当前位置： SCI文献检索 > Journal of the American Heart Association期刊下所有文献 > Influence of race and sex on thrombogenicity in a large cohort of coronary artery disease patients.

Influence of race and sex on thrombogenicity in a large cohort of coronary artery disease patients.

Abstract：

BACKGROUND:It is uncertain whether sex and race affect thrombogenicity in patients with coronary artery disease. We evaluated the effects of sex and race on thrombogenicity in patients with coronary artery disease treated with aspirin. METHODS AND RESULTS:Patients on aspirin therapy for 1 week or longer with known or suspected coronary artery disease undergoing nonurgent cardiac catheterization (n=1172), of whom 924 were on aspirin and clopidogrel therapy, were studied. The primary end point was thrombin-induced platelet-fibrin clot strength (MAKH) measured by thrombelastography. Secondary end points included coagulation index, a measure of overall coagulation; G, another measure of clot strength; and maximal platelet aggregation. Women had greater MAKH, G, and coagulation index than men, both with and without clopidogrel therapy (with clopidogrel: 68.3±6 versus 65.8±6 mm, P<0.0001; 11.4±3 versus 9.5±4 dyne/cm(2), P<0.0001; and 0.12±3 versus -0.7±3, P=0.003, respectively). Platelet aggregation (induced by ADP, thrombin receptor activating peptide, or collagen) did not differ between sexes. Black patients had greater MAKH and G than white patients (with clopidogrel: 67.8±7 versus 66.4±6 mm, P=0.005; 11±4 versus 10±3 dyne/cm(2), P=0.02, respectively). Black women had the highest MAKH levels. By multivariate analysis, sex, race, diabetes, platelet count, and hemoglobin level were independently associated with MAKH . Sex, but not race, was also associated with the frequency of MAKH ≥72 mm (a threshold related to ischemic event occurrence in patients undergoing coronary intervention). CONCLUSIONS:Sex and race independently influence platelet-fibrin clot strength. Black women appear to have the highest thrombogenicity profile, potentially conferring a high-risk phenotype for thrombotic event occurrence.

journal_name

J Am Heart Assoc

journal_title

Journal of the American Heart Association

authors

Lev EI,Bliden KP,Jeong YH,Pandya S,Kang K,Franzese C,Tantry US,Gurbel PA

doi

10.1161/JAHA.114.001167

subject

Has Abstract

pub_date

2014-10-20 00:00:00

pages

e001167

issue

issn

2047-9980

pii

jah3710

journal_volume

pub_type

杂志文章

在线工具

Influence of race and sex on thrombogenicity in a large cohort of coronary artery disease patients.