Changes in Cardiovascular Health in the United States, 2003-2011.

abstract：BACKGROUND:Long chain acyl-CoA synthetases (ACSL) catalyze long-chain fatty acids (FA) conversion to acyl-CoAs. Temporal ACSL1 inactivation in mouse hearts (Acsl1(H-/-)) impaired FA oxidation and dramatically increased glucose uptake, glucose oxidation, and mTOR activation, resulting in cardiac hypertrophy. We used unb...

journal_title：Journal of the American Heart Association

authors： Schisler JC,Grevengoed TJ,Pascual F,Cooper DE,Ellis JM,Paul DS,Willis MS,Patterson C,Jia W,Coleman RA

更新日期：2015-02-24 00:00:00

abstract：BACKGROUND:Low high-density lipoprotein (HDL) levels are major predictors of cardiovascular (CV) events, even in patients on statin treatment with low-density lipoprotein (LDL) at target. In animal models HDLs protect LDL from oxidation and blunt platelet activation. Our study aimed to examine whether HDL levels are re...

journal_title：Journal of the American Heart Association

authors： Vazzana N,Ganci A,Cefalù AB,Lattanzio S,Noto D,Santoro N,Saggini R,Puccetti L,Averna M,Davì G

更新日期：2013-04-04 00:00:00

abstract：BACKGROUND:The 2005 Bethesda Conference Guidelines advise patients with long QT syndrome against competitive sports. We assessed cardiac event rates during competitive and recreational sports, and daily activities among treated long QT syndrome patients. METHODS AND RESULTS:Long QT syndrome patients aged ≥4 years trea...

journal_title：Journal of the American Heart Association

authors： Chambers KD,Beausejour Ladouceur V,Alexander ME,Hylind RJ,Bevilacqua L,Mah DY,Bezzerides V,Triedman JK,Walsh EP,Abrams DJ

更新日期：2017-09-21 00:00:00

abstract：:Background Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide-ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients. Methods and Results TTS patients from the International Takotsubo Registry we...

journal_title：Journal of the American Heart Association

authors： Jurisic S,Gili S,Cammann VL,Kato K,Szawan KA,D'Ascenzo F,Jaguszewski M,Bossone E,Citro R,Sarcon A,Napp LC,Franke J,Noutsias M,Knorr M,Heiner S,Burgdorf C,Koenig W,Pott A,Kherad B,Rajan L,Michels G,Pfister R,Cu

更新日期：2019-11-05 00:00:00

abstract：:Background Norwood surgery provides a palliative surgical option for hypoplastic left heart syndrome and has been available in Sweden since 1993. The practice of prenatal ultrasound screening was gradually implemented in the same era, resulting in an increased prenatal detection rate. Our primary aims were to study ch...

journal_title：Journal of the American Heart Association

authors： Öhman A,El-Segaier M,Bergman G,Hanséus K,Malm T,Nilsson B,Pivodic A,Rydberg A,Sonesson SE,Mellander M

更新日期：2019-01-22 00:00:00

abstract：:Background Global fractional flow reserve (FFR) (ie, the sum of the FFR values in the 3 major coronary arteries) is a physiologic correlate of global atherosclerotic burden. The objective of the present study was to investigate the value of global FFR in predicting long-term clinical outcome of patients with stable co...

journal_title：Journal of the American Heart Association

authors： Fournier S,Collet C,Xaplanteris P,Zimmermann FM,Toth GG,Tonino PAL,Pijls NHJ,Colaiori I,Di Gioia G,Barbato E,Jüni P,Fearon WF,De Bruyne B

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:Transcription of the myristoylated alanine-rich C kinase substrate (MARCKS) is upregulated in animal models of intimal hyperplasia. MARCKS knockdown inhibits vascular smooth muscle cell (VSMC) migration in vitro; however, the mechanism is as yet unknown. We sought to elucidate the mechanism of MARCKS-mediate...

journal_title：Journal of the American Heart Association

authors： Yu D,Makkar G,Strickland DK,Blanpied TA,Stumpo DJ,Blackshear PJ,Sarkar R,Monahan TS

更新日期：2015-10-08 00:00:00

abstract：BACKGROUND:Greater understanding of differences between men and women with coronary heart disease is needed. METHODS AND RESULTS:In this post hoc analysis of the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) trial, we described psychosocial factors, treatments, and outcomes of...

journal_title：Journal of the American Heart Association

authors： Guimarães PO,Granger CB,Stebbins A,Chiswell K,Held C,Hochman JS,Krug-Gourley S,Lonn E,Lopes RD,Stewart RAH,Vinereanu D,Wallentin L,White HD,Hagström E,Danchin N

更新日期：2017-09-14 00:00:00

abstract：:Background Myocardial infarction (MI) size is a key predictor of prognosis in post-MI patients. Cardiovascular magnetic resonance (CMR) is the gold standard test for MI quantification, but the ECG is less expensive and more widely available. We sought to quantify the relationship between ECG markers and cardiovascular...

journal_title：Journal of the American Heart Association

authors： Lee DC,Albert CM,Narula D,Kadish AH,Panicker GK,Wu E,Schaechter A,Pester J,Chatterjee NA,Cook NR,Goldberger JJ

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:NO bioavailability has not been systematically examined in congenital heart disease (CHD). To assess NO in patients with CHD, we measured nasal NO (nNO) generated by the nasal epithelia, given blood NO is difficult to measure (half-life, <2 ms). Given NO's role in hemodynamic regulation and the association o...

journal_title：Journal of the American Heart Association

authors： Adams PS,Zahid M,Khalifa O,Feingold B,Lo CW

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:The aim of this study was to elucidate the correlation between angiographic coronary vasomotor responses to intracoronary acetylcholine (ACh) injection, clinical features, and long-term prognosis in patients with vasospastic angina (VSA). METHODS AND RESULTS:This is a retrospective, observational, single-ce...

journal_title：Journal of the American Heart Association

authors： Sato K,Kaikita K,Nakayama N,Horio E,Yoshimura H,Ono T,Ohba K,Tsujita K,Kojima S,Tayama S,Hokimoto S,Matsui K,Sugiyama S,Yamabe H,Ogawa H

更新日期：2013-07-15 00:00:00

abstract：BACKGROUND:Light chain amyloidosis (AL) is associated with high mortality, especially in patients with advanced cardiovascular involvement. It is caused by toxicity of misfolded light chain proteins (LC) in vascular, cardiac, and other tissues. There is no treatment to reverse LC tissue toxicity. We tested the hypothes...

journal_title：Journal of the American Heart Association

authors： Franco DA,Truran S,Weissig V,Guzman-Villanueva D,Karamanova N,Senapati S,Burciu C,Ramirez-Alvarado M,Blancas-Mejia LM,Lindsay S,Hari P,Migrino RQ

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:Diagnosis of atrial fibrillation (AF) can be difficult, requiring cumbersome investigations. We aimed to determine the association of established whole-blood gene expression scores with prevalent AF and to evaluate their performance for the identification of AF in a SIRS (Steroids in Cardiac Surgery) trial c...

journal_title：Journal of the American Heart Association

authors： Thériault S,Whitlock R,Raman K,Vincent J,Yusuf S,Paré G

更新日期：2017-06-30 00:00:00

abstract：BACKGROUND:The American Heart Association (AHA) recently developed the Cardiovascular Health Index (CVHI), a health metric consisting of 7 modifiable risk factors. The relationship of the CVHI with preclinical markers, such as carotid intima-media thickness (CIMT) has not been assessed. METHODS:We examined 490 male mo...

journal_title：Journal of the American Heart Association

authors： Kulshreshtha A,Goyal A,Veledar E,McClellan W,Judd S,Eufinger SC,Bremner JD,Goldberg J,Vaccarino V

更新日期：2014-01-02 00:00:00

abstract：BACKGROUND:Lower levels of circulating progenitor cells (PCs) reflect impaired endogenous regenerative capacity and are associated with aging, vascular disease, and poor outcomes. Whether biologic sex and sex hormones influence PC numbers remains a subject of controversy. We sought to determine sex differences in circu...

journal_title：Journal of the American Heart Association

authors： Topel ML,Hayek SS,Ko YA,Sandesara PB,Samman Tahhan A,Hesaroieh I,Mahar E,Martin GS,Waller EK,Quyyumi AA

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:The natural history of coronary artery aneurysms (CAA) after intravenous immunoglobulin (IVIG) treatment in the United States is not well described. We describe the natural history of CAA in US Kawasaki disease (KD) patients and identify factors associated with major adverse cardiac events (MACE) and CAA reg...

journal_title：Journal of the American Heart Association

authors： Friedman KG,Gauvreau K,Hamaoka-Okamoto A,Tang A,Berry E,Tremoulet AH,Mahavadi VS,Baker A,deFerranti SD,Fulton DR,Burns JC,Newburger JW

更新日期：2016-09-15 00:00:00

abstract：:Background Improving health-related quality of life is an important goal in the management of patients with heart failure (HF). Defining health-related quality of life changes over time in patients with HF with preserved (HFpEF) or reduced ejection fraction and showing their association with other important clinical e...

journal_title：Journal of the American Heart Association

authors： Sepehrvand N,Savu A,Spertus JA,Dyck JRB,Anderson T,Howlett J,Paterson I,Oudit GY,Kaul P,McAlister FA,Ezekowitz JA,Alberta HEART Investigators*.

更新日期：2020-09-01 00:00:00

abstract：:Background Congenital heart disease is common in patients with Trisomy 13 (T13) and Trisomy 18 (T18), but offering cardiac surgery to these patients has been controversial. We describe the landscape of surgical management across the United States, perioperative risk factors, and surgical outcomes in patients with T13 ...

journal_title：Journal of the American Heart Association

authors： Cooper DS,Riggs KW,Zafar F,Jacobs JP,Hill KD,Pasquali SK,Swanson SK,Gelehrter SK,Wallace A,Jacobs ML,Morales DLS,Bryant R 3rd

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:Bypass grafting remains the standard of care for coronary artery disease and severe lower extremity ischemia. Efficacy is limited by poor long-term venous graft patency secondary to intimal hyperplasia (IH) caused by venous injury upon exposure to arterial pressure. We investigate whether photochemical tissu...

journal_title：Journal of the American Heart Association

authors： Goldstone RN,McCormack MC,Khan SI,Salinas HM,Meppelink A,Randolph MA,Watkins MT,Redmond RW,Austen WG Jr

更新日期：2016-07-27 00:00:00

abstract：BACKGROUND:Although several risk factors for acute kidney injury (AKI) have been identified, early detection of AKI in acute decompensated heart failure patients remains a challenge. The aim of this study was to develop and validate a risk score for early prediction of AKI in acute decompensated heart failure patients....

journal_title：Journal of the American Heart Association

authors： Zhou LZ,Yang XB,Guan Y,Xu X,Tan MT,Hou FF,Chen PY

更新日期：2016-11-16 00:00:00

abstract：BACKGROUND:Recent trends of hospitalizations and in-hospital mortality are not well defined in sarcoidosis. We examined aforementioned trends and prevalence of cardiovascular manifestations and explored rates of implantable cardioverter-defibrillator implantation in hospitalizations with sarcoidosis. METHODS AND RESUL...

journal_title：Journal of the American Heart Association

authors： Patel N,Kalra R,Doshi R,Arora H,Bajaj NS,Arora G,Arora P

更新日期：2018-01-22 00:00:00

abstract：BACKGROUND:Microvascular injury (MVI) after primary percutaneous coronary intervention for ST-elevation myocardial infarction (STEMI) is a major determinant of adverse clinical outcome. Experimental data indicate an impact of hypercholesterolemia on MVI; however, there is a lack of clinical studies confirming this rela...

journal_title：Journal of the American Heart Association

authors： Reindl M,Reinstadler SJ,Feistritzer HJ,Theurl M,Basic D,Eigler C,Holzknecht M,Mair J,Mayr A,Klug G,Metzler B

更新日期：2017-10-10 00:00:00

abstract：:Background A previous study reported histologic abnormalities in the pulmonary artery ( PA ) of patients with tetralogy of Fallot ( TOF ). However, the potential effect of these anatomical findings on PA vascular function has not been studied. We hypothesized that TOF patients had abnormal PA vascular function, and th...

journal_title：Journal of the American Heart Association

authors： Egbe AC,Anavekar NS,Connolly HM

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:In atrial fibrillation (AF), a more extensively fibrotic left atrium (LA) provides a substrate for arrhythmias and increases risk of relapse following ablation. Fibrocytes are bone marrow-derived circulating mesenchymal progenitors that have been identified in the atrium of patients with AF who have valvular...

journal_title：Journal of the American Heart Association

authors： Liu Y,Niu XH,Yin X,Liu YJ,Han C,Yang J,Huang X,Yu X,Gao L,Yang YZ,Xia YL,Li HH

更新日期：2018-03-13 00:00:00

abstract：:The use of extracorporeal cardiopulmonary resuscitation (E-CPR) for the treatment of patients with out-of-hospital cardiac arrest who do not respond to conventional cardiopulmonary resuscitation CPR) has increased significantly in the past 10 years, in response to case reports and observational studies reporting encou...

journal_title：Journal of the American Heart Association

authors： Dennis M,Lal S,Forrest P,Nichol A,Lamhaut L,Totaro RJ,Burns B,Sandroni C

更新日期：2020-05-18 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is a major risk factor for the development of chronic kidney disease. Nuclear factor-κB is a nuclear transcription factor activated post-ischemia, responsible for the transcription of proinflammatory proteins. The role of nuclear factor-κB in the renal fibrosis post-AKI is unknown. ...

journal_title：Journal of the American Heart Association

authors： Johnson FL,Patel NSA,Purvis GSD,Chiazza F,Chen J,Sordi R,Hache G,Merezhko VV,Collino M,Yaqoob MM,Thiemermann C

更新日期：2017-07-03 00:00:00

abstract：BACKGROUND:Middle-aged adults with ideal blood pressure, cholesterol, and glucose levels exhibit substantially lower cardiovascular mortality than those with unfavorable levels. Four healthy lifestyle components-optimal body weight, diet, physical activity, and not smoking-are recommended for cardiovascular health (CVH...

journal_title：Journal of the American Heart Association

authors： Gooding HC,Shay CM,Ning H,Gillman MW,Chiuve SE,Reis JP,Allen NB,Lloyd-Jones DM

更新日期：2015-10-29 00:00:00

abstract：BACKGROUND:Recent studies have shown improving survival after cardiac arrest. However, data regarding sex-based disparities in treatment and outcomes after cardiac arrest are limited. METHODS AND RESULTS:We performed a retrospective analysis of all patients suffering cardiac arrest between 2003 and 2012 using the Nati...

journal_title：Journal of the American Heart Association

authors： Kim LK,Looser P,Swaminathan RV,Horowitz J,Friedman O,Shin JH,Minutello RM,Bergman G,Singh H,Wong SC,Feldman DN

更新日期：2016-06-22 00:00:00

abstract：BACKGROUND:Remote ischemic conditioning (RIC) is a noninvasive therapeutic strategy that uses brief cycles of blood pressure cuff inflation and deflation to protect the myocardium against ischemia-reperfusion injury. The objective of this systematic review was to determine the impact of RIC on myocardial salvage index,...

journal_title：Journal of the American Heart Association

authors： McLeod SL,Iansavichene A,Cheskes S

更新日期：2017-05-17 00:00:00

abstract：:Background For patients with ST-segment-elevation myocardial infarction (STEMI) and multivessel coronary artery disease, the optimal treatment of the non-infarct-related artery has been controversial. This up-to-date meta-analysis focusing on individual clinical end points was performed to further evaluate the benefit...

journal_title：Journal of the American Heart Association

authors： Ahmad Y,Howard JP,Arnold A,Prasad M,Seligman H,Cook CM,Warisawa T,Shun-Shun M,Ali Z,Parikh MA,Al-Lamee R,Sen S,Francis D,Moses JW,Leon MB,Stone GW,Karmpaliotis D

更新日期：2020-06-16 00:00:00