Abstract:
:Background Evidence suggests that enlarged perivascular spaces (PVSs) may represent a marker for cerebral small-vessel disease. We investigated whether vascular risk factors are correlated with visible PVS in older adults. Methods and Results This population-based study included 530 participants (age ≥60 years) who were free from dementia and functional dependence, derived from the Swedish National study on Aging and Care in Kungsholmen (2001-2003). We collected data on demographics, vascular risk factors, and health conditions through interviews, clinical examinations, laboratory tests, and patient registers. Cerebral PVSs and white matter hyperintensities on magnetic resonance images were visually assessed with semiquantitative visual rating scales. Data were analyzed using the general linear regression models. After controlling for demographics and cardiovascular disease, very high blood pressure (≥160/100 mm Hg) was significantly associated with global PVS score (β-coefficient, 1.30; 95% CI, 0.06-2.53) and orthostatic hypotension was associated with PVS score in the basal ganglia (β-coefficient 0.37; 0.03-0.70), but the associations became non-significant when adjusting for white matter hyperintensity load. Orthostatic hypotension was significantly associated with global and lobar PVS scores in carriers but not in noncarriers of the APOE ε4 allele. Global or regional PVS score was not significantly associated with other traditional vascular risk factors such as smoking, diabetes mellitus, physical inactivity, and overweight or obesity. Conclusions This study provides limited evidence supporting a correlation of magnetic resonance imaging-visible PVS with traditional vascular risk factors in older adults. The association of orthostatic hypotension with lobar PVS among APOE ε4 carriers suggests that lobar PVS may be a marker for amyloid-associated small-vessel disease.
journal_name
J Am Heart Assocjournal_title
Journal of the American Heart Associationauthors
Laveskog A,Wang R,Vetrano DL,Bronge L,Wahlund LO,Qiu Cdoi
10.1161/JAHA.119.015229subject
Has Abstractpub_date
2020-08-18 00:00:00pages
e015229issue
16issn
2047-9980journal_volume
9pub_type
杂志文章abstract::Background Exposure to chronic psychosocial stress is a risk factor for atherosclerosis-based cardiovascular disease. We previously demonstrated the increased expressions of cathepsin S (CatS) in atherosclerotic lesions. Whether CatS participates directly in stress-related neointimal hyperplasia has been unknown. Meth...
journal_title:Journal of the American Heart Association
pub_type: 杂志文章
doi:10.1161/JAHA.119.011994
更新日期:2019-07-16 00:00:00
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journal_title:Journal of the American Heart Association
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章,多中心研究
doi:10.1161/JAHA.117.007207
更新日期:2017-12-13 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
doi:10.1161/JAHA.115.002447
更新日期:2016-02-23 00:00:00
abstract:BACKGROUND:The influence of coronary artery disease (CAD) on clinical and echocardiographic outcomes after transcatheter aortic valve replacement (TAVR) is still controversial. We sought to evaluate the impact of CAD severity as measured by the SYNTAX score (SS) on patients undergoing TAVR. METHODS AND RESULTS:A total...
journal_title:Journal of the American Heart Association
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/JAHA.116.005070
更新日期:2017-02-20 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章,随机对照试验
doi:10.1161/JAHA.117.005549
更新日期:2017-07-21 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
doi:10.1161/JAHA.120.018306
更新日期:2020-12-01 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章,多中心研究
doi:10.1161/JAHA.117.007611
更新日期:2017-11-16 00:00:00
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journal_title:Journal of the American Heart Association
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doi:10.1161/JAHA.118.008664
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journal_title:Journal of the American Heart Association
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doi:10.1161/JAHA.119.015316
更新日期:2020-04-21 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
doi:10.1161/JAHA.120.016292
更新日期:2020-06-16 00:00:00
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journal_title:Journal of the American Heart Association
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doi:10.1161/JAHA.119.013209
更新日期:2020-05-05 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章,meta分析,评审
doi:10.1161/JAHA.117.006432
更新日期:2017-08-04 00:00:00
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journal_title:Journal of the American Heart Association
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doi:10.1161/JAHA.116.004310
更新日期:2016-10-17 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
doi:10.1161/JAHA.114.001626
更新日期:2015-04-22 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
doi:10.1161/JAHA.116.003289
更新日期:2016-09-15 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
doi:10.1161/JAHA.113.000486
更新日期:2014-03-04 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
doi:10.1161/JAHA.117.006460
更新日期:2018-01-25 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
doi:10.1161/JAHA.113.000072
更新日期:2013-05-31 00:00:00
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doi:10.1161/JAHA.120.016075
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doi:10.1161/JAHA.119.013675
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doi:10.1161/JAHA.115.002779
更新日期:2016-04-18 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2016-12-19 00:00:00
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journal_title:Journal of the American Heart Association
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doi:10.1161/JAHA.118.009600
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章,多中心研究
doi:10.1161/JAHA.117.006196
更新日期:2017-08-10 00:00:00
abstract::See Article Ramkumar et al. ...
journal_title:Journal of the American Heart Association
pub_type: 评论,社论
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更新日期:2019-09-03 00:00:00
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pub_type: 杂志文章
doi:10.1161/JAHA.120.016799
更新日期:2020-10-20 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-05-18 00:00:00
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更新日期:2017-09-21 00:00:00