Ambient Particle Components and Newborn Blood Pressure in Project Viva.

abstract：BACKGROUND:Long chain acyl-CoA synthetases (ACSL) catalyze long-chain fatty acids (FA) conversion to acyl-CoAs. Temporal ACSL1 inactivation in mouse hearts (Acsl1(H-/-)) impaired FA oxidation and dramatically increased glucose uptake, glucose oxidation, and mTOR activation, resulting in cardiac hypertrophy. We used unb...

journal_title：Journal of the American Heart Association

authors： Schisler JC,Grevengoed TJ,Pascual F,Cooper DE,Ellis JM,Paul DS,Willis MS,Patterson C,Jia W,Coleman RA

更新日期：2015-02-24 00:00:00

abstract：:Background Atherosclerotic vertebrobasilar disease is a significant etiology of posterior circulation stroke. The prospective observational VERiTAS (Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke) study demonstrated that distal hemodynamic status is a robust predictor of subsequent ve...

journal_title：Journal of the American Heart Association

authors： See AP,Pandey DK,Du X,Rose-Finnell L,Charbel FT,Derdeyn CP,Amin-Hanjani S,VERiTAS Study Group* †.

更新日期：2020-06-16 00:00:00

abstract：:Background Circulating proteins are exposed to vascular endothelial layer and influence their functions. Among them, adipsin is a member of the trypsin family of peptidases and is mainly secreted from adipocytes, monocytes, and macrophages, catalyzing the rate-limiting step of the alternative complement pathway. Howev...

journal_title：Journal of the American Heart Association

authors： Ohtsuki T,Satoh K,Shimizu T,Ikeda S,Kikuchi N,Satoh T,Kurosawa R,Nogi M,Sunamura S,Yaoita N,Omura J,Aoki T,Tatebe S,Sugimura K,Takahashi J,Miyata S,Shimokawa H

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:A higher milk consumption may be associated with a lower stroke risk. We conducted a comprehensive systematic review and dose-response meta-analysis of milk and other dairy products in relation to stroke risk. METHODS AND RESULTS:Through a systematic literature search, prospective cohort studies of dairy fo...

journal_title：Journal of the American Heart Association

authors： de Goede J,Soedamah-Muthu SS,Pan A,Gijsbers L,Geleijnse JM

更新日期：2016-05-20 00:00:00

abstract：BACKGROUND:Vascular complications and abnormal platelet function contribute to morbidity and mortality in diabetes mellitus. We hypothesized that the Rho-related GTPase protein, Rac1, can influence both endothelial and platelet function and might represent a potential novel therapeutic target in diabetes mellitus. MET...

journal_title：Journal of the American Heart Association

authors： Schiattarella GG,Carrizzo A,Ilardi F,Damato A,Ambrosio M,Madonna M,Trimarco V,Marino M,De Angelis E,Settembrini S,Perrino C,Trimarco B,Esposito G,Vecchione C

更新日期：2018-04-06 00:00:00

abstract：:Background The Institute of Medicine has called for actions to understand and target sex-related differences in care and outcomes for out-of-hospital cardiac arrest patients. We assessed changes in bystander and first-responder interventions and outcomes for males versus females after statewide efforts to improve card...

journal_title：Journal of the American Heart Association

authors： Malta Hansen C,Kragholm K,Dupre ME,Pearson DA,Tyson C,Monk L,Rea TD,Starks MA,Nelson D,Jollis JG,McNally B,Corbett CM,Granger CB

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:We aimed to determine how single and combination antihypertensive therapy alters risk for diabetes mellitus (DM).Thiazide diuretics (TD), β blockers (BB), and renin-angiotensin system blockers (RASB) impact DM risk while calcium channel blockers (CCB) are neutral. DM risk associated with combinations is uncl...

journal_title：Journal of the American Heart Association

authors： Cooper--DeHoff RM,Bird ST,Nichols GA,Delaney JA,Winterstein AG

更新日期：2013-06-10 00:00:00

abstract：:Background Limited data are available on mid-range ejection fraction (mrEF) patients with dilated cardiomyopathy. We sought to define the characteristics, evolution, and long-term prognosis of dilated cardiomyopathy patients with mrEF at diagnosis. Methods and Results We analyzed all dilated cardiomyopathy patients co...

journal_title：Journal of the American Heart Association

authors： Gentile P,Merlo M,Cannatà A,Gobbo M,Artico J,Stolfo D,Gigli M,Ramani F,Barbati G,Pinamonti B,Sinagra G

更新日期：2019-09-03 00:00:00

abstract：:Background Epigenome-wide association studies for cardiometabolic risk factors have discovered multiple loci associated with incident cardiovascular disease (CVD). However, few studies have sought to directly optimize a predictor of CVD risk. Furthermore, it is challenging to train multivariate models across multiple ...

journal_title：Journal of the American Heart Association

authors： Westerman K,Fernández-Sanlés A,Patil P,Sebastiani P,Jacques P,Starr JM,J Deary I,Liu Q,Liu S,Elosua R,DeMeo DL,Ordovás JM

更新日期：2020-04-21 00:00:00

abstract：:Background Meta-analyses are expected to follow a standardized process, and thus, they have become highly formulaic, although there is little evidence that such regimentation yields high-quality results. Methods and Results This article describes the results of a critical examination of 14 published meta-analyses of c...

journal_title：Journal of the American Heart Association

authors： Packer M

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:The structure of the aorta is considered to influence exercise systolic blood pressure (SBP) response, which, in turn, might impact upon adverse outcomes. The current study sought to investigate the relationship of aortic calcification and exercise SBP with adverse outcomes among elderly individuals. METHOD...

journal_title：Journal of the American Heart Association

authors： Cho IJ,Chang HJ,Cho I,Heo R,Lee SE,Shim CY,Hong GR,Chung N

更新日期：2016-04-22 00:00:00

abstract：:Despite consensus that excessive circulating concentrations of apoB-lipoproteins is a key driver for the atherosclerotic process and that treatments that low-density lipoprotein cholesterol lowering by up-regulation of low-density lipoprotein cholesterol receptor expression reduces that risk, divergent viewpoints on i...

journal_title：Journal of the American Heart Association

authors： Orringer CE,Tokgozoglu L,Maki KC,Ray KK,Saseen JJ,Catapano AL

更新日期：2020-11-03 00:00:00

abstract：:Background Ticagrelor reduces ischaemic end points in acute coronary syndromes. However, outcomes of ticagrelor versus clopidogrel in real-world patients with acute coronary syndromes treated with percutaneous coronary intervention (PCI) remain unclear. We sought to examine whether treatment with ticagrelor is superio...

journal_title：Journal of the American Heart Association

authors： Völz S,Petursson P,Odenstedt J,Ioanes D,Haraldsson I,Angerås O,Dworeck C,Hirlekar G,Myredal A,Albertsson P,Råmunddal T,Redfors B,Omerovic E

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:Although guidelines for antiarrhythmic drug therapy in atrial fibrillation (AF) were published in 2006, it remains uncertain whether adherence to these guidelines affects patient outcomes. METHODS AND RESULTS:We retrospectively evaluated the records of 5976 consecutive AF patients who were prescribed at lea...

journal_title：Journal of the American Heart Association

authors： Qin D,Leef G,Alam MB,Rattan R,Munir MB,Patel D,Khattak F,Vaghasia N,Adelstein E,Jain SK,Saba S

更新日期：2015-04-06 00:00:00

abstract：:Background Neurocognitive impairment is a common complication of congenital heart disease (CHD) as well as acquired cardiovascular disease. Data are limited on neurocognitive function in adults with CHD (ACHD). Methods and Results A total of 1020 individuals with mild-to-moderate ACHD and 497 987 individuals without A...

journal_title：Journal of the American Heart Association

authors： Perrotta ML,Saha P,Zawadzki R,Beidelman M,Ingelsson E,Lui GK,Priest JR

更新日期：2020-10-20 00:00:00

abstract：:Background Pregnancy increases the risk of acute myocardial infarction (AMI). The purpose of this study was to examine timing and risk factors for AMI in pregnancy and poor outcome. Methods and Results National Inpatient Sample (2003-2015) was screened in pregnancy, labor and delivery, and postpartum. There were 11 29...

journal_title：Journal of the American Heart Association

authors： Balgobin CA,Zhang X,Lima FV,Avila C,Parikh PB,Yang J,Stergiopoulos K

更新日期：2020-11-03 00:00:00

abstract：BACKGROUND:Left ventricular noncompaction (LVNC) has since been classified as a primary genetic cardiomyopathy, but the genetic basis is not fully evaluated. The aim of the present study was to identify the genetic spectrum using next-generation sequencing and to evaluate genotype-phenotype correlations in LVNC patient...

journal_title：Journal of the American Heart Association

authors： Wang C,Hata Y,Hirono K,Takasaki A,Ozawa SW,Nakaoka H,Saito K,Miyao N,Okabe M,Ibuki K,Nishida N,Origasa H,Yu X,Bowles NE,Ichida F,for LVNC Study Collaborators.

更新日期：2017-08-30 00:00:00

abstract：:Background Arterial stiffness is an independent risk factor for cardiovascular disease and can be beneficially influenced by physical activity. However, it is not clear how an individual's physical activity pattern over a week is associated with arterial stiffness. Therefore, we examined the associations of the amount...

journal_title：Journal of the American Heart Association

authors： Vandercappellen EJ,Henry RMA,Savelberg HHCM,van der Berg JD,Reesink KD,Schaper NC,Eussen SJPM,van Dongen MCJM,Dagnelie PC,Schram MT,van Greevenbroek MMJ,Wesselius A,van der Kallen CJH,Köhler S,Stehouwer CDA,Koster A

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Middle-aged adults with ideal blood pressure, cholesterol, and glucose levels exhibit substantially lower cardiovascular mortality than those with unfavorable levels. Four healthy lifestyle components-optimal body weight, diet, physical activity, and not smoking-are recommended for cardiovascular health (CVH...

journal_title：Journal of the American Heart Association

authors： Gooding HC,Shay CM,Ning H,Gillman MW,Chiuve SE,Reis JP,Allen NB,Lloyd-Jones DM

更新日期：2015-10-29 00:00:00

abstract：BACKGROUND:Whether the sympathetic nervous system can directly alter central aortic stiffness remains controversial, mainly because of the difficulty in experimentally augmenting peripheral vasoconstrictor activity without changing blood pressure. METHODS AND RESULTS:To address this limitation, we utilized low-level c...

journal_title：Journal of the American Heart Association

authors： Nardone M,Incognito AV,Millar PJ

更新日期：2018-01-29 00:00:00

abstract：BACKGROUND:The aim of this study was to elucidate the correlation between angiographic coronary vasomotor responses to intracoronary acetylcholine (ACh) injection, clinical features, and long-term prognosis in patients with vasospastic angina (VSA). METHODS AND RESULTS:This is a retrospective, observational, single-ce...

journal_title：Journal of the American Heart Association

authors： Sato K,Kaikita K,Nakayama N,Horio E,Yoshimura H,Ono T,Ohba K,Tsujita K,Kojima S,Tayama S,Hokimoto S,Matsui K,Sugiyama S,Yamabe H,Ogawa H

更新日期：2013-07-15 00:00:00

abstract：:Background NT-proBNP (N-terminal pro-B-type natriuretic peptide) improves the discriminatory ability of risk-prediction models in type 2 diabetes mellitus (T2DM) but is not yet used in clinical practice. We assessed the discriminatory strength of NT-proBNP by itself for death and cardiovascular events in high-risk pat...

journal_title：Journal of the American Heart Association

authors： Malachias MVB,Jhund PS,Claggett BL,Wijkman MO,Bentley-Lewis R,Chaturvedi N,Desai AS,Haffner SM,Parving HH,Prescott MF,Solomon SD,De Zeeuw D,McMurray JJV,Pfeffer MA

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Natriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to hypertension (HTN) and cardiac hypertrophy, conditions more common among African Americans. Hospital-based studies suggest that African Americans may have reduced circulating natriur...

journal_title：Journal of the American Heart Association

authors： Gupta DK,Claggett B,Wells Q,Cheng S,Li M,Maruthur N,Selvin E,Coresh J,Konety S,Butler KR,Mosley T,Boerwinkle E,Hoogeveen R,Ballantyne CM,Solomon SD

更新日期：2015-05-21 00:00:00

abstract：BACKGROUND:Sex-based differences in clinical presentation, pathophysiology, and outcomes of patients with acute chest pain are increasingly being recognized, but are not implemented in guidelines and clinical prediction tools. We evaluated the performance of the HEART score in women versus men, because sex-based differ...

journal_title：Journal of the American Heart Association

authors： Bank IEM,de Hoog VC,de Kleijn DPV,Pasterkamp G,Doevendans PA,den Ruijter HM,Dalmeijer G,Wildbergh TX,Mosterd A,Timmers L

更新日期：2017-06-21 00:00:00

abstract：BACKGROUND:Periaortic fat, because of its contiguity with the aorta, may promote vascular remodeling and aortic dilatation. However, the relations between perioartic fat depots and aortic dimensions have not been previously described. METHODS AND RESULTS:A total of 3001 individuals (mean age 50 ± 10 years, 49% women) ...

journal_title：Journal of the American Heart Association

authors： Thanassoulis G,Massaro JM,Corsini E,Rogers I,Schlett CL,Meigs JB,Hoffmann U,O'Donnell CJ,Fox CS

更新日期：2012-12-01 00:00:00

abstract：:Background Characterizing associations of sleep characteristics with blood-glucose-level factors among blacks may clarify the underlying mechanisms of impaired glucose metabolism and help identify treatment targets to prevent diabetes mellitus in blacks. Methods and Results Cross-sectional analyses were conducted in 7...

journal_title：Journal of the American Heart Association

authors： Yano Y,Gao Y,Johnson DA,Carnethon M,Correa A,Mittleman MA,Sims M,Mostofsky E,Wilson JG,Redline S

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:Quercetin, the most abundant dietary flavonol, has antioxidant effects in cardiovascular disease, but the evidence regarding its effects on blood pressure (BP) has not been conclusive. We assessed the impact of quercetin on BP through a systematic review and meta-analysis of available randomized controlled t...

journal_title：Journal of the American Heart Association

authors： Serban MC,Sahebkar A,Zanchetti A,Mikhailidis DP,Howard G,Antal D,Andrica F,Ahmed A,Aronow WS,Muntner P,Lip GY,Graham I,Wong N,Rysz J,Banach M,Lipid and Blood Pressure Meta‐analysis Collaboration (LBPMC) Group.

更新日期：2016-07-12 00:00:00

abstract：BACKGROUND:It is uncertain whether sex and race affect thrombogenicity in patients with coronary artery disease. We evaluated the effects of sex and race on thrombogenicity in patients with coronary artery disease treated with aspirin. METHODS AND RESULTS:Patients on aspirin therapy for 1 week or longer with known or ...

journal_title：Journal of the American Heart Association

authors： Lev EI,Bliden KP,Jeong YH,Pandya S,Kang K,Franzese C,Tantry US,Gurbel PA

更新日期：2014-10-20 00:00:00

abstract：BACKGROUND:The 4-variable risk score from University of California, Los Angeles (UCLA) demonstrated superior discrimination in advanced heart failure, compared to established risk scores. However, the model has not been externally validated, and its suitability as a selection tool for heart transplantation (HT) and lef...

journal_title：Journal of the American Heart Association

authors： Sartipy U,Goda A,Mancini DM,Lund LH

更新日期：2014-06-06 00:00:00

abstract：:Background Atrial fibrillation ( AF ) and cancer are frequent diseases worldwide. The timewise association between the diagnosis of AF and a subsequent diagnosis of cancer may clarify whether a mutual cause exists, and may also guide clinicians about time windows of high risk of cancer occurrence. Methods and Results ...

journal_title：Journal of the American Heart Association

authors： Vinter N,Christesen AMS,Fenger-Grøn M,Tjønneland A,Frost L

更新日期：2018-09-04 00:00:00