Postural tachycardia syndrome and inappropriate sinus tachycardia: role of autonomic modulation and sinus node automaticity.

abstract：BACKGROUND:The mechanisms behind the association of atrial fibrillation (AF) and dementia are unknown. We previously found a significantly increased risk of dementia in AF patients taking warfarin with a low percentage of time in therapeutic range. The purpose of this study was to determine the extent to which AF itsel...

journal_title：Journal of the American Heart Association

authors： Bunch TJ,May HT,Bair TL,Crandall BG,Cutler MJ,Day JD,Jacobs V,Mallender C,Osborn JS,Stevens SM,Weiss JP,Woller SC

更新日期：2016-07-11 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea (OSA) is a common condition associated with cardiovascular disease. Its potential effect on progression of subclinical atherosclerosis is not well understood. We tested the hypothesis that self-reported OSA is associated with progression of coronary artery calcium (CAC). We also evalu...

journal_title：Journal of the American Heart Association

authors： Kwon Y,Duprez DA,Jacobs DR,Nagayoshi M,McClelland RL,Shahar E,Budoff M,Redline S,Shea S,Carr JJ,Lutsey PL

更新日期：2014-09-26 00:00:00

abstract：:Background Recent studies suggest that mavacamten (Myk461), a small myosin-binding molecule, decreases hypercontractility in myocardium expressing hypertrophic cardiomyopathy-causing missense mutations in myosin heavy chain. However, the predominant feature of most mutations in cardiac myosin binding protein-C ( cMyBP...

journal_title：Journal of the American Heart Association

authors： Mamidi R,Li J,Doh CY,Verma S,Stelzer JE

更新日期：2018-09-04 00:00:00

abstract：:Background Chronic kidney disease is a recognized independent risk factor for cardiovascular disease, but whether the risks of ST-segment-elevation myocardial infarction ( STEMI ) and non-ST-segment-elevation myocardial infarction ( NSTEMI ) differ in the chronic kidney disease population is unknown. Methods and Resul...

journal_title：Journal of the American Heart Association

authors： de Chickera SN,Bota SE,Kuwornu JP,Wijeysundera HC,Molnar AO,Lam NN,Silver SA,Clark EG,Sood MM

更新日期：2018-10-16 00:00:00

abstract：:See Editorial by Cenko et al. ...

journal_title：Journal of the American Heart Association

authors： Pande AN,Jacobs AK

更新日期：2019-02-19 00:00:00

abstract：:Background Vascular calcification (VC) is associated with high morbidity and mortality among older adults, a population that exhibits a higher tendency for developing frailty at the same time. Whether VC serves as a risk factor for the development of frailty in this population remains unclear. Methods and Results We a...

journal_title：Journal of the American Heart Association

authors： Lee SY,Chao CT,Huang JW,Huang KC

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:Short-term exposures to fine (<2.5 μm aerodynamic diameter) ambient particulate-matter (PM) have been related with increased blood pressure (BP) in controlled-human exposure and community-based studies. However, whether coarse (2.5 to 10 μm) PM exposure increases BP is uncertain. Recent observational studies...

journal_title：Journal of the American Heart Association

authors： Bellavia A,Urch B,Speck M,Brook RD,Scott JA,Albetti B,Behbod B,North M,Valeri L,Bertazzi PA,Silverman F,Gold D,Baccarelli AA

更新日期：2013-06-19 00:00:00

abstract：:Background The incidence of conduction abnormalities requiring permanent pacemaker implantation (PPI) after transcatheter aortic valve replacement (TAVR) with early and later generation prostheses remains debated. Methods and Results Based on the administrative hospital-discharge database, we collected information for...

journal_title：Journal of the American Heart Association

authors： Bisson A,Bodin A,Herbert J,Lacour T,Saint Etienne C,Pierre B,Clementy N,Deharo P,Babuty D,Fauchier L

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:Beta-blockers (BB) are recommended in secondary prevention of acute myocardial infarction (AMI), but adherence to prescription medication is a recognized problem. Most literature on the consequences of poor adherence to prescribed BB is limited by the possibility of "healthy adherer bias" and better-designed...

journal_title：Journal of the American Heart Association

authors： Di Bartolomeo S,Marino M,Guastaroba P,Valent F,De Palma R

更新日期：2015-01-07 00:00:00

abstract：BACKGROUND:The natural history of coronary artery aneurysms (CAA) after intravenous immunoglobulin (IVIG) treatment in the United States is not well described. We describe the natural history of CAA in US Kawasaki disease (KD) patients and identify factors associated with major adverse cardiac events (MACE) and CAA reg...

journal_title：Journal of the American Heart Association

authors： Friedman KG,Gauvreau K,Hamaoka-Okamoto A,Tang A,Berry E,Tremoulet AH,Mahavadi VS,Baker A,deFerranti SD,Fulton DR,Burns JC,Newburger JW

更新日期：2016-09-15 00:00:00

abstract：BACKGROUND:Patients with normalized mean pulmonary artery pressure (mPAP) after pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH) do not always regain normal exercise capacity. We evaluated right ventricular function, its interaction with both pulsatile and resistive afterload, an...

journal_title：Journal of the American Heart Association

authors： Claessen G,La Gerche A,Dymarkowski S,Claus P,Delcroix M,Heidbuchel H

更新日期：2015-03-23 00:00:00

abstract：:Background The majority of studies evaluating cardiorespiratory fitness ( CRF ) as a cardiovascular risk factor use cardiovascular mortality and not cardiovascular disease events as the primary end point, and generally do not include women. The aim of this study was to investigate the association of estimated CRF ( eC...

journal_title：Journal of the American Heart Association

authors： Shigdel R,Dalen H,Sui X,Lavie CJ,Wisløff U,Ernstsen L

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Right ventricular (RV) diastolic function is impaired in patients with pulmonary arterial hypertension (PAH). Our previous study showed that elevated cardiomyocyte stiffness and myofilament Ca(2+) sensitivity underlie diastolic dysfunction in PAH. This study investigates protein modifications contributing to...

journal_title：Journal of the American Heart Association

authors： Rain S,Bos Dda S,Handoko ML,Westerhof N,Stienen G,Ottenheijm C,Goebel M,Dorfmüller P,Guignabert C,Humbert M,Bogaard HJ,Remedios CD,Saripalli C,Hidalgo CG,Granzier HL,Vonk-Noordegraaf A,van der Velden J,de Man FS

更新日期：2014-06-03 00:00:00

abstract：BACKGROUND:There is paucity of knowledge concerning the specific age in youth when the associations of metabolic syndrome (MetS) begin to be operative. Thus, we investigated the relation of age to the associations of childhood MetS with adult MetS, type 2 diabetes mellitus and high carotid intima-media thickness. METH...

journal_title：Journal of the American Heart Association

authors： Koskinen J,Magnussen CG,Sinaiko A,Woo J,Urbina E,Jacobs DR Jr,Steinberger J,Prineas R,Sabin MA,Burns T,Berenson G,Bazzano L,Venn A,Viikari JSA,Hutri-Kähönen N,Raitakari O,Dwyer T,Juonala M

更新日期：2017-08-16 00:00:00

abstract：BACKGROUND:Regression of left ventricular (LV) hypertrophy (LVH) has been a goal in clinical trials. This study tests the external validity of results of clinical trials on LVH regression using a large registry from a tertiary care center, to identify phenotypes less likely to achieve regression of LVH. METHODS AND RE...

journal_title：Journal of the American Heart Association

authors： Lønnebakken MT,Izzo R,Mancusi C,Gerdts E,Losi MA,Canciello G,Giugliano G,De Luca N,Trimarco B,de Simone G

更新日期：2017-03-08 00:00:00

abstract：BACKGROUND:Recent literature suggests that blood pressure variability (BPV) predicts outcome beyond blood pressure level (BPL) and that antihypertensive drug classes differentially influence BPV. We compared calcium channel blockers, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockade for effect...

journal_title：Journal of the American Heart Association

authors： Asayama K,Ohkubo T,Hanazawa T,Watabe D,Hosaka M,Satoh M,Yasui D,Staessen JA,Imai Y,Hypertensive Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED‐BP) Study Investigators.

更新日期：2016-03-23 00:00:00

abstract：:Background A previous study reported histologic abnormalities in the pulmonary artery ( PA ) of patients with tetralogy of Fallot ( TOF ). However, the potential effect of these anatomical findings on PA vascular function has not been studied. We hypothesized that TOF patients had abnormal PA vascular function, and th...

journal_title：Journal of the American Heart Association

authors： Egbe AC,Anavekar NS,Connolly HM

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:Diagnosis of atrial fibrillation (AF) can be difficult, requiring cumbersome investigations. We aimed to determine the association of established whole-blood gene expression scores with prevalent AF and to evaluate their performance for the identification of AF in a SIRS (Steroids in Cardiac Surgery) trial c...

journal_title：Journal of the American Heart Association

authors： Thériault S,Whitlock R,Raman K,Vincent J,Yusuf S,Paré G

更新日期：2017-06-30 00:00:00

abstract：:Background Hospitals in the United States vary in their use of intensive care units (ICUs) for hemodynamically stable patients with non-ST-segment-elevation myocardial infarction (NSTEMI). The association between ICU use and long-term outcomes after NSTEMI is unknown. Methods and Results Using data from the National C...

journal_title：Journal of the American Heart Association

authors： Fanaroff AC,Chen AY,van Diepen S,Peterson ED,Wang TY

更新日期：2020-03-17 00:00:00

abstract：:Background Sepsis is the overwhelming host response to infection leading to shock and multiple organ dysfunction. Cardiovascular complications greatly increase sepsis-associated mortality. Although murine models are routinely used for preclinical studies, the benefit of using genetically engineered mice in sepsis is c...

journal_title：Journal of the American Heart Association

authors： Hoffman M,Kyriazis ID,Lucchese AM,de Lucia C,Piedepalumbo M,Bauer M,Schulze PC,Bonios MJ,Koch WJ,Drosatos K

更新日期：2019-05-21 00:00:00

abstract：BACKGROUND:The impact of the 2013 American College of Cardiology/American Heart Association cholesterol guidelines on statin eligibility in individuals otherwise destined to experience cardiovascular disease (CVD) events is unclear. METHODS AND RESULTS:We analyzed a prospective cohort of consecutive ST-segment elevati...

journal_title：Journal of the American Heart Association

authors： Miedema MD,Garberich RF,Schnaidt LJ,Peterson E,Strauss C,Sharkey S,Knickelbine T,Newell MC,Henry TD

更新日期：2017-04-12 00:00:00

abstract：:Background In statin trials, men and women derived similar relative risk reductions in cardiovascular events per 39 mg/ dL low-density lipoprotein cholesterol ( LDL -C) reduction. We explored whether lower LDL -C levels and greater LDL -C percentage reductions than those achieved with statins are associated with reduc...

journal_title：Journal of the American Heart Association

authors： Vallejo-Vaz AJ,Ginsberg HN,Davidson MH,Eckel RH,Cannon CP,Lee LV,Bessac L,Pordy R,Letierce A,Ray KK

更新日期：2018-09-18 00:00:00

abstract：:Background Sex differences in the management of cardiovascular disease have been reported in secondary care. We conducted a systematic review with meta-analysis of systematically investigated sex differences in cardiovascular medication prescription among patients at high risk or with established cardiovascular diseas...

journal_title：Journal of the American Heart Association

authors： Zhao M,Woodward M,Vaartjes I,Millett ERC,Klipstein-Grobusch K,Hyun K,Carcel C,Peters SAE

更新日期：2020-06-02 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate whether the association between baseline cardiovascular health (CVH) and incident cardiovascular disease differs according to coronary heart disease (CHD) and stroke subtypes, and to assess the mediating effect of inflammatory and hemostatic blood biomarkers. METHODS...

journal_title：Journal of the American Heart Association

authors： Gaye B,Tafflet M,Arveiler D,Montaye M,Wagner A,Ruidavets JB,Kee F,Evans A,Amouyel P,Ferrieres J,Empana JP

更新日期：2017-10-17 00:00:00

abstract：:Background Genetic testing in pediatric primary dilated cardiomyopathy (DCM) patients has identified numerous disease-causing variants, but few studies have evaluated genetic testing outcomes in this population in the context of patient and familial clinical data or assessed the clinical implications of temporal chang...

journal_title：Journal of the American Heart Association

authors： Quiat D,Witkowski L,Zouk H,Daly KP,Roberts AE

更新日期：2020-06-02 00:00:00

abstract：BACKGROUND:The intersection of heart failure (HF) and atrial fibrillation (AF) is common, but the burden of AF among black patients with HF is poorly characterized. We sought to determine the prevalence of AF, characteristics, in-hospital outcomes, and warfarin use associated with AF in patients hospitalized with HF as...

journal_title：Journal of the American Heart Association

authors： Thomas KL,Piccini JP,Liang L,Fonarow GC,Yancy CW,Peterson ED,Hernandez AF,Get With the Guidelines Steering Committee and Hospitals.

更新日期：2013-09-26 00:00:00

abstract：BACKGROUND:Epidemiological evidence suggests a cardioprotective role of α-linolenic acid (ALA), a plant-derived ω-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a...

journal_title：Journal of the American Heart Association

authors： Sala-Vila A,Guasch-Ferré M,Hu FB,Sánchez-Tainta A,Bulló M,Serra-Mir M,López-Sabater C,Sorlí JV,Arós F,Fiol M,Muñoz MA,Serra-Majem L,Martínez JA,Corella D,Fitó M,Salas-Salvadó J,Martínez-González MA,Estruch R,Ros E,P

更新日期：2016-01-26 00:00:00

abstract：:Background Evidence suggests that enlarged perivascular spaces (PVSs) may represent a marker for cerebral small-vessel disease. We investigated whether vascular risk factors are correlated with visible PVS in older adults. Methods and Results This population-based study included 530 participants (age ≥60 years) who we...

journal_title：Journal of the American Heart Association

authors： Laveskog A,Wang R,Vetrano DL,Bronge L,Wahlund LO,Qiu C

更新日期：2020-08-18 00:00:00

abstract：BACKGROUND:Depression is known to increase the risk of coronary artery disease, but few studies have evaluated the association between depression and peripheral artery disease (PAD). We examined the association of depression with PAD and evaluated potential mediators of this association. METHODS AND RESULTS:We used da...

journal_title：Journal of the American Heart Association

authors： Grenon SM,Hiramoto J,Smolderen KG,Vittinghoff E,Whooley MA,Cohen BE

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus (DM) is a major risk factor for cardiovascular events. We aimed to investigate the coronary plaque phenotype of diabetic patients who presented with acute coronary syndromes by optical coherence tomography. METHODS AND RESULTS:A total of 322 patients with acute coronary syndromes who under...

journal_title：Journal of the American Heart Association

authors： Sugiyama T,Yamamoto E,Bryniarski K,Xing L,Fracassi F,Lee H,Jang IK

更新日期：2018-07-13 00:00:00