当前位置： SCI文献检索 > Journal of the American Heart Association期刊下所有文献 > Association Between Stroke Risk and Metformin Use in Hemodialysis Patients With Diabetes Mellitus: A Nested Case-Control Study.

Association Between Stroke Risk and Metformin Use in Hemodialysis Patients With Diabetes Mellitus: A Nested Case-Control Study.

Abstract：

BACKGROUND:Metformin use reduces the incidence and severity of stroke in patients with type 2 diabetes mellitus (DM). The benefits of metformin for stroke have not been examined in hemodialysis patients with DM. METHODS AND RESULTS:Using the National Health Insurance Research Database, we identified 17 760 patients with DM and new-onset hemodialysis between 2001 and 2013. Of these, 1898 patients hospitalized for either ischemic or hemorrhagic stroke were matched to 7592 control patients according to sex, age, and year of initial hemodialysis therapy by using incidence sampling. The association between metformin use and stroke risk was estimated using conditional logistic regression after adjustment for hemodialysis frequency, comorbidity, and prescribed medications. Metformin use was recorded before the date of stroke admission and the date of pseudostroke of the case and control patients, respectively. Results showed that hemodialysis patients with ischemic stroke were more likely to use metformin than the controls 1 year before the date of stroke admission (adjusted odds ratio: 1.64; 95% confidence interval, 1.32-2.04). The association was evident within 90 days before the index date (adjusted odds ratio: 1.81; 95% confidence interval, 1.27-2.60). The results were consistent with those of hemodialysis patients with hemorrhagic stroke. Metformin use remained a risk factor for stroke in patients treated with antihypertensive, sulfonylurea, and antiplatelet drugs. CONCLUSIONS:This nested case-control study is the first to show that metformin use is associated with stroke risk in hemodialysis patients with DM. We suggest that metformin should not be used by hemodialysis patients with DM.

journal_name

J Am Heart Assoc

journal_title

Journal of the American Heart Association

authors

Chien LN,Chou CL,Chen HH,Kao CC,Lin YC,Wu YL,Chen JS,Chen LY,Fang TC

doi

10.1161/JAHA.117.007611

subject

Has Abstract

pub_date

2017-11-16 00:00:00

issue

11

issn

2047-9980

pii

JAHA.117.007611

journal_volume

6

pub_type

杂志文章,多中心研究

相关文献

Journal of the American Heart Association文献大全
  • Galectin-3 Is Associated With Stage B Metabolic Heart Disease and Pulmonary Hypertension in Young Obese Patients.

    abstract：:Background Obesity is a precursor to heart failure with preserved ejection fraction. Biomarkers that identify preclinical metabolic heart disease ( MHD ) in young obese patients would help identify high-risk individuals for heart failure prevention strategies. We assessed the predictive value of GAL3 (galectin-3), FST...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.118.011100

    authors： Gopal DM,Ayalon N,Wang YC,Siwik D,Sverdlov A,Donohue C,Perez A,Downing J,Apovian C,Silva V,Panagia M,Kolachalama V,Ho JE,Liang CS,Gokce N,Colucci WS

    更新日期：2019-04-02 00:00:00

  • Pacemaker Implantation After Balloon- or Self-Expandable Transcatheter Aortic Valve Replacement in Patients With Aortic Stenosis.

    abstract：:Background The incidence of conduction abnormalities requiring permanent pacemaker implantation (PPI) after transcatheter aortic valve replacement (TAVR) with early and later generation prostheses remains debated. Methods and Results Based on the administrative hospital-discharge database, we collected information for...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.120.015896

    authors： Bisson A,Bodin A,Herbert J,Lacour T,Saint Etienne C,Pierre B,Clementy N,Deharo P,Babuty D,Fauchier L

    更新日期：2020-05-05 00:00:00

  • Inhibition of Platelets by Clopidogrel Suppressed Ang II-Induced Vascular Inflammation, Oxidative Stress, and Remodeling.

    abstract：:Background Platelets play a role in promoting inflammatory responses under several disease conditions. Platelets are activated in hypertensive patients. However, the mechanisms responsible for platelet-mediating vascular inflammation are unknown. The present study investigated the role of platelets in promoting vascul...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.118.009600

    authors： An X,Jiang G,Cheng C,Lv Z,Liu Y,Wang F

    更新日期：2018-11-06 00:00:00

  • Limited AT1 Receptor Internalization Is a Novel Mechanism Underlying Sustained Vasoconstriction Induced by AT1 Receptor Autoantibody From Preeclampsia.

    abstract：:Background Angiotensin II type 1 receptor ( AT 1R) autoantibody ( AT 1- AA ) was first identified as a causative factor in preeclampsia. Unlike physiological ligand angiotensin II (Ang II ), AT 1- AA can induce vasoconstriction in a sustained manner, causing a series of adverse effects, such as vascular injury and poo...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.118.011179

    authors： Bian J,Lei J,Yin X,Wang P,Wu Y,Yang X,Wang L,Zhang S,Liu H,Fu MLX

    更新日期：2019-03-19 00:00:00

  • Dynamic Relation of Changes in Weight and Indices of Fat Distribution With Cardiac Structure and Function: The Dallas Heart Study.

    abstract：BACKGROUND:Obesity may increase heart failure risk through cardiac remodeling. Cross-sectional associations between adiposity and cardiac structure and function have been elucidated, but the impact of longitudinal changes in adiposity on cardiac remodeling is less well understood. METHODS AND RESULTS:Participants in t...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.117.005897

    authors： Wilner B,Garg S,Ayers CR,Maroules CD,McColl R,Matulevicius SA,de Lemos JA,Drazner MH,Peshock R,Neeland IJ

    更新日期：2017-07-19 00:00:00

  • Dipeptidyl Peptidase-4 Regulates Hematopoietic Stem Cell Activation in Response to Chronic Stress.

    abstract：BACKGROUND:DPP4 (Dipeptidyl peptidase-4)-GLP-1 (glucagon-like peptide-1) and its receptor (GLP-1R) axis has been involved in several intracellular signaling pathways. The Adrβ3 (β3-adrenergic receptor)/CXCL12 (C-X-C motif chemokine 12) signal was required for the hematopoiesis. We investigated the novel molecular requi...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.117.006394

    authors： Zhu E,Hu L,Wu H,Piao L,Zhao G,Inoue A,Kim W,Yu C,Xu W,Bando YK,Li X,Lei Y,Hao CN,Takeshita K,Kim WS,Okumura K,Murohara T,Kuzuya M,Cheng XW

    更新日期：2017-07-14 00:00:00

  • Effect of Vegan Fecal Microbiota Transplantation on Carnitine- and Choline-Derived Trimethylamine-N-Oxide Production and Vascular Inflammation in Patients With Metabolic Syndrome.

    abstract：BACKGROUND:Intestinal microbiota have been found to be linked to cardiovascular disease via conversion of the dietary compounds choline and carnitine to the atherogenic metabolite TMAO (trimethylamine-N-oxide). Specifically, a vegan diet was associated with decreased plasma TMAO levels and nearly absent TMAO production...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,随机对照试验

    doi：10.1161/JAHA.117.008342

    authors： Smits LP,Kootte RS,Levin E,Prodan A,Fuentes S,Zoetendal EG,Wang Z,Levison BS,Cleophas MCP,Kemper EM,Dallinga-Thie GM,Groen AK,Joosten LAB,Netea MG,Stroes ESG,de Vos WM,Hazen SL,Nieuwdorp M

    更新日期：2018-03-26 00:00:00

  • Outcome by Sex in Patients With Long QT Syndrome With an Implantable Cardioverter Defibrillator.

    abstract：:Background Sex differences in outcome have been reported in patients with congenital long QT syndrome. We aimed to report on the incidence of time-dependent life-threatening events in male and female patients with long QT syndrome with an implantable cardioverter defibrillator (ICD). Methods and Results A total of 60 ...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.120.016398

    authors： Younis A,Aktas MK,Rosero S,Kutyifa V,Polonsky B,McNitt S,Sotoodehnia N,Kudenchuk P,Rea TD,Arking DE,Goldenberg I,Zareba W

    更新日期：2020-10-20 00:00:00

  • Reactive oxygen metabolites are closely associated with the diagnosis and prognosis of coronary artery disease.

    abstract：BACKGROUND:Reactive oxygen species (ROS) are associated with development of coronary artery disease (CAD). However, there's no useful biomarker of ROS in CAD. METHODS AND RESULTS:We recruited 395 consecutive CAD patients who were performed coronary angiography (262 male and 133 female, age 70.2±10), and we measured se...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.114.001451

    authors： Hirata Y,Yamamoto E,Tokitsu T,Kusaka H,Fujisue K,Kurokawa H,Sugamura K,Maeda H,Tsujita K,Kaikita K,Hokimoto S,Sugiyama S,Ogawa H

    更新日期：2015-01-28 00:00:00

  • Relationship Between Changes in Fat and Lean Depots Following Weight Loss and Changes in Cardiovascular Disease Risk Markers.

    abstract：BACKGROUND:Gluteofemoral fat mass has been associated with improved cardiovascular disease risk factors. It is not clear if loss of this protective fat during weight loss partially negates the effect of loss of visceral fat. The aim of this study was to examine regional fat loss in a large weight-loss cohort from one c...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.118.008675

    authors： Clifton PM

    更新日期：2018-04-04 00:00:00

  • Methodological and Clinical Heterogeneity and Extraction Errors in Meta-Analyses of Catheter Ablation for Atrial Fibrillation in Heart Failure.

    abstract：:Background Meta-analyses are expected to follow a standardized process, and thus, they have become highly formulaic, although there is little evidence that such regimentation yields high-quality results. Methods and Results This article describes the results of a critical examination of 14 published meta-analyses of c...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.119.013779

    authors： Packer M

    更新日期：2019-11-05 00:00:00

  • Associations of Vascular Risk Factors and APOE Genotype With Perivascular Spaces Among Community-Dwelling Older Adults.

    abstract：:Background Evidence suggests that enlarged perivascular spaces (PVSs) may represent a marker for cerebral small-vessel disease. We investigated whether vascular risk factors are correlated with visible PVS in older adults. Methods and Results This population-based study included 530 participants (age ≥60 years) who we...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.119.015229

    authors： Laveskog A,Wang R,Vetrano DL,Bronge L,Wahlund LO,Qiu C

    更新日期：2020-08-18 00:00:00

  • Assessment of a University of California, Los Angeles 4-variable risk score for advanced heart failure.

    abstract：BACKGROUND:The 4-variable risk score from University of California, Los Angeles (UCLA) demonstrated superior discrimination in advanced heart failure, compared to established risk scores. However, the model has not been externally validated, and its suitability as a selection tool for heart transplantation (HT) and lef...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.114.000998

    authors： Sartipy U,Goda A,Mancini DM,Lund LH

    更新日期：2014-06-06 00:00:00

  • Diagnostic Accuracy of Tissue Doppler Index E/e' for Evaluating Left Ventricular Filling Pressure and Diastolic Dysfunction/Heart Failure With Preserved Ejection Fraction: A Systematic Review and Meta-Analysis.

    abstract：BACKGROUND:Tissue Doppler index E/e' is used clinically and in multidisciplinary research for estimation of left ventricular filling pressure (LVFP) and diastolic dysfunction (DD)/heart failure with preserved ejection fraction (HFpEF). Its diagnostic accuracy is not well studied. METHODS AND RESULTS:From the PubMed, S...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,meta分析,评审

    doi：10.1161/JAHA.115.002530

    authors： Sharifov OF,Schiros CG,Aban I,Denney TS,Gupta H

    更新日期：2016-01-25 00:00:00

  • Myocardial Strain and Cardiac Output are Preferable Measurements for Cardiac Dysfunction and Can Predict Mortality in Septic Mice.

    abstract：:Background Sepsis is the overwhelming host response to infection leading to shock and multiple organ dysfunction. Cardiovascular complications greatly increase sepsis-associated mortality. Although murine models are routinely used for preclinical studies, the benefit of using genetically engineered mice in sepsis is c...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.119.012260

    authors： Hoffman M,Kyriazis ID,Lucchese AM,de Lucia C,Piedepalumbo M,Bauer M,Schulze PC,Bonios MJ,Koch WJ,Drosatos K

    更新日期：2019-05-21 00:00:00

  • Heart Rhythm Complexity Predicts Long-Term Cardiovascular Outcomes in Peritoneal Dialysis Patients: A Prospective Cohort Study.

    abstract：:Background Cardiovascular disease is the leading cause of morbidity and mortality in patients with end-stage renal disease. Heart rhythm complexity analysis has been shown to be useful in predicting outcomes in various diseases; however, data on patients with end-stage renal disease are limited. In this study, we anal...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.119.013036

    authors： Tsai CH,Huang JW,Lin C,Ma HP,Lo MT,Liu LD,Lin LY,Lin CT,Hung CS,Peng CK,Lin YH

    更新日期：2020-01-21 00:00:00

  • Association Between Modifiable Risk Factors and Pharmaceutical Expenditures Among Adults With Atherosclerotic Cardiovascular Disease in the United States: 2012-2013 Medical Expenditures Panel Survey.

    abstract：BACKGROUND:Atherosclerotic cardiovascular disease (ASCVD) causes most deaths in the United States and accounts for the highest healthcare spending. The association between the modifiable risk factors (MRFs) of ASCVD and pharmaceutical expenditures are largely unknown. METHODS AND RESULTS:We examined the association be...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究

    doi：10.1161/JAHA.116.004996

    authors： Salami JA,Valero-Elizondo J,Ogunmoroti O,Spatz ES,Rana JS,Virani SS,Blankstein R,Younus A,Arrieta A,Blaha MJ,Veledar E,Nasir K

    更新日期：2017-06-09 00:00:00

  • Impact of Plasma Potassium Normalization on Short-Term Mortality in Patients With Hypertension and Hyperkalemia.

    abstract：:Background Hyperkalemia can be harmful, but the effect of correcting hyperkalemia is sparsely studied. We used nationwide data to examine hyperkalemia follow-up in patients with hypertension. Methods and Results We identified 7620 patients with hypertension, who had the first plasma potassium measurement ≥4.7 mmol/L (...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.120.017087

    authors： Krogager ML,Søgaard P,Torp-Pedersen C,Bøggild H,Gislason G,Kragholm K

    更新日期：2020-12-15 00:00:00

  • Optimal Lifestyle Components in Young Adulthood Are Associated With Maintaining the Ideal Cardiovascular Health Profile Into Middle Age.

    abstract：BACKGROUND:Middle-aged adults with ideal blood pressure, cholesterol, and glucose levels exhibit substantially lower cardiovascular mortality than those with unfavorable levels. Four healthy lifestyle components-optimal body weight, diet, physical activity, and not smoking-are recommended for cardiovascular health (CVH...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究

    doi：10.1161/JAHA.115.002048

    authors： Gooding HC,Shay CM,Ning H,Gillman MW,Chiuve SE,Reis JP,Allen NB,Lloyd-Jones DM

    更新日期：2015-10-29 00:00:00

  • Temporal Trends in the Practice Pattern for Venous Thromboembolism in Japan: Insight From JROAD-DPC.

    abstract：:Background Recently, direct oral anticoagulants have been introduced for venous thromboembolism (VTE), which might change the management strategies of VTE. However, there have been limited data on the current real-world practice pattern for VTE in Asian countries. Methods and Results The JROAD-DPC (Japanese Registry o...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.119.014582

    authors： Yamashita Y,Morimoto T,Yoshikawa Y,Yaku H,Sumita Y,Nakai M,Ono K,Kimura T

    更新日期：2020-01-21 00:00:00

  • Associations of Left Ventricular Structure and Function With Blood Pressure in Heart Failure With Preserved Ejection Fraction: Analysis of the TOPCAT Trial.

    abstract：:Background Data on the association of systolic and diastolic blood pressure with the structure and function of failing hearts with preserved ejection fraction (EF) are sparse. Methods and Results This analysis included 935 patients with heart failure (49.4% women; mean age, 69.9 years) with preserved EF (≥45%) enrolle...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.119.016009

    authors： Wei FF,Xue R,Thijs L,Liang W,Owusu-Agyeman M,He X,Staessen JA,Dong Y,Liu C

    更新日期：2020-08-04 00:00:00

  • Burden of Uncontrolled Metabolic Risk Factors and Left Ventricular Structure and Function in Patients With Type 2 Diabetes Mellitus.

    abstract：:Background Type 2 diabetes mellitus is closely associated with metabolic risk factors that all contribute to impairment of the left ventricle. The implications of having type 2 diabetes mellitus with well-controlled metabolic risk factors compared to an increasing burden of uncontrolled metabolic risk factors on left ...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,多中心研究

    doi：10.1161/JAHA.118.008856

    authors： Jørgensen PG,Jensen MT,Biering-Sørensen T,Mogelvang R,Fritz-Hansen T,Vilsbøll T,Rossing P,Jensen JS

    更新日期：2018-10-02 00:00:00

  • Inhibition of Vascular c-Jun N-Terminal Kinase 2 Improves Obesity-Induced Endothelial Dysfunction After Roux-en-Y Gastric Bypass.

    abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGB) reduces obesity-associated comorbidities and cardiovascular mortality. RYGB improves endothelial dysfunction, reducing c-Jun N-terminal kinase (JNK) vascular phosphorylation. JNK activation links obesity with insulin resistance and endothelial dysfunction. Herein, we examined ...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.117.006441

    authors： Doytcheva P,Bächler T,Tarasco E,Marzolla V,Engeli M,Pellegrini G,Stivala S,Rohrer L,Tona F,Camici GG,Vanhoutte PM,Matter CM,Lutz TA,Lüscher TF,Osto E

    更新日期：2017-11-14 00:00:00

  • Anesthetizing the Fibrillating Heart.

    abstract：:See Article Lee et al. ...

    journal_title：Journal of the American Heart Association

    pub_type： 评论,社论

    doi：10.1161/JAHA.119.012713

    authors： Hanna P,Zhu C,Rajendran PS,Shivkumar K

    更新日期：2019-05-21 00:00:00

  • Thrombocytopenia as a Preoperative Risk Assessment Tool in Patients With Rheumatic Heart Disease Undergoing Valve Replacement Surgery.

    abstract：BACKGROUND:Postoperative thrombocytopenia has been reported to be correlated with adverse events, but the prognostic value of baseline thrombocytopenia is unclear. This study was undertaken to evaluate the relationship between preoperative thrombocytopenia and adverse outcomes in patients with rheumatic heart disease w...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.117.006988

    authors： Wei XB,Jiang L,Liu YH,Feng D,He PC,Chen JY,Tan N,Yu DQ

    更新日期：2017-12-04 00:00:00

  • Hemodynamic Profile of Patients With Heart Failure and Preserved Ejection Fraction Vary by Age.

    abstract：BACKGROUND:Patients with heart failure with preserved ejection fraction (HFpEF) exhibit a range of cardiovascular phenotypic profiles modified by several common comorbidities. In particular, patients with HFpEF tend to be older; however, it is unclear whether the effects of cardiovascular aging per se modify the expres...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.116.005434

    authors： Nanayakkara S,Haykowsky M,Mariani J,Van Empel V,Maeder MT,Vizi D,Kaye DM

    更新日期：2017-09-22 00:00:00

  • Inverse Association Between Serum Non-High-Density Lipoprotein Cholesterol Levels and Mortality in Patients Undergoing Incident Hemodialysis.

    abstract：BACKGROUND:There is accumulating evidence that serum levels of non-high-density lipoprotein cholesterol (non-HDL-C) are a more accurate predictor of cardiovascular outcomes when compared with low-density lipoprotein cholesterol. However, we recently found that higher serum concentrations of triglycerides are associated...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.118.009096

    authors： Chang TI,Streja E,Ko GJ,Naderi N,Rhee CM,Kovesdy CP,Kashyap ML,Vaziri ND,Kalantar-Zadeh K,Moradi H

    更新日期：2018-06-09 00:00:00

  • Membrane-Tethered Metalloproteinase Expressed by Vascular Smooth Muscle Cells Limits the Progression of Proliferative Atherosclerotic Lesions.

    abstract：BACKGROUND:The MMP (matrix metalloproteinase) family plays diverse and critical roles in directing vascular wall remodeling in atherosclerosis. Unlike secreted-type MMPs, a member of the membrane-type MMP family, MT1-MMP (membrane-type 1 MMP; MMP14), mediates pericellular extracellular matrix degradation that is indisp...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.116.003693

    authors： Barnes RH 2nd,Akama T,Öhman MK,Woo MS,Bahr J,Weiss SJ,Eitzman DT,Chun TH

    更新日期：2017-07-22 00:00:00

  • Antihypertensive drug class interactions and risk for incident diabetes: a nested case-control study.

    abstract：BACKGROUND:We aimed to determine how single and combination antihypertensive therapy alters risk for diabetes mellitus (DM).Thiazide diuretics (TD), β blockers (BB), and renin-angiotensin system blockers (RASB) impact DM risk while calcium channel blockers (CCB) are neutral. DM risk associated with combinations is uncl...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章

    doi：10.1161/JAHA.113.000125

    authors： Cooper--DeHoff RM,Bird ST,Nichols GA,Delaney JA,Winterstein AG

    更新日期：2013-06-10 00:00:00

  • Vitamin C Intravenous Treatment In the Setting of Atrial Fibrillation Ablation: Results From the Randomized, Double-Blinded, Placebo-Controlled CITRIS-AF Pilot Study.

    abstract：:Background Catheter ablation is an effective treatment for atrial fibrillation (AF), but high levels of post-procedure inflammation predict adverse clinical events. Ascorbic acid (AA) has shown promise in reducing inflammation but is untested in this population. We sought to test the feasibility, safety, and prelimina...

    journal_title：Journal of the American Heart Association

    pub_type： 杂志文章,随机对照试验

    doi：10.1161/JAHA.119.014213

    authors： Trankle CR,Puckett L,Swift-Scanlan T,DeWilde C,Priday A,Sculthorpe R,Ellenbogen KA,Fowler A,Koneru JN

    更新日期：2020-02-04 00:00:00