Adults With Mild-to-Moderate Congenital Heart Disease Demonstrate Measurable Neurocognitive Deficits.

abstract：BACKGROUND:Time to peak velocity (TPV) is an echocardiographic variable that can be easily measured and reflects a late peaking murmur, a classic physical finding suggesting severe aortic stenosis (AS). The aim of this study was to investigate the usefulness of TPV to evaluate AS severity. METHODS AND RESULTS:This stu...

journal_title：Journal of the American Heart Association

authors： Kamimura D,Hans S,Suzuki T,Fox ER,Hall ME,Musani SK,McMullan MR,Little WC

更新日期：2016-10-22 00:00:00

abstract：:Background Although PAR-1 (protease-activated receptor-1) exerts important functions in the pathophysiology of the cardiovascular system, the role of PAR-1 signaling in heart failure development remains largely unknown. We tested the hypothesis that PAR-1 signaling inhibition has protective effects on the progression ...

journal_title：Journal of the American Heart Association

authors： Yokono Y,Hanada K,Narita M,Tatara Y,Kawamura Y,Miura N,Kitayama K,Nakata M,Nozaka M,Kato T,Kudo N,Tsushima M,Toyama Y,Itoh K,Tomita H

更新日期：2020-06-16 00:00:00

abstract：BACKGROUND:Sex-based differences in clinical presentation, pathophysiology, and outcomes of patients with acute chest pain are increasingly being recognized, but are not implemented in guidelines and clinical prediction tools. We evaluated the performance of the HEART score in women versus men, because sex-based differ...

journal_title：Journal of the American Heart Association

authors： Bank IEM,de Hoog VC,de Kleijn DPV,Pasterkamp G,Doevendans PA,den Ruijter HM,Dalmeijer G,Wildbergh TX,Mosterd A,Timmers L

更新日期：2017-06-21 00:00:00

abstract：:Background Action potential alternans can induce ventricular tachyarrhythmias and manifest on the surface ECG as T-wave alternans (TWA) and QRS alternans (QRSA). We sought to evaluate microvolt QRSA in cardiomyopathy patients in relation to TWA and ventricular tachyarrhythmia outcomes. Methods and Results Prospectivel...

journal_title：Journal of the American Heart Association

authors： Suszko A,Nayyar S,Labos C,Nanthakumar K,Pinter A,Crystal E,Chauhan VS

更新日期：2020-09-01 00:00:00

abstract：:Background To assess differences in platelet inhibition during ticagrelor monotherapy (TIC) or dual therapy with ticagrelor and aspirin (TIC+ASP) in patients after percutaneous coronary intervention using a comprehensive panel of functional tests. Methods and Results In a single-center parallel group, open label, rand...

journal_title：Journal of the American Heart Association

authors： Johnson TW,Baos S,Collett L,Hutchinson JL,Nkau M,Molina M,Aungraheeta R,Reilly-Stitt C,Bowles R,Reeves BC,Rogers CA,Mundell SJ,Baumbach A,Mumford AD

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:The liver X receptors (LXRs; α/β) are nuclear receptors known to regulate cholesterol homeostasis and the production of select hematopoietic populations. The objective of this study was to determine the importance of LXRs and a high-fat high-cholesterol diet on global hematopoiesis, with special emphasis on ...

journal_title：Journal of the American Heart Association

authors： Rasheed A,Tsai R,Cummins CL

更新日期：2018-05-08 00:00:00

abstract：:Background Unruptured intracerebral aneurysm wall enhancement (AWE) on vessel wall magnetic resonance imaging scans may be a promising predictor for rupture-prone intracerebral aneurysms. However, the pathophysiology of AWE remains unclear. To this end, the association between AWE and histopathological changes was ass...

journal_title：Journal of the American Heart Association

authors： Zhong W,Su W,Li T,Tan X,Chen C,Wang Q,Wang D,Su W,Wang Y

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Data are sparse regarding the value of physical activity (PA) surveillance among older adults-particularly among those with mobility limitations. The objective of this study was to examine longitudinal associations between objectively measured daily PA and the incidence of cardiovascular events among older a...

journal_title：Journal of the American Heart Association

authors： Cochrane SK,Chen SH,Fitzgerald JD,Dodson JA,Fielding RA,King AC,McDermott MM,Manini TM,Marsh AP,Newman AB,Pahor M,Tudor-Locke C,Ambrosius WT,Buford TW,LIFE Study Research Group.

更新日期：2017-12-02 00:00:00

abstract：:Background Ankle-brachial indexes (ABI) are a noninvasive diagnostic tool for peripheral arterial disease and a marker of increased cardiovascular risk. ABI is calculated using the highest systolic blood pressure of the 4 ankle arteries (bilateral dorsalis pedis and posterior tibial). Accordingly, patients may be assi...

journal_title：Journal of the American Heart Association

authors： Firth C,Tseng AS,Abdelmalek M,Girardo M,Atwal D,Cooper L,McBane R,Pollak A,Liedl D,Wennberg P,Shamoun FE

更新日期：2020-06-02 00:00:00

abstract：:Background Postpericardiotomy syndrome ( PPS ) is a common complication after cardiac surgery. However, large-scale epidemiological studies about the effect of procedure type on the occurrence of PPS and mortality of patients with PPS have not yet been performed. Methods and Results We studied the association of PPS o...

journal_title：Journal of the American Heart Association

authors： Lehto J,Kiviniemi T,Gunn J,Airaksinen J,Rautava P,Kytö V

更新日期：2018-11-20 00:00:00

abstract：:Background We aimed to determine if there is an association between hospital quality and the likelihood of a given hospital being a preferred transfer destination for stroke patients. Methods and Results Data from Medicare claims identified acute ischemic stroke transferred between 394 northeast US hospitals from 2007...

journal_title：Journal of the American Heart Association

authors： Zachrison KS,Onnela JP,Reeves MJ,Hernandez A,Camargo CA Jr,Zhao X,Matsouaka RA,Goldstein JN,Metlay JP,Schwamm LH

更新日期：2020-01-07 00:00:00

abstract：BACKGROUND:The incidence of abdominal aortic aneurysms (AAAs) will significantly increase during the next decade. Novel biomarkers, besides diameter, are needed for a better characterization of aneurysms and the estimation of the risk of rupture. Fibrin is a key protein in the formation of focal hematoma associated wit...

journal_title：Journal of the American Heart Association

authors： Botnar RM,Brangsch J,Reimann C,Janssen CHP,Razavi R,Hamm B,Makowski MR

更新日期：2018-05-30 00:00:00

abstract：BACKGROUND:Our laboratory has previously demonstrated the importance of a cytoskeletal-based survival signaling pathway using in vitro models of ischemia/reperfusion (IR). However, the importance of this pathway in mediating stress-elicited survival signaling in vivo is unknown. METHODS AND RESULTS:The essential cytos...

journal_title：Journal of the American Heart Association

authors： Perricone AJ,Bivona BJ,Jackson FR,Vander Heide RS

更新日期：2013-09-30 00:00:00

abstract：BACKGROUND:Contemporary rates of oral anticoagulant (OAC) therapy and associated outcomes among patients undergoing percutaneous coronary intervention (PCI) have been poorly described. METHODS AND RESULTS:Using data from an integrated health care system from 2009 to 2014, we identified patients on OACs within 30 days ...

journal_title：Journal of the American Heart Association

authors： Secemsky EA,Butala NM,Kartoun U,Mahmood S,Wasfy JH,Kennedy KF,Shaw SY,Yeh RW

更新日期：2016-10-17 00:00:00

abstract：BACKGROUND:Previous studies have suggested that n-3 polyunsaturated fatty acids (n-3 PUFAs) have antiarrhythmic effects on atrial fibrillation (AF). We aimed to assess the effects of therapy with n-3 PUFAs on the incidence of recurrent AF and on postoperative AF. METHODS AND RESULTS:Electronic searches were conducted ...

journal_title：Journal of the American Heart Association

authors： Mariani J,Doval HC,Nul D,Varini S,Grancelli H,Ferrante D,Tognoni G,Macchia A

更新日期：2013-02-19 00:00:00

abstract：:Background There are spatial disparities in cardiovascular disease (CVD) mortality related to area-level socioeconomic status (SES) disadvantage, but little is known about the spatial distribution of CVD mortality according to built environment factors. We examined joint associations of neighborhood walkability attrib...

journal_title：Journal of the American Heart Association

authors： Koohsari MJ,Nakaya T,Hanibuchi T,Shibata A,Ishii K,Sugiyama T,Owen N,Oka K

更新日期：2020-06-16 00:00:00

abstract：BACKGROUND:Whether heart rate upon discharge following hospitalization for heart failure is associated with long-term adverse outcomes and whether this association differs between patients with sinus rhythm (SR) and atrial fibrillation (AF) have not been well studied. METHODS AND RESULTS:We conducted a retrospective c...

journal_title：Journal of the American Heart Association

authors： Laskey WK,Alomari I,Cox M,Schulte PJ,Zhao X,Hernandez AF,Heidenreich PA,Eapen ZJ,Yancy C,Bhatt DL,Fonarow GC,AHA Get With The Guidelines®‐Heart Failure Program.

更新日期：2015-04-22 00:00:00

abstract：:Background After the coronavirus disease 2019 outbreak, social isolation measures were introduced to contain infection. Although there is currently a slowing down of the infection, a reduction of hospitalizations, especially for myocardial infarction, was observed. The aim of our study is to evaluate the impact of the...

journal_title：Journal of the American Heart Association

authors： Cammalleri V,Muscoli S,Benedetto D,Stifano G,Macrini M,Di Landro A,Di Luozzo M,Marchei M,Mariano EG,Cota L,Sergi D,Bezzeccheri A,Bonanni M,Baluci M,De Vico P,Romeo F

更新日期：2020-10-20 00:00:00

abstract：:Background Turner syndrome ( TS ) is the most common sex chromosome abnormality in women and is associated with increased morbidity and mortality. We describe long-term outcomes in a large cohort of patients with TS . Methods and Results Retrospective review of patients with TS followed at Mayo Clinic Rochester from 1...

journal_title：Journal of the American Heart Association

authors： Fuchs MM,Attenhofer Jost C,Babovic-Vuksanovic D,Connolly HM,Egbe A

更新日期：2019-06-04 00:00:00

abstract：:Background Both elemental metals and particulate air pollution have been reported to influence adult blood pressure (BP). The aim of this study is to examine which elemental components of particle mass with diameter ≤2.5 μm (PM2.5) are responsible for previously reported associations between PM2.5 and neonatal BP. Met...

journal_title：Journal of the American Heart Association

authors： Zanobetti A,Coull BA,Luttmann-Gibson H,van Rossem L,Rifas-Shiman SL,Kloog I,Schwartz JD,Oken E,Bobb JF,Koutrakis P,Gold DR

更新日期：2021-01-05 00:00:00

abstract：:Background Bleeding is a common, morbid, and costly complication of percutaneous coronary intervention. While bleeding avoidance strategies ( BAS ) are effective, they are used paradoxically less in patients at high risk of bleeding. Whether a patient-centered approach to specifically increase the risk-concordant use ...

journal_title：Journal of the American Heart Association

authors： Amin AP,Miller S,Rahn B,Caruso M,Pierce A,Sorensen K,Kurz H,Zajarias A,Bach R,Singh J,Lasala JM,Kulkarni H,Crimmins-Reda P

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:A higher milk consumption may be associated with a lower stroke risk. We conducted a comprehensive systematic review and dose-response meta-analysis of milk and other dairy products in relation to stroke risk. METHODS AND RESULTS:Through a systematic literature search, prospective cohort studies of dairy fo...

journal_title：Journal of the American Heart Association

authors： de Goede J,Soedamah-Muthu SS,Pan A,Gijsbers L,Geleijnse JM

更新日期：2016-05-20 00:00:00

abstract：:Background We systematically reviewed trials comparing different reperfusion strategies for ST-segment-elevation myocardial infarction and used multivariate network meta-analysis to compare outcomes across these strategies. Methods and Results We identified 31 contemporary trials in which patients with ST-segment-elev...

journal_title：Journal of the American Heart Association

authors： Fazel R,Joseph TI,Sankardas MA,Pinto DS,Yeh RW,Kumbhani DJ,Nallamothu BK

更新日期：2020-06-16 00:00:00

abstract：BACKGROUND:There are few data relating novel measures of left ventricular (LV) mechanical function to cardiovascular disease (CVD) outcomes in the community. Whether distinct components of LV mechanical function provide information regarding risk for different CVD outcomes is unclear. METHODS AND RESULTS:We used speck...

journal_title：Journal of the American Heart Association

authors： Cheng S,McCabe EL,Larson MG,Merz AA,Osypiuk E,Lehman BT,Stantchev P,Aragam J,Solomon SD,Benjamin EJ,Vasan RS

更新日期：2015-10-27 00:00:00

abstract：:Background Regulator of G protein signaling 6 ( RGS 6) is an important member of the RGS family and produces pleiotropic regulatory effects on cardiac pathophysiology. However, the role of RGS 6 protein in cardiomyocytes during angiotensin II - and pressure overload-induced cardiac hypertrophy remain unknown. Methods ...

journal_title：Journal of the American Heart Association

authors： Huang Z,Shu J,Jiang W,Jiang M,Lu Y,Dai H,Xu N,Yuan H,Cai J

更新日期：2018-10-02 00:00:00

abstract：:Background Delayed enhancement ( DE ) on magnetic resonance imaging is associated with ventricular arrhythmias, adverse events, and worse left ventricular mechanics. We investigated the impact of DE on cardiac resynchronization therapy ( CRT ) outcomes and the effect of CRT optimization. Methods and Results We studied...

journal_title：Journal of the American Heart Association

authors： Gage RM,Khan AH,Syed IS,Bajpai A,Burns KV,Curtin AE,Blanchard AL,Gillberg JM,Ghosh S,Bank AJ

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Insulin resistance, characterized by hyperinsulinemia and normal or elevated serum glucose, is an established precursor to diabetes and cardiovascular disease. Despite fasting serum C-peptide levels being an accurate and stable marker of endogenous insulin production used in patients with diabetes, it is unk...

journal_title：Journal of the American Heart Association

authors： Patel N,Taveira TH,Choudhary G,Whitlatch H,Wu WC

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Chest pain is a common reason for referral to pediatric cardiologists. Although pediatric chest pain is rarely attributable to serious cardiac pathology, extensive and costly evaluation is often performed. We have implemented a standardized approach to pediatric chest pain in our pediatric cardiology clinics...

journal_title：Journal of the American Heart Association

authors： Verghese GR,Friedman KG,Rathod RH,Meiri A,Saleeb SF,Graham DA,Geggel RL,Fulton DR

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Middle-aged adults with ideal blood pressure, cholesterol, and glucose levels exhibit substantially lower cardiovascular mortality than those with unfavorable levels. Four healthy lifestyle components-optimal body weight, diet, physical activity, and not smoking-are recommended for cardiovascular health (CVH...

journal_title：Journal of the American Heart Association

authors： Gooding HC,Shay CM,Ning H,Gillman MW,Chiuve SE,Reis JP,Allen NB,Lloyd-Jones DM

更新日期：2015-10-29 00:00:00

abstract：BACKGROUND:Few studies have examined the impact of lifecourse socioeconomic position (SEP) on cardiovascular disease (CVD) risk among African Americans. METHODS AND RESULTS:We used data from the Jackson Heart Study (JHS) to examine the associations of multiple measures of lifecourse SEP with CVD events in a large coho...

journal_title：Journal of the American Heart Association

authors： Gebreab SY,Diez Roux AV,Brenner AB,Hickson DA,Sims M,Subramanyam M,Griswold ME,Wyatt SB,James SA

更新日期：2015-05-27 00:00:00