal of the American Heart Association

authors： Caspi O,Habib M,Cohen Y,Kerner A,Roguin A,Abergel E,Boulos M,Kapeliovich MR,Beyar R,Nikolsky E,Aronson D

更新日期：2017-06-24 00:00:00

abstract：BACKGROUND:Coronary heart disease and peripheral arterial disease (PAD) affect different vascular territories. Supplementing baseline findings with assays from stored serum, we compared their 20-year predictors. METHODS AND RESULTS:We randomly recruited 15 737 disease-free men and women aged 30 to 75 years across Scot...

journal_title：Journal of the American Heart Association

authors： Tunstall-Pedoe H,Peters SAE,Woodward M,Struthers AD,Belch JJF

更新日期：2017-09-18 00:00:00

abstract：BACKGROUND:Perioperative antiplatelet agents potentially increase bleeding after non-ST-segment elevation (NSTE) acute coronary syndromes (ACS). The protease-activated receptor 1 antagonist vorapaxar reduced cardiovascular events and was associated with increased bleeding versus placebo in NSTE ACS, but its efficacy an...

journal_title：Journal of the American Heart Association

authors： van Diepen S,Tricoci P,Podder M,Westerhout CM,Aylward PE,Held C,Van de Werf F,Strony J,Wallentin L,Moliterno DJ,White HD,Mahaffey KW,Harrington RA,Armstrong PW

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:Diabetes is associated with coronary arteriolar endothelial dysfunction. We investigated the role of the small/intermediate (SK(Ca)/IK(Ca)) conductance of calcium-activated potassium channels in diabetes-related endothelial dysfunction. METHODS AND RESULTS:Coronary arterioles (80 to 150 μm in diameter) were...

journal_title：Journal of the American Heart Association

authors： Liu Y,Xie A,Singh AK,Ehsan A,Choudhary G,Dudley S,Sellke FW,Feng J

更新日期：2015-08-24 00:00:00

abstract：BACKGROUND:Previous studies have suggested that n-3 polyunsaturated fatty acids (n-3 PUFAs) have antiarrhythmic effects on atrial fibrillation (AF). We aimed to assess the effects of therapy with n-3 PUFAs on the incidence of recurrent AF and on postoperative AF. METHODS AND RESULTS:Electronic searches were conducted ...

journal_title：Journal of the American Heart Association

authors： Mariani J,Doval HC,Nul D,Varini S,Grancelli H,Ferrante D,Tognoni G,Macchia A

更新日期：2013-02-19 00:00:00

abstract：:Background Left ventricular assist devices (LVADs) generate electromagnetic interference that causes high-frequency noise artifacts on 12-lead ECGs. We describe the causes of this interference and potential solutions to aid ECG interpretation in patients with LVAD. Methods and Results Waveform data from ECGs performed...

journal_title：Journal of the American Heart Association

authors： Loring Z,Sen S,Black-Maier E,Atwater BD,Russell SD,DeVore AD,Piccini JP

更新日期：2020-08-18 00:00:00

abstract：:Background Soluble urokinase plasminogen activator receptor (su PAR ) is a proinflammatory biomarker associated with immune activation and fibrinolysis inhibition. Plasminogen activator inhibitor ( PAI -1) is associated with excessive fibrin accumulation, thrombus formation, and atherosclerosis. The relationship betwe...

journal_title：Journal of the American Heart Association

authors： Corban MT,Prasad A,Nesbitt L,Loeffler D,Herrmann J,Lerman LO,Lerman A

更新日期：2018-08-07 00:00:00

abstract：BACKGROUND:Relevant clinical studies have been small and have not convincingly demonstrated whether the perioperative initiation of beta-blockers should be considered in patients with diabetes mellitus undergoing noncardiac surgery. METHODS AND RESULTS:In this nationwide propensity score-matched study, we included pat...

journal_title：Journal of the American Heart Association

authors： Chen RJ,Chu H,Tsai LW

更新日期：2017-01-10 00:00:00

abstract：:Background Acute type A aortic dissection presents with abrupt onset of pain that requires emergency surgery. However, minimal research exists on posttraumatic stress disorder (PTSD) in survivors. We aimed to quantify the prevalence and describe characteristics of PTSD in patients following dissection. Methods and Res...

journal_title：Journal of the American Heart Association

authors： Pasadyn SR,Roselli EE,Artis AS,Pasadyn CL,Phelan D,Hurley K,Desai MY,Blackstone EH

更新日期：2020-05-05 00:00:00

abstract：:Background Data on race- and ethnicity-based disparities in the utilization and outcomes of structural heart disease interventions in the United States are scarce. Methods and Results We used the National Inpatient Sample (2011-2016) to examine racial and ethnic differences in the utilization, in-hospital outcomes, an...

journal_title：Journal of the American Heart Association

authors： Alkhouli M,Alqahtani F,Holmes DR,Berzingi C

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:Extracellular fluid (ECF) excess is an independent predictor of cardiovascular morbidity in patients undergoing dialysis. This study aimed to investigate the relationship between ECF status, which is affected by renal function, and coronary artery calcification (CAC), which is a marker of cardiovascular dise...

journal_title：Journal of the American Heart Association

authors： Park S,Lee CJ,Jhee JH,Yun HR,Kim H,Jung SY,Kee YK,Yoon CY,Park JT,Kim HC,Han SH,Kang SW,Park S,Yoo TH

更新日期：2018-06-30 00:00:00

abstract：:Background The overall goal of this longitudinal study was to determine if the Black population has decreased myocardial function, which has the potential to lead to the early development of congestive heart failure, compared with the White population. Methods and Results A total of 673 subjects were evaluated over a ...

journal_title：Journal of the American Heart Association

authors： Kapuku G,Howie M,Ghosh S,Doshi V,Bykhovsky M,Ange B,Halbert JD,Robinson V,Bagi Z,Harshfield G,George V

更新日期：2021-01-18 00:00:00

abstract：BACKGROUND:DPP4 (Dipeptidyl peptidase-4)-GLP-1 (glucagon-like peptide-1) and its receptor (GLP-1R) axis has been involved in several intracellular signaling pathways. The Adrβ3 (β3-adrenergic receptor)/CXCL12 (C-X-C motif chemokine 12) signal was required for the hematopoiesis. We investigated the novel molecular requi...

journal_title：Journal of the American Heart Association

authors： Zhu E,Hu L,Wu H,Piao L,Zhao G,Inoue A,Kim W,Yu C,Xu W,Bando YK,Li X,Lei Y,Hao CN,Takeshita K,Kim WS,Okumura K,Murohara T,Kuzuya M,Cheng XW

更新日期：2017-07-14 00:00:00

abstract：:Background Mortality is increased following a hospitalization for decompensated heart failure (HF), during which diuretics are usually intensified. It is unclear how risk is affected after outpatient intensification of diuretic therapy for HF. Methods and Results From nationwide administrative registers, we identified...

journal_title：Journal of the American Heart Association

authors： Madelaire C,Gustafsson F,Stevenson LW,Kristensen SL,Køber L,Andersen J,D'Souza M,Biering-Sørensen T,Andersson C,Torp-Pedersen C,Gislason G,Schou M

更新日期：2020-07-21 00:00:00

abstract：:See Article Lee et al. ...

journal_title：Journal of the American Heart Association

authors： Hanna P,Zhu C,Rajendran PS,Shivkumar K

更新日期：2019-05-21 00:00:00

abstract：BACKGROUND:Remote ischemic conditioning (RIC) is a noninvasive therapeutic strategy that uses brief cycles of blood pressure cuff inflation and deflation to protect the myocardium against ischemia-reperfusion injury. The objective of this systematic review was to determine the impact of RIC on myocardial salvage index,...

journal_title：Journal of the American Heart Association

authors： McLeod SL,Iansavichene A,Cheskes S

更新日期：2017-05-17 00:00:00

abstract：BACKGROUND:Depression is known to increase the risk of coronary artery disease, but few studies have evaluated the association between depression and peripheral artery disease (PAD). We examined the association of depression with PAD and evaluated potential mediators of this association. METHODS AND RESULTS:We used da...

journal_title：Journal of the American Heart Association

authors： Grenon SM,Hiramoto J,Smolderen KG,Vittinghoff E,Whooley MA,Cohen BE

更新日期：2012-08-01 00:00:00

abstract：:Background The purpose of this study was to determine whether the presence of antegrade blood flow was related to stroke subtype in patients with acute intracranial large artery occlusion. Methods and Results The prospectively collected data for consecutive patients who had occlusion of the unilateral M1 segment of th...

journal_title：Journal of the American Heart Association

authors： Zhang M,Chen Z,Xu J,Gong X,Shi F,Lou M

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:The scientific evidence base in support of population-wide salt reduction is strong, but current high-quality data about salt intake levels in India are mostly absent. This project sought to estimate daily salt consumption levels in selected communities of Delhi and Haryana in north India and Andhra Pradesh ...

journal_title：Journal of the American Heart Association

authors： Johnson C,Mohan S,Rogers K,Shivashankar R,Thout SR,Gupta P,He FJ,MacGregor GA,Webster J,Krishnan A,Maulik PK,Reddy KS,Prabhakaran D,Neal B

更新日期：2017-01-06 00:00:00

abstract：BACKGROUND:Carotid atherosclerosis (CA) is a reflector of generalized atherosclerosis that is associated with systemic vascular disease. Data are limited on the epidemiology of carotid lesions in a large, nationally representative population sample. We aimed to evaluate the prevalence of CA detected by carotid ultrason...

journal_title：Journal of the American Heart Association

authors： Wang X,Li W,Song F,Wang L,Fu Q,Cao S,Gan Y,Zhang W,Yue W,Yan F,Shi W,Wang X,Zhang H,Zhang H,Wang Z,Lu Z

更新日期：2018-04-05 00:00:00

abstract：:Background Hypertensive myocardial fibrosis (MF) is characterized by excessive deposition of extracellular matrix and cardiac fibroblast proliferation, which can lead to heart failure, malignant arrhythmia, and sudden death. In recent years, with the deepening of research, microRNAs have been found to have an importan...

journal_title：Journal of the American Heart Association

authors： Zhang W,Wang Q,Feng Y,Chen X,Yang L,Xu M,Wang X,Li W,Niu X,Gao D

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:Elevated albuminuria as well as an increased serum uric acid concentration is associated with poor cardiovascular outcome. We questioned whether these 2 variables (albuminuria and serum uric concentration) may be interrelated via tubular uric acid reabsorption. METHODS AND RESULTS:Included were 7688 partici...

journal_title：Journal of the American Heart Association

authors： Scheven L,Joosten MM,de Jong PE,Bakker SJ,Gansevoort RT,PREVEND study group.

更新日期：2014-01-01 00:00:00

abstract：:Background Autonomic dysregulation represents a hallmark of coronary artery disease (CAD). Therefore, we investigated the effects of exercise-based cardiac rehabilitation (CR) on autonomic function and neuro-cardiovascular stress reactivity in CAD patients. Methods and Results Twenty-two CAD patients (4 women; 62±8 ye...

journal_title：Journal of the American Heart Association

authors： Badrov MB,Wood KN,Lalande S,Sawicki CP,Borrell LJ,Barron CC,Vording JL,Fleischhauer A,Suskin N,McGowan CL,Shoemaker JK

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Neuregulin-1β (NRG-1β) is a growth factor critical for cardiac development and repair with therapeutic potential for heart failure. We previously showed that the glial growth factor 2 (GGF2) isoform of NRG-1β improves cardiac function in rodents after myocardial infarction (MI), but its efficacy in a large a...

journal_title：Journal of the American Heart Association

authors： Galindo CL,Kasasbeh E,Murphy A,Ryzhov S,Lenihan S,Ahmad FA,Williams P,Nunnally A,Adcock J,Song Y,Harrell FE,Tran TL,Parry TJ,Iaci J,Ganguly A,Feoktistov I,Stephenson MK,Caggiano AO,Sawyer DB,Cleator JH

更新日期：2014-10-23 00:00:00

abstract：BACKGROUND:Greater understanding of differences between men and women with coronary heart disease is needed. METHODS AND RESULTS:In this post hoc analysis of the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) trial, we described psychosocial factors, treatments, and outcomes of...

journal_title：Journal of the American Heart Association

authors： Guimarães PO,Granger CB,Stebbins A,Chiswell K,Held C,Hochman JS,Krug-Gourley S,Lonn E,Lopes RD,Stewart RAH,Vinereanu D,Wallentin L,White HD,Hagström E,Danchin N

更新日期：2017-09-14 00:00:00

abstract：:Background Programs targeting the standard modifiable cardiovascular risk factors (SMuRFs: hypertension, diabetes mellitus, hypercholesterolemia, smoking) are critical to tackling coronary heart disease at a community level. However, myocardial infarction in SMuRF-less individuals is not uncommon. This study uses 2 se...

journal_title：Journal of the American Heart Association

authors： Vernon ST,Coffey S,D'Souza M,Chow CK,Kilian J,Hyun K,Shaw JA,Adams M,Roberts-Thomson P,Brieger D,Figtree GA

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:It is unclear whether the incidence of non-valvular atrial fibrillation (NVAF) has been increasing over time. We aimed to provide contemporary estimates of the incidence and case-fatality of NVAF in a well-defined population. METHODS AND RESULTS:We used the computerized databases of the Régie de l'assurance...

journal_title：Journal of the American Heart Association

authors： Renoux C,Patenaude V,Suissa S

更新日期：2014-11-03 00:00:00

abstract：BACKGROUND:Fatty infiltration of the pancreas is an enigmatic manifestation of ectopic fat deposition in obesity. Studies have shown that pancreatic lipid accumulation interferes with insulin secretion in humans. However, the prevalence of fatty pancreas and its associated factors in the general population remain uncle...

journal_title：Journal of the American Heart Association

authors： Wang CY,Ou HY,Chen MF,Chang TC,Chang CJ

更新日期：2014-02-26 00:00:00

abstract：BACKGROUND:The intersection of heart failure (HF) and atrial fibrillation (AF) is common, but the burden of AF among black patients with HF is poorly characterized. We sought to determine the prevalence of AF, characteristics, in-hospital outcomes, and warfarin use associated with AF in patients hospitalized with HF as...

journal_title：Journal of the American Heart Association

authors： Thomas KL,Piccini JP,Liang L,Fonarow GC,Yancy CW,Peterson ED,Hernandez AF,Get With the Guidelines Steering Committee and Hospitals.

更新日期：2013-09-26 00:00:00

abstract：:Background Sepsis is the overwhelming host response to infection leading to shock and multiple organ dysfunction. Cardiovascular complications greatly increase sepsis-associated mortality. Although murine models are routinely used for preclinical studies, the benefit of using genetically engineered mice in sepsis is c...

journal_title：Journal of the American Heart Association

authors： Hoffman M,Kyriazis ID,Lucchese AM,de Lucia C,Piedepalumbo M,Bauer M,Schulze PC,Bonios MJ,Koch WJ,Drosatos K

更新日期：2019-05-21 00:00:00