Assessing Baseline and Temporal Changes in Cardiometabolic Risk Using Metabolic Syndrome Severity and Common Risk Scores.

abstract：BACKGROUND:Magnetic resonance imaging of carotid plaque can aid in stroke risk stratification in patients with carotid stenosis. However, the prevalence of complicated carotid plaque in patients with cryptogenic stroke is uncertain, especially as assessed by plaque imaging techniques routinely included in acute stroke ...

journal_title：Journal of the American Heart Association

authors： Gupta A,Gialdini G,Lerario MP,Baradaran H,Giambrone A,Navi BB,Marshall RS,Iadecola C,Kamel H

更新日期：2015-06-15 00:00:00

abstract：BACKGROUND:The impact of the 2013 American College of Cardiology/American Heart Association cholesterol guidelines on statin eligibility in individuals otherwise destined to experience cardiovascular disease (CVD) events is unclear. METHODS AND RESULTS:We analyzed a prospective cohort of consecutive ST-segment elevati...

journal_title：Journal of the American Heart Association

authors： Miedema MD,Garberich RF,Schnaidt LJ,Peterson E,Strauss C,Sharkey S,Knickelbine T,Newell MC,Henry TD

更新日期：2017-04-12 00:00:00

abstract：:Background Turner syndrome ( TS ) is the most common sex chromosome abnormality in women and is associated with increased morbidity and mortality. We describe long-term outcomes in a large cohort of patients with TS . Methods and Results Retrospective review of patients with TS followed at Mayo Clinic Rochester from 1...

journal_title：Journal of the American Heart Association

authors： Fuchs MM,Attenhofer Jost C,Babovic-Vuksanovic D,Connolly HM,Egbe A

更新日期：2019-06-04 00:00:00

abstract：BACKGROUND:Optimal thromboprophylaxis after cardiac surgery is uncertain. This systematic review aimed to define the incidence and risk factors for deep vein thrombosis (DVT), fatal and nonfatal pulmonary embolism (PE), and assess whether venous thromboembolism (VTE) prophylaxis was effective in reducing VTE without co...

journal_title：Journal of the American Heart Association

authors： Ho KM,Bham E,Pavey W

更新日期：2015-10-26 00:00:00

abstract：:Background While high levels of lipids and lipid variability are established risk factors for atherosclerotic cardiovascular disease, their roles in the development of atrial fibrillation (AF) are unclear, with previous studies suggesting a "cholesterol paradox." Methods and Results A nationwide population-based cohor...

journal_title：Journal of the American Heart Association

authors： Lee HJ,Lee SR,Choi EK,Han KD,Oh S

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:The American Heart Association (AHA) recently developed the Cardiovascular Health Index (CVHI), a health metric consisting of 7 modifiable risk factors. The relationship of the CVHI with preclinical markers, such as carotid intima-media thickness (CIMT) has not been assessed. METHODS:We examined 490 male mo...

journal_title：Journal of the American Heart Association

authors： Kulshreshtha A,Goyal A,Veledar E,McClellan W,Judd S,Eufinger SC,Bremner JD,Goldberg J,Vaccarino V

更新日期：2014-01-02 00:00:00

abstract：:Background Tetrahydrobiopterin is a cofactor of endothelial NO synthase ( eNOS ), which is critical to embryonic heart development. We aimed to study the effects of sapropterin (Kuvan), an orally active synthetic form of tetrahydrobiopterin on eNOS uncoupling and congenital heart defects ( CHD s) induced by pregestati...

journal_title：Journal of the American Heart Association

authors： Engineer A,Saiyin T,Lu X,Kucey AS,Urquhart BL,Drysdale TA,Norozi K,Feng Q

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Cystathionine γ-lyase, cystathionine β-synthase, and 3-mercaptopyruvate sulfurtransferase are endogenous enzymatic sources of hydrogen sulfide (H2S). Functions of H2S are mediated by several targets including ion channels and signaling proteins. Nuclear factor-erythroid 2-related factor 2 is responsible for ...

journal_title：Journal of the American Heart Association

authors： Islam KN,Polhemus DJ,Donnarumma E,Brewster LP,Lefer DJ

更新日期：2015-05-14 00:00:00

abstract：BACKGROUND:We sought to characterize growth between birth and age 3 years in infants with hypoplastic left heart syndrome who underwent the Norwood procedure. METHODS AND RESULTS:We performed a secondary analysis using the Single Ventricle Reconstruction Trial database after excluding patients <37 weeks gestation (N=4...

journal_title：Journal of the American Heart Association

authors： Burch PT,Gerstenberger E,Ravishankar C,Hehir DA,Davies RR,Colan SD,Sleeper LA,Newburger JW,Clabby ML,Williams IA,Li JS,Uzark K,Cooper DS,Lambert LM,Pemberton VL,Pike NA,Anderson JB,Dunbar-Masterson C,Khaikin S,Zyble

更新日期：2014-06-23 00:00:00

abstract：BACKGROUND:Cardiac mesenchymal cell (CMC) administration improves cardiac function in animal models of heart failure. Although the precise mechanisms remain unclear, transdifferentiation and paracrine signaling are suggested to underlie their cardiac reparative effects. We have shown that histone deacetylase 1 (HDAC1) ...

journal_title：Journal of the American Heart Association

authors： Moore JB 4th,Zhao J,Fischer AG,Keith MCL,Hagan D,Wysoczynski M,Bolli R

更新日期：2017-07-05 00:00:00

abstract：BACKGROUND:A higher milk consumption may be associated with a lower stroke risk. We conducted a comprehensive systematic review and dose-response meta-analysis of milk and other dairy products in relation to stroke risk. METHODS AND RESULTS:Through a systematic literature search, prospective cohort studies of dairy fo...

journal_title：Journal of the American Heart Association

authors： de Goede J,Soedamah-Muthu SS,Pan A,Gijsbers L,Geleijnse JM

更新日期：2016-05-20 00:00:00

abstract：:Background Gait speed is a reliable measure of physical function and frailty in patients with aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). Slow gait speed pre-TAVR predicts worse clinical outcomes post-TAVR. The consequences of improved versus worsened physical function post-TAVR are unkno...

journal_title：Journal of the American Heart Association

authors： Goel K,O'Leary JM,Barker CM,Levack M,Rajagopal V,Makkar RR,Bajwa T,Kleiman N,Linke A,Kereiakes DJ,Waksman R,Allocco DJ,Rizik DG,Reardon MJ,Lindman BR

更新日期：2020-09-01 00:00:00

abstract：:Background Crossover dilutes treatment effect and reduces statistical power of intention-to-treat analysis. We examined incidence and impact on cardiac surgery randomized controlled trial (RCT) outcomes of crossover from experimental to control interventions, or vice versa. Methods and Results MEDLINE, EMBASE, and Coc...

journal_title：Journal of the American Heart Association

authors： Gaudino M,Fremes SE,Ruel M,Di Franco A,Di Mauro M,Chikwe J,Frati G,Girardi LN,Taggart DP,Biondi-Zoccai G

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:Hypertension is a frequent risk factor for the development of heart failure with preserved ejection fraction (HFPEF). Progressive extracellular matrix accumulation has been presumed to be the fundamental pathophysiologic mechanism that leads to the transition to impaired diastolic reserve. However, the contr...

journal_title：Journal of the American Heart Association

authors： van Empel VP,Mariani J,Borlaug BA,Kaye DM

更新日期：2014-12-02 00:00:00

abstract：:Background We aimed to determine if there is an association between hospital quality and the likelihood of a given hospital being a preferred transfer destination for stroke patients. Methods and Results Data from Medicare claims identified acute ischemic stroke transferred between 394 northeast US hospitals from 2007...

journal_title：Journal of the American Heart Association

authors： Zachrison KS,Onnela JP,Reeves MJ,Hernandez A,Camargo CA Jr,Zhao X,Matsouaka RA,Goldstein JN,Metlay JP,Schwamm LH

更新日期：2020-01-07 00:00:00

abstract：BACKGROUND:Although guidelines for antiarrhythmic drug therapy in atrial fibrillation (AF) were published in 2006, it remains uncertain whether adherence to these guidelines affects patient outcomes. METHODS AND RESULTS:We retrospectively evaluated the records of 5976 consecutive AF patients who were prescribed at lea...

journal_title：Journal of the American Heart Association

authors： Qin D,Leef G,Alam MB,Rattan R,Munir MB,Patel D,Khattak F,Vaghasia N,Adelstein E,Jain SK,Saba S

更新日期：2015-04-06 00:00:00

abstract：BACKGROUND:The geometric organization of myocytes in the ventricular wall comprises the structural underpinnings of cardiac mechanical function. Cardiac myosin binding protein-C (MYBPC3) is a sarcomeric protein, for which phosphorylation modulates myofilament binding, sarcomere morphology, and myocyte alignment in the ...

journal_title：Journal of the American Heart Association

authors： Taylor EN,Hoffman MP,Barefield DY,Aninwene GE 2nd,Abrishamchi AD,Lynch TL 4th,Govindan S,Osinska H,Robbins J,Sadayappan S,Gilbert RJ

更新日期：2016-03-15 00:00:00

abstract：:Background Little attention has been paid to the importance of sex in the long-term prognosis of patients undergoing cardiac surgery. Methods and Results We conducted a retrospective cohort study of Ontario residents, aged ≥40 years, who underwent coronary artery bypass grafting (CABG) and/or aortic, mitral, or tricus...

journal_title：Journal of the American Heart Association

authors： Johnston A,Mesana TG,Lee DS,Eddeen AB,Sun LY

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Extracorporeal cardiopulmonary resuscitation (ECPR) is widely proposed for the treatment of refractory cardiac arrest. It should be associated with coronary angiography if coronary artery disease is suspected. However, the prioritization of care remains unclear in this situation. Our goal was to determine wh...

journal_title：Journal of the American Heart Association

authors： Hutin A,Lamhaut L,Lidouren F,Kohlhauer M,Mongardon N,Carli P,Berdeaux A,Ghaleh B,Tissier R

更新日期：2016-12-22 00:00:00

abstract：BACKGROUND:Galectin-3 may play a role in cardiac and noncardiac fibrosis, and elevated circulating levels of this protein predict adverse outcomes in patients with heart failure who do not have congenital heart disease. We investigated galectin-3 in adults with single-ventricle Fontan circulation, patients who are pron...

journal_title：Journal of the American Heart Association

authors： Opotowsky AR,Baraona F,Owumi J,Loukas B,Singh MN,Valente AM,Wu F,Cheng S,Veldtman G,Rimm EB,Landzberg MJ

更新日期：2016-01-11 00:00:00

abstract：BACKGROUND:It is uncertain whether sex and race affect thrombogenicity in patients with coronary artery disease. We evaluated the effects of sex and race on thrombogenicity in patients with coronary artery disease treated with aspirin. METHODS AND RESULTS:Patients on aspirin therapy for 1 week or longer with known or ...

journal_title：Journal of the American Heart Association

authors： Lev EI,Bliden KP,Jeong YH,Pandya S,Kang K,Franzese C,Tantry US,Gurbel PA

更新日期：2014-10-20 00:00:00

abstract：BACKGROUND:Although statins reduce cardiovascular events, residual risk remains. Therefore, additional modalities are needed to reduce risk. We evaluated the effect of eicosapentaenoic acid and docosahexaenoic acid in pharmacologic doses added to statin treatment on coronary artery plaque volume. METHODS AND RESULTS:A...

journal_title：Journal of the American Heart Association

authors： Alfaddagh A,Elajami TK,Ashfaque H,Saleh M,Bistrian BR,Welty FK

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:Although a stroke event often leads to work disability, diagnoses behind work disability before and after stroke are largely unknown. We examined the pre-event and postevent trends in diagnosis-specific work disability among patients of working age. METHODS AND RESULTS:We included all new nonfatal stroke ev...

journal_title：Journal of the American Heart Association

authors： Lallukka T,Ervasti J,Lundström E,Mittendorfer-Rutz E,Friberg E,Virtanen M,Alexanderson K

更新日期：2018-01-04 00:00:00

abstract：BACKGROUND:Long chain acyl-CoA synthetases (ACSL) catalyze long-chain fatty acids (FA) conversion to acyl-CoAs. Temporal ACSL1 inactivation in mouse hearts (Acsl1(H-/-)) impaired FA oxidation and dramatically increased glucose uptake, glucose oxidation, and mTOR activation, resulting in cardiac hypertrophy. We used unb...

journal_title：Journal of the American Heart Association

authors： Schisler JC,Grevengoed TJ,Pascual F,Cooper DE,Ellis JM,Paul DS,Willis MS,Patterson C,Jia W,Coleman RA

更新日期：2015-02-24 00:00:00

abstract：:Background Among people with lower extremity peripheral artery disease, obesity is associated with faster functional decline than normal weight. The association of weight loss with functional decline in peripheral artery disease is unknown. Methods and Results Adults with an ankle-brachial index <0.90 were identified ...

journal_title：Journal of the American Heart Association

authors： Polonsky TS,Tian L,Zhang D,Bazzano LA,Criqui MH,Ferrucci L,Guralnik JM,Kibbe MR,Leeuwenburgh C,Sufit RL,McDermott MM

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:We previously identified peritoneal B1a cells that secrete natural IgM as a key atheroprotective B cell subset. However, the molecules that activate atheroprotective B1a cells are unknown. Here, we investigated whether Toll-like receptors (TLRs) TLR2, TLR4, and TLR9 expressed by B1a cells are required for Ig...

journal_title：Journal of the American Heart Association

authors： Hosseini H,Li Y,Kanellakis P,Tay C,Cao A,Liu E,Peter K,Tipping P,Toh BH,Bobik A,Kyaw T

更新日期：2016-11-14 00:00:00

abstract：BACKGROUND:Depression is known to increase the risk of coronary artery disease, but few studies have evaluated the association between depression and peripheral artery disease (PAD). We examined the association of depression with PAD and evaluated potential mediators of this association. METHODS AND RESULTS:We used da...

journal_title：Journal of the American Heart Association

authors： Grenon SM,Hiramoto J,Smolderen KG,Vittinghoff E,Whooley MA,Cohen BE

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Excess accumulation of abdominal subcutaneous (SAT) and visceral adipose tissue (VAT) is associated with adverse levels of adipokines and cardiovascular disease risk. Whether fat quality is associated with adipokines has not been firmly established. This study examined the association between abdominal SAT a...

journal_title：Journal of the American Heart Association

authors： Lee JJ,Pedley A,Hoffmann U,Massaro JM,Keaney JF Jr,Vasan RS,Fox CS

更新日期：2016-02-29 00:00:00

abstract：:Background Unruptured intracerebral aneurysm wall enhancement (AWE) on vessel wall magnetic resonance imaging scans may be a promising predictor for rupture-prone intracerebral aneurysms. However, the pathophysiology of AWE remains unclear. To this end, the association between AWE and histopathological changes was ass...

journal_title：Journal of the American Heart Association

authors： Zhong W,Su W,Li T,Tan X,Chen C,Wang Q,Wang D,Su W,Wang Y

更新日期：2021-01-19 00:00:00

abstract：:Background Ticagrelor reduces ischaemic end points in acute coronary syndromes. However, outcomes of ticagrelor versus clopidogrel in real-world patients with acute coronary syndromes treated with percutaneous coronary intervention (PCI) remain unclear. We sought to examine whether treatment with ticagrelor is superio...

journal_title：Journal of the American Heart Association

authors： Völz S,Petursson P,Odenstedt J,Ioanes D,Haraldsson I,Angerås O,Dworeck C,Hirlekar G,Myredal A,Albertsson P,Råmunddal T,Redfors B,Omerovic E

更新日期：2020-07-21 00:00:00