Gender-specific risk factors for peripheral artery disease in a voluntary screening population.


BACKGROUND:Women have high rates of peripheral artery disease (PAD) despite fewer cardiovascular disease (CVD) risk factors, compared to men. We sought to determine the gender-specific prevalence of low ankle brachial index (ABI) and the relationship to C-reactive protein (CRP) levels and CVD risk factors in the Life Line Screening population. METHODS AND RESULTS:Between April 2005 and August 2011, 133 750 women and 71 996 men had ABI and CRP measured at a Life Line Screening Center. Women were slightly older than men, whereas men were more likely to be current smokers, have diabetes mellitus (DM), and coronary artery disease (CAD) (P<0.001 for each). Women were more likely to have ABI≤1.0, compared to men (26.6% versus 14.4%, respectively; P<0.001), as well as ABI≤0.9 (4.1% women versus 2.6% men; P<0.001). Women had higher median CRP levels (1.94 mg/L; interquartile range [IQR], 0.89, 4.44 mg/L), compared to men (1.35 mg/L; IQR, 0.73, 2.80 mg/L; P<0.001). Men and women shared similar risk factors for ABI≤0.9, including older age, black race, smoking, DM, hypertension, hypercholesterolemia, CAD, and elevated CRP levels. In an adjusted model, there were significant interactions between gender and age (P<0.001), CRP (P<0.001), CAD (P=0.03), and DM (P=0.06) with ABI as the outcome. The associations between age, CRP, CAD, and DM with ABI≤0.9 were stronger in men than in women. CONCLUSIONS:Women participating in the Life Line Screening had higher CRP levels and a higher prevalence of PAD, compared to men. Neither higher CRP levels nor conventional CVD risk factors explained the excess prevalence of PAD in women.


J Am Heart Assoc


Hiramoto JS,Katz R,Weisman S,Conte M




Has Abstract


2014-03-13 00:00:00












  • miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation.

    abstract:BACKGROUND:Previously we found that smooth muscle cell (SMC)-specific knockout of miR-17~92 attenuates hypoxia-induced pulmonary hypertension. However, the mechanism underlying miR-17~92-mediated pulmonary artery SMC (PASMC) proliferation remains unclear. We sought to investigate whether miR-17~92 regulates hypoxia-ind...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Chen T,Zhou Q,Tang H,Bozkanat M,Yuan JX,Raj JU,Zhou G

    更新日期:2016-12-05 00:00:00

  • Effects of Preoperative Statin on Acute Kidney Injury After Off-Pump Coronary Artery Bypass Grafting.

    abstract::Background Although many patients with coronary artery disease are using statins before off-pump coronary artery bypass grafting ( OPCAB ) following current guidelines, recent studies have raised concerns regarding adverse effects of preoperative statins on postoperative kidney function. We evaluated the effects of pr...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Park J,Lee JH,Kim KA,Lee SH,Lee YT,Kim WS,Min JJ

    更新日期:2019-04-02 00:00:00

  • Acute failure of catheter ablation for ventricular tachycardia due to structural heart disease: causes and significance.

    abstract:BACKGROUND:Acute end points of catheter ablation for ventricular tachycardia (VT) remain incompletely defined. The aim of this study is to identify causes for failure in patients with structural heart disease and to assess the relation of this acute outcome to longer-term management and outcomes. METHODS AND RESULTS:F...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Tokuda M,Kojodjojo P,Tung S,Tedrow UB,Nof E,Inada K,Koplan BA,Michaud GF,John RM,Epstein LM,Stevenson WG

    更新日期:2013-05-31 00:00:00

  • Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells.

    abstract:BACKGROUND:Platelet-derived growth factor BB, a potent mitogen of pulmonary artery smooth muscle cells (PASMCs), has been implicated in pulmonary arterial remodeling, which is a key pathogenic feature of pulmonary arterial hypertension. Previous microRNA profiling in platelet-derived growth factor BB-treated PASMCs fou...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Li Y,Li L,Qian Z,Lin B,Chen J,Luo Y,Qu J,Raj JU,Gou D

    更新日期:2018-03-07 00:00:00

  • Cardiovascular Risk and Resilience Among Black Adults: Rationale and Design of the MECA Study.

    abstract::Background Cardiovascular disease incidence, prevalence, morbidity, and mortality have declined in the past several decades; however, disparities persist among subsets of the population. Notably, blacks have not experienced the same improvements on the whole as whites. Furthermore, frequent reports of relatively poore...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Islam SJ,Kim JH,Topel M,Liu C,Ko YA,Mujahid MS,Sims M,Mubasher M,Ejaz K,Morgan-Billingslea J,Jones K,Waller EK,Jones D,Uppal K,Dunbar SB,Pemu P,Vaccarino V,Searles CD,Baltrus P,Lewis TT,Quyyumi AA,Taylor H

    更新日期:2020-05-05 00:00:00

  • Randomized Controlled Trial of Social Media: Effect of Increased Intensity of the Intervention.

    abstract:BACKGROUND:A prior randomized controlled trial of social media exposure at Circulation determined that social media did not increase 30-day page views. Whether insufficient social media intensity contributed to these results is uncertain. METHODS AND RESULTS:Original article manuscripts were randomized to social media...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,随机对照试验


    authors: Fox CS,Gurary EB,Ryan J,Bonaca M,Barry K,Loscalzo J,Massaro J

    更新日期:2016-04-27 00:00:00

  • Association of Major Depression With Risk of Ischemic Heart Disease in a Mega-Cohort of Chinese Adults: The China Kadoorie Biobank Study.

    abstract:BACKGROUND:Increasing evidence has suggested that major depression (MD) is associated with an increased risk of ischemic heart disease (IHD). We examined this association in Chinese adults using data from the China Kadoorie Biobank study. METHODS AND RESULTS:Over 0.5 million adults aged 30 to 79 years were followed fr...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,多中心研究


    authors: Liu N,Pan XF,Yu C,Lv J,Guo Y,Bian Z,Yang L,Chen Y,Wu T,Chen Z,Pan A,Li L,China Kadoorie Biobank Collaborative Group.

    更新日期:2016-12-21 00:00:00

  • Albuminuria, Reduced Kidney Function, and the Risk of ST - and non-ST-segment-elevation myocardial infarction.

    abstract::Background Chronic kidney disease is a recognized independent risk factor for cardiovascular disease, but whether the risks of ST-segment-elevation myocardial infarction ( STEMI ) and non-ST-segment-elevation myocardial infarction ( NSTEMI ) differ in the chronic kidney disease population is unknown. Methods and Resul...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: de Chickera SN,Bota SE,Kuwornu JP,Wijeysundera HC,Molnar AO,Lam NN,Silver SA,Clark EG,Sood MM

    更新日期:2018-10-16 00:00:00

  • Bleeding Complications in Anticoagulated Patients With Atrial Fibrillation and Sepsis: A Propensity-Weighted Cohort Study.

    abstract:BACKGROUND:Sepsis may adversely affect bleeding risk in anticoagulated patients with atrial fibrillation (AF), but the impact of warfarin treatment in such patients is poorly described. This registry-based nationwide cohort study examined safety of oral anticoagulant treatment (OAC) in patients with preexisting AF who ...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,多中心研究


    authors: Søgaard M,Skjøth F,Kjældgaard JN,Lip GYH,Larsen TB

    更新日期:2017-11-09 00:00:00

  • Systematic Review and Meta-Analysis of Medication Reviews Conducted by Pharmacists on Cardiovascular Diseases Risk Factors in Ambulatory Care.

    abstract::Background Pharmacists-led medication reviews (MRs) are claimed to be effective for the control of cardiovascular diseases; however, the evidence in the literature is conflicting. The main objective of this meta-analysis was to analyze the impact of pharmacist-led MRs on cardiovascular disease risk factors overall and...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,meta分析


    authors: Martínez-Mardones F,Fernandez-Llimos F,Benrimoj SI,Ahumada-Canale A,Plaza-Plaza JC,S Tonin F,Garcia-Cardenas V

    更新日期:2019-11-19 00:00:00

  • Early and Late Effects of Cardiac Resynchronization Therapy in Adult Congenital Heart Disease.

    abstract::Background There are limited data about cardiac resynchronization therapy (CRT) in adult congenital heart disease. We aimed to assess early and late outcomes of CRT among patients with adult congenital heart disease. Methods and Results We retrospectively studied 54 patients with adult congenital heart disease (median...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Yin Y,Dimopoulos K,Shimada E,Lascelles K,Griffiths S,Wong T,Gatzoulis MA,Babu-Narayan SV,Li W

    更新日期:2019-11-05 00:00:00

  • Ambient Particle Components and Newborn Blood Pressure in Project Viva.

    abstract::Background Both elemental metals and particulate air pollution have been reported to influence adult blood pressure (BP). The aim of this study is to examine which elemental components of particle mass with diameter ≤2.5 μm (PM2.5) are responsible for previously reported associations between PM2.5 and neonatal BP. Met...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Zanobetti A,Coull BA,Luttmann-Gibson H,van Rossem L,Rifas-Shiman SL,Kloog I,Schwartz JD,Oken E,Bobb JF,Koutrakis P,Gold DR

    更新日期:2021-01-05 00:00:00

  • Contemporary Risk Stratification After Myocardial Infarction in the Community: Performance of Scores and Incremental Value of Soluble Suppression of Tumorigenicity-2.

    abstract:BACKGROUND:Current American Heart Association/American College of Cardiology guidelines recommend the GRACE (Global Registry of Acute Coronary Events) and TIMI (Thrombolysis in Myocardial Infarction) scores to assess myocardial infarction (MI) prognosis. Changes in the epidemiological characteristics of MI and the avai...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Gerber Y,Weston SA,Enriquez-Sarano M,Jaffe AS,Manemann SM,Jiang R,Roger VL

    更新日期:2017-10-20 00:00:00

  • Xanthine Oxidase Inhibitor Allopurinol Prevents Oxidative Stress-Mediated Atrial Remodeling in Alloxan-Induced Diabetes Mellitus Rabbits.

    abstract:BACKGROUND:There are several mechanisms, including inflammation, oxidative stress and abnormal calcium homeostasis, involved in the pathogenesis of atrial fibrillation. In diabetes mellitus (DM), increased oxidative stress may be attributable to higher xanthine oxidase activity. In this study, we examined the relations...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Yang Y,Zhao J,Qiu J,Li J,Liang X,Zhang Z,Zhang X,Fu H,Korantzopoulos P,Letsas KP,Tse G,Li G,Liu T

    更新日期:2018-05-02 00:00:00

  • Impact of Plasma Potassium Normalization on Short-Term Mortality in Patients With Hypertension and Hyperkalemia.

    abstract::Background Hyperkalemia can be harmful, but the effect of correcting hyperkalemia is sparsely studied. We used nationwide data to examine hyperkalemia follow-up in patients with hypertension. Methods and Results We identified 7620 patients with hypertension, who had the first plasma potassium measurement ≥4.7 mmol/L (...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Krogager ML,Søgaard P,Torp-Pedersen C,Bøggild H,Gislason G,Kragholm K

    更新日期:2020-12-15 00:00:00

  • Nativity Status and Cardiovascular Disease Mortality Among Hispanic Adults.

    abstract:BACKGROUND:Hispanic persons represent a heterogeneous and growing population of any race with origins in Mexico, the Caribbean, Central America, South America, or other Spanish-speaking countries. Previous studies have documented variation in cardiovascular risk and outcomes among Hispanic subgroups. Few studies have i...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,多中心研究


    authors: Rodriguez F,Hastings KG,Hu J,Lopez L,Cullen M,Harrington RA,Palaniappan LP

    更新日期:2017-12-13 00:00:00

  • Role of QRS Fragmentation for Risk Stratification in Adults With Tetralogy of Fallot.

    abstract::Background Patients with tetralogy of Fallot ( TOF ) remain at risk for cardiovascular events despite successful repair. Some of the current risk stratification tools require advanced imaging and invasive studies, and hence are difficult to apply to routine patient care. A recent study showed that QRS fragmentation ( ...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Egbe AC,Miranda WR,Mehra N,Ammash NM,Missula VR,Madhavan M,Deshmukh AJ,Farouk Abdelsamid M,Kothapalli S,Connolly HM

    更新日期:2018-12-18 00:00:00

  • Determinants of Patient and Surrogate Experiences With Acute Care Research Consent: A Key Informant Interview Study.

    abstract::Background Informed consent for acute myocardial infarction and stroke research is challenging. Time for enrollment decisions is limited, patients and family are usually stressed, and being asked to participate in research is often unexpected. Despite these barriers, patients and surrogates have reported a preference ...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Scicluna VM,Goldkind SF,Mitchell AR,Pentz RD,Speight CD,Silbergleit R,Dickert NW

    更新日期:2019-11-19 00:00:00

  • Mean Dietary Salt Intake in Urban and Rural Areas in India: A Population Survey of 1395 Persons.

    abstract:BACKGROUND:The scientific evidence base in support of population-wide salt reduction is strong, but current high-quality data about salt intake levels in India are mostly absent. This project sought to estimate daily salt consumption levels in selected communities of Delhi and Haryana in north India and Andhra Pradesh ...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Johnson C,Mohan S,Rogers K,Shivashankar R,Thout SR,Gupta P,He FJ,MacGregor GA,Webster J,Krishnan A,Maulik PK,Reddy KS,Prabhakaran D,Neal B

    更新日期:2017-01-06 00:00:00

  • Eliciting Patient Risk Willingness in Clinical Consultations as a Means of Improving Decision-Making of Aortic Valve Replacement.

    abstract:BACKGROUND:Treatment decisions for aortic valve replacement (AVR) should be sensitive to patient preferences. However, we lack knowledge of patient preferences and how to obtain them. METHODS AND RESULTS:We assessed the mortality risk patients were willing to accept when undergoing AVR by using the Standard Gamble met...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Hussain AI,Garratt AM,Brunborg C,Aakhus S,Gullestad L,Pettersen KI

    更新日期:2016-03-18 00:00:00

  • Improving Care of STEMI in the United States 2008 to 2012.

    abstract::Background We aimed to determine the change in treatment strategies and times to treatment over the first 5 years of the Mission: Lifeline program. Methods and Results We assessed pre- and in-hospital care and outcomes from 2008 to 2012 for patients with ST -segment-elevation myocardial infarction at US hospitals, usi...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,多中心研究


    authors: Granger CB,Bates ER,Jollis JG,Antman EM,Nichol G,O'Connor RE,Gregory T,Roettig ML,Peng SA,Ellrodt G,Henry TD,French WJ,Jacobs AK

    更新日期:2019-01-08 00:00:00

  • Elevated Transglutaminase Activity Triggers Angiotensin Receptor Activating Autoantibody Production and Pathophysiology of Preeclampsia.

    abstract:BACKGROUND:Preeclampsia (PE) is a life-threatening hypertensive disorder of pregnancy associated with autoantibodies, termed AT1-AA, that activate the AT1 angiotensin receptor. Although the pathogenic nature of these autoantibodies has been extensively studied, little is known about the molecular cause of their generat...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Liu C,Luo R,Elliott SE,Wang W,Parchim NF,Iriyama T,Daugherty PS,Blackwell SC,Sibai BM,Kellems RE,Xia Y

    更新日期:2015-12-16 00:00:00

  • Dynamic Relation of Changes in Weight and Indices of Fat Distribution With Cardiac Structure and Function: The Dallas Heart Study.

    abstract:BACKGROUND:Obesity may increase heart failure risk through cardiac remodeling. Cross-sectional associations between adiposity and cardiac structure and function have been elucidated, but the impact of longitudinal changes in adiposity on cardiac remodeling is less well understood. METHODS AND RESULTS:Participants in t...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Wilner B,Garg S,Ayers CR,Maroules CD,McColl R,Matulevicius SA,de Lemos JA,Drazner MH,Peshock R,Neeland IJ

    更新日期:2017-07-19 00:00:00

  • Sensitivity, specificity, and sex differences in symptoms reported on the 13-item acute coronary syndrome checklist.

    abstract:BACKGROUND:Clinical symptoms are part of the risk stratification approaches used in the emergency department (ED) to evaluate patients with suspected acute coronary syndromes (ACS). The objective of this study was to determine the sensitivity, specificity, and predictive value of 13 symptoms for a discharge diagnosis o...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,多中心研究


    authors: Devon HA,Rosenfeld A,Steffen AD,Daya M

    更新日期:2014-04-02 00:00:00

  • Effects of a Vegetarian Diet on Cardiometabolic Risk Factors, Gut Microbiota, and Plasma Metabolome in Subjects With Ischemic Heart Disease: A Randomized, Crossover Study.

    abstract::Background A vegetarian diet (VD) may reduce future cardiovascular risk in patients with ischemic heart disease. Methods and Results A randomized crossover study was conducted in subjects with ischemic heart disease, assigned to 4-week intervention periods of isocaloric VD and meat diet (MD) with individually designed...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Djekic D,Shi L,Brolin H,Carlsson F,Särnqvist C,Savolainen O,Cao Y,Bäckhed F,Tremaroli V,Landberg R,Frøbert O

    更新日期:2020-09-15 00:00:00

  • Pacemaker-Mediated Programmable Hypertension Control Therapy.

    abstract:BACKGROUND:Many patients requiring a pacemaker have persistent hypertension with systolic blood pressures above recommended levels. We evaluated a pacemaker-based Programmable Hypertension Control (PHC) therapy that uses a sequence of variably timed shorter and longer atrioventricular intervals. METHODS AND RESULTS:Pa...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Neuzil P,Merkely B,Erglis A,Marinskis G,de Groot JR,Schmidinger H,Rodriguez Venegas M,Voskuil M,Sturmberger T,Petru J,Jongejan N,Aichinger J,Kamzola G,Aidietis A,Gellér L,Mraz T,Osztheimer I,Mika Y,Evans S,Burkhoff

    更新日期:2017-12-23 00:00:00

  • Reversing the "Risk-Treatment Paradox" of Bleeding in Patients Undergoing Percutaneous Coronary Intervention: Risk-Concordant Use of Bleeding Avoidance Strategies Is Associated With Reduced Bleeding and Lower Costs.

    abstract::Background Bleeding is a common, morbid, and costly complication of percutaneous coronary intervention. While bleeding avoidance strategies ( BAS ) are effective, they are used paradoxically less in patients at high risk of bleeding. Whether a patient-centered approach to specifically increase the risk-concordant use ...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Amin AP,Miller S,Rahn B,Caruso M,Pierce A,Sorensen K,Kurz H,Zajarias A,Bach R,Singh J,Lasala JM,Kulkarni H,Crimmins-Reda P

    更新日期:2018-11-06 00:00:00

  • Death and Myocardial Infarction Following Initial Revascularization Versus Optimal Medical Therapy in Chronic Coronary Syndromes With Myocardial Ischemia: A Systematic Review and Meta-Analysis of Contemporary Randomized Controlled Trials.

    abstract::Background In chronic coronary syndromes, myocardial ischemia is associated with a greater risk of death and nonfatal myocardial infarction (MI). We sought to compare the effect of initial revascularization with percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) plus optimal medical the...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Soares A,Boden WE,Hueb W,Brooks MM,Vlachos HEA,O'Fee K,Hardi A,Brown DL

    更新日期:2021-01-19 00:00:00

  • Variation in Practice Regarding Pretreatment With Dual Antiplatelet Therapy for Patients With Non-ST Elevation Myocardial Infarction.

    abstract:BACKGROUND:Despite guideline recommendations, a significant number of patients with non-ST elevation myocardial infarction (NSTEMI) do not receive dual antiplatelet therapy (DAPT) before angiography "pretreatment." While there may be valid clinical reasons to not pretreat, such as concern for bleeding or multivessel di...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章,多中心研究


    authors: Shafiq A,Valle J,Jang JS,Qintar M,Gosch K,Cohen DJ,Singh M,Bach R,Spertus JA

    更新日期:2016-06-10 00:00:00

  • Incidence of Syncope During Pregnancy: Temporal Trends and Outcomes.

    abstract::Background We examined temporal trends, timing, and frequency, as well as adverse neonatal and maternal outcomes occurring in the first year postpartum among women experiencing syncope during pregnancy. Methods and Results This was a retrospective study of pregnancies between January 1, 2005, and December 31, 2014, in...

    journal_title:Journal of the American Heart Association

    pub_type: 杂志文章


    authors: Chatur S,Islam S,Moore LE,Sandhu RK,Sheldon RS,Kaul P

    更新日期:2019-05-21 00:00:00