Abstract:
:Background Aerobic exercise capacity is inversely associated with cardiovascular and all-cause mortality in men and women without coronary artery disease (CAD); however, a higher amount of vigorous exercise is associated with a J-shaped relationship in CAD patients. Therefore, the optimal type and amount of exercise for CAD patients is unclear. Coronary artery calcification (CAC) is associated with increased cardiovascular disease (CVD) events and mortality. Fatty plaque is more likely to rupture and cause coronary events than other types. We examined the association between exercise capacity, fatty plaque, CAC score and CVD events in CAD patients. Methods and Results A total of 270 subjects with stable CAD were divided into tertiles based on metabolic equivalents of task (METs) calculated from exercise treadmill testing. Self-reported exercise was obtained. Coronary computed tomographic angiography measured coronary plaque volume and CAC score. After adjustment, fatty plaque volume was not different among the 3 MET groups. For each 1 MET increase, CAC was 66.2 units lower (P=0.017). Those with CAC >400 and ≥8.2 METs had fewer CVD events over 30 months compared to <8.2 METs (P=0.037). Of moderate intensity exercisers (median, 240 min/wk; 78% walking only), 62.4% achieved ≥8.2 METs and lower CAC scores (P=0.07). Intensity and duration of exercise had no adverse impact on coronary plaque or CVD events. Conclusions Achieving ≥8.2 METs with moderate exercise intensity and volume as walking resulted in lower CAC scores and fewer CVD events. Therefore, vigorous exercise intensity and volume may not be needed for CAD patients to derive benefit. Registration URL: https://www.clinicaltrials.gov; Unique Identifier: NCT01624727.
journal_name
J Am Heart Assocjournal_title
Journal of the American Heart Associationauthors
Malik A,Kanduri JS,Asbeutah AAA,Khraishah H,Shen C,Welty FKdoi
10.1161/JAHA.119.014919subject
Has Abstractpub_date
2020-04-07 00:00:00pages
e014919issue
7issn
2047-9980journal_volume
9pub_type
杂志文章abstract:BACKGROUND:Atrial fibrillation (AF) is associated with increased risk of hospitalization. Little is known about the impact of AF on utilization of noninpatient health care or about sex or race differences in AF-related utilization. We examined rates of inpatient and outpatient utilization by AF status in the Atheroscle...
journal_title:Journal of the American Heart Association
pub_type: 杂志文章,多中心研究
doi:10.1161/JAHA.114.001006
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更新日期:2020-06-16 00:00:00
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journal_title:Journal of the American Heart Association
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abstract:BACKGROUND:Accumulated research has shown that the older adult brain is significantly more vulnerable to stroke than the young adult brain. Although recent evidence in young adult rats demonstrates that single-whisker stimulation can result in complete protection from ischemic damage after permanent middle cerebral art...
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doi:10.1161/JAHA.112.001255
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-02-20 00:00:00
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更新日期:2020-07-21 00:00:00
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更新日期:2017-10-20 00:00:00
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pub_type: 杂志文章
doi:10.1161/JAHA.119.013779
更新日期:2019-11-05 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2017-06-09 00:00:00
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journal_title:Journal of the American Heart Association
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更新日期:2013-06-10 00:00:00
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journal_title:Journal of the American Heart Association
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doi:10.1161/JAHA.116.003621
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pub_type: 杂志文章,多中心研究
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更新日期:2014-02-28 00:00:00
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更新日期:2018-03-13 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:Journal of the American Heart Association
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