Stim1 Polymorphism Disrupts Immune Signaling and Creates Renal Injury in Hypertension.

abstract：:Background For individuals with an out-of-hospital cardiac arrest (OHCA), survival may be influenced by the neighborhood in which the arrest occurs. Methods and Results Within the national CARES (Cardiac Arrest Registry to Enhance Survival) registry, we identified 169 502 patients with OHCA from 2013 to 2017. On the b...

journal_title：Journal of the American Heart Association

authors： Chan PS,McNally B,Vellano K,Tang Y,Spertus JA

更新日期：2020-02-18 00:00:00

abstract：:Background In complex congenital heart disease patients such as those with tetralogy of Fallot, the right ventricle (RV) is subject to pressure overload, leading to RV hypertrophy and eventually RV failure. The mechanisms that promote the transition from stable RV hypertrophy to RV failure are unknown. We evaluated th...

journal_title：Journal of the American Heart Association

authors： Hwang HV,Sandeep N,Nair RV,Hu DQ,Zhao M,Lan IS,Fajardo G,Matkovich SJ,Bernstein D,Reddy S

更新日期：2021-01-30 00:00:00

abstract：:Background Race influences medical decision making, but its impact on advanced heart failure therapy allocation is unknown. We sought to determine whether patient race influences allocation of advanced heart failure therapies. Methods and Results Members of a national heart failure organization were randomized to clin...

journal_title：Journal of the American Heart Association

authors： Breathett K,Yee E,Pool N,Hebdon M,Crist JD,Knapp S,Larsen A,Solola S,Luy L,Herrera-Theut K,Zabala L,Stone J,McEwen MM,Calhoun E,Sweitzer NK

更新日期：2019-11-19 00:00:00

abstract：:Background Informed consent for acute myocardial infarction and stroke research is challenging. Time for enrollment decisions is limited, patients and family are usually stressed, and being asked to participate in research is often unexpected. Despite these barriers, patients and surrogates have reported a preference ...

journal_title：Journal of the American Heart Association

authors： Scicluna VM,Goldkind SF,Mitchell AR,Pentz RD,Speight CD,Silbergleit R,Dickert NW

更新日期：2019-11-19 00:00:00

abstract：BACKGROUND:Pulse pressure (PP) is related to cardiac function, arterial stiffness, fluid status, and vascular events. This study aimed to explore the prognostic role of PP upon admission in patients with acute ischemic stroke (AIS) based on a nation-wide stroke registry. METHODS AND RESULTS:We evaluated the associatio...

journal_title：Journal of the American Heart Association

authors： Tang SC,Yin JH,Liu CH,Sun MH,Lee JT,Sun Y,Hsu CS,Sun MC,Lin CH,Chen CH,Lien LM,Muo CH,Jeng JS,Hsu CY,Taiwan Stroke Registry Investigators.

更新日期：2017-06-22 00:00:00

abstract：:Background Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide-ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients. Methods and Results TTS patients from the International Takotsubo Registry we...

journal_title：Journal of the American Heart Association

authors： Jurisic S,Gili S,Cammann VL,Kato K,Szawan KA,D'Ascenzo F,Jaguszewski M,Bossone E,Citro R,Sarcon A,Napp LC,Franke J,Noutsias M,Knorr M,Heiner S,Burgdorf C,Koenig W,Pott A,Kherad B,Rajan L,Michels G,Pfister R,Cu

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:Impaired generation and signaling of nitric oxide (NO) contribute substantially to cardiovascular (CV) risk (CVR) associated with hypertension, hyperlipidemia, and diabetes mellitus. In our rapidly aging society, advanced age is, in itself, a consistent and independent CVR factor. Many processes involved in ...

journal_title：Journal of the American Heart Association

authors： Sverdlov AL,Ngo DT,Chan WP,Chirkov YY,Horowitz JD

更新日期：2014-08-18 00:00:00

abstract：BACKGROUND:Fatty acids constitute the critical components of cell structure and function, and dysregulation of fatty acid composition may exert diverging vascular effects including proliferation, migration, and differentiation of vascular smooth muscle cells (VSMCs). However, direct evidence for this hypothesis has bee...

journal_title：Journal of the American Heart Association

authors： Sunaga H,Matsui H,Anjo S,Syamsunarno MR,Koitabashi N,Iso T,Matsuzaka T,Shimano H,Yokoyama T,Kurabayashi M

更新日期：2016-11-23 00:00:00

abstract：BACKGROUND:Clinical guidelines recommend using predicted atherosclerotic cardiovascular disease (ASCVD) risk to inform treatment decisions. The objective was to compare the contribution of changes in modifiable risk factors versus aging to the development of high 10-year predicted ASCVD risk. METHODS AND RESULTS:A pro...

journal_title：Journal of the American Heart Association

authors： Bress AP,Colantonio LD,Booth JN 3rd,Spruill TM,Ravenell J,Butler M,Shallcross AJ,Seals SR,Reynolds K,Ogedegbe G,Shimbo D,Muntner P

更新日期：2017-02-08 00:00:00

abstract：BACKGROUND:Transcatheter pulmonary valve implantation is approved for the treatment of dysfunctional right ventricle to pulmonary artery conduits. However, the literature is limited because of a small patient population, and it does not reflect changing procedural practice patterns over the last decade. METHODS AND RE...

journal_title：Journal of the American Heart Association

authors： Chatterjee A,Bajaj NS,McMahon WS,Cribbs MG,White JS,Mukherjee A,Law MA

更新日期：2017-08-04 00:00:00

abstract：:Background Programs targeting the standard modifiable cardiovascular risk factors (SMuRFs: hypertension, diabetes mellitus, hypercholesterolemia, smoking) are critical to tackling coronary heart disease at a community level. However, myocardial infarction in SMuRF-less individuals is not uncommon. This study uses 2 se...

journal_title：Journal of the American Heart Association

authors： Vernon ST,Coffey S,D'Souza M,Chow CK,Kilian J,Hyun K,Shaw JA,Adams M,Roberts-Thomson P,Brieger D,Figtree GA

更新日期：2019-11-05 00:00:00

abstract：:Background Aerobic exercise capacity is inversely associated with cardiovascular and all-cause mortality in men and women without coronary artery disease (CAD); however, a higher amount of vigorous exercise is associated with a J-shaped relationship in CAD patients. Therefore, the optimal type and amount of exercise f...

journal_title：Journal of the American Heart Association

authors： Malik A,Kanduri JS,Asbeutah AAA,Khraishah H,Shen C,Welty FK

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Time-limited acute stroke treatments are underused, primarily due to prehospital delay. One approach to decreasing prehospital delay is to increase stroke preparedness, the ability to recognize stroke, and the intention to immediately call emergency medical services, through community engagement with high-ri...

journal_title：Journal of the American Heart Association

authors： Skolarus LE,Zimmerman MA,Bailey S,Dome M,Murphy JB,Kobrossi C,Dombrowski SU,Burke JF,Morgenstern LB

更新日期：2016-05-20 00:00:00

abstract：:Background Exposure to fine airborne particulate matter ( PM 2.5) induces quantitative and qualitative defects in bone marrow-derived endothelial progenitor cells of mice, and similar outcomes in humans may contribute to vascular dysfunction and the cardiovascular morbidity and mortality associated with PM 2.5 exposur...

journal_title：Journal of the American Heart Association

authors： Abplanalp W,Haberzettl P,Bhatnagar A,Conklin DJ,O'Toole TE

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:The optimal timing to administer non-vitamin K oral anticoagulants (NOACs) in patients with acute ischemic stroke and atrial fibrillation is unclear. This prospective observational multicenter study evaluated the rates of early recurrence and major bleeding (within 90 days) and their timing in patients with ...

journal_title：Journal of the American Heart Association

authors： Paciaroni M,Agnelli G,Falocci N,Tsivgoulis G,Vadikolias K,Liantinioti C,Chondrogianni M,Bovi P,Carletti M,Cappellari M,Zedde M,Ntaios G,Karagkiozi E,Athanasakis G,Makaritsis K,Silvestrelli G,Lanari A,Ciccone A,Putaala

更新日期：2017-11-29 00:00:00

abstract：BACKGROUND:Pediatric syncope is common. Cardiac causes are rarely found. We describe and assess a pragmatic approach to these patients first seen by a pediatric cardiologist in the New England region, using Standardized Clinical Assessment and Management Plans (SCAMPs). METHODS AND RESULTS:Ambulatory patients aged 7 t...

journal_title：Journal of the American Heart Association

authors： Paris Y,Toro-Salazar OH,Gauthier NS,Rotondo KM,Arnold L,Hamershock R,Saudek DE,Fulton DR,Renaud A,Alexander ME,New England Congenital Cardiology Association (NECCA).

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:Whether heart rate upon discharge following hospitalization for heart failure is associated with long-term adverse outcomes and whether this association differs between patients with sinus rhythm (SR) and atrial fibrillation (AF) have not been well studied. METHODS AND RESULTS:We conducted a retrospective c...

journal_title：Journal of the American Heart Association

authors： Laskey WK,Alomari I,Cox M,Schulte PJ,Zhao X,Hernandez AF,Heidenreich PA,Eapen ZJ,Yancy C,Bhatt DL,Fonarow GC,AHA Get With The Guidelines®‐Heart Failure Program.

更新日期：2015-04-22 00:00:00

abstract：BACKGROUND:Postural tachycardia syndrome (POTS) is a disorder of chronic orthostatic intolerance accompanied by excessive orthostatic tachycardia. Patients with POTS commonly have comorbid conditions such as attention deficit hyperactivity disorder, depression, or fibromyalgia that are treated with medications that inh...

journal_title：Journal of the American Heart Association

authors： Green EA,Raj V,Shibao CA,Biaggioni I,Black BK,Dupont WD,Robertson D,Raj SR

更新日期：2013-09-03 00:00:00

abstract：:Despite numerous advances in the prevention and treatment of atherosclerosis, cardiovascular disease remains a leading cause of morbidity and mortality. Novel and inexpensive interventions that can contribute to the primary and secondary prevention of cardiovascular disease are of interest. Numerous studies have repor...

journal_title：Journal of the American Heart Association

authors： Levine GN,Lange RA,Bairey-Merz CN,Davidson RJ,Jamerson K,Mehta PK,Michos ED,Norris K,Ray IB,Saban KL,Shah T,Stein R,Smith SC Jr,American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nur

更新日期：2017-09-28 00:00:00

abstract：:Background Ischemic heart disease continues to be a leading cause of mortality in patients. Extracellular vesicles (EVs) provide a potential for treatment that may induce collateral vessel growth to increase myocardial perfusion. Methods and Results Nineteen male Yorkshire pigs were given a high-fat diet for 4 weeks, ...

journal_title：Journal of the American Heart Association

authors： Scrimgeour LA,Potz BA,Aboul Gheit A,Shi G,Stanley M,Zhang Z,Sodha NR,Ahsan N,Abid MR,Sellke FW

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:The presence and implications of abnormal arterial stiffness, a potential independent predictor of outcomes, in community-dwelling treated hypertensives is unknown. Furthermore, limited data exist regarding the risk of cardiovascular disease (CVD) associated with arterial stiffness across the entire range of...

journal_title：Journal of the American Heart Association

authors： Niiranen TJ,Kalesan B,Hamburg NM,Benjamin EJ,Mitchell GF,Vasan RS

更新日期：2016-10-26 00:00:00

abstract：BACKGROUND:Contemporary rates of oral anticoagulant (OAC) therapy and associated outcomes among patients undergoing percutaneous coronary intervention (PCI) have been poorly described. METHODS AND RESULTS:Using data from an integrated health care system from 2009 to 2014, we identified patients on OACs within 30 days ...

journal_title：Journal of the American Heart Association

authors： Secemsky EA,Butala NM,Kartoun U,Mahmood S,Wasfy JH,Kennedy KF,Shaw SY,Yeh RW

更新日期：2016-10-17 00:00:00

abstract：BACKGROUND:Reactive oxygen species (ROS) are associated with development of coronary artery disease (CAD). However, there's no useful biomarker of ROS in CAD. METHODS AND RESULTS:We recruited 395 consecutive CAD patients who were performed coronary angiography (262 male and 133 female, age 70.2±10), and we measured se...

journal_title：Journal of the American Heart Association

authors： Hirata Y,Yamamoto E,Tokitsu T,Kusaka H,Fujisue K,Kurokawa H,Sugamura K,Maeda H,Tsujita K,Kaikita K,Hokimoto S,Sugiyama S,Ogawa H

更新日期：2015-01-28 00:00:00

abstract：BACKGROUND:A cohort study found that 9/11-related environmental exposures and posttraumatic stress disorder increased self-reported cardiovascular disease risk. We attempted to replicate these findings using objectively defined cardiovascular disease hospitalizations in the same cohort. METHODS AND RESULTS:Data for ad...

journal_title：Journal of the American Heart Association

authors： Jordan HT,Stellman SD,Morabia A,Miller-Archie SA,Alper H,Laskaris Z,Brackbill RM,Cone JE

更新日期：2013-10-24 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging of carotid plaque can aid in stroke risk stratification in patients with carotid stenosis. However, the prevalence of complicated carotid plaque in patients with cryptogenic stroke is uncertain, especially as assessed by plaque imaging techniques routinely included in acute stroke ...

journal_title：Journal of the American Heart Association

authors： Gupta A,Gialdini G,Lerario MP,Baradaran H,Giambrone A,Navi BB,Marshall RS,Iadecola C,Kamel H

更新日期：2015-06-15 00:00:00

abstract：BACKGROUND:The impact of dispatcher-assisted bystander cardiopulmonary resuscitation (CPR) on neurological outcomes in children is unclear. We investigated whether dispatcher-assisted bystander CPR shows favorable neurological outcomes (Cerebral Performance Category scale 1 or 2) in children with out-of-hospital cardia...

journal_title：Journal of the American Heart Association

authors： Goto Y,Maeda T,Goto Y

更新日期：2014-04-30 00:00:00

abstract：:Background The "no-reflow phenomenon" compromises percutaneous coronary intervention outcomes. There is an unmet need for a device that prevents no-reflow phenomenon. Our goal was to develop a guidewire platform comprising a nondisruptive hydrophilic coating that allows continuous delivery of adenosine throughout a pe...

journal_title：Journal of the American Heart Association

authors： Forman MB,Brewer EC,Brown ZR,Menshikova EV,Lowman AM,Jackson EK,Brewer

更新日期：2021-01-26 00:00:00

abstract：:Background Use of inpatient brain magnetic resonance imaging (MRI) in patients with acute ischemic stroke is highly institution dependent and has been associated with increased length and cost of hospital stay. We examined whether inpatient brain MRI in patients with acute ischemic stroke is associated with improved c...

journal_title：Journal of the American Heart Association

authors： Lee H,Yang Y,Liu B,Castro SA,Shi T

更新日期：2020-10-20 00:00:00

abstract：:Background In the 2000s, adults with HIV had a higher risk for atherosclerotic cardiovascular disease (ASCVD) compared with those without HIV. There is uncertainty if this excess risk still exists in the United States given changes in antiretroviral therapies and increased statin use. Methods and Results We compared t...

journal_title：Journal of the American Heart Association

authors： Rosenson RS,Hubbard D,Monda KL,Reading SR,Chen L,Dluzniewski PJ,Burkholder GA,Muntner P,Colantonio LD

更新日期：2020-01-07 00:00:00

abstract：BACKGROUND:Left ventricular noncompaction (LVNC) has since been classified as a primary genetic cardiomyopathy, but the genetic basis is not fully evaluated. The aim of the present study was to identify the genetic spectrum using next-generation sequencing and to evaluate genotype-phenotype correlations in LVNC patient...

journal_title：Journal of the American Heart Association

authors： Wang C,Hata Y,Hirono K,Takasaki A,Ozawa SW,Nakaoka H,Saito K,Miyao N,Okabe M,Ibuki K,Nishida N,Origasa H,Yu X,Bowles NE,Ichida F,for LVNC Study Collaborators.

更新日期：2017-08-30 00:00:00