Sample Size in Clinical Cardioprotection Trials Using Myocardial Salvage Index, Infarct Size, or Biochemical Markers as Endpoint.

abstract：BACKGROUND:Coronary heart disease and peripheral arterial disease (PAD) affect different vascular territories. Supplementing baseline findings with assays from stored serum, we compared their 20-year predictors. METHODS AND RESULTS:We randomly recruited 15 737 disease-free men and women aged 30 to 75 years across Scot...

journal_title：Journal of the American Heart Association

authors： Tunstall-Pedoe H,Peters SAE,Woodward M,Struthers AD,Belch JJF

更新日期：2017-09-18 00:00:00

abstract：:Background Little attention has been paid to the importance of sex in the long-term prognosis of patients undergoing cardiac surgery. Methods and Results We conducted a retrospective cohort study of Ontario residents, aged ≥40 years, who underwent coronary artery bypass grafting (CABG) and/or aortic, mitral, or tricus...

journal_title：Journal of the American Heart Association

authors： Johnston A,Mesana TG,Lee DS,Eddeen AB,Sun LY

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Increased platelet aggregation during antiplatelet therapy may predict cardiovascular events in patients with coronary artery disease. The majority of these patients receive aspirin monotherapy. We aimed to investigate whether high platelet-aggregation levels predict cardiovascular events in stable coronary ...

journal_title：Journal of the American Heart Association

authors： Larsen SB,Grove EL,Neergaard-Petersen S,Würtz M,Hvas AM,Kristensen SD

更新日期：2017-08-05 00:00:00

abstract：BACKGROUND:The time-sensitive hazard of perioperative cardiac troponin T (cTnT) elevation and whether long-term mortality differs by mechanism of myocardial injury are poorly understood. METHODS AND RESULTS:In this observational study of 12 882 patients who underwent noncardiac vascular surgery, patients were assessed...

journal_title：Journal of the American Heart Association

authors： Reed GW,Horr S,Young L,Clevenger J,Malik U,Ellis SG,Lincoff AM,Nissen SE,Menon V

更新日期：2017-06-06 00:00:00

abstract：:See Editorial by Cenko et al. ...

journal_title：Journal of the American Heart Association

authors： Pande AN,Jacobs AK

更新日期：2019-02-19 00:00:00

abstract：BACKGROUND:Extracellular fluid (ECF) excess is an independent predictor of cardiovascular morbidity in patients undergoing dialysis. This study aimed to investigate the relationship between ECF status, which is affected by renal function, and coronary artery calcification (CAC), which is a marker of cardiovascular dise...

journal_title：Journal of the American Heart Association

authors： Park S,Lee CJ,Jhee JH,Yun HR,Kim H,Jung SY,Kee YK,Yoon CY,Park JT,Kim HC,Han SH,Kang SW,Park S,Yoo TH

更新日期：2018-06-30 00:00:00

abstract：BACKGROUND:The presence and implications of abnormal arterial stiffness, a potential independent predictor of outcomes, in community-dwelling treated hypertensives is unknown. Furthermore, limited data exist regarding the risk of cardiovascular disease (CVD) associated with arterial stiffness across the entire range of...

journal_title：Journal of the American Heart Association

authors： Niiranen TJ,Kalesan B,Hamburg NM,Benjamin EJ,Mitchell GF,Vasan RS

更新日期：2016-10-26 00:00:00

abstract：:Background This study was performed to characterize the metabolic, functional, and structural cardiac changes in a canine model of radiation-induced heart disease by serial in vivo imaging and ex vivo analyses. Methods and Results Thirty-six dogs were randomly assigned to control or irradiated groups at 3 time points ...

journal_title：Journal of the American Heart Association

authors： Yan R,Li X,Song J,Guo M,Cai H,Wu Z,Wu P,Li L,Yang M,Wang Y,Li S

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:Fatty acids constitute the critical components of cell structure and function, and dysregulation of fatty acid composition may exert diverging vascular effects including proliferation, migration, and differentiation of vascular smooth muscle cells (VSMCs). However, direct evidence for this hypothesis has bee...

journal_title：Journal of the American Heart Association

authors： Sunaga H,Matsui H,Anjo S,Syamsunarno MR,Koitabashi N,Iso T,Matsuzaka T,Shimano H,Yokoyama T,Kurabayashi M

更新日期：2016-11-23 00:00:00

abstract：BACKGROUND:Previous studies have suggested that n-3 polyunsaturated fatty acids (n-3 PUFAs) have antiarrhythmic effects on atrial fibrillation (AF). We aimed to assess the effects of therapy with n-3 PUFAs on the incidence of recurrent AF and on postoperative AF. METHODS AND RESULTS:Electronic searches were conducted ...

journal_title：Journal of the American Heart Association

authors： Mariani J,Doval HC,Nul D,Varini S,Grancelli H,Ferrante D,Tognoni G,Macchia A

更新日期：2013-02-19 00:00:00

abstract：BACKGROUND:The optimal timing to administer non-vitamin K oral anticoagulants (NOACs) in patients with acute ischemic stroke and atrial fibrillation is unclear. This prospective observational multicenter study evaluated the rates of early recurrence and major bleeding (within 90 days) and their timing in patients with ...

journal_title：Journal of the American Heart Association

authors： Paciaroni M,Agnelli G,Falocci N,Tsivgoulis G,Vadikolias K,Liantinioti C,Chondrogianni M,Bovi P,Carletti M,Cappellari M,Zedde M,Ntaios G,Karagkiozi E,Athanasakis G,Makaritsis K,Silvestrelli G,Lanari A,Ciccone A,Putaala

更新日期：2017-11-29 00:00:00

abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGB) reduces obesity-associated comorbidities and cardiovascular mortality. RYGB improves endothelial dysfunction, reducing c-Jun N-terminal kinase (JNK) vascular phosphorylation. JNK activation links obesity with insulin resistance and endothelial dysfunction. Herein, we examined ...

journal_title：Journal of the American Heart Association

authors： Doytcheva P,Bächler T,Tarasco E,Marzolla V,Engeli M,Pellegrini G,Stivala S,Rohrer L,Tona F,Camici GG,Vanhoutte PM,Matter CM,Lutz TA,Lüscher TF,Osto E

更新日期：2017-11-14 00:00:00

abstract：BACKGROUND:Diabetes mellitus (DM) is a major risk factor for cardiovascular events. We aimed to investigate the coronary plaque phenotype of diabetic patients who presented with acute coronary syndromes by optical coherence tomography. METHODS AND RESULTS:A total of 322 patients with acute coronary syndromes who under...

journal_title：Journal of the American Heart Association

authors： Sugiyama T,Yamamoto E,Bryniarski K,Xing L,Fracassi F,Lee H,Jang IK

更新日期：2018-07-13 00:00:00

abstract：:Background It has been suggested that endocardial and epicardial ablation of ventricular tachycardia ( VT ) improves outcome in arrhythmogenic right ventricular cardiomyopathy/dysplasia. We investigated our sequential approach for VT ablation in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia i...

journal_title：Journal of the American Heart Association

authors： Mathew S,Saguner AM,Schenker N,Kaiser L,Zhang P,Yashuiro Y,Lemes C,Fink T,Maurer T,Santoro F,Wohlmuth P,Reißmann B,Heeger CH,Tilz R,Wissner E,Rillig A,Metzner A,Kuck KH,Ouyang F

更新日期：2019-03-05 00:00:00

abstract：:Background There are limited data about cardiac resynchronization therapy (CRT) in adult congenital heart disease. We aimed to assess early and late outcomes of CRT among patients with adult congenital heart disease. Methods and Results We retrospectively studied 54 patients with adult congenital heart disease (median...

journal_title：Journal of the American Heart Association

authors： Yin Y,Dimopoulos K,Shimada E,Lascelles K,Griffiths S,Wong T,Gatzoulis MA,Babu-Narayan SV,Li W

更新日期：2019-11-05 00:00:00

abstract：:Background The Institute of Medicine has called for actions to understand and target sex-related differences in care and outcomes for out-of-hospital cardiac arrest patients. We assessed changes in bystander and first-responder interventions and outcomes for males versus females after statewide efforts to improve card...

journal_title：Journal of the American Heart Association

authors： Malta Hansen C,Kragholm K,Dupre ME,Pearson DA,Tyson C,Monk L,Rea TD,Starks MA,Nelson D,Jollis JG,McNally B,Corbett CM,Granger CB

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:History of gestational diabetes mellitus (GDM) increases lifetime risk of type 2 diabetes (DM) and the metabolic syndrome (MetS), which increase risk of cardiovascular disease. It is unclear, however, whether GDM increases risk of early atherosclerosis independent of pre-pregnancy obesity and subsequent meta...

journal_title：Journal of the American Heart Association

authors： Gunderson EP,Chiang V,Pletcher MJ,Jacobs DR,Quesenberry CP,Sidney S,Lewis CE

更新日期：2014-03-12 00:00:00

abstract：BACKGROUND:Clinical guidelines recommend using predicted atherosclerotic cardiovascular disease (ASCVD) risk to inform treatment decisions. The objective was to compare the contribution of changes in modifiable risk factors versus aging to the development of high 10-year predicted ASCVD risk. METHODS AND RESULTS:A pro...

journal_title：Journal of the American Heart Association

authors： Bress AP,Colantonio LD,Booth JN 3rd,Spruill TM,Ravenell J,Butler M,Shallcross AJ,Seals SR,Reynolds K,Ogedegbe G,Shimbo D,Muntner P

更新日期：2017-02-08 00:00:00

abstract：:Background Type 2 diabetes mellitus is closely associated with metabolic risk factors that all contribute to impairment of the left ventricle. The implications of having type 2 diabetes mellitus with well-controlled metabolic risk factors compared to an increasing burden of uncontrolled metabolic risk factors on left ...

journal_title：Journal of the American Heart Association

authors： Jørgensen PG,Jensen MT,Biering-Sørensen T,Mogelvang R,Fritz-Hansen T,Vilsbøll T,Rossing P,Jensen JS

更新日期：2018-10-02 00:00:00

abstract：BACKGROUND:A prior randomized controlled trial of social media exposure at Circulation determined that social media did not increase 30-day page views. Whether insufficient social media intensity contributed to these results is uncertain. METHODS AND RESULTS:Original article manuscripts were randomized to social media...

journal_title：Journal of the American Heart Association

authors： Fox CS,Gurary EB,Ryan J,Bonaca M,Barry K,Loscalzo J,Massaro J

更新日期：2016-04-27 00:00:00

abstract：BACKGROUND:Although statins reduce cardiovascular events, residual risk remains. Therefore, additional modalities are needed to reduce risk. We evaluated the effect of eicosapentaenoic acid and docosahexaenoic acid in pharmacologic doses added to statin treatment on coronary artery plaque volume. METHODS AND RESULTS:A...

journal_title：Journal of the American Heart Association

authors： Alfaddagh A,Elajami TK,Ashfaque H,Saleh M,Bistrian BR,Welty FK

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:Carotid atherosclerosis (CA) is a reflector of generalized atherosclerosis that is associated with systemic vascular disease. Data are limited on the epidemiology of carotid lesions in a large, nationally representative population sample. We aimed to evaluate the prevalence of CA detected by carotid ultrason...

journal_title：Journal of the American Heart Association

authors： Wang X,Li W,Song F,Wang L,Fu Q,Cao S,Gan Y,Zhang W,Yue W,Yan F,Shi W,Wang X,Zhang H,Zhang H,Wang Z,Lu Z

更新日期：2018-04-05 00:00:00

abstract：BACKGROUND:Novel therapies aimed at modulating the autonomic nervous system, including thoracic epidural anesthesia (TEA), have been shown in small case series to be beneficial in treating medically refractory ventricular tachycardia (VT) storm. However, it is not clear when these options should be considered. We revie...

journal_title：Journal of the American Heart Association

authors： Do DH,Bradfield J,Ajijola OA,Vaseghi M,Le J,Rahman S,Mahajan A,Nogami A,Boyle NG,Shivkumar K

更新日期：2017-10-27 00:00:00

abstract：:Background Healthcare resource utilization is substantial for single-ventricle cardiac defects ( SVCD ), with effort commencing at time of fetal diagnosis through staged surgical palliation. We sought to characterize and identify variables that influence resource utilization for SVCD from fetal diagnosis through death...

journal_title：Journal of the American Heart Association

authors： Zielonka B,Snarr BS,Liu MY,Zhang X,Mascio CE,Fuller S,Gaynor JW,Spray TL,Rychik J

更新日期：2019-06-04 00:00:00

abstract：BACKGROUND:We sought to characterize growth between birth and age 3 years in infants with hypoplastic left heart syndrome who underwent the Norwood procedure. METHODS AND RESULTS:We performed a secondary analysis using the Single Ventricle Reconstruction Trial database after excluding patients <37 weeks gestation (N=4...

journal_title：Journal of the American Heart Association

authors： Burch PT,Gerstenberger E,Ravishankar C,Hehir DA,Davies RR,Colan SD,Sleeper LA,Newburger JW,Clabby ML,Williams IA,Li JS,Uzark K,Cooper DS,Lambert LM,Pemberton VL,Pike NA,Anderson JB,Dunbar-Masterson C,Khaikin S,Zyble

更新日期：2014-06-23 00:00:00

abstract：:Background Dietary micronutrient deficiencies have been shown to predict event-free survival in other countries but have not been examined in patients with heart failure living in the United States. The purpose of this study was to determine whether number of dietary micronutrient deficiencies in patients with heart f...

journal_title：Journal of the American Heart Association

authors： Lennie TA,Andreae C,Rayens MK,Song EK,Dunbar SB,Pressler SJ,Heo S,Kim J,Moser DK

更新日期：2018-09-04 00:00:00

abstract：BACKGROUND:The 2013 American College of Cardiology/American Heart Association cholesterol guidelines recommend high-intensity statins for patients after myocardial infarction (MI) rather than treating to a low-density lipoprotein cholesterol goal, as the previous ATP III (Adult Treatment Panel third report) guidelines ...

journal_title：Journal of the American Heart Association

authors： Wang WT,Hellkamp A,Doll JA,Thomas L,Navar AM,Fonarow GC,Julien HM,Peterson ED,Wang TY

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:Postural tachycardia syndrome (POTS) is a disorder of chronic orthostatic intolerance accompanied by excessive orthostatic tachycardia. Patients with POTS commonly have comorbid conditions such as attention deficit hyperactivity disorder, depression, or fibromyalgia that are treated with medications that inh...

journal_title：Journal of the American Heart Association

authors： Green EA,Raj V,Shibao CA,Biaggioni I,Black BK,Dupont WD,Robertson D,Raj SR

更新日期：2013-09-03 00:00:00

abstract：BACKGROUND:Right ventricular (RV) diastolic function is impaired in patients with pulmonary arterial hypertension (PAH). Our previous study showed that elevated cardiomyocyte stiffness and myofilament Ca(2+) sensitivity underlie diastolic dysfunction in PAH. This study investigates protein modifications contributing to...

journal_title：Journal of the American Heart Association

authors： Rain S,Bos Dda S,Handoko ML,Westerhof N,Stienen G,Ottenheijm C,Goebel M,Dorfmüller P,Guignabert C,Humbert M,Bogaard HJ,Remedios CD,Saripalli C,Hidalgo CG,Granzier HL,Vonk-Noordegraaf A,van der Velden J,de Man FS

更新日期：2014-06-03 00:00:00

abstract：:Background NT-proBNP (N-terminal pro-B-type natriuretic peptide) improves the discriminatory ability of risk-prediction models in type 2 diabetes mellitus (T2DM) but is not yet used in clinical practice. We assessed the discriminatory strength of NT-proBNP by itself for death and cardiovascular events in high-risk pat...

journal_title：Journal of the American Heart Association

authors： Malachias MVB,Jhund PS,Claggett BL,Wijkman MO,Bentley-Lewis R,Chaturvedi N,Desai AS,Haffner SM,Parving HH,Prescott MF,Solomon SD,De Zeeuw D,McMurray JJV,Pfeffer MA

更新日期：2020-10-20 00:00:00