Coronary Artery Aneurysms in Kawasaki Disease: Risk Factors for Progressive Disease and Adverse Cardiac Events in the US Population.

abstract：:Background Higher fibroblast growth factor-23 ( FGF -23) levels are associated with incident heart failure ( HF ) in MESA (the Multiethnic Study of Atherosclerosis). FGF -23 is also associated with left ventricular hypertrophy. Whether the FGF -23 association with HF is similar for heart failure with reduced ejection ...

journal_title：Journal of the American Heart Association

authors： Almahmoud MF,Soliman EZ,Bertoni AG,Kestenbaum B,Katz R,Lima JAC,Ouyang P,Miller PE,Michos ED,Herrington DM

更新日期：2018-09-18 00:00:00

abstract：:Background Aerobic exercise capacity is inversely associated with cardiovascular and all-cause mortality in men and women without coronary artery disease (CAD); however, a higher amount of vigorous exercise is associated with a J-shaped relationship in CAD patients. Therefore, the optimal type and amount of exercise f...

journal_title：Journal of the American Heart Association

authors： Malik A,Kanduri JS,Asbeutah AAA,Khraishah H,Shen C,Welty FK

更新日期：2020-04-07 00:00:00

abstract：:Background There are no risk scores designed specifically for mortality risk prediction in unselected cardiac intensive care unit (CICU) patients. We sought to develop a novel CICU-specific risk score for prediction of hospital mortality using variables available at the time of CICU admission. Methods and Results A da...

journal_title：Journal of the American Heart Association

authors： Jentzer JC,Anavekar NS,Bennett C,Murphree DH,Keegan MT,Wiley B,Morrow DA,Murphy JG,Bell MR,Barsness GW

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Levels of LDL (low-density lipoprotein) cholesterol in the population are declining, and increasing attention is being focused on residual lipid-related pathways of atherosclerotic cardiovascular disease risk beyond LDL cholesterol. Among individuals with low (<130 mg/dL) LDL cholesterol, we undertook detail...

journal_title：Journal of the American Heart Association

authors： Lawler PR,Akinkuolie AO,Chu AY,Shah SH,Kraus WE,Craig D,Padmanabhan L,Glynn RJ,Ridker PM,Chasman DI,Mora S

更新日期：2017-07-21 00:00:00

abstract：:Background Hyperkalemia has been associated with increased mortality in patients with myocardial infarction, but few data exist regarding hyperkalemia in cardiac intensive care unit ( CICU ) patients. We hypothesize that hyperkalemia is associated with increased mortality in unselected CICU patients. Methods and Resul...

journal_title：Journal of the American Heart Association

authors： Brueske B,Sidhu MS,Schulman-Marcus J,Kashani KB,Barsness GW,Jentzer JC

更新日期：2019-04-02 00:00:00

abstract：:Background Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy. Current guidelines endorse management in expert centers, but patient socioeconomic status can affect access to specialty care. The effect of socioeconomic status and specialty care access on HCM outcomes has not been examined. Me...

journal_title：Journal of the American Heart Association

authors： Thomas A,Papoutsidakis N,Spatz E,Testani J,Soucier R,Chou J,Ahmad T,Darr U,Hu X,Li F,Chen ME,Bellumkonda L,Sumathipala A,Jacoby D

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:Diabetes is associated with coronary arteriolar endothelial dysfunction. We investigated the role of the small/intermediate (SK(Ca)/IK(Ca)) conductance of calcium-activated potassium channels in diabetes-related endothelial dysfunction. METHODS AND RESULTS:Coronary arterioles (80 to 150 μm in diameter) were...

journal_title：Journal of the American Heart Association

authors： Liu Y,Xie A,Singh AK,Ehsan A,Choudhary G,Dudley S,Sellke FW,Feng J

更新日期：2015-08-24 00:00:00

abstract：BACKGROUND:Lower levels of circulating progenitor cells (PCs) reflect impaired endogenous regenerative capacity and are associated with aging, vascular disease, and poor outcomes. Whether biologic sex and sex hormones influence PC numbers remains a subject of controversy. We sought to determine sex differences in circu...

journal_title：Journal of the American Heart Association

authors： Topel ML,Hayek SS,Ko YA,Sandesara PB,Samman Tahhan A,Hesaroieh I,Mahar E,Martin GS,Waller EK,Quyyumi AA

更新日期：2017-10-03 00:00:00

abstract：:Background Exposure to chronic psychosocial stress is a risk factor for atherosclerosis-based cardiovascular disease. We previously demonstrated the increased expressions of cathepsin S (CatS) in atherosclerotic lesions. Whether CatS participates directly in stress-related neointimal hyperplasia has been unknown. Meth...

journal_title：Journal of the American Heart Association

authors： Wang H,Meng X,Piao L,Inoue A,Xu W,Yu C,Nakamura K,Hu L,Sasaki T,Wu H,Unno K,Umegaki H,Murohara T,Shi GP,Kuzuya M,Cheng XW

更新日期：2019-07-16 00:00:00

abstract：BACKGROUND:Transseptal puncture is a critical step in achieving left atrial (LA) access for a variety of cardiac procedures. Although the mechanical Brockenbrough needle has historically been used for this procedure, a needle employing radiofrequency (RF) energy has more recently been approved for clinical use. We soug...

journal_title：Journal of the American Heart Association

authors： Hsu JC,Badhwar N,Gerstenfeld EP,Lee RJ,Mandyam MC,Dewland TA,Imburgia KE,Hoffmayer KS,Vedantham V,Lee BK,Tseng ZH,Scheinman MM,Olgin JE,Marcus GM

更新日期：2013-09-17 00:00:00

abstract：:Background White matter hyperintensities ( WMHs ) are commonly asymmetric between hemispheres but for unknown reasons. We investigated asymmetric WMHs associated with lacunar infarcts. Methods and Results A total of 267 consecutive patients with small first-ever supratentorial infarcts (≤20 mm) were included. None had...

journal_title：Journal of the American Heart Association

authors： Ryu WS,Schellingerhout D,Ahn HS,Park SH,Hong KS,Jeong SW,Park MS,Choi KH,Kim JT,Kim BJ,Han MK,Lee J,Cha JK,Kim DH,Nah HW,Lee SJ,Cho YJ,Lee BC,Yu KH,Oh MS,Park JM,Kang K,Lee KB,Park TH,Park SS,Smith EE,

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:The time-sensitive hazard of perioperative cardiac troponin T (cTnT) elevation and whether long-term mortality differs by mechanism of myocardial injury are poorly understood. METHODS AND RESULTS:In this observational study of 12 882 patients who underwent noncardiac vascular surgery, patients were assessed...

journal_title：Journal of the American Heart Association

authors： Reed GW,Horr S,Young L,Clevenger J,Malik U,Ellis SG,Lincoff AM,Nissen SE,Menon V

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:Sedentary behaviors have been directly associated with all-cause mortality. However, little is known about different types of sedentary behaviors in relation to overall mortality. Our objective was to assess the association between different sedentary behaviors and all-cause mortality. METHODS AND RESULTS:I...

journal_title：Journal of the American Heart Association

authors： Basterra-Gortari FJ,Bes-Rastrollo M,Gea A,Núñez-Córdoba JM,Toledo E,Martínez-González MÁ

更新日期：2014-06-25 00:00:00

abstract：BACKGROUND:Recent literature suggests that blood pressure variability (BPV) predicts outcome beyond blood pressure level (BPL) and that antihypertensive drug classes differentially influence BPV. We compared calcium channel blockers, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockade for effect...

journal_title：Journal of the American Heart Association

authors： Asayama K,Ohkubo T,Hanazawa T,Watabe D,Hosaka M,Satoh M,Yasui D,Staessen JA,Imai Y,Hypertensive Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED‐BP) Study Investigators.

更新日期：2016-03-23 00:00:00

abstract：BACKGROUND:Cardiovascular disease is the leading cause of death in the United States, making improving cardiovascular health a key population health goal. As part of efforts to achieve this, the American Heart Association has developed the first comprehensive cardiovascular health index (CVHI). Our objective was to inv...

journal_title：Journal of the American Heart Association

authors： Pilkerton CS,Singh SS,Bias TK,Frisbee SJ

更新日期：2015-09-22 00:00:00

abstract：:Background Cardiogenic shock ( CS ) following acute myocardial infarction ( AMI ) portends a poor prognosis. Both venoarterial extracorporeal membrane oxygenation ( VA - ECMO ) and a percutaneous ventricular assist device ( pVAD ) provide hemodynamic support for patients with CS, but little is known about the best dev...

journal_title：Journal of the American Heart Association

authors： Garan AR,Takeda K,Salna M,Vandenberge J,Doshi D,Karmpaliotis D,Kirtane AJ,Takayama H,Kurlansky P

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Coronary heart disease and peripheral arterial disease (PAD) affect different vascular territories. Supplementing baseline findings with assays from stored serum, we compared their 20-year predictors. METHODS AND RESULTS:We randomly recruited 15 737 disease-free men and women aged 30 to 75 years across Scot...

journal_title：Journal of the American Heart Association

authors： Tunstall-Pedoe H,Peters SAE,Woodward M,Struthers AD,Belch JJF

更新日期：2017-09-18 00:00:00

abstract：BACKGROUND:Light chain amyloidosis (AL) is associated with high mortality, especially in patients with advanced cardiovascular involvement. It is caused by toxicity of misfolded light chain proteins (LC) in vascular, cardiac, and other tissues. There is no treatment to reverse LC tissue toxicity. We tested the hypothes...

journal_title：Journal of the American Heart Association

authors： Franco DA,Truran S,Weissig V,Guzman-Villanueva D,Karamanova N,Senapati S,Burciu C,Ramirez-Alvarado M,Blancas-Mejia LM,Lindsay S,Hari P,Migrino RQ

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:Whether the sympathetic nervous system can directly alter central aortic stiffness remains controversial, mainly because of the difficulty in experimentally augmenting peripheral vasoconstrictor activity without changing blood pressure. METHODS AND RESULTS:To address this limitation, we utilized low-level c...

journal_title：Journal of the American Heart Association

authors： Nardone M,Incognito AV,Millar PJ

更新日期：2018-01-29 00:00:00

abstract：BACKGROUND:We investigated whether disease location influences survival in patients with peripheral arterial disease. METHODS AND RESULTS:Patients (n = 12,731; mean age, 67.5 ± 12.7 years; 57.4% male) who underwent outpatient noninvasive lower extremity arterial evaluation were followed up for 5.9 ± 3.1 years for all-...

journal_title：Journal of the American Heart Association

authors： Chen Q,Smith CY,Bailey KR,Wennberg PW,Kullo IJ

更新日期：2013-10-21 00:00:00

abstract：BACKGROUND:To address the lack of knowledge regarding the long-term risk of intracranial hemorrhage (ICH) after acute myocardial infarction (AMI), the aims of this study were to: (1) investigate the incidence, time trends, and predictors of ICH in a large population within 1 year of discharge after AMI; (2) investigate...

journal_title：Journal of the American Heart Association

authors： Graipe A,Binsell-Gerdin E,Söderström L,Mooe T

更新日期：2015-12-11 00:00:00

abstract：BACKGROUND:Cardiovascular disease in women often develops without conventional risk factors. Prenatal loss is a common pregnancy outcome that may result in physiological changes can increase the potential future risk of cardiovascular disease. Insufficient information exists regarding the impact of pregnancy loss on ea...

journal_title：Journal of the American Heart Association

authors： Hartasanchez SA,Flores-Torres M,Monge A,Yunes E,Rodriguez B,Cantu-Brito C,Colaci D,Lamadrid-Figueroa H,Lopez-Ridaura R,Lajous M

更新日期：2018-01-13 00:00:00

abstract：:Background There are limited data about cardiac resynchronization therapy (CRT) in adult congenital heart disease. We aimed to assess early and late outcomes of CRT among patients with adult congenital heart disease. Methods and Results We retrospectively studied 54 patients with adult congenital heart disease (median...

journal_title：Journal of the American Heart Association

authors： Yin Y,Dimopoulos K,Shimada E,Lascelles K,Griffiths S,Wong T,Gatzoulis MA,Babu-Narayan SV,Li W

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:The intersection of heart failure (HF) and atrial fibrillation (AF) is common, but the burden of AF among black patients with HF is poorly characterized. We sought to determine the prevalence of AF, characteristics, in-hospital outcomes, and warfarin use associated with AF in patients hospitalized with HF as...

journal_title：Journal of the American Heart Association

authors： Thomas KL,Piccini JP,Liang L,Fonarow GC,Yancy CW,Peterson ED,Hernandez AF,Get With the Guidelines Steering Committee and Hospitals.

更新日期：2013-09-26 00:00:00

abstract：:Background Educational attainment is an indicator of socioeconomic status and is inversely associated with coronary artery disease risk. Whether educational attainment level (EAL) among patients with coronary artery disease influences outcomes remains understudied. Methods and Results Patients undergoing cardiac cathe...

journal_title：Journal of the American Heart Association

authors： Kelli HM,Mehta A,Tahhan AS,Liu C,Kim JH,Dong TA,Dhindsa DS,Ghazzal B,Choudhary MK,Sandesara PB,Hayek SS,Topel ML,Alkhoder AA,Martini MA,Sidoti A,Ko YA,Lewis TT,Vaccarino V,Sperling LS,Quyyumi AA

更新日期：2019-09-03 00:00:00

abstract：:Background Patients with a Fontan circulation achieve lower peak heart rates ( HR ) during exercise. Whether this impaired chronotropic response reflects pathology of the sinoatrial node or is a consequence of altered cardiac hemodynamics is uncertain. We evaluated the adequacy of HR acceleration throughout exercise r...

journal_title：Journal of the American Heart Association

authors： Claessen G,La Gerche A,Van De Bruaene A,Claeys M,Willems R,Dymarkowski S,Bogaert J,Claus P,Budts W,Heidbuchel H,Gewillig M

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGB) reduces obesity-associated comorbidities and cardiovascular mortality. RYGB improves endothelial dysfunction, reducing c-Jun N-terminal kinase (JNK) vascular phosphorylation. JNK activation links obesity with insulin resistance and endothelial dysfunction. Herein, we examined ...

journal_title：Journal of the American Heart Association

authors： Doytcheva P,Bächler T,Tarasco E,Marzolla V,Engeli M,Pellegrini G,Stivala S,Rohrer L,Tona F,Camici GG,Vanhoutte PM,Matter CM,Lutz TA,Lüscher TF,Osto E

更新日期：2017-11-14 00:00:00

abstract：:Background Mortality is increased following a hospitalization for decompensated heart failure (HF), during which diuretics are usually intensified. It is unclear how risk is affected after outpatient intensification of diuretic therapy for HF. Methods and Results From nationwide administrative registers, we identified...

journal_title：Journal of the American Heart Association

authors： Madelaire C,Gustafsson F,Stevenson LW,Kristensen SL,Køber L,Andersen J,D'Souza M,Biering-Sørensen T,Andersson C,Torp-Pedersen C,Gislason G,Schou M

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:Clinical symptoms are part of the risk stratification approaches used in the emergency department (ED) to evaluate patients with suspected acute coronary syndromes (ACS). The objective of this study was to determine the sensitivity, specificity, and predictive value of 13 symptoms for a discharge diagnosis o...

journal_title：Journal of the American Heart Association

authors： Devon HA,Rosenfeld A,Steffen AD,Daya M

更新日期：2014-04-02 00:00:00

abstract：BACKGROUND:Cardiac magnetic resonance (CMR) can quantify myocardial infarct (MI) size and myocardium at risk (MaR), enabling assessment of myocardial salvage index (MSI). We assessed how MSI impacts the number of patients needed to reach statistical power in relation to MI size alone and levels of biochemical markers i...

journal_title：Journal of the American Heart Association

authors： Engblom H,Heiberg E,Erlinge D,Jensen SE,Nordrehaug JE,Dubois-Randé JL,Halvorsen S,Hoffmann P,Koul S,Carlsson M,Atar D,Arheden H

更新日期：2016-03-09 00:00:00