Effects of 6 Months of Exercise-Based Cardiac Rehabilitation on Autonomic Function and Neuro-Cardiovascular Stress Reactivity in Coronary Artery Disease Patients.

abstract：BACKGROUND:Previously we found that smooth muscle cell (SMC)-specific knockout of miR-17~92 attenuates hypoxia-induced pulmonary hypertension. However, the mechanism underlying miR-17~92-mediated pulmonary artery SMC (PASMC) proliferation remains unclear. We sought to investigate whether miR-17~92 regulates hypoxia-ind...

journal_title：Journal of the American Heart Association

authors： Chen T,Zhou Q,Tang H,Bozkanat M,Yuan JX,Raj JU,Zhou G

更新日期：2016-12-05 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea is associated with high blood pressure. The magnitude of blood pressure effects from sleep apnea treatment is unclear. We aimed to determine the effect of mandibular advancement device therapy on ambulatory nighttime and daytime blood pressure in women and men with daytime sleepiness ...

journal_title：Journal of the American Heart Association

authors： Rietz H,Franklin KA,Carlberg B,Sahlin C,Marklund M

更新日期：2018-06-21 00:00:00

abstract：BACKGROUND:Inappropriate sinus tachycardia (IST) and postural tachycardia syndrome (POTS) are 2 disorders characterized by sinus tachycardia. It is debated whether the pathophysiology of IST and POTS results from abnormal autonomic regulation or abnormal sinus node function. We hypothesized that intrinsic heart rate (I...

journal_title：Journal of the American Heart Association

authors： Nwazue VC,Paranjape SY,Black BK,Biaggioni I,Diedrich A,Dupont WD,Robertson D,Raj SR

更新日期：2014-04-10 00:00:00

abstract：BACKGROUND:Hospital procedures have been associated with cognitive change in older patients. This study aimed to document the prevalence of mild cognitive impairment in individuals undergoing left heart catheterization (LHC) before the procedure and the incidence of cognitive decline to 3 months afterwards. METHODS AN...

journal_title：Journal of the American Heart Association

authors： Scott DA,Evered L,Maruff P,MacIsaac A,Maher S,Silbert BS

更新日期：2018-03-10 00:00:00

abstract：BACKGROUND:Psychosocial characteristics have a strong effect on risk of depression, and their direct treatment with behavioral interventions reduces rates of depression. Because new-onset poststroke depression (NPSD) is frequent, devastating, and often treatment-resistant, novel preventive efforts are needed. As a firs...

journal_title：Journal of the American Heart Association

authors： Salinas J,Ray RM,Nassir R,Lakshminarayan K,Dording C,Smoller J,Wassertheil-Smoller S,Rosand J,Dunn EC

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Fatty acids constitute the critical components of cell structure and function, and dysregulation of fatty acid composition may exert diverging vascular effects including proliferation, migration, and differentiation of vascular smooth muscle cells (VSMCs). However, direct evidence for this hypothesis has bee...

journal_title：Journal of the American Heart Association

authors： Sunaga H,Matsui H,Anjo S,Syamsunarno MR,Koitabashi N,Iso T,Matsuzaka T,Shimano H,Yokoyama T,Kurabayashi M

更新日期：2016-11-23 00:00:00

abstract：:Background Type 2 diabetes mellitus (T2 DM ) is considered a cardiovascular disease ( CVD ) risk equivalent, thereby linking assessment of cardiometabolic risk with that of CVD risk over time. Our goal was to determine how commonly used CVD risk scores and metabolic syndrome (MetS) severity performed in predicting T2 ...

journal_title：Journal of the American Heart Association

authors： Gurka MJ,Filipp SL,Pearson TA,DeBoer MD

更新日期：2018-08-21 00:00:00

abstract：BACKGROUND:Peripheral arterial disease (PAD) shares several risk factors with atrial fibrillation (AF), and persons with PAD have an increased risk of stroke. It is unclear if PAD is associated with an increased risk for AF and whether this potential association explains the increased risk of stroke observed in those w...

journal_title：Journal of the American Heart Association

authors： O'Neal WT,Efird JT,Nazarian S,Alonso A,Heckbert SR,Soliman EZ

更新日期：2014-11-17 00:00:00

abstract：BACKGROUND:Higher circulatory corin in patients with cardiac diseases is associated with improved cardiovascular outcomes, and chronic cardiac dysfunction is a well-known cause of progressive renal dysfunction. This study aimed to determine the role of serum corin in predicting short-term and long-term renal outcomes a...

journal_title：Journal of the American Heart Association

authors： Yang SF,Chou RH,Li SY,Huang SS,Huang PH

更新日期：2018-05-04 00:00:00

abstract：BACKGROUND:A cohort study found that 9/11-related environmental exposures and posttraumatic stress disorder increased self-reported cardiovascular disease risk. We attempted to replicate these findings using objectively defined cardiovascular disease hospitalizations in the same cohort. METHODS AND RESULTS:Data for ad...

journal_title：Journal of the American Heart Association

authors： Jordan HT,Stellman SD,Morabia A,Miller-Archie SA,Alper H,Laskaris Z,Brackbill RM,Cone JE

更新日期：2013-10-24 00:00:00

abstract：BACKGROUND:The mechanisms and relevance of impaired glucose homeostasis in advanced heart failure (HF) are poorly understood. The study goals were to examine glucose regulation, pancreatic endocrine function, and metabolic factors related to prognosis in patients with nondiabetic advanced HF. METHODS AND RESULTS:In to...

journal_title：Journal of the American Heart Association

authors： Melenovsky V,Benes J,Franekova J,Kovar J,Borlaug BA,Segetova M,Tura A,Pelikanova T

更新日期：2017-08-07 00:00:00

abstract：BACKGROUND:Metabolic syndrome increases risk for atherosclerotic coronary artery disease, and its prevalence increases with increasing age and body mass index. Adults with congenital heart disease (ACHD) are now living longer and accruing coronary artery disease risk factors. However, the prevalence of metabolic syndro...

journal_title：Journal of the American Heart Association

authors： Deen JF,Krieger EV,Slee AE,Arslan A,Arterburn D,Stout KK,Portman MA

更新日期：2016-02-12 00:00:00

abstract：:Background Apolipoprotein CIII (apo CIII ) is a crucial player in triglyceride-rich lipoprotein metabolism, but may also act pleiotropically, provoking inflammatory responses and stimulating coagulation. Elevated apo CIII plasma levels have been associated with increased activity of coagulation factors. Since these fe...

journal_title：Journal of the American Heart Association

authors： Olivieri O,Turcato G,Moruzzi S,Castagna A,Girelli D,Pizzolo F,Friso S,Sandri M,Bassi A,Martinelli N

更新日期：2019-01-22 00:00:00

abstract：BACKGROUND:Ticagrelor is a P2Y12 receptor inhibitor used in acute coronary syndromes to reduce platelet activity and to decrease thrombus formation. Ticagrelor is associated with a reduction in mortality incremental to that observed with clopidogrel, potentially related to its non-antiplatelet effects. Evidence from an...

journal_title：Journal of the American Heart Association

authors： Pelletier-Galarneau M,Hunter CRRN,Ascah KJ,Beanlands RSB,Dwivedi G,deKemp RA,Chow BJW,Ruddy TD

更新日期：2017-05-02 00:00:00

abstract：:Background Gait speed is a reliable measure of physical function and frailty in patients with aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). Slow gait speed pre-TAVR predicts worse clinical outcomes post-TAVR. The consequences of improved versus worsened physical function post-TAVR are unkno...

journal_title：Journal of the American Heart Association

authors： Goel K,O'Leary JM,Barker CM,Levack M,Rajagopal V,Makkar RR,Bajwa T,Kleiman N,Linke A,Kereiakes DJ,Waksman R,Allocco DJ,Rizik DG,Reardon MJ,Lindman BR

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Diminished growth hormone (GH) is associated with impaired endothelial function and fibrinolysis. GH-releasing hormone is the primary stimulus for GH secretion and a substrate of dipeptidyl peptidase-4. We tested the hypothesis that dipeptidyl peptidase-4 inhibition with sitagliptin increases stimulated GH s...

journal_title：Journal of the American Heart Association

authors： Wilson JR,Brown NJ,Nian H,Yu C,Bidlingmaier M,Devin JK

更新日期：2018-02-25 00:00:00

abstract：BACKGROUND:Vascular proliferative diseases such as atherosclerosis are inflammatory disorders involving multiple cell types including macrophages, lymphocytes, endothelial cells, and smooth muscle cells (SMCs). Although activation of the nuclear factor-κB (NF-κB) pathway in vessels has been shown to be critical for the...

journal_title：Journal of the American Heart Association

authors： Yoshida T,Yamashita M,Horimai C,Hayashi M

更新日期：2013-05-23 00:00:00

abstract：BACKGROUND:Although clinical trials have proved that statin can be used prophylactically against cardiovascular events, the direct effects of statin on plaque development are not well understood. We generated low-density lipoprotein receptor knockout (LDLR(-/-)) pigs to study the effects of early statin administration ...

journal_title：Journal of the American Heart Association

authors： Li Y,Fuchimoto D,Sudo M,Haruta H,Lin QF,Takayama T,Morita S,Nochi T,Suzuki S,Sembon S,Nakai M,Kojima M,Iwamoto M,Hashimoto M,Yoda S,Kunimoto S,Hiro T,Matsumoto T,Mitsumata M,Sugitani M,Saito S,Hirayama A,Onish

更新日期：2016-04-18 00:00:00

abstract：BACKGROUND:Family history of coronary heart disease (CHD) as well as genetic predisposition to CHD assessed by a genetic risk score (GRS) are predictors of CHD risk. It is, however, uncertain to what extent these risk predictors are mediated by major metabolic pathways. METHODS AND RESULTS:Total effects of self-report...

journal_title：Journal of the American Heart Association

authors： Fritz J,Shiffman D,Melander O,Tada H,Ulmer H

更新日期：2017-03-20 00:00:00

abstract：:Background In the 2000s, adults with HIV had a higher risk for atherosclerotic cardiovascular disease (ASCVD) compared with those without HIV. There is uncertainty if this excess risk still exists in the United States given changes in antiretroviral therapies and increased statin use. Methods and Results We compared t...

journal_title：Journal of the American Heart Association

authors： Rosenson RS,Hubbard D,Monda KL,Reading SR,Chen L,Dluzniewski PJ,Burkholder GA,Muntner P,Colantonio LD

更新日期：2020-01-07 00:00:00

abstract：:Background Many observational studies and trials have shown that coronary artery bypass grafting improves the survival in patients with ischemic cardiomyopathy. However, these results are based on data generated from developed countries. Poor socioeconomic statuses, lack of uniformity in healthcare delivery, differenc...

journal_title：Journal of the American Heart Association

authors： Jose R,Shetty A,Krishna N,Chathoth V,Bhaskaran R,Jayant A,Varma PK

更新日期：2019-05-21 00:00:00

abstract：:Background The purpose of this study was to determine whether the presence of antegrade blood flow was related to stroke subtype in patients with acute intracranial large artery occlusion. Methods and Results The prospectively collected data for consecutive patients who had occlusion of the unilateral M1 segment of th...

journal_title：Journal of the American Heart Association

authors： Zhang M,Chen Z,Xu J,Gong X,Shi F,Lou M

更新日期：2020-10-20 00:00:00

abstract：:Background The overall goal of this longitudinal study was to determine if the Black population has decreased myocardial function, which has the potential to lead to the early development of congestive heart failure, compared with the White population. Methods and Results A total of 673 subjects were evaluated over a ...

journal_title：Journal of the American Heart Association

authors： Kapuku G,Howie M,Ghosh S,Doshi V,Bykhovsky M,Ange B,Halbert JD,Robinson V,Bagi Z,Harshfield G,George V

更新日期：2021-01-18 00:00:00

abstract：BACKGROUND:Intestinal microbiota have been found to be linked to cardiovascular disease via conversion of the dietary compounds choline and carnitine to the atherogenic metabolite TMAO (trimethylamine-N-oxide). Specifically, a vegan diet was associated with decreased plasma TMAO levels and nearly absent TMAO production...

journal_title：Journal of the American Heart Association

authors： Smits LP,Kootte RS,Levin E,Prodan A,Fuentes S,Zoetendal EG,Wang Z,Levison BS,Cleophas MCP,Kemper EM,Dallinga-Thie GM,Groen AK,Joosten LAB,Netea MG,Stroes ESG,de Vos WM,Hazen SL,Nieuwdorp M

更新日期：2018-03-26 00:00:00

abstract：BACKGROUND:Pulse pressure (PP) is related to cardiac function, arterial stiffness, fluid status, and vascular events. This study aimed to explore the prognostic role of PP upon admission in patients with acute ischemic stroke (AIS) based on a nation-wide stroke registry. METHODS AND RESULTS:We evaluated the associatio...

journal_title：Journal of the American Heart Association

authors： Tang SC,Yin JH,Liu CH,Sun MH,Lee JT,Sun Y,Hsu CS,Sun MC,Lin CH,Chen CH,Lien LM,Muo CH,Jeng JS,Hsu CY,Taiwan Stroke Registry Investigators.

更新日期：2017-06-22 00:00:00

abstract：:Background Arterial stiffness is an independent risk factor for cardiovascular disease and can be beneficially influenced by physical activity. However, it is not clear how an individual's physical activity pattern over a week is associated with arterial stiffness. Therefore, we examined the associations of the amount...

journal_title：Journal of the American Heart Association

authors： Vandercappellen EJ,Henry RMA,Savelberg HHCM,van der Berg JD,Reesink KD,Schaper NC,Eussen SJPM,van Dongen MCJM,Dagnelie PC,Schram MT,van Greevenbroek MMJ,Wesselius A,van der Kallen CJH,Köhler S,Stehouwer CDA,Koster A

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is a major risk factor for the development of chronic kidney disease. Nuclear factor-κB is a nuclear transcription factor activated post-ischemia, responsible for the transcription of proinflammatory proteins. The role of nuclear factor-κB in the renal fibrosis post-AKI is unknown. ...

journal_title：Journal of the American Heart Association

authors： Johnson FL,Patel NSA,Purvis GSD,Chiazza F,Chen J,Sordi R,Hache G,Merezhko VV,Collino M,Yaqoob MM,Thiemermann C

更新日期：2017-07-03 00:00:00

abstract：:Background Application of 18F-sodium fluoride (18F-NaF) positron emission tomography ( PET ) to coronary artery disease has attracted interest. We investigated the utility of 18F-NaF uptake for predicting coronary events and evaluated the combined use of coronary computed tomography (CT) angiography ( CCTA ) and 18F-N...

journal_title：Journal of the American Heart Association

authors： Kitagawa T,Yamamoto H,Nakamoto Y,Sasaki K,Toshimitsu S,Tatsugami F,Awai K,Hirokawa Y,Kihara Y

更新日期：2018-10-16 00:00:00

abstract：:Background Should all out-of-hospital cardiac arrest (OHCA) patients be directly transported to cardiac arrest centers (CACs) remains under debate. Our study evaluated the impacts of different transport time and destination hospital on the outcomes of OHCA patients. Methods and Results Data were collected from 6655 OH...

journal_title：Journal of the American Heart Association

authors： Chien CY,Tsai SL,Tsai LH,Chen CB,Seak CJ,Weng YM,Lin CC,Ng CJ,Chien WC,Huang CH,Lin CY,Chaou CH,Liu PH,Tseng HJ,Fang CT

更新日期：2020-06-02 00:00:00

abstract：:Background Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy. Current guidelines endorse management in expert centers, but patient socioeconomic status can affect access to specialty care. The effect of socioeconomic status and specialty care access on HCM outcomes has not been examined. Me...

journal_title：Journal of the American Heart Association

authors： Thomas A,Papoutsidakis N,Spatz E,Testani J,Soucier R,Chou J,Ahmad T,Darr U,Hu X,Li F,Chen ME,Bellumkonda L,Sumathipala A,Jacoby D

更新日期：2020-02-04 00:00:00