Hydrogen Sulfide Levels and Nuclear Factor-Erythroid 2-Related Factor 2 (NRF2) Activity Are Attenuated in the Setting of Critical Limb Ischemia (CLI).

abstract：BACKGROUND:We sought to characterize growth between birth and age 3 years in infants with hypoplastic left heart syndrome who underwent the Norwood procedure. METHODS AND RESULTS:We performed a secondary analysis using the Single Ventricle Reconstruction Trial database after excluding patients <37 weeks gestation (N=4...

journal_title：Journal of the American Heart Association

authors： Burch PT,Gerstenberger E,Ravishankar C,Hehir DA,Davies RR,Colan SD,Sleeper LA,Newburger JW,Clabby ML,Williams IA,Li JS,Uzark K,Cooper DS,Lambert LM,Pemberton VL,Pike NA,Anderson JB,Dunbar-Masterson C,Khaikin S,Zyble

更新日期：2014-06-23 00:00:00

abstract：:Background Hyperoxia during cardiopulmonary resuscitation (CPR) may lead to oxidative injury from mitochondrial-derived reactive oxygen species, despite guidelines recommending 1.0 inspired oxygen during CPR. We hypothesized exposure to 1.0 inspired oxygen during CPR would result in cerebral hyperoxia, higher mitochon...

journal_title：Journal of the American Heart Association

authors： Marquez AM,Morgan RW,Ko T,Landis WP,Hefti MM,Mavroudis CD,McManus MJ,Karlsson M,Starr J,Roberts AL,Lin Y,Nadkarni V,Licht DJ,Berg RA,Sutton RM,Kilbaugh TJ

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co-occur, we hypothesized that there may be shared genetic risk factors for IAs, AAAs, and TAAs. METHODS AND RESULTS:We performed a...

journal_title：Journal of the American Heart Association

authors： van 't Hof FN,Ruigrok YM,Lee CH,Ripke S,Anderson G,de Andrade M,Baas AF,Blankensteijn JD,Böttinger EP,Bown MJ,Broderick J,Bijlenga P,Carrell DS,Crawford DC,Crosslin DR,Ebeling C,Eriksson JG,Fornage M,Foroud T,von Un

更新日期：2016-07-14 00:00:00

abstract：BACKGROUND:Epidemiology of myocarditis in childhood is largely unknown. Men are known to have a higher incidence of myocarditis than women in adults aged <50 years, but whether this is true by sex in pediatric age groups is unknown. We set out to study the occurrence and potential sex differences of myocarditis in a ge...

journal_title：Journal of the American Heart Association

authors： Arola A,Pikkarainen E,Sipilä JO,Pykäri J,Rautava P,Kytö V

更新日期：2017-11-18 00:00:00

abstract：BACKGROUND:Left ventricular noncompaction (LVNC) has since been classified as a primary genetic cardiomyopathy, but the genetic basis is not fully evaluated. The aim of the present study was to identify the genetic spectrum using next-generation sequencing and to evaluate genotype-phenotype correlations in LVNC patient...

journal_title：Journal of the American Heart Association

authors： Wang C,Hata Y,Hirono K,Takasaki A,Ozawa SW,Nakaoka H,Saito K,Miyao N,Okabe M,Ibuki K,Nishida N,Origasa H,Yu X,Bowles NE,Ichida F,for LVNC Study Collaborators.

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:Early reperfusion in the setting of an ST-elevation myocardial infarction (STEMI) is of utmost importance. However, the effects of early versus late reperfusion in this patient group undergoing primary percutaneous coronary intervention (PCI) have so far been inconsistent in previous studies. The purpose of ...

journal_title：Journal of the American Heart Association

authors： Koul S,Andell P,Martinsson A,Gustav Smith J,van der Pals J,Scherstén F,Jernberg T,Lagerqvist B,Erlinge D

更新日期：2014-03-04 00:00:00

abstract：BACKGROUND:Atherosclerosis is a chronic inflammatory disorder whose development is inversely correlated with high-density lipoprotein concentration. Current therapies involve pharmaceuticals that significantly elevate plasma high-density lipoprotein cholesterol concentrations. Our studies were conducted to investigate ...

journal_title：Journal of the American Heart Association

authors： Kaul S,Xu H,Zabalawi M,Maruko E,Fulp BE,Bluemn T,Brzoza-Lewis KL,Gerelus M,Weerasekera R,Kallinger R,James R,Zhang YS,Thomas MJ,Sorci-Thomas MG

更新日期：2016-11-07 00:00:00

abstract：:Background Young women with coronary artery disease ( CAD ), a group with high psychosocial burden, were previously shown to have higher levels of interleukin-6 ( IL -6) compared with men of similar age. We sought to examine IL -6 response to acute stress in CAD patients across sex and age, and contrast results to hea...

journal_title：Journal of the American Heart Association

authors： Sullivan S,Hammadah M,Wilmot K,Ramadan R,Pearce BD,Shah A,Kaseer B,Gafeer MM,Lima BB,Kim JH,Ward L,Ko YA,Lewis TT,Hankus A,Elon L,Li L,Bremner JD,Raggi P,Quyyumi A,Vaccarino V

更新日期：2018-12-04 00:00:00

abstract：:Background The incidence of conduction abnormalities requiring permanent pacemaker implantation (PPI) after transcatheter aortic valve replacement (TAVR) with early and later generation prostheses remains debated. Methods and Results Based on the administrative hospital-discharge database, we collected information for...

journal_title：Journal of the American Heart Association

authors： Bisson A,Bodin A,Herbert J,Lacour T,Saint Etienne C,Pierre B,Clementy N,Deharo P,Babuty D,Fauchier L

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:Intramyocardial injection of mesenchymal stem cells (MSCs) in chronic ischemic cardiomyopathy is associated with reverse remodeling in experimental models and humans. Here, we tested the hypothesis that allogeneic MSC therapy drives ventricular remodeling by producing durable and progressive scar size reduct...

journal_title：Journal of the American Heart Association

authors： Williams AR,Suncion VY,McCall F,Guerra D,Mather J,Zambrano JP,Heldman AW,Hare JM

更新日期：2013-05-17 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate whether the association between baseline cardiovascular health (CVH) and incident cardiovascular disease differs according to coronary heart disease (CHD) and stroke subtypes, and to assess the mediating effect of inflammatory and hemostatic blood biomarkers. METHODS...

journal_title：Journal of the American Heart Association

authors： Gaye B,Tafflet M,Arveiler D,Montaye M,Wagner A,Ruidavets JB,Kee F,Evans A,Amouyel P,Ferrieres J,Empana JP

更新日期：2017-10-17 00:00:00

abstract：:Background Recent evidence suggests that racial/ethnic differences in circulating levels of free or bioavailable 25-hydroxy vitamin D (25[ OH ]D) rather than total 25( OH )D may explain apparent racial disparities in cardiovascular disease ( CVD ). We prospectively examined black-white differences in the associations ...

journal_title：Journal of the American Heart Association

authors： Zhang X,Tu W,Manson JE,Tinker L,Liu S,Cauley JA,Qi L,Mouton C,Martin LW,Hou L,Song Y

更新日期：2019-02-19 00:00:00

abstract：:We, the Editors of the Journal of the American Heart Association, sincerely regret the publication of the article "Diversity, Inclusion, and Equity: Evolution of Race and Ethnicity Considerations for the Cardiology Workforce in the United States of America From 1969 to 2019".1 We are aware that the publication of this...

journal_title：Journal of the American Heart Association

authors： London B,Ahmad F,Eitzman DT,Gupta AK,Jneid H,Peterson P,Remme CA,Rice K,Schelbert EB,Simon MA,Sullivan LM,Weinberg JM

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Hispanic persons represent a heterogeneous and growing population of any race with origins in Mexico, the Caribbean, Central America, South America, or other Spanish-speaking countries. Previous studies have documented variation in cardiovascular risk and outcomes among Hispanic subgroups. Few studies have i...

journal_title：Journal of the American Heart Association

authors： Rodriguez F,Hastings KG,Hu J,Lopez L,Cullen M,Harrington RA,Palaniappan LP

更新日期：2017-12-13 00:00:00

abstract：BACKGROUND:Inappropriate sinus tachycardia (IST) and postural tachycardia syndrome (POTS) are 2 disorders characterized by sinus tachycardia. It is debated whether the pathophysiology of IST and POTS results from abnormal autonomic regulation or abnormal sinus node function. We hypothesized that intrinsic heart rate (I...

journal_title：Journal of the American Heart Association

authors： Nwazue VC,Paranjape SY,Black BK,Biaggioni I,Diedrich A,Dupont WD,Robertson D,Raj SR

更新日期：2014-04-10 00:00:00

abstract：BACKGROUND:Regression of left ventricular (LV) hypertrophy (LVH) has been a goal in clinical trials. This study tests the external validity of results of clinical trials on LVH regression using a large registry from a tertiary care center, to identify phenotypes less likely to achieve regression of LVH. METHODS AND RE...

journal_title：Journal of the American Heart Association

authors： Lønnebakken MT,Izzo R,Mancusi C,Gerdts E,Losi MA,Canciello G,Giugliano G,De Luca N,Trimarco B,de Simone G

更新日期：2017-03-08 00:00:00

abstract：BACKGROUND:Postoperative thrombocytopenia has been reported to be correlated with adverse events, but the prognostic value of baseline thrombocytopenia is unclear. This study was undertaken to evaluate the relationship between preoperative thrombocytopenia and adverse outcomes in patients with rheumatic heart disease w...

journal_title：Journal of the American Heart Association

authors： Wei XB,Jiang L,Liu YH,Feng D,He PC,Chen JY,Tan N,Yu DQ

更新日期：2017-12-04 00:00:00

abstract：BACKGROUND:It is unclear whether the incidence of non-valvular atrial fibrillation (NVAF) has been increasing over time. We aimed to provide contemporary estimates of the incidence and case-fatality of NVAF in a well-defined population. METHODS AND RESULTS:We used the computerized databases of the Régie de l'assurance...

journal_title：Journal of the American Heart Association

authors： Renoux C,Patenaude V,Suissa S

更新日期：2014-11-03 00:00:00

abstract：BACKGROUND:The associations between high-sensitivity troponin I (hsTnI) levels and coronary artery disease (CAD) severity and progression remain unclear. We investigated whether there is an association between hsTnI and angiographic severity and progression of CAD and whether the predictive value of hsTnI level for inc...

journal_title：Journal of the American Heart Association

authors： Samman Tahhan A,Sandesara P,Hayek SS,Hammadah M,Alkhoder A,Kelli HM,Topel M,O'Neal WT,Ghasemzadeh N,Ko YA,Gafeer MM,Abdelhadi N,Choudhary F,Patel K,Beshiri A,Murtagh G,Kim J,Wilson P,Shaw L,Vaccarino V,Epstein SE

更新日期：2018-02-21 00:00:00

abstract：BACKGROUND:Optimal thromboprophylaxis after cardiac surgery is uncertain. This systematic review aimed to define the incidence and risk factors for deep vein thrombosis (DVT), fatal and nonfatal pulmonary embolism (PE), and assess whether venous thromboembolism (VTE) prophylaxis was effective in reducing VTE without co...

journal_title：Journal of the American Heart Association

authors： Ho KM,Bham E,Pavey W

更新日期：2015-10-26 00:00:00

abstract：:Background Patients undergoing lead extraction for infected devices have worse outcomes compared with those with noninfected devices. We assessed predictors of in-hospital mortality and procedure-related major adverse events (MAEs) in a large cohort undergoing lead extraction. Methods and Results Deidentified hospital...

journal_title：Journal of the American Heart Association

authors： Aleong RG,Zipse MM,Tompkins C,Aftab M,Varosy P,Sauer W,Kao D

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Obesity is causally associated with atherosclerosis, and adipose tissue (AT)-derived exosomes may be implicated in the metabolic complications of obesity. However, the precise role of AT-exosomes in atherogenesis remains unclear. We herein aimed to assess the effect of AT-exosomes on macrophage foam cell for...

journal_title：Journal of the American Heart Association

authors： Xie Z,Wang X,Liu X,Du H,Sun C,Shao X,Tian J,Gu X,Wang H,Tian J,Yu B

更新日期：2018-03-03 00:00:00

abstract：BACKGROUND:We investigated whether disease location influences survival in patients with peripheral arterial disease. METHODS AND RESULTS:Patients (n = 12,731; mean age, 67.5 ± 12.7 years; 57.4% male) who underwent outpatient noninvasive lower extremity arterial evaluation were followed up for 5.9 ± 3.1 years for all-...

journal_title：Journal of the American Heart Association

authors： Chen Q,Smith CY,Bailey KR,Wennberg PW,Kullo IJ

更新日期：2013-10-21 00:00:00

abstract：:Background Cardiovascular disease is the leading cause of morbidity and mortality in patients with end-stage renal disease. Heart rhythm complexity analysis has been shown to be useful in predicting outcomes in various diseases; however, data on patients with end-stage renal disease are limited. In this study, we anal...

journal_title：Journal of the American Heart Association

authors： Tsai CH,Huang JW,Lin C,Ma HP,Lo MT,Liu LD,Lin LY,Lin CT,Hung CS,Peng CK,Lin YH

更新日期：2020-01-21 00:00:00

abstract：:Background Cardiovascular disease incidence, prevalence, morbidity, and mortality have declined in the past several decades; however, disparities persist among subsets of the population. Notably, blacks have not experienced the same improvements on the whole as whites. Furthermore, frequent reports of relatively poore...

journal_title：Journal of the American Heart Association

authors： Islam SJ,Kim JH,Topel M,Liu C,Ko YA,Mujahid MS,Sims M,Mubasher M,Ejaz K,Morgan-Billingslea J,Jones K,Waller EK,Jones D,Uppal K,Dunbar SB,Pemu P,Vaccarino V,Searles CD,Baltrus P,Lewis TT,Quyyumi AA,Taylor H

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:The p.Gln554X mutation in desmocollin-2 (DSC2) is prevalent in ≈10% of the Hutterite population. While the homozygous mutation causes severe biventricular arrhythmogenic right ventricular cardiomyopathy, the phenotypic features and prognosis of heterozygotes remain incompletely understood. METHODS AND RESUL...

journal_title：Journal of the American Heart Association

authors： Wong JA,Duff HJ,Yuen T,Kolman L,Exner DV,Weeks SG,Gerull B

更新日期：2014-12-11 00:00:00

abstract：BACKGROUND:The aim of this study was to elucidate the correlation between angiographic coronary vasomotor responses to intracoronary acetylcholine (ACh) injection, clinical features, and long-term prognosis in patients with vasospastic angina (VSA). METHODS AND RESULTS:This is a retrospective, observational, single-ce...

journal_title：Journal of the American Heart Association

authors： Sato K,Kaikita K,Nakayama N,Horio E,Yoshimura H,Ono T,Ohba K,Tsujita K,Kojima S,Tayama S,Hokimoto S,Matsui K,Sugiyama S,Yamabe H,Ogawa H

更新日期：2013-07-15 00:00:00

abstract：BACKGROUND:Women have high rates of peripheral artery disease (PAD) despite fewer cardiovascular disease (CVD) risk factors, compared to men. We sought to determine the gender-specific prevalence of low ankle brachial index (ABI) and the relationship to C-reactive protein (CRP) levels and CVD risk factors in the Life L...

journal_title：Journal of the American Heart Association

authors： Hiramoto JS,Katz R,Weisman S,Conte M

更新日期：2014-03-13 00:00:00

abstract：:Background Sex differences in outcome have been reported in patients with congenital long QT syndrome. We aimed to report on the incidence of time-dependent life-threatening events in male and female patients with long QT syndrome with an implantable cardioverter defibrillator (ICD). Methods and Results A total of 60 ...

journal_title：Journal of the American Heart Association

authors： Younis A,Aktas MK,Rosero S,Kutyifa V,Polonsky B,McNitt S,Sotoodehnia N,Kudenchuk P,Rea TD,Arking DE,Goldenberg I,Zareba W

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Perioperative antiplatelet agents potentially increase bleeding after non-ST-segment elevation (NSTE) acute coronary syndromes (ACS). The protease-activated receptor 1 antagonist vorapaxar reduced cardiovascular events and was associated with increased bleeding versus placebo in NSTE ACS, but its efficacy an...

journal_title：Journal of the American Heart Association

authors： van Diepen S,Tricoci P,Podder M,Westerhout CM,Aylward PE,Held C,Van de Werf F,Strony J,Wallentin L,Moliterno DJ,White HD,Mahaffey KW,Harrington RA,Armstrong PW

更新日期：2015-12-15 00:00:00