Optimal Lifestyle Components in Young Adulthood Are Associated With Maintaining the Ideal Cardiovascular Health Profile Into Middle Age.

abstract：:Background Both elemental metals and particulate air pollution have been reported to influence adult blood pressure (BP). The aim of this study is to examine which elemental components of particle mass with diameter ≤2.5 μm (PM2.5) are responsible for previously reported associations between PM2.5 and neonatal BP. Met...

journal_title：Journal of the American Heart Association

authors： Zanobetti A,Coull BA,Luttmann-Gibson H,van Rossem L,Rifas-Shiman SL,Kloog I,Schwartz JD,Oken E,Bobb JF,Koutrakis P,Gold DR

更新日期：2021-01-05 00:00:00

abstract：:Background Pregnancy increases the risk of acute myocardial infarction (AMI). The purpose of this study was to examine timing and risk factors for AMI in pregnancy and poor outcome. Methods and Results National Inpatient Sample (2003-2015) was screened in pregnancy, labor and delivery, and postpartum. There were 11 29...

journal_title：Journal of the American Heart Association

authors： Balgobin CA,Zhang X,Lima FV,Avila C,Parikh PB,Yang J,Stergiopoulos K

更新日期：2020-11-03 00:00:00

abstract：BACKGROUND:Clinical symptoms are part of the risk stratification approaches used in the emergency department (ED) to evaluate patients with suspected acute coronary syndromes (ACS). The objective of this study was to determine the sensitivity, specificity, and predictive value of 13 symptoms for a discharge diagnosis o...

journal_title：Journal of the American Heart Association

authors： Devon HA,Rosenfeld A,Steffen AD,Daya M

更新日期：2014-04-02 00:00:00

abstract：BACKGROUND:Primary-prevention implantable cardioverter-defibrillators (ICDs) reduce total mortality in patients with severe left ventricular systolic function. However, only a minority of patients benefit from these devices. We designed the Prospective Observational Study of Implantable Cardioverter-Defibrillators (PRO...

journal_title：Journal of the American Heart Association

authors： Cheng A,Dalal D,Butcher B,Norgard S,Zhang Y,Dickfeld T,Eldadah ZA,Ellenbogen KA,Guallar E,Tomaselli GF

更新日期：2013-02-22 00:00:00

abstract：BACKGROUND:The structure of the aorta is considered to influence exercise systolic blood pressure (SBP) response, which, in turn, might impact upon adverse outcomes. The current study sought to investigate the relationship of aortic calcification and exercise SBP with adverse outcomes among elderly individuals. METHOD...

journal_title：Journal of the American Heart Association

authors： Cho IJ,Chang HJ,Cho I,Heo R,Lee SE,Shim CY,Hong GR,Chung N

更新日期：2016-04-22 00:00:00

abstract：:Background Although coffee consumption is often reported as a trigger for atrial fibrillation (AF) among patients with paroxysmal AF, prospective studies on the relation of coffee consumption with AF risk have been inconsistent. Hence, we sought to assess the association between coffee consumption and risk of AF in me...

journal_title：Journal of the American Heart Association

authors： Bodar V,Chen J,Gaziano JM,Albert C,Djoussé L

更新日期：2019-08-06 00:00:00

abstract：:Background Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy. Current guidelines endorse management in expert centers, but patient socioeconomic status can affect access to specialty care. The effect of socioeconomic status and specialty care access on HCM outcomes has not been examined. Me...

journal_title：Journal of the American Heart Association

authors： Thomas A,Papoutsidakis N,Spatz E,Testani J,Soucier R,Chou J,Ahmad T,Darr U,Hu X,Li F,Chen ME,Bellumkonda L,Sumathipala A,Jacoby D

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:CSL112 is a new formulation of human apolipoprotein A-I (apoA-I) being developed to reduce cardiovascular events following acute coronary syndrome. This phase 2a, randomized, double-blind, multicenter, dose-ranging trial represents the first clinical investigation to assess the safety and pharmacokinetics/ph...

journal_title：Journal of the American Heart Association

authors： Tricoci P,D'Andrea DM,Gurbel PA,Yao Z,Cuchel M,Winston B,Schott R,Weiss R,Blazing MA,Cannon L,Bailey A,Angiolillo DJ,Gille A,Shear CL,Wright SD,Alexander JH

更新日期：2015-08-25 00:00:00

abstract：:Background While high levels of lipids and lipid variability are established risk factors for atherosclerotic cardiovascular disease, their roles in the development of atrial fibrillation (AF) are unclear, with previous studies suggesting a "cholesterol paradox." Methods and Results A nationwide population-based cohor...

journal_title：Journal of the American Heart Association

authors： Lee HJ,Lee SR,Choi EK,Han KD,Oh S

更新日期：2019-12-03 00:00:00

abstract：:Background Platelets play a role in promoting inflammatory responses under several disease conditions. Platelets are activated in hypertensive patients. However, the mechanisms responsible for platelet-mediating vascular inflammation are unknown. The present study investigated the role of platelets in promoting vascul...

journal_title：Journal of the American Heart Association

authors： An X,Jiang G,Cheng C,Lv Z,Liu Y,Wang F

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Biventricular pacing (CRT) shows clear benefits in heart failure with wide QRS, but results in narrow QRS have appeared conflicting. We tested the hypothesis that study design might have influenced findings. METHOD AND RESULTS:We identified all reports of CRT-P/D therapy in subjects with narrow QRS reportin...

journal_title：Journal of the American Heart Association

authors： Jabbour RJ,Shun-Shin MJ,Finegold JA,Afzal Sohaib SM,Cook C,Nijjer SS,Whinnett ZI,Manisty CH,Brugada J,Francis DP

更新日期：2015-01-06 00:00:00

abstract：BACKGROUND:Sex-based differences in clinical presentation, pathophysiology, and outcomes of patients with acute chest pain are increasingly being recognized, but are not implemented in guidelines and clinical prediction tools. We evaluated the performance of the HEART score in women versus men, because sex-based differ...

journal_title：Journal of the American Heart Association

authors： Bank IEM,de Hoog VC,de Kleijn DPV,Pasterkamp G,Doevendans PA,den Ruijter HM,Dalmeijer G,Wildbergh TX,Mosterd A,Timmers L

更新日期：2017-06-21 00:00:00

abstract：:Background Regulator of G protein signaling 6 ( RGS 6) is an important member of the RGS family and produces pleiotropic regulatory effects on cardiac pathophysiology. However, the role of RGS 6 protein in cardiomyocytes during angiotensin II - and pressure overload-induced cardiac hypertrophy remain unknown. Methods ...

journal_title：Journal of the American Heart Association

authors： Huang Z,Shu J,Jiang W,Jiang M,Lu Y,Dai H,Xu N,Yuan H,Cai J

更新日期：2018-10-02 00:00:00

abstract：BACKGROUND:Transcription of the myristoylated alanine-rich C kinase substrate (MARCKS) is upregulated in animal models of intimal hyperplasia. MARCKS knockdown inhibits vascular smooth muscle cell (VSMC) migration in vitro; however, the mechanism is as yet unknown. We sought to elucidate the mechanism of MARCKS-mediate...

journal_title：Journal of the American Heart Association

authors： Yu D,Makkar G,Strickland DK,Blanpied TA,Stumpo DJ,Blackshear PJ,Sarkar R,Monahan TS

更新日期：2015-10-08 00:00:00

abstract：:Background The objectives of the present study were (1) to evaluate the echocardiographic prognostic factors associated with improved left ventricular (LV) systolic function after aortic valve replacement, and (2) to compare the long-term outcomes after aortic valve replacement in chronic aortic regurgitation (AR) pat...

journal_title：Journal of the American Heart Association

authors： Kim MS,Kim JH,Joo HC,Lee S,Youn YN,Lee SH

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:Platelet activation can lead to enhanced oxidative stress, inflammatory response, and endothelial dysfunction. To quantify the effects of platelet inhibition on endothelial function, we assessed platelet activity of healthy persons before and after clopidogrel administration and evaluated its effects on endo...

journal_title：Journal of the American Heart Association

authors： Salimi S,Lewis JP,Yerges-Armstrong LM,Mitchell BD,Saeed F,O'Connell JR,Perry JA,Ryan KA,Shuldiner AR,Parsa A

更新日期：2016-10-31 00:00:00

abstract：:Background Race influences medical decision making, but its impact on advanced heart failure therapy allocation is unknown. We sought to determine whether patient race influences allocation of advanced heart failure therapies. Methods and Results Members of a national heart failure organization were randomized to clin...

journal_title：Journal of the American Heart Association

authors： Breathett K,Yee E,Pool N,Hebdon M,Crist JD,Knapp S,Larsen A,Solola S,Luy L,Herrera-Theut K,Zabala L,Stone J,McEwen MM,Calhoun E,Sweitzer NK

更新日期：2019-11-19 00:00:00

abstract：BACKGROUND:Patients receiving oral anticoagulation in addition to dual-antiplatelet therapy are known to be at high risk for bleeding events; thus, the selection of a drug-eluting stent (DES) versus a bare metal stent (BMS) can have important implications for patients with atrial fibrillation (AF) presenting with acute...

journal_title：Journal of the American Heart Association

authors： Vora AN,Wang TY,Li S,Chiswell K,Hess C,Lopes RD,Rao SV,Peterson ED

更新日期：2017-08-21 00:00:00

abstract：BACKGROUND:Although clinical trials have proved that statin can be used prophylactically against cardiovascular events, the direct effects of statin on plaque development are not well understood. We generated low-density lipoprotein receptor knockout (LDLR(-/-)) pigs to study the effects of early statin administration ...

journal_title：Journal of the American Heart Association

authors： Li Y,Fuchimoto D,Sudo M,Haruta H,Lin QF,Takayama T,Morita S,Nochi T,Suzuki S,Sembon S,Nakai M,Kojima M,Iwamoto M,Hashimoto M,Yoda S,Kunimoto S,Hiro T,Matsumoto T,Mitsumata M,Sugitani M,Saito S,Hirayama A,Onish

更新日期：2016-04-18 00:00:00

abstract：:Background Left ventricular assist devices (LVADs) generate electromagnetic interference that causes high-frequency noise artifacts on 12-lead ECGs. We describe the causes of this interference and potential solutions to aid ECG interpretation in patients with LVAD. Methods and Results Waveform data from ECGs performed...

journal_title：Journal of the American Heart Association

authors： Loring Z,Sen S,Black-Maier E,Atwater BD,Russell SD,DeVore AD,Piccini JP

更新日期：2020-08-18 00:00:00

abstract：:Background Programs targeting the standard modifiable cardiovascular risk factors (SMuRFs: hypertension, diabetes mellitus, hypercholesterolemia, smoking) are critical to tackling coronary heart disease at a community level. However, myocardial infarction in SMuRF-less individuals is not uncommon. This study uses 2 se...

journal_title：Journal of the American Heart Association

authors： Vernon ST,Coffey S,D'Souza M,Chow CK,Kilian J,Hyun K,Shaw JA,Adams M,Roberts-Thomson P,Brieger D,Figtree GA

更新日期：2019-11-05 00:00:00

abstract：:Background Antazoline mesylate represents an antihistamine capable of rapid and safe cardioversion of atrial fibrillation, yet evidence concerning its efficacy in comparison to other medications is insufficient. The study aimed to evaluate the success rate and safety of pharmacological cardioversion of atrial fibrilla...

journal_title：Journal of the American Heart Association

authors： Wybraniec MT,Wróbel W,Wilkosz K,Wrona K,Bula K,Mizia-Stec K

更新日期：2018-10-16 00:00:00

abstract：:Background A combination of clinical and electrocardiographic risk factors is used for risk stratification in Brugada syndrome. In this study, we tested the hypothesis that the incorporation of latent variables between variables using nonnegative matrix factorization can improve risk stratification compared with logis...

journal_title：Journal of the American Heart Association

authors： Tse G,Zhou J,Lee S,Liu T,Bazoukis G,Mililis P,Wong ICK,Chen C,Xia Y,Kamakura T,Aiba T,Kusano K,Zhang Q,Letsas KP

更新日期：2020-11-17 00:00:00

abstract：:Background Data on race- and ethnicity-based disparities in the utilization and outcomes of structural heart disease interventions in the United States are scarce. Methods and Results We used the National Inpatient Sample (2011-2016) to examine racial and ethnic differences in the utilization, in-hospital outcomes, an...

journal_title：Journal of the American Heart Association

authors： Alkhouli M,Alqahtani F,Holmes DR,Berzingi C

更新日期：2019-08-06 00:00:00

abstract：:Background Whether physical activity is a determinant of peripheral artery disease (PAD) remains unclear. We therefore assessed the association of physical activity (amount and intensity) with subsequent risk of hospitalization with PAD and its severe form, critical limb ischemia, in the ARIC (Atherosclerosis Risk in ...

journal_title：Journal of the American Heart Association

authors： Lu Y,Ballew SH,Kwak L,Selvin E,Kalbaugh CA,Schrack JA,Matsushita K,Szklo M

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:We sought to characterize growth between birth and age 3 years in infants with hypoplastic left heart syndrome who underwent the Norwood procedure. METHODS AND RESULTS:We performed a secondary analysis using the Single Ventricle Reconstruction Trial database after excluding patients <37 weeks gestation (N=4...

journal_title：Journal of the American Heart Association

authors： Burch PT,Gerstenberger E,Ravishankar C,Hehir DA,Davies RR,Colan SD,Sleeper LA,Newburger JW,Clabby ML,Williams IA,Li JS,Uzark K,Cooper DS,Lambert LM,Pemberton VL,Pike NA,Anderson JB,Dunbar-Masterson C,Khaikin S,Zyble

更新日期：2014-06-23 00:00:00

abstract：BACKGROUND:Women have high rates of peripheral artery disease (PAD) despite fewer cardiovascular disease (CVD) risk factors, compared to men. We sought to determine the gender-specific prevalence of low ankle brachial index (ABI) and the relationship to C-reactive protein (CRP) levels and CVD risk factors in the Life L...

journal_title：Journal of the American Heart Association

authors： Hiramoto JS,Katz R,Weisman S,Conte M

更新日期：2014-03-13 00:00:00

abstract：:Background In this nationwide study, we used the unique Danish registries to estimate the risk of suicide and deliberate self-harm in patients with congenital heart disease (CHD). Methods and Results We identified all Danish citizens receiving a diagnosis of CHD between 1977 and 2007. As a reference cohort, we randoml...

journal_title：Journal of the American Heart Association

authors： Udholm S,Nyboe C,Lundbye-Christensen S,Nordentoft M,Hjortdal VE

更新日期：2020-05-18 00:00:00

abstract：:Background Hyperhomocysteinemia is a risk factor for ischemic stroke; however, a targeted treatment strategy is lacking partly because of limited understanding of the causal role of homocysteine in cerebrovascular pathogenesis. Methods and Results In a genetic model of cystathionine beta synthase (CBS) deficiency, we ...

journal_title：Journal of the American Heart Association

authors： Gu SX,Sonkar VK,Katare PB,Kumar R,Kruger WD,Arning E,Bottiglieri T,Lentz SR,Dayal S

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:Preeclampsia (PE) is a life-threatening hypertensive disorder of pregnancy associated with autoantibodies, termed AT1-AA, that activate the AT1 angiotensin receptor. Although the pathogenic nature of these autoantibodies has been extensively studied, little is known about the molecular cause of their generat...

journal_title：Journal of the American Heart Association

authors： Liu C,Luo R,Elliott SE,Wang W,Parchim NF,Iriyama T,Daugherty PS,Blackwell SC,Sibai BM,Kellems RE,Xia Y

更新日期：2015-12-16 00:00:00