Micronutrient Deficiency Independently Predicts Time to Event in Patients With Heart Failure.

abstract：BACKGROUND:The intersection of heart failure (HF) and atrial fibrillation (AF) is common, but the burden of AF among black patients with HF is poorly characterized. We sought to determine the prevalence of AF, characteristics, in-hospital outcomes, and warfarin use associated with AF in patients hospitalized with HF as...

journal_title：Journal of the American Heart Association

authors： Thomas KL,Piccini JP,Liang L,Fonarow GC,Yancy CW,Peterson ED,Hernandez AF,Get With the Guidelines Steering Committee and Hospitals.

更新日期：2013-09-26 00:00:00

abstract：BACKGROUND:Although a stroke event often leads to work disability, diagnoses behind work disability before and after stroke are largely unknown. We examined the pre-event and postevent trends in diagnosis-specific work disability among patients of working age. METHODS AND RESULTS:We included all new nonfatal stroke ev...

journal_title：Journal of the American Heart Association

authors： Lallukka T,Ervasti J,Lundström E,Mittendorfer-Rutz E,Friberg E,Virtanen M,Alexanderson K

更新日期：2018-01-04 00:00:00

abstract：:Background Recent literature reports a strong thrombotic tendency in patients hospitalized for a coronavirus disease 2019 (COVID-19) infection. This characteristic is unusual and seems specific to COVID-19 infections, especially in their severe form. Viral infections can trigger acquired thrombophilia, which can then ...

journal_title：Journal of the American Heart Association

authors： Ferrari E,Sartre B,Squara F,Contenti J,Occelli C,Lemoel F,Levraut J,Doyen D,Dellamonica J,Mondain V,Chirio D,Risso K,Cua E,Orban JC,Ichai C,Labbaoui M,Mossaz B,Moceri P,Appert-Flory A,Fischer F,Toulon P

更新日期：2020-11-03 00:00:00

abstract：:Background Hyperoxia during cardiopulmonary resuscitation (CPR) may lead to oxidative injury from mitochondrial-derived reactive oxygen species, despite guidelines recommending 1.0 inspired oxygen during CPR. We hypothesized exposure to 1.0 inspired oxygen during CPR would result in cerebral hyperoxia, higher mitochon...

journal_title：Journal of the American Heart Association

authors： Marquez AM,Morgan RW,Ko T,Landis WP,Hefti MM,Mavroudis CD,McManus MJ,Karlsson M,Starr J,Roberts AL,Lin Y,Nadkarni V,Licht DJ,Berg RA,Sutton RM,Kilbaugh TJ

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:NO bioavailability has not been systematically examined in congenital heart disease (CHD). To assess NO in patients with CHD, we measured nasal NO (nNO) generated by the nasal epithelia, given blood NO is difficult to measure (half-life, <2 ms). Given NO's role in hemodynamic regulation and the association o...

journal_title：Journal of the American Heart Association

authors： Adams PS,Zahid M,Khalifa O,Feingold B,Lo CW

更新日期：2017-12-06 00:00:00

abstract：:Background Spontaneously hypertensive rats of the stroke-prone line (SHR-A3) develop hypertensive renal disease as a result of naturally occurring genetic variation. Our prior work identified a single-nucleotide polymorphism unique to SHR-A3 that results in truncation of the carboxy terminus of STIM1. The SHR-B2 line,...

journal_title：Journal of the American Heart Association

authors： Dhande IS,Zhu Y,Kneedler SC,Joshi AS,Hicks MJ,Wenderfer SE,Braun MC,Doris PA

更新日期：2020-03-03 00:00:00

abstract：:Background We aimed to determine the change in treatment strategies and times to treatment over the first 5 years of the Mission: Lifeline program. Methods and Results We assessed pre- and in-hospital care and outcomes from 2008 to 2012 for patients with ST -segment-elevation myocardial infarction at US hospitals, usi...

journal_title：Journal of the American Heart Association

authors： Granger CB,Bates ER,Jollis JG,Antman EM,Nichol G,O'Connor RE,Gregory T,Roettig ML,Peng SA,Ellrodt G,Henry TD,French WJ,Jacobs AK

更新日期：2019-01-08 00:00:00

abstract：:Background Muscular dystrophy (MD) causes a progressive cardiomyopathy characterized by diffuse fibrosis, arrhythmia, heart failure, and early death. Activation of the thromboxane-prostanoid receptor (TPr) increases calcium transients in cardiomyocytes and is proarrhythmic and profibrotic. We hypothesized that TPr act...

journal_title：Journal of the American Heart Association

authors： West JD,Galindo CL,Kim K,Shin JJ,Atkinson JB,Macias-Perez I,Pavliv L,Knollmann BC,Soslow JH,Markham LW,Carrier EJ

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:The atherosclerosis cardiovascular disease (ASCVD) Pooled Cohort risk equations have shown different calibration across US populations with varied levels of social deprivation. METHODS AND RESULTS:We analyzed the calibration and discrimination of the Pooled Cohort risk equations by social deprivation status...

journal_title：Journal of the American Heart Association

authors： Colantonio LD,Richman JS,Carson AP,Lloyd-Jones DM,Howard G,Deng L,Howard VJ,Safford MM,Muntner P,Goff DC Jr

更新日期：2017-03-17 00:00:00

abstract：:Background Catheter ablation is an effective treatment for atrial fibrillation (AF), but high levels of post-procedure inflammation predict adverse clinical events. Ascorbic acid (AA) has shown promise in reducing inflammation but is untested in this population. We sought to test the feasibility, safety, and prelimina...

journal_title：Journal of the American Heart Association

authors： Trankle CR,Puckett L,Swift-Scanlan T,DeWilde C,Priday A,Sculthorpe R,Ellenbogen KA,Fowler A,Koneru JN

更新日期：2020-02-04 00:00:00

abstract：:Background Bleeding is a common, morbid, and costly complication of percutaneous coronary intervention. While bleeding avoidance strategies ( BAS ) are effective, they are used paradoxically less in patients at high risk of bleeding. Whether a patient-centered approach to specifically increase the risk-concordant use ...

journal_title：Journal of the American Heart Association

authors： Amin AP,Miller S,Rahn B,Caruso M,Pierce A,Sorensen K,Kurz H,Zajarias A,Bach R,Singh J,Lasala JM,Kulkarni H,Crimmins-Reda P

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:No data are available on the long-term performance of ultrathin strut biodegradable polymer sirolimus-eluting stents (BP-SES). We reported 2-year clinical outcomes of the BIOSCIENCE (Ultrathin Strut Biodegradable Polymer Sirolimus-Eluting Stent Versus Durable Polymer Everolimus-Eluting Stent for Percutaneous...

journal_title：Journal of the American Heart Association

authors： Zbinden R,Piccolo R,Heg D,Roffi M,Kurz DJ,Muller O,Vuilliomenet A,Cook S,Weilenmann D,Kaiser C,Jamshidi P,Franzone A,Eberli F,Jüni P,Windecker S,Pilgrim T

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:Natriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to hypertension (HTN) and cardiac hypertrophy, conditions more common among African Americans. Hospital-based studies suggest that African Americans may have reduced circulating natriur...

journal_title：Journal of the American Heart Association

authors： Gupta DK,Claggett B,Wells Q,Cheng S,Li M,Maruthur N,Selvin E,Coresh J,Konety S,Butler KR,Mosley T,Boerwinkle E,Hoogeveen R,Ballantyne CM,Solomon SD

更新日期：2015-05-21 00:00:00

abstract：BACKGROUND:Intramyocardial injection of mesenchymal stem cells (MSCs) in chronic ischemic cardiomyopathy is associated with reverse remodeling in experimental models and humans. Here, we tested the hypothesis that allogeneic MSC therapy drives ventricular remodeling by producing durable and progressive scar size reduct...

journal_title：Journal of the American Heart Association

authors： Williams AR,Suncion VY,McCall F,Guerra D,Mather J,Zambrano JP,Heldman AW,Hare JM

更新日期：2013-05-17 00:00:00

abstract：:Background Duchenne muscular dystrophy (DMD) is a neuromuscular disorder caused by mutations within the dystrophin gene. DMD is characterized by progressive skeletal muscle degeneration and atrophy and progressive cardiomyopathy. It has been observed the severity of cardiomyopathy varies in patients with DMD. Methods ...

journal_title：Journal of the American Heart Association

authors： Jiang X,Shao Y,Araj FG,Amin AA,Greenberg BM,Drazner MH,Xing C,Mammen PPA

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Perioperative antiplatelet agents potentially increase bleeding after non-ST-segment elevation (NSTE) acute coronary syndromes (ACS). The protease-activated receptor 1 antagonist vorapaxar reduced cardiovascular events and was associated with increased bleeding versus placebo in NSTE ACS, but its efficacy an...

journal_title：Journal of the American Heart Association

authors： van Diepen S,Tricoci P,Podder M,Westerhout CM,Aylward PE,Held C,Van de Werf F,Strony J,Wallentin L,Moliterno DJ,White HD,Mahaffey KW,Harrington RA,Armstrong PW

更新日期：2015-12-15 00:00:00

abstract：:Background Hyperkalemia has been associated with increased mortality in patients with myocardial infarction, but few data exist regarding hyperkalemia in cardiac intensive care unit ( CICU ) patients. We hypothesize that hyperkalemia is associated with increased mortality in unselected CICU patients. Methods and Resul...

journal_title：Journal of the American Heart Association

authors： Brueske B,Sidhu MS,Schulman-Marcus J,Kashani KB,Barsness GW,Jentzer JC

更新日期：2019-04-02 00:00:00

abstract：:Background Programs targeting the standard modifiable cardiovascular risk factors (SMuRFs: hypertension, diabetes mellitus, hypercholesterolemia, smoking) are critical to tackling coronary heart disease at a community level. However, myocardial infarction in SMuRF-less individuals is not uncommon. This study uses 2 se...

journal_title：Journal of the American Heart Association

authors： Vernon ST,Coffey S,D'Souza M,Chow CK,Kilian J,Hyun K,Shaw JA,Adams M,Roberts-Thomson P,Brieger D,Figtree GA

更新日期：2019-11-05 00:00:00

abstract：:Background Neurocognitive impairment is a common complication of congenital heart disease (CHD) as well as acquired cardiovascular disease. Data are limited on neurocognitive function in adults with CHD (ACHD). Methods and Results A total of 1020 individuals with mild-to-moderate ACHD and 497 987 individuals without A...

journal_title：Journal of the American Heart Association

authors： Perrotta ML,Saha P,Zawadzki R,Beidelman M,Ingelsson E,Lui GK,Priest JR

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Vascular smooth muscle cell proliferation, migration, and dedifferentiation are critical for vascular diseases. Recently, it was demonstrated that Notch receptors have opposing effects on intima formation after vessel injury. Therefore, it is important to investigate the specific regulatory pathways that act...

journal_title：Journal of the American Heart Association

authors： Jiang D,Zhuang J,Peng W,Lu Y,Liu H,Zhao Q,Chi C,Li X,Zhu G,Xu X,Yan C,Xu Y,Ge J,Pang J

更新日期：2017-07-11 00:00:00

abstract：BACKGROUND:Atherosclerotic cardiovascular disease (ASCVD) causes most deaths in the United States and accounts for the highest healthcare spending. The association between the modifiable risk factors (MRFs) of ASCVD and pharmaceutical expenditures are largely unknown. METHODS AND RESULTS:We examined the association be...

journal_title：Journal of the American Heart Association

authors： Salami JA,Valero-Elizondo J,Ogunmoroti O,Spatz ES,Rana JS,Virani SS,Blankstein R,Younus A,Arrieta A,Blaha MJ,Veledar E,Nasir K

更新日期：2017-06-09 00:00:00

abstract：:Background Detection of flow reserve ( FR ) by dobutamine stress echocardiography is used for risk stratification in low-gradient aortic stenosis ( AS ). Prognostic significance of dobutamine stress echocardiography in the transcatheter aortic valve replacement era is unclear. We aimed to assess the current relevance ...

journal_title：Journal of the American Heart Association

authors： Sato K,Sankaramangalam K,Kandregula K,Bullen JA,Kapadia SR,Krishnaswamy A,Mick S,Rodriguez LL,Grimm RA,Menon V,Desai MY,Svensson LG,Griffin BP,Popović ZB

更新日期：2019-03-19 00:00:00

abstract：:Background There are no risk scores designed specifically for mortality risk prediction in unselected cardiac intensive care unit (CICU) patients. We sought to develop a novel CICU-specific risk score for prediction of hospital mortality using variables available at the time of CICU admission. Methods and Results A da...

journal_title：Journal of the American Heart Association

authors： Jentzer JC,Anavekar NS,Bennett C,Murphree DH,Keegan MT,Wiley B,Morrow DA,Murphy JG,Bell MR,Barsness GW

更新日期：2019-09-03 00:00:00

abstract：:Background The blood-brain barrier (BBB) is critical for cerebrovascular health. Although aging impairs the integrity of the BBB, the mechanisms behind this phenomenon are not clear. As mitochondrial components activate inflammation as mitochondria become dysfunctional, we examined how aging impacts cerebrovascular mi...

journal_title：Journal of the American Heart Association

authors： Tyrrell DJ,Blin MG,Song J,Wood SC,Goldstein DR

更新日期：2020-12-01 00:00:00

abstract：:Compared with the extensive data on left-sided infective endocarditis (IE), there is much less published information on the features and management of right-sided IE. Right-sided IE accounts for 5% to 10% of all IE cases, and compared with left-sided IE, it is more often associated with intravenous drug use, intracard...

journal_title：Journal of the American Heart Association

authors： Shmueli H,Thomas F,Flint N,Setia G,Janjic A,Siegel RJ

更新日期：2020-08-04 00:00:00

abstract：:Background Patients with a Fontan circulation achieve lower peak heart rates ( HR ) during exercise. Whether this impaired chronotropic response reflects pathology of the sinoatrial node or is a consequence of altered cardiac hemodynamics is uncertain. We evaluated the adequacy of HR acceleration throughout exercise r...

journal_title：Journal of the American Heart Association

authors： Claessen G,La Gerche A,Van De Bruaene A,Claeys M,Willems R,Dymarkowski S,Bogaert J,Claus P,Budts W,Heidbuchel H,Gewillig M

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Gluteofemoral fat mass has been associated with improved cardiovascular disease risk factors. It is not clear if loss of this protective fat during weight loss partially negates the effect of loss of visceral fat. The aim of this study was to examine regional fat loss in a large weight-loss cohort from one c...

journal_title：Journal of the American Heart Association

authors： Clifton PM

更新日期：2018-04-04 00:00:00

abstract：:Background Impaired heart rate variability (HRV) is associated with increased mortality in sinus rhythm. However, HRV has not been systematically assessed in patients with atrial fibrillation (AF). We hypothesized that parameters of HRV may be predictive of cardiovascular death in patients with AF. Methods and Results...

journal_title：Journal of the American Heart Association

authors： Hämmerle P,Eick C,Blum S,Schlageter V,Bauer A,Rizas KD,Eken C,Coslovsky M,Aeschbacher S,Krisai P,Meyre P,Vesin JM,Rodondi N,Moutzouri E,Beer J,Moschovitis G,Kobza R,Di Valentino M,Corino VDA,Laureanti R,Mainardi L

更新日期：2020-08-04 00:00:00

abstract：BACKGROUND:In-stent hyperplasia (ISH) may develop in regions of low endothelial shear stress (ESS), but the relationship between the magnitude of low ESS, the extent of ISH, and subsequent clinical events has not been investigated. METHODS AND RESULTS:We assessed the association of poststent ESS with neointimal ISH an...

journal_title：Journal of the American Heart Association

authors： Shishido K,Antoniadis AP,Takahashi S,Tsuda M,Mizuno S,Andreou I,Papafaklis MI,Coskun AU,O'Brien C,Feldman CL,Saito S,Edelman ER,Stone PH

更新日期：2016-09-14 00:00:00

abstract：:Background Neutrophil gelatinase-associated lipocalin ( NGAL ) or lipocalin 2 may promote atherosclerosis and plaque instability leading to increased risk of cardiac events. We investigated the relationships between plasma NGAL , cardiovascular disease biomarkers, and long-term cardiac events. Methods and Results The ...

journal_title：Journal of the American Heart Association

authors： Chong JJH,Prince RL,Thompson PL,Thavapalachandran S,Ooi E,Devine A,Lim EEM,Byrnes E,Wong G,Lim WH,Lewis JR

更新日期：2019-01-08 00:00:00